Gene: TLR2

7097
CD282|TIL4
toll like receptor 2
protein-coding
4q31.3
Ensembl:ENSG00000137462 MIM:603028 Vega:OTTHUMG00000161525 UniprotKB:O60603
NG_016229.1
PubMed
CD|OD|ND|AD
40   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.439e-1 (AD)  6.920e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FCGR2A0.951
LAIR10.94
RUNX10.932
SLC11A10.929
WAS0.927
ABI30.927
HCLS10.926
RHBDF20.925
FCGR1A0.924
PARVG0.923

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.537
CPLX3-0.515
WNT7A-0.508
NEUROD6-0.501
MARCH4-0.496
ZSCAN1-0.479
TMEM179-0.473
ATP2C2-0.464
SLC7A4-0.463
ABCC12-0.462

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00045Lyme disease vaccine (recombinant OspA)BiotechDrugApproved|WithdrawnTarget
DB03963S-(Dimethylarsenic)CysteineSmall MoleculeExperimentalTarget
DB05475GolotimodSmall Molecule229305-39-9InvestigationalTarget
DB11601Tuberculin Purified Protein DerivativeBiotechDrugApprovedTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TLR2 mRNA"28903501
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]"20174873
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TLR2 mRNA"20174873
C0152621,6-hexamethylene diisocyanate"1,6-hexamethylene diisocyanate affects the expression of TLR2 mRNA"19110044
C4681141-palmitoyl-2-arachidonyl-3-phosphorylcholine1-palmitoyl-2-arachidonyl-3-phosphorylcholine metabolite results in decreased activity of TLR2 protein27020609
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TLR2 mRNA]"21474333
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 protein]]"24612634
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone promotes the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 mRNA]]"24612634
C0382932,3-bis(palmitoyloxy)-2-propyl-N-palmitoyl-cysteinyl-seryl-seryl-asparaginyl-alanine"2,3-bis(palmitoyloxy)-2-propyl-N-palmitoyl-cysteinyl-seryl-seryl-asparaginyl-alanine binds to and results in increased activity of TLR2 protein"16299289
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of TLR2 mRNA"25710175
C0453052,4-dinitrofluorobenzene sulfonic acid"2,4-dinitrofluorobenzene sulfonic acid results in increased expression of TLR2 mRNA"17936526
C0038982-anisidine2-anisidine results in decreased expression of TLR2 mRNA28089782
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]"23452621
D000082AcetaminophenAcetaminophen results in increased expression of TLR2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of TLR2 mRNA17562736
D000111AcetylcysteineAcetylcysteine results in decreased expression of TLR2 mRNA22385246
D000111AcetylcysteineAcetylcysteine inhibits the reaction [iberin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]]25294874
D000119Acetylmuramyl-Alanyl-IsoglutamineAcetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of TLR2 protein15905553
D000119Acetylmuramyl-Alanyl-IsoglutamineAcetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of TLR2 protein15905553
D000119Acetylmuramyl-Alanyl-IsoglutamineTLR2 protein results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine analog15905553
D000068816AdapaleneAdapalene results in decreased expression of TLR2 protein17518990
C016601afimoxifeneafimoxifene results in increased expression of TLR2 mRNA23373633
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TLR2 mRNA28789997
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TLR2 protein22445859
C029753aflatoxin B2aflatoxin B2 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]22445859
C027955aflatoxin G1aflatoxin G1 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]22445859
D000447AldehydesAldehydes results in increased expression of TLR2 mRNA25014914
C008088alfacalcidolalfacalcidol results in decreased expression of TLR2 protein15946915
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TLR2 mRNA21298039
C018453ammonium hexachloroplatinateammonium hexachloroplatinate affects the expression of TLR2 mRNA19110044
D000666Amphotericin BTLR2 affects the susceptibility to Amphotericin B18466103
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TLR2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of TLR2 mRNA20471514
C006632arsenic trioxideBortezomib inhibits the reaction [arsenic trioxide results in decreased expression of TLR2 mRNA]20471514
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of TLR2 mRNA"23634900|2535159
D001205Ascorbic Acid[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA23692848
D001205Ascorbic Acid[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein23692848
D001205Ascorbic AcidCAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]23692848
D001205Ascorbic AcidCAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]23692848
D001205Ascorbic Acid"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]"23692848
D001205Ascorbic Acid"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]"23692848
D016589AstemizoleAstemizole results in decreased expression of TLR2 mRNA20221588
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of TLR2 protein16387846
D001379AzathioprineAzathioprine results in decreased expression of TLR2 mRNA19192274
D001379AzathioprineAzathioprine results in increased expression of TLR2 mRNA24184165
C547126AZM551248AZM551248 results in increased expression of TLR2 mRNA22323515
D001554BenzeneBenzene results in increased expression of TLR2 mRNA15929907|1916216
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of TLR2 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TLR2 mRNA22228805
D004958EstradiolEstradiol results in increased expression of TLR2 mRNA23373633
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of TLR2 mRNA17404688
D004958EstradiolEstradiol results in increased expression of TLR2 mRNA19484750
C034786bis(4-hydroxycinnamoyl)methane[bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of TLR2 mRNA22029407
C034786bis(4-hydroxycinnamoyl)methane[bis(4-hydroxycinnamoyl)methane co-treated with APP protein] results in increased expression of TLR2 mRNA22029407
C543008bis(4-hydroxyphenyl)sulfone[bis(4-hydroxyphenyl)sulfone co-treated with Pam(3)CSK(4) peptide] results in decreased expression of TLR2 mRNA28806546
C543008bis(4-hydroxyphenyl)sulfone[bis(4-hydroxyphenyl)sulfone co-treated with Poly I-C] results in decreased expression of TLR2 mRNA28806546
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of TLR2 mRNA28806546
C006780bisphenol A[bisphenol A co-treated with Pam(3)CSK(4) peptide] results in decreased expression of TLR2 mRNA28806546
C006780bisphenol A[bisphenol A co-treated with Poly I-C] results in decreased expression of TLR2 mRNA28806546
C006780bisphenol Abisphenol A results in decreased expression of TLR2 mRNA28806546
C006780bisphenol Abisphenol A results in decreased expression of TLR2 mRNA20678512
C006780bisphenol Abisphenol A results in decreased expression of TLR2 mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of TLR2 mRNA25181051
C000611646bisphenol F[bisphenol F co-treated with Pam(3)CSK(4) peptide] results in decreased expression of TLR2 mRNA28806546
