Gene info: ID 7097

Gene: TLR2

GENE ID: 7097

Synonyms: CD282|TIL4

Description: toll like receptor 2

Gene type: protein-coding

Location: 4q31.3

dbXrefs: Ensembl:ENSG00000137462 MIM:603028 Vega:OTTHUMG00000161525 UniprotKB:O60603

RefSeq: NG_016229.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 40

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.439e-1 (AD) 6.920e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FCGR2A	0.951
LAIR1	0.94
RUNX1	0.932
SLC11A1	0.929
WAS	0.927
ABI3	0.927
HCLS1	0.926
RHBDF2	0.925
FCGR1A	0.924
PARVG	0.923

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KCNIP3	-0.537
CPLX3	-0.515
WNT7A	-0.508
NEUROD6	-0.501
MARCH4	-0.496
ZSCAN1	-0.479
TMEM179	-0.473
ATP2C2	-0.464
SLC7A4	-0.463
ABCC12	-0.462

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00045	Lyme disease vaccine (recombinant OspA)	BiotechDrug		Approved\|Withdrawn	Target
DB03963	S-(Dimethylarsenic)Cysteine	Small Molecule		Experimental	Target
DB05475	Golotimod	Small Molecule	229305-39-9	Investigational	Target
DB11601	Tuberculin Purified Protein Derivative	BiotechDrug		Approved	Target