C000611646bisphenol F[bisphenol F co-treated with Poly I-C] results in decreased expression of TLR2 mRNA28806546
C000611646bisphenol Fbisphenol F results in decreased expression of TLR2 mRNA28806546
D000069286BortezomibBortezomib inhibits the reaction [arsenic trioxide results in decreased expression of TLR2 mRNA]20471514
D000069286BortezomibBortezomib results in increased expression of TLR2 mRNA20471514
D001966BromineBromine results in increased expression of TLR2 mRNA21391292
D019328Buthionine Sulfoximine[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of TLR2 mRNA23986454
C018475butyraldehydebutyraldehyde results in increased expression of TLR2 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TLR2 mRNA20061341
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TLR2 mRNA29286200
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TLR2 mRNA21291945|2760129
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TLR2 protein21291945|2621827
D002251Carbon Tetrachlorideferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]21291945
D002251Carbon Tetrachlorideferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein]21291945
D002251Carbon TetrachlorideQuercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]27601294
D002251Carbon TetrachlorideQuercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein]26218279|2760129
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TLR2 mRNA22683883
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TLR2 protein22683883
D002251Carbon TetrachlorideCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]22683883
D002251Carbon TetrachlorideCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein]22683883
D002509CephaloridineCephaloridine results in increased expression of TLR2 mRNA18500788
C026690cerous chloridecerous chloride results in increased expression of TLR2 mRNA21656643
C026690cerous chloridecerous chloride results in increased expression of TLR2 protein21656643
D048271ChitosanChitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA]21329777
D048271ChitosanChitosan results in decreased expression of TLR2 mRNA21329777
C023676chloroquine diphosphatechloroquine diphosphate results in decreased expression of TLR2 mRNA19192274
D004390ChlorpyrifosChlorpyrifos results in decreased expression of TLR225643018
D002922CiguatoxinsCiguatoxins affects the expression of TLR2 mRNA18353800
D002953CitrininCitrinin results in increased expression of TLR2 mRNA22771370
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in decreased expression of TLR2 mRNA18078969
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [TLR2 protein binds to MYD88 protein]25780291
D003474CurcuminCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]23452621
D003474CurcuminCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]22683883
D003474CurcuminCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein]22683883
C038459curdlancurdlan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA]21329777
C038459curdlancurdlan results in decreased expression of TLR2 mRNA21329777
D016572CyclosporineCyclosporine results in increased expression of TLR2 mRNA20106945|2798913
C093628cyproconazolecyproconazole results in increased expression of TLR2 mRNA22334560
C007262deoxynivalenoldeoxynivalenol results in decreased expression of TLR2 mRNA22968694
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of TLR2 mRNA28962523
D002945CisplatinCisplatin results in increased expression of TLR2 protein16803524
D002945CisplatinCisplatin results in increased expression of TLR2 mRNA26546572
D004008DiclofenacDiclofenac results in decreased expression of TLR2 mRNA19192274
D004008DiclofenacDiclofenac results in increased expression of TLR2 mRNA26934552
D004041Dietary FatsDietary Fats results in increased expression of TLR2 mRNA22609946
D004041Dietary FatsDietary Fats results in increased expression of TLR2 mRNA22010203
D004041Dietary FatsTestosterone inhibits the reaction [Dietary Fats results in increased expression of TLR2 mRNA]22010203
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of TLR2 mRNA18164116
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of TLR2 mRNA"22485181
D004229DithiothreitolDithiothreitol inhibits the reaction [iberin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]]25294874
D004298DopamineDopamine results in increased expression of TLR2 mRNA21983523
D004317DoxorubicinTLR2 gene mutant form inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]15505089
D004317DoxorubicinTLR2 gene mutant form inhibits the reaction [Doxorubicin results in increased activity of RELA protein]15505089
D004317DoxorubicinTLR2 gene mutant form inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]15505089
D004317DoxorubicinTLR2 gene mutant form inhibits the reaction [Doxorubicin results in increased expression of IL6 protein]15505089
D004317DoxorubicinTLR2 gene mutant form inhibits the reaction [Doxorubicin results in increased expression of TNF protein]15505089
D004317DoxorubicinTLR2 gene mutant form results in decreased susceptibility to Doxorubicin15505089
D004317Doxorubicin[Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of TLR2 mRNA27181935
D004391DustDust results in increased expression of TLR2 mRNA22118940|2328113
D004391DustTLR2 gene mutant form inhibits the reaction [Dust results in increased expression of CCL2 protein]26882889
D004391DustTLR2 gene mutant form inhibits the reaction [Dust results in increased expression of CCL3 protein]26882889
D004391DustTLR2 gene mutant form inhibits the reaction [Dust results in increased expression of [IL12A protein binds to IL12B protein]]26882889
D004391DustTLR2 gene mutant form inhibits the reaction [Dust results in increased expression of IL6 protein]26882889
D004391DustTLR2 gene mutant form inhibits the reaction [Dust results in increased expression of TNF protein]26882889
D004391DustTLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein]26882889
D004391DustTLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL2 protein]26882889
D004391DustTLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL7 protein]26882889
D004391DustTLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein]26882889
D004391DustTLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL4 protein]26882889
D004391DustTLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL5 protein]26882889
D004391DustVitamin D inhibits the reaction [Dust results in increased expression of TLR2 mRNA]23281135
D015777EicosanoidsTLR2 protein promotes the reaction [Pam(3)CSK(4) peptide results in increased metabolism of Eicosanoids]17369491
D015777EicosanoidsTLR2 protein promotes the reaction [Peptidoglycan results in increased metabolism of Eicosanoids]17369491
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR2 protein]27890776
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR2 protein]27890776
C109476epoxiconazoleepoxiconazole results in increased expression of TLR2 mRNA22334560
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TLR2 mRNA17557909
D015025ZearalenoneZearalenone results in increased expression of TLR2 mRNA25455459
D018818FenoldopamFenoldopam results in increased expression of TLR2 mRNA21983523
C000499ferric oxideferric oxide analog results in increased expression of TLR2 mRNA24525745
C020748ferrous sulfate[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA23692848
C020748ferrous sulfate[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein23692848
C020748ferrous sulfateCAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]23692848
C020748ferrous sulfateCAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]23692848
C020748ferrous sulfate"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]"23692848
C020748ferrous sulfate"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]"23692848
C004999ferulic acidferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]21291945
C004999ferulic acidferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein]21291945
D004397FonofosFonofos results in increased methylation of TLR2 promoter22847954
C460864FSL-1 lipoprotein, synthetic"FSL-1 lipoprotein, synthetic binds to and results in increased activity of TLR2 protein"17938187
C460864FSL-1 lipoprotein, synthetic"[FSL-1 lipoprotein, synthetic binds to and results in increased activity of TLR2 protein] which affects the localization of and affects the activity of RELA protein"17938187
C460864FSL-1 lipoprotein, synthetic"TLR2 protein affects the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]"25200491
C460864FSL-1 lipoprotein, synthetic"TLR2 protein affects the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein]"25200491
C460864FSL-1 lipoprotein, synthetic"FSL-1 lipoprotein, synthetic binds to and results in increased activity of TLR2 protein"17938187
C460864FSL-1 lipoprotein, synthetic"FSL-1 lipoprotein, synthetic binds to and results in increased activity of TLR2 protein"23266719
D062610Fungal Polysaccharides[Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of TLR2 mRNA27181935
C039281furanfuran results in increased methylation of TLR2 gene22079235
D019833GenisteinGenistein inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]23452621
D005947GlucoseGlucose results in decreased expression of TLR2 protein20200188
D005978GlutathioneGlutathione results in decreased expression of TLR2 mRNA22385246
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in decreased expression of TLR2 mRNA19192274
D006632HistamineHistamine promotes the reaction [TLR2 results in increased expression of PTGS2]20040740
D006632HistamineHistamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone]20040740
D006632HistamineHRH1 affects the reaction [Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]]20040740
D017313FenretinideFenretinide results in increased expression of TLR2 mRNA28973697
D006820Hyaluronic AcidHyaluronic Acid metabolite results in increased expression of TLR2 mRNA23692848
D006820Hyaluronic AcidHyaluronic Acid metabolite results in increased expression of TLR2 protein23692848
D006820Hyaluronic Acid"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Hyaluronic Acid metabolite results in increased expression of TLR2 mRNA]"23692848
D006820Hyaluronic Acid"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Hyaluronic Acid metabolite results in increased expression of TLR2 protein]"23692848
D006854HydrocortisoneHydrocortisone results in increased expression of TLR2 mRNA17033190
C020755hydroxycitronellalhydroxycitronellal results in increased expression of TLR2 mRNA17936526
C082585iberinAcetylcysteine inhibits the reaction [iberin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]]25294874
C082585iberinDithiothreitol inhibits the reaction [iberin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]]25294874
C082585iberiniberin analog binds to TLR2 protein25294874
C082585iberiniberin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR2 protein]]25294874
C082585iberiniberin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR6 protein binds to TLR2 protein]]25294874
C082585iberiniberin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]25294874
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TLR2 mRNA25613284
C036643isoeugenolisoeugenol results in increased expression of TLR2 mRNA17936526
C561695(+)-JQ1 compound"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR2 mRNA]"24799421
C561695(+)-JQ1 compound"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR2 protein]"24799421
C064309kaempferol 3-O-sophorosidekaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein]22178603
D008055Lipids[Methotrexate analog binds to Lipids] which results in decreased expression of TLR2 mRNA24065615
C014643lipopeptidophosphoglycanCD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR2 protein]15910421
C014643lipopeptidophosphoglycanlipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein15910421
C014643lipopeptidophosphoglycan[lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] results in increased activity of [NFKB1 protein binds to RELA protein]15910421
C014643lipopeptidophosphoglycan[lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of CXCL8 protein15910421
C014643lipopeptidophosphoglycan[lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL10 protein15910421
C014643lipopeptidophosphoglycan[lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL12B protein15910421
C014643lipopeptidophosphoglycan[lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of TNF protein15910421
C014643lipopeptidophosphoglycanlipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein15910421
C014643lipopeptidophosphoglycanTLR2 protein results in increased susceptibility to lipopeptidophosphoglycan15910421
C433788lipopolysaccharide, E. coli O26-B6"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TLR2 mRNA]"21474333
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in decreased expression of TLR2 mRNA"23090859
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of TLR2 mRNA"21474333
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of TLR2 protein"21474333
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of TLR2 protein"17630318
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of TLR2 mRNA"11991888|1283267
C482199lipopolysaccharide, E coli O55-B5"Particulate Matter analog promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TLR2 mRNA]"12832678
C482199lipopolysaccharide, E coli O55-B5"Vehicle Emissions analog promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TLR2 mRNA]"12832678
C482199lipopolysaccharide, E coli O55-B5"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of TLR2 mRNA"20371263
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR2 mRNA"23840549
C440499lipopolysaccharide, Escherichia coli O111 B4"[Pam(3)CSK(4) peptide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR2 mRNA"23840549