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TLR2 mRNA"	28903501
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]"	20174873
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TLR2 mRNA"	20174873
C015262	1,6-hexamethylene diisocyanate	"1,6-hexamethylene diisocyanate affects the expression of TLR2 mRNA"	19110044
C468114	1-palmitoyl-2-arachidonyl-3-phosphorylcholine	1-palmitoyl-2-arachidonyl-3-phosphorylcholine metabolite results in decreased activity of TLR2 protein	27020609
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TLR2 mRNA]"	21474333
C019273	2,2-bis(4-glycidyloxyphenyl)propane	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 protein]]"	24612634
C019273	2,2-bis(4-glycidyloxyphenyl)propane	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone promotes the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 mRNA]]"	24612634
C038293	2,3-bis(palmitoyloxy)-2-propyl-N-palmitoyl-cysteinyl-seryl-seryl-asparaginyl-alanine	"2,3-bis(palmitoyloxy)-2-propyl-N-palmitoyl-cysteinyl-seryl-seryl-asparaginyl-alanine binds to and results in increased activity of TLR2 protein"	16299289
C013186	2,3-pentanedione	"2,3-pentanedione results in decreased expression of TLR2 mRNA"	25710175
C045305	2,4-dinitrofluorobenzene sulfonic acid	"2,4-dinitrofluorobenzene sulfonic acid results in increased expression of TLR2 mRNA"	17936526
C003898	2-anisidine	2-anisidine results in decreased expression of TLR2 mRNA	28089782
C524042	3,5-bis(2-fluorobenzylidene)piperidin-4-one	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]"	23452621
D000082	Acetaminophen	Acetaminophen results in increased expression of TLR2 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of TLR2 mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine results in decreased expression of TLR2 mRNA	22385246
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [iberin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]]	25294874
D000119	Acetylmuramyl-Alanyl-Isoglutamine	Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of TLR2 protein	15905553
D000119	Acetylmuramyl-Alanyl-Isoglutamine	Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of TLR2 protein	15905553
D000119	Acetylmuramyl-Alanyl-Isoglutamine	TLR2 protein results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine analog	15905553
D000068816	Adapalene	Adapalene results in decreased expression of TLR2 protein	17518990
C016601	afimoxifene	afimoxifene results in increased expression of TLR2 mRNA	23373633
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TLR2 mRNA	28789997
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TLR2 protein	22445859
C029753	aflatoxin B2	aflatoxin B2 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]	22445859
C027955	aflatoxin G1	aflatoxin G1 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]	22445859
D000447	Aldehydes	Aldehydes results in increased expression of TLR2 mRNA	25014914
C008088	alfacalcidol	alfacalcidol results in decreased expression of TLR2 protein	15946915
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of TLR2 mRNA	21298039
C018453	ammonium hexachloroplatinate	ammonium hexachloroplatinate affects the expression of TLR2 mRNA	19110044
D000666	Amphotericin B	TLR2 affects the susceptibility to Amphotericin B	18466103
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of TLR2 mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of TLR2 mRNA	20471514
C006632	arsenic trioxide	Bortezomib inhibits the reaction [arsenic trioxide results in decreased expression of TLR2 mRNA]	20471514
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of TLR2 mRNA"	23634900\|2535159
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA	23692848
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein	23692848
D001205	Ascorbic Acid	CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]	23692848
D001205	Ascorbic Acid	CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]	23692848
D001205	Ascorbic Acid	"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]"	23692848
D001205	Ascorbic Acid	"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]"	23692848
D016589	Astemizole	Astemizole results in decreased expression of TLR2 mRNA	20221588
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased expression of TLR2 protein	16387846
D001379	Azathioprine	Azathioprine results in decreased expression of TLR2 mRNA	19192274
D001379	Azathioprine	Azathioprine results in increased expression of TLR2 mRNA	24184165
C547126	AZM551248	AZM551248 results in increased expression of TLR2 mRNA	22323515
D001554	Benzene	Benzene results in increased expression of TLR2 mRNA	15929907\|1916216
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of TLR2 mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TLR2 mRNA	22228805
D004958	Estradiol	Estradiol results in increased expression of TLR2 mRNA	23373633
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of TLR2 mRNA	17404688
D004958	Estradiol	Estradiol results in increased expression of TLR2 mRNA	19484750
C034786	bis(4-hydroxycinnamoyl)methane	[bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of TLR2 mRNA	22029407
C034786	bis(4-hydroxycinnamoyl)methane	[bis(4-hydroxycinnamoyl)methane co-treated with APP protein] results in increased expression of TLR2 mRNA	22029407
C543008	bis(4-hydroxyphenyl)sulfone	[bis(4-hydroxyphenyl)sulfone co-treated with Pam(3)CSK(4) peptide] results in decreased expression of TLR2 mRNA	28806546
C543008	bis(4-hydroxyphenyl)sulfone	[bis(4-hydroxyphenyl)sulfone co-treated with Poly I-C] results in decreased expression of TLR2 mRNA	28806546
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of TLR2 mRNA	28806546
C006780	bisphenol A	[bisphenol A co-treated with Pam(3)CSK(4) peptide] results in decreased expression of TLR2 mRNA	28806546
C006780	bisphenol A	[bisphenol A co-treated with Poly I-C] results in decreased expression of TLR2 mRNA	28806546
C006780	bisphenol A	bisphenol A results in decreased expression of TLR2 mRNA	28806546
C006780	bisphenol A	bisphenol A results in decreased expression of TLR2 mRNA	20678512
C006780	bisphenol A	bisphenol A results in decreased expression of TLR2 mRNA	25594700
C006780	bisphenol A	bisphenol A results in increased expression of TLR2 mRNA	25181051
C000611646	bisphenol F	[bisphenol F co-treated with Pam(3)CSK(4) peptide] results in decreased expression of TLR2 mRNA	28806546
C000611646	bisphenol F	[bisphenol F co-treated with Poly I-C] results in decreased expression of TLR2 mRNA	28806546
C000611646	bisphenol F	bisphenol F results in decreased expression of TLR2 mRNA	28806546
D000069286	Bortezomib	Bortezomib inhibits the reaction [arsenic trioxide results in decreased expression of TLR2 mRNA]	20471514
D000069286	Bortezomib	Bortezomib results in increased expression of TLR2 mRNA	20471514
D001966	Bromine	Bromine results in increased expression of TLR2 mRNA	21391292
D019328	Buthionine Sulfoximine	[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of TLR2 mRNA	23986454
C018475	butyraldehyde	butyraldehyde results in increased expression of TLR2 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TLR2 mRNA	20061341