C440499lipopolysaccharide, Escherichia coli O111 B4"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR2 mRNA]"24799421
C440499lipopolysaccharide, Escherichia coli O111 B4"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR2 protein]"24799421
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR2 mRNA"24799421
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR2 protein"24799421
C442865lipopolysaccharide, Helicobacter pylori"DDIT3 protein inhibits the reaction [TLR2 protein promotes the reaction [lipopolysaccharide, Helicobacter pylori results in increased expression of CCL20 mRNA]]"21220698
C442865lipopolysaccharide, Helicobacter pylori"DDIT3 protein inhibits the reaction [TLR2 protein promotes the reaction [lipopolysaccharide, Helicobacter pylori results in increased expression of CXCL8 mRNA]]"21220698
C442865lipopolysaccharide, Helicobacter pylori"lipopolysaccharide, Helicobacter pylori binds to and results in increased activity of TLR2 protein"21220698
C442865lipopolysaccharide, Helicobacter pylori"TLR2 protein promotes the reaction [lipopolysaccharide, Helicobacter pylori results in increased expression of CXCL8 mRNA]"21220698
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TLR2 mRNA19336472
D008070Lipopolysaccharides"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]"20174873
D008070LipopolysaccharidesChitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA]21329777
D008070Lipopolysaccharidescurdlan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA]21329777
D008070LipopolysaccharidesLipopolysaccharides binds to and results in increased activity of TLR2 protein12734376
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of TLR2 mRNA21329777
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TLR2 mRNA16443229|1971273
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TLR2 protein12176910|1644322
D008070Lipopolysaccharideslycopene inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]22429818
D008070LipopolysaccharidesSimvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]16443229
D008070LipopolysaccharidesTLR2 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAP2K4 protein]21112663
D008070LipopolysaccharidesTLR2 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]21112663
D008070LipopolysaccharidesZymosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA]21329777
D008070Lipopolysaccharidesaflatoxin B2 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]22445859
D008070Lipopolysaccharidesaflatoxin G1 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]22445859
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Ozone] results in increased expression of TLR2 mRNA16864405
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TLR2 mRNA12888452|1686440
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TLR2 protein10823826|2244585
D008070LipopolysaccharidesPolysaccharides inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]21875662
D008070LipopolysaccharidesSB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]12888452
D008070LipopolysaccharidesSN50 peptide inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]12888452
D008070LipopolysaccharidesSulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]12888452
D008070LipopolysaccharidesTLR2 affects the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]22905218
D008070LipopolysaccharidesTLR2 protein affects the susceptibility to Lipopolysaccharides15593098
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Titanium] results in increased expression of TLR2 mRNA21308757
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TLR2 mRNA21051124
D008070Lipopolysaccharidestributyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]21051124
D008070Lipopolysaccharidesiberin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR2 protein]]25294874
D008070Lipopolysaccharidesiberin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR6 protein binds to TLR2 protein]]25294874
C009900lipoteichoic acidlipoteichoic acid results in increased activity of TLR2 protein28003376
C009900lipoteichoic acidlipoteichoic acid binds to and results in increased activity of TLR2 protein18845389
C009900lipoteichoic acid[lipoteichoic acid binds to and results in increased activity of TLR2 protein] which results in increased expression of TNF mRNA18845389
C009900lipoteichoic acidlipoteichoic acid results in increased activity of TLR2 protein28003376
C009900lipoteichoic acidTLR2 protein affects the reaction [lipoteichoic acid results in increased abundance of Nitrites]19573522
C009900lipoteichoic acidTLR2 protein affects the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]19573522
C009900lipoteichoic acidTLR2 protein affects the reaction [lipoteichoic acid results in increased phosphorylation of RAF1 protein]19573522
C015329lycopenelycopene inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein]22429818
C015329lycopenelycopene inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]22429818
C106335macrophage stimulatory lipopeptide 2macrophage stimulatory lipopeptide 2 binds to and results in increased activity of TLR2 protein18096868|2060021
D058185Magnetite NanoparticlesMagnetite Nanoparticles results in increased expression of TLR2 mRNA24525745
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of TLR2 mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of TLR2 mRNA19564919
D008727Methotrexate[Methotrexate analog binds to Lipids] which results in decreased expression of TLR2 mRNA24065615
D008727MethotrexateMethotrexate results in decreased expression of TLR2 mRNA19192274
D008727MethotrexateMethotrexate results in increased expression of TLR2 mRNA21678067
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TLR2 mRNA26011545
D008775MethylprednisoloneMethylprednisolone results in decreased expression of TLR2 mRNA19192274
C008493methylselenic acidmethylselenic acid results in increased expression of TLR2 mRNA12517777
C502230Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]"23692848
C502230Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]"23692848
C502230Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Hyaluronic Acid metabolite results in increased expression of TLR2 mRNA]"23692848
C502230Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Hyaluronic Acid metabolite results in increased expression of TLR2 protein]"23692848
C523799MRK 003TLR2 results in increased susceptibility to MRK 00319903844
D009151Mustard GasMustard Gas results in increased expression of TLR2 mRNA18955075
D009151Mustard GasMustard Gas results in increased expression of TLR2 mRNA18988085
D037742Nanotubes, Carbon"Nanotubes, Carbon inhibits the reaction [TLR2 protein results in increased secretion of IL10 protein]"23266719
D037742Nanotubes, Carbon"Nanotubes, Carbon promotes the reaction [TLR2 protein results in increased secretion of IL6 protein]"23266719
D037742Nanotubes, Carbon"Nanotubes, Carbon promotes the reaction [TLR2 protein results in increased secretion of TNF protein]"23266719
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TLR2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TLR2 mRNA"25554681
D009532NickelNickel results in increased expression of TLR2 mRNA25583101
D009573NitritesTLR2 protein affects the reaction [lipoteichoic acid results in increased abundance of Nitrites]19573522
D009599Nitroprusside[Nitroprusside co-treated with TNF co-treated with IFNG] results in increased expression of TLR2 mRNA15153526
D010047OvalbuminTLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein]26882889
D010047OvalbuminTLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL2 protein]26882889
D010047OvalbuminTLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL7 protein]26882889
D010047OvalbuminTLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein]26882889
D010047OvalbuminTLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL4 protein]26882889
D010047OvalbuminTLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL5 protein]26882889
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of TLR2 mRNA25729387
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine binds to and results in decreased activity of TLR2 protein23500011
D010100Oxygen"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]"23452621
D010100OxygenCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]23452621
D010100OxygenGenistein inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]23452621
D010100OxygenOxygen deficiency results in increased expression of TLR2 mRNA23452621
D010100OxygenPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]23452621
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]23452621
D010126Ozone[Lipopolysaccharides co-treated with Ozone] results in increased expression of TLR2 mRNA16864405
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of TLR2 mRNA25658374
D010126OzoneOzone results in increased expression of TLR2 mRNA17626835
D010126OzoneTLR2 gene mutant form inhibits the reaction [Ozone results in increased expression of CXCL1 mRNA]17626835
D010126OzoneTLR2 gene mutant form inhibits the reaction [Ozone results in increased expression of IL6 mRNA]17626835
D010126OzoneTLR2 gene mutant form inhibits the reaction [Ozone results in increased expression of IL6 protein]17626835
D010126OzoneTLR2 gene mutant form results in decreased susceptibility to Ozone17626835
C508075Pam(3)CSK(4) peptide[bis(4-hydroxyphenyl)sulfone co-treated with Pam(3)CSK(4) peptide] results in decreased expression of TLR2 mRNA28806546
C508075Pam(3)CSK(4) peptide[bisphenol A co-treated with Pam(3)CSK(4) peptide] results in decreased expression of TLR2 mRNA28806546
C508075Pam(3)CSK(4) peptide[bisphenol F co-treated with Pam(3)CSK(4) peptide] results in decreased expression of TLR2 mRNA28806546
C508075Pam(3)CSK(4) peptidePam(3)CSK(4) peptide results in increased expression of TLR2 mRNA28806546
C508075Pam(3)CSK(4) peptide"[Pam(3)CSK(4) peptide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR2 mRNA"23840549
C508075Pam(3)CSK(4) peptidePam(3)CSK(4) peptide results in increased expression of TLR2 mRNA23840549
C508075Pam(3)CSK(4) peptideTLR2 protein promotes the reaction [Pam(3)CSK(4) peptide results in increased metabolism of Eicosanoids]17369491
C508075Pam(3)CSK(4) peptideAcetylcysteine inhibits the reaction [iberin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]]25294874
C508075Pam(3)CSK(4) peptideDithiothreitol inhibits the reaction [iberin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]]25294874
C508075Pam(3)CSK(4) peptideiberin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]25294874
C508075Pam(3)CSK(4) peptidePam(3)CSK(4) peptide binds to and results in increased activity of TLR2 protein23266719
C508075Pam(3)CSK(4) peptidePam(3)CSK(4) peptide results in increased activity of TLR2 protein25294874
C508075Pam(3)CSK(4) peptideQuercetin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]25294874
C508075Pam(3)CSK(4) peptidespiraeoside analog inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]25294874
D010269Paraquatepigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR2 protein]27890776
D010269ParaquatParaquat results in increased expression of TLR2 protein27890776
D010269Paraquatepigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR2 protein]27890776
D010269ParaquatParaquat results in increased expression of TLR2 protein27890776
D010278ParathionParathion results in increased methylation of TLR2 promoter22847954
D052638Particulate MatterParticulate Matter results in decreased expression of TLR2 protein17630318
D052638Particulate MatterTLR2 protein affects the reaction [Particulate Matter results in increased secretion of IL6 protein]20549640
D052638Particulate Matter"Particulate Matter analog promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TLR2 mRNA]"12832678
D052638Particulate MatterTLR2 gene mutant form inhibits the reaction [Particulate Matter results in increased secretion of CCL3 protein]23896513
D052638Particulate MatterTLR2 gene mutant form inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]23896513
D052638Particulate MatterTLR2 gene mutant form inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]23896513
D010416PentachlorophenolPentachlorophenol results in increased expression of TLR2 mRNA23892564
C046012pentanalpentanal results in increased expression of TLR2 mRNA26079696
D010457PeptidoglycanPeptidoglycan binds to and results in increased activity of TLR2 protein12734376
D010457PeptidoglycanPeptidoglycan binds to and results in increased activity of TLR2 protein15593098
D010457PeptidoglycanPeptidoglycan results in increased expression of TLR2 mRNA15593098
D010457PeptidoglycanPeptidoglycan results in increased expression of TLR2 protein15593098
D010457PeptidoglycanTLR2 protein affects the susceptibility to Peptidoglycan15593098
D010457PeptidoglycanTLR2 protein promotes the reaction [Peptidoglycan results in increased metabolism of Eicosanoids]17369491
D015232DinoprostoneHistamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone]20040740
D015232Dinoprostone[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone20040740
D010634PhenobarbitalPhenobarbital affects the expression of TLR2 mRNA19159669
D010672Phenytoin[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of TLR2 mRNA23986454
D010672PhenytoinPhenytoin results in increased expression of TLR2 mRNA23986454
D010862PilocarpinePilocarpine results in increased expression of TLR2 mRNA15193289
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TLR2 mRNA19710929
D010894PiroxicamPiroxicam results in decreased expression of TLR2 mRNA19192274
D010936Plant ExtractsPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]23452621
D011070Poly I-C[bis(4-hydroxyphenyl)sulfone co-treated with Poly I-C] results in decreased expression of TLR2 mRNA28806546
D011070Poly I-C[bisphenol A co-treated with Poly I-C] results in decreased expression of TLR2 mRNA28806546
D011070Poly I-C[bisphenol F co-treated with Poly I-C] results in decreased expression of TLR2 mRNA28806546
D011070Poly I-CPoly I-C results in increased expression of TLR2 mRNA17669408
D011134PolysaccharidesPolysaccharides inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]21875662
D011239PrednisolonePrednisolone results in decreased expression of TLR2 mRNA19192274
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of TLR2 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of TLR2 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of TLR2 mRNA21549006
D011374ProgesteroneProgesterone results in increased expression of TLR2 protein21549006
C045950propiconazolepropiconazole results in increased expression of TLR2 mRNA21278054|2233456
C005556propionaldehydepropionaldehyde results in increased expression of TLR2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of TLR2 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TLR2 mRNA27029645
D011794QuercetinQuercetin results in decreased expression of TLR2 mRNA20828867
D011794QuercetinQuercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]27601294
D011794QuercetinQuercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein]26218279|2760129
D011794QuercetinQuercetin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]25294874
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in decreased expression of TLR2 mRNA25800948
C059514resveratrol[resveratrol co-treated with TLR2 protein] results in decreased secretion of IL10 protein24035785
C059514resveratrol[resveratrol co-treated with TLR2 protein] results in increased secretion of IL6 protein24035785
C059514resveratrol[resveratrol co-treated with TLR2 protein] results in increased secretion of TNF protein24035785
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]23452621
C059514resveratrolresveratrol results in decreased activity of TLR2 protein24617573
C059514resveratrolresveratrol results in decreased expression of TLR2 protein23661603
C059514resveratrolresveratrol results in increased expression of TLR2 mRNA25905778
C034206RibomunylRibomunyl results in increased activity of TLR2 protein21817197
C034206RibomunylRibomunyl results in increased expression of TLR2 mRNA21817197
C089730rosiglitazone"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 protein]]"24612634
C089730rosiglitazone"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone promotes the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 mRNA]]"24612634
C089730rosiglitazonerosiglitazone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 protein]24612634
C089730rosiglitazonerosiglitazone promotes the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 mRNA]24612634
C093642SB 203580SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]12888452
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of TLR2 mRNA19564919
D012822Silicon DioxideSilicon Dioxide results in increased expression of TLR2 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of TLR2 mRNA23221170
D012822Silicon DioxideSilicon Dioxide results in increased expression of TLR2 mRNA21602193
D019821SimvastatinSimvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]16443229
D019821SimvastatinSimvastatin results in increased expression of TLR2 protein16387846
C118258SN50 peptideSN50 peptide inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]12888452
C016104sodium bichromatesodium bichromate results in decreased expression of TLR2 mRNA22561333
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of TLR2 mRNA17936526
D018038Sodium SeleniteSodium Selenite results in decreased expression of TLR2 mRNA23274088
D053260SootSoot results in increased expression of TLR2 mRNA22461453
C080613spiraeosidespiraeoside analog inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]25294874
C025971staphylococcal delta toxinstaphylococcal delta toxin binds to and results in increased activity of TLR2 protein15388451
D012460SulfasalazineSulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]12888452
D013467Sulindac"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of TLR2 mRNA"20371263
C490727T 91825T 91825 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 protein]27397760
C012568terbufosterbufos results in increased methylation of TLR2 promoter22847954
D013739TestosteroneTestosterone inhibits the reaction [Dietary Fats results in increased expression of TLR2 mRNA]22010203
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of TLR2 mRNA25461914
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone promotes the reaction [HMGB1 protein binds to TLR2 protein]27413111
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased expression of TLR2 mRNA27413111
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased expression of TLR2 protein27413111
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TLR2 mRNA21570461
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of TLR2 protein28720485
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TLR2 mRNA25613284
D014025Titanium[Lipopolysaccharides co-treated with Titanium] results in increased expression of TLR2 mRNA21308757
C009495titanium dioxidetitanium dioxide results in increased expression of TLR2 mRNA23409001|2355797
D014028Tobacco Smoke PollutionT 91825 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 protein]27397760
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TLR2 mRNA27404394
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TLR2 mRNA27480279|2786577
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TLR2 protein27397760|2872048
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TLR2 mRNA20133372
D014028Tobacco Smoke Pollution"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 protein]]"24612634
D014028Tobacco Smoke Pollution"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone promotes the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 mRNA]]"24612634
D014028Tobacco Smoke Pollutionrosiglitazone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 protein]24612634
D014028Tobacco Smoke Pollutionrosiglitazone promotes the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 mRNA]24612634
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TLR2 mRNA24612634
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TLR2 protein24612634
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of TLR2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of TLR2 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of TLR2 mRNA"19682533
C005830tributyrintributyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]21051124
C015559trimellitic anhydridetrimellitic anhydride affects the expression of TLR2 mRNA19110044
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of TLR216891783
D010853Picryl ChlorideTLR2 protein affects the reaction [TLR4 protein results in increased susceptibility to Picryl Chloride]18725520
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in decreased expression of TLR2 mRNA18078969
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of TLR2 protein17630318
D001335Vehicle Emissions"Vehicle Emissions analog promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TLR2 mRNA]"12832678
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TLR2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of TLR2 mRNA18629315
C029297vinylidene chloridevinylidene chloride results in increased expression of TLR2 mRNA26682919
D014801Vitamin AVitamin A results in increased expression of TLR2 mRNA17033190
D014807Vitamin DVitamin D results in decreased expression of TLR2 mRNA23281135
D014807Vitamin DVitamin D results in decreased expression of TLR2 protein23281135
D014807Vitamin DVitamin D inhibits the reaction [Dust results in increased expression of TLR2 mRNA]23281135
D015034Zinc Oxide[Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TLR2 protein25127755
D015034Zinc OxideZinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR2 mRNA]25127755
C017803zinc protoporphyrinzinc protoporphyrin promotes the reaction [TLR2 protein binds to MYD88 protein]25780291
D015054ZymosanZymosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA]21329777
D015054ZymosanZymosan results in decreased expression of TLR2 mRNA21329777
D015054ZymosanTLR2 protein promotes the reaction [Zymosan affects the activity of IFNG protein]17257219
D015054ZymosanTLR2 protein promotes the reaction [Zymosan results in increased expression of IL10 protein]17312158
D015054ZymosanTLR2 protein promotes the reaction [Zymosan results in increased expression of [IL12A protein binds to IL12B protein]]17312158
D015054ZymosanTLR2 protein promotes the reaction [Zymosan results in increased expression of IL2 protein]17312158
D015054ZymosanZymosan results in decreased expression of TLR2 mRNA14726497
D015054ZymosanZymosan results in increased expression of TLR2 protein10823826|1732146

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001530lipopolysaccharide binding-IDA11274165  
GO:0001540amyloid-beta binding-IDA22198949  
GO:0001540amyloid-beta binding-ISS-  
GO:0001875lipopolysaccharide receptor activity-TAS11518816  
GO:0005515protein binding-IPI10854325  11441107  12594264  15657077  16622205  16880211  
17095513  17126326  18765807  19509286  19880448  20802527  
23155421  23376921  24658140  
GO:0008329signaling pattern recognition receptor activity-IDA10384090  
GO:0035325Toll-like receptor binding-IPI16880211  
GO:0038023signaling receptor activity-TAS10426995  
GO:0042497triacyl lipopeptide binding-IDA17889651  
GO:0042802identical protein binding-IPI23155421  
GO:0042834peptidoglycan binding-IDA11986301  
GO:0044877protein-containing complex binding-IPI22198949  
GO:0046982protein heterodimerization activity-IDA17889651  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IEA-  
GO:0001774microglial cell activation-IEA-  
GO:0001775cell activation-IDA15294986  
GO:0002224toll-like receptor signaling pathway-IBA21873635  
GO:0002224toll-like receptor signaling pathway-TAS-  
GO:0002374cytokine secretion involved in immune response-IMP20441518  
GO:0002755MyD88-dependent toll-like receptor signaling pathway-TAS-  
GO:0006691leukotriene metabolic process-IEA-  
GO:0006915apoptotic process-TAS10426996  
GO:0006954inflammatory response-IBA21873635  
GO:0006954inflammatory response-IEA-  
GO:0006955immune response-TAS10426995  
GO:0007165signal transduction-TAS11044375  
GO:0007252I-kappaB phosphorylation-IDA19740627  
GO:0007612learning-ISS-  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0009636response to toxic substance-IEA-  
GO:0010628positive regulation of gene expression-IMP23817958  26649771  
GO:0014005microglia development-ISS-  
GO:0030177positive regulation of Wnt signaling pathway-IMP16601243  
GO:0031663lipopolysaccharide-mediated signaling pathway-IEA-  
GO:0032289central nervous system myelin formation-IEA-  
GO:0032570response to progesterone-IEA-  
GO:0032613interleukin-10 production-IDA23826189  
GO:0032640tumor necrosis factor production-ISS-  
GO:0032722positive regulation of chemokine production-IDA19740627  
GO:0032728positive regulation of interferon-beta production-ISS-  
GO:0032733positive regulation of interleukin-10 production-IEA-  
GO:0032735positive regulation of interleukin-12 production-ISS-  
GO:0032741positive regulation of interleukin-18 production-ISS-  
GO:0032755positive regulation of interleukin-6 production-IDA19740627  
GO:0032757positive regulation of interleukin-8 production-IDA17128265  19740627  
GO:0032760positive regulation of tumor necrosis factor production-ISS-  
GO:0032868response to insulin-IEA-  
GO:0034123positive regulation of toll-like receptor signaling pathway-IDA17128265  
GO:0034134toll-like receptor 2 signaling pathway-IEA-  
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway-TAS-  
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway-TAS-  
GO:0042495detection of triacyl bacterial lipopeptide-IDA19931471  
GO:0042496detection of diacyl bacterial lipopeptide-IDA19931471  
GO:0043312neutrophil degranulation-TAS-  
GO:0045087innate immune response-TAS15356140  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0046209nitric oxide metabolic process-IEA-  
GO:0048714positive regulation of oligodendrocyte differentiation-IEA-  
GO:0050729positive regulation of inflammatory response-IC19740627  
GO:0050765negative regulation of phagocytosis-ISS-  
GO:0050830defense response to Gram-positive bacterium-IDA11521063  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA12594207  21618349  
GO:0051770positive regulation of nitric-oxide synthase biosynthetic process-ISS-  
GO:0051964negative regulation of synapse assembly-ISS-  
GO:0070542response to fatty acid-IEA-  
GO:0071221cellular response to bacterial lipopeptide-TAS15356140  
GO:0071223cellular response to lipoteichoic acid-IDA12594207  
GO:0071223cellular response to lipoteichoic acid-IMP26649771  
GO:0071346cellular response to interferon-gamma-IDA11672593  
GO:0071726cellular response to diacyl bacterial lipopeptide-IDA16880211  19931471  
GO:0071727cellular response to triacyl bacterial lipopeptide-IDA16880211  19931471  
GO:1901224positive regulation of NIK/NF-kappaB signaling-IDA19740627  
GO:1903974positive regulation of cellular response to macrophage colony-stimulating factor stimulus-IDA11672593  
GO:2000484positive regulation of interleukin-8 secretion-IGI22198949  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA19740627  
GO:0005794Golgi apparatus-IDA16880211  
GO:0005886plasma membrane-IDA19740627  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS9435236  
GO:0009986cell surface-IDA12443841  
GO:0030667secretory granule membrane-TAS-  
GO:0030670phagocytic vesicle membrane-IEA-  
GO:0031226intrinsic component of plasma membrane-IBA21873635  
GO:0031226intrinsic component of plasma membrane-IDA11274165  
GO:0035354Toll-like receptor 1-Toll-like receptor 2 protein complex-IDA17889651  
GO:0042995cell projection-IEA-  
GO:0044297cell body-IEA-  
GO:0045121membrane raft-IDA16880211  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04620Toll-like receptor signaling pathway
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05144Malaria
hsa05145Toxoplasmosis
hsa05146Amoebiasis
hsa05323Rheumatoid arthritis
Reactome ID Reactome Term Evidence
R-HSA-1236974ER-Phagosome pathwayTAS
R-HSA-1236975Antigen processing-Cross presentationTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1461957Beta defensinsTAS
R-HSA-1461973DefensinsTAS
R-HSA-1643685DiseaseTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-5260271Diseases of Immune SystemTAS
R-HSA-5602358Diseases associated with the TLR signaling cascadeTAS
R-HSA-5602498MyD88 deficiency (TLR2/4)TAS
R-HSA-5603041IRAK4 deficiency (TLR2/4)TAS
R-HSA-5686938Regulation of TLR by endogenous ligandTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6803157Antimicrobial peptidesTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23823019A TLR6 polymorphism is associated with increased risk of Legionnaires' disease. (2013 Oct)Misch EAGenes Immun
22251071Common genetic risk variants of TLR2 are not associated with periodontitis in large European case-control populations. (2012 Apr)Richter GMJ Clin Periodontol
27274225Effects of budesonide on toll-like receptor expression in alveolar macrophages from smokers with and without COPD. (2016)Ji JInt J Chron Obstruct Pulmon Dis
26846412Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study. (2016 Feb 5)Ramos BRBMC Pregnancy Childbirth
28009434Gene polymorphisms of TLR2 and TLR3 in HBV clearance and HBV-related hepatocellular carcinoma in a Chinese male population. (2017 May 4)Chen DInt J Biol Markers
28956832Multiple Gene-Environment Interactions on the Angiogenesis Gene-Pathway Impact Rectal Cancer Risk and Survival. (2017 Sep 28)Sharafeldin NInt J Environ Res Public Health
24454004Effects of polymorphisms of innate immunity genes and environmental factors on the risk of noncardia gastric cancer. (2013 Dec)Kim JCancer Res Treat
16870663Maternal smoking is associated with impaired neonatal toll-like-receptor-mediated immune responses. (2006 Oct)Noakes PSEur Respir J
21738617Bone marrow mononuclear cells up-regulate toll-like receptor expression and produce inflammatory mediators in response to cigarette smoke extract. (2011)Zhou JPLoS One
23998736Role of Toll-like receptor 2 (-196 to -174) polymorphism in susceptibility to pulmonary tuberculosis in Pakistani population. (2014 Apr)Khan AUInt J Immunogenet
17332447Toll receptor polymorphisms and carotid artery intima-media thickness. (2007 Apr)Labrum RStroke
20337891The del/del genotype of the nuclear factor-kappaB -94ATTG polymorphism and its relation to aggressive periodontitis. (2010 Jun)Schulz SJ Periodontal Res
24612634PPARgamma agonists regulate tobacco smoke-induced Toll like receptor 4 expression in alveolar macrophages. (2014 Mar 11)Yin YRespir Res
28656364The critical role of macrophages in the pathogenesis of hidradenitis suppurativa. (2017 Nov)Shah AInflamm Res
26208141TLR2 and TLR4 Expression and Inflammatory Cytokines are Altered in the Airway Epithelium of Those with Alcohol Use Disorders. (2015 Sep)Bailey KLAlcohol Clin Exp Res
26072521A Candidate-Pathway Approach to Identify Gene-Environment Interactions: Analyses of Colon Cancer Risk and Survival. (2015 Sep)Sharafeldin NJ Natl Cancer Inst
28518213Relationship between toll-like receptor 2 R753Q and T16934A polymorphisms and Staphylococcus aureus nasal carriage. (2017)Zukowski MAnaesthesiol Intensive Ther
22994343Toll-like receptors 2, 3 and 4 and thymic stromal lymphopoietin expression in fatal asthma. (2012 Oct)Ferreira DSClin Exp Allergy
21224062Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFkappaB activation resulting in a microenvironment predisposed to ectopic pregnancy. (2011 Jan)Shaw JLAm J Pathol
29066918Asthma with bronchial hypersecretion: expression of mucins and toll-like receptors in sputum and blood. (2017)Crespo-Lessmann AJ Asthma Allergy
16844729Innate immune activation in neutrophilic asthma and bronchiectasis. (2007 Mar)Simpson JLThorax
22878868Nicotine treatment improves Toll-like receptor 2 and Toll-like receptor 9 responsiveness in active pulmonary sarcoidosis. (2013 Feb 1)Julian MWChest
22999059Functional polymorphisms of Toll-like receptors 2 and 4 alter the risk for colorectal carcinoma in Europeans. (2013 Jan)Pimentel-Nunes PDig Liver Dis
19766998High expression level of Toll-like receptor 2 on monocytes is an important risk factor for arteriosclerotic disease. (2010 Mar)Kuwahata SAtherosclerosis
26371589A toll-like receptor 9 (rs352140) variant is associated with placental inflammation in newborn infants. (2016)Karody VJ Matern Fetal Neonatal Med
28560381Hypomethylation of the Toll-like receptor-2 gene increases the risk of essential hypertension. (2017 Jul)Mao SMol Med Rep
21439805Toll-like receptor expression in smokers with and without COPD. (2011 Aug)von Scheele IRespir Med
26860188Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis. (2016 Feb 9)Liao KJ Neuroinflammation
24776844Associations between functional polymorphisms in the NFkappaB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease. (2014 Dec)Bank SPharmacogenomics J
18034897Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke. (2007 Nov 22)MacRedmond RERespir Res
21792899Toll-like receptor genes and their association with colon and rectal cancer development and prognosis. (2012 Jun 15)Slattery MLInt J Cancer
23606791Influence of age, past smoking, and disease severity on TLR2, neutrophilic inflammation, and MMP-9 levels in COPD. (2013)Simpson JLMediators Inflamm
27920557Effect of smoking on the genetic makeup of toll-like receptors 2 and 6. (2016)Kohailan MOnco Targets Ther
25346143Expression of nucleic acid-sensing Toll-like receptors predicts HPV16 clearance associated with an E6-directed cell-mediated response. (2015 May 15)Scott MEInt J Cancer
26880585Association of toll-like receptor 2 22 and risk for gastric cancer considering main effects and interactions with smoking: a matched case-control study from Mizoram, India. (2016 Aug)Mukherjee DTumour Biol
23206318High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence. (2013 Apr 1)Crews FTBiol Psychiatry
26617606Cigarette Smoke Amplifies Inflammatory Response and Atherosclerosis Progression Through Activation of the H1R-TLR2/4-COX2 Axis. (2015)Barua RSFront Immunol
19675120Altered innate immune response in farmers and smokers. (2010 Feb)Sahlander KInnate Immun
27397760Effects of ceftaroline on the innate immune and on the inflammatory responses of bronchial epithelial cells exposed to cigarette smoke. (2016 Sep 6)Pace EToxicol Lett
21425908Toll-like receptor expression and activation in astroglia: differential regulation by HIV-1 Tat, gp120, and morphine. (2011)El-Hage NImmunol Invest