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of TLR2 mRNA	29286200
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TLR2 mRNA	21291945\|2760129
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TLR2 protein	21291945\|2621827
D002251	Carbon Tetrachloride	ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]	21291945
D002251	Carbon Tetrachloride	ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein]	21291945
D002251	Carbon Tetrachloride	Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]	27601294
D002251	Carbon Tetrachloride	Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein]	26218279\|2760129
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TLR2 mRNA	22683883
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TLR2 protein	22683883
D002251	Carbon Tetrachloride	Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]	22683883
D002251	Carbon Tetrachloride	Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein]	22683883
D002509	Cephaloridine	Cephaloridine results in increased expression of TLR2 mRNA	18500788
C026690	cerous chloride	cerous chloride results in increased expression of TLR2 mRNA	21656643
C026690	cerous chloride	cerous chloride results in increased expression of TLR2 protein	21656643
D048271	Chitosan	Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA]	21329777
D048271	Chitosan	Chitosan results in decreased expression of TLR2 mRNA	21329777
C023676	chloroquine diphosphate	chloroquine diphosphate results in decreased expression of TLR2 mRNA	19192274
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of TLR2	25643018
D002922	Ciguatoxins	Ciguatoxins affects the expression of TLR2 mRNA	18353800
D002953	Citrinin	Citrinin results in increased expression of TLR2 mRNA	22771370
D003035	Cobalt	[tungsten carbide co-treated with Cobalt] results in decreased expression of TLR2 mRNA	18078969
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [TLR2 protein binds to MYD88 protein]	25780291
D003474	Curcumin	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]	23452621
D003474	Curcumin	Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]	22683883
D003474	Curcumin	Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein]	22683883
C038459	curdlan	curdlan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA]	21329777
C038459	curdlan	curdlan results in decreased expression of TLR2 mRNA	21329777
D016572	Cyclosporine	Cyclosporine results in increased expression of TLR2 mRNA	20106945\|2798913
C093628	cyproconazole	cyproconazole results in increased expression of TLR2 mRNA	22334560
C007262	deoxynivalenol	deoxynivalenol results in decreased expression of TLR2 mRNA	22968694
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of TLR2 mRNA	28962523
D002945	Cisplatin	Cisplatin results in increased expression of TLR2 protein	16803524
D002945	Cisplatin	Cisplatin results in increased expression of TLR2 mRNA	26546572
D004008	Diclofenac	Diclofenac results in decreased expression of TLR2 mRNA	19192274
D004008	Diclofenac	Diclofenac results in increased expression of TLR2 mRNA	26934552
D004041	Dietary Fats	Dietary Fats results in increased expression of TLR2 mRNA	22609946
D004041	Dietary Fats	Dietary Fats results in increased expression of TLR2 mRNA	22010203
D004041	Dietary Fats	Testosterone inhibits the reaction [Dietary Fats results in increased expression of TLR2 mRNA]	22010203
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of TLR2 mRNA	18164116
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of TLR2 mRNA"	22485181
D004229	Dithiothreitol	Dithiothreitol inhibits the reaction [iberin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]]	25294874
D004298	Dopamine	Dopamine results in increased expression of TLR2 mRNA	21983523
D004317	Doxorubicin	TLR2 gene mutant form inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]	15505089
D004317	Doxorubicin	TLR2 gene mutant form inhibits the reaction [Doxorubicin results in increased activity of RELA protein]	15505089
D004317	Doxorubicin	TLR2 gene mutant form inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]	15505089
D004317	Doxorubicin	TLR2 gene mutant form inhibits the reaction [Doxorubicin results in increased expression of IL6 protein]	15505089
D004317	Doxorubicin	TLR2 gene mutant form inhibits the reaction [Doxorubicin results in increased expression of TNF protein]	15505089
D004317	Doxorubicin	TLR2 gene mutant form results in decreased susceptibility to Doxorubicin	15505089
D004317	Doxorubicin	[Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of TLR2 mRNA	27181935
D004391	Dust	Dust results in increased expression of TLR2 mRNA	22118940\|2328113
D004391	Dust	TLR2 gene mutant form inhibits the reaction [Dust results in increased expression of CCL2 protein]	26882889
D004391	Dust	TLR2 gene mutant form inhibits the reaction [Dust results in increased expression of CCL3 protein]	26882889
D004391	Dust	TLR2 gene mutant form inhibits the reaction [Dust results in increased expression of [IL12A protein binds to IL12B protein]]	26882889
D004391	Dust	TLR2 gene mutant form inhibits the reaction [Dust results in increased expression of IL6 protein]	26882889
D004391	Dust	TLR2 gene mutant form inhibits the reaction [Dust results in increased expression of TNF protein]	26882889
D004391	Dust	TLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein]	26882889
D004391	Dust	TLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL2 protein]	26882889
D004391	Dust	TLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL7 protein]	26882889
D004391	Dust	TLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein]	26882889
D004391	Dust	TLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL4 protein]	26882889
D004391	Dust	TLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL5 protein]	26882889
D004391	Dust	Vitamin D inhibits the reaction [Dust results in increased expression of TLR2 mRNA]	23281135
D015777	Eicosanoids	TLR2 protein promotes the reaction [Pam(3)CSK(4) peptide results in increased metabolism of Eicosanoids]	17369491
D015777	Eicosanoids	TLR2 protein promotes the reaction [Peptidoglycan results in increased metabolism of Eicosanoids]	17369491
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR2 protein]	27890776
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR2 protein]	27890776
C109476	epoxiconazole	epoxiconazole results in increased expression of TLR2 mRNA	22334560
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of TLR2 mRNA	17557909
D015025	Zearalenone	Zearalenone results in increased expression of TLR2 mRNA	25455459
D018818	Fenoldopam	Fenoldopam results in increased expression of TLR2 mRNA	21983523
C000499	ferric oxide	ferric oxide analog results in increased expression of TLR2 mRNA	24525745
C020748	ferrous sulfate	[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA	23692848
C020748	ferrous sulfate	[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein	23692848
C020748	ferrous sulfate	CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]	23692848
C020748	ferrous sulfate	CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]	23692848
C020748	ferrous sulfate	"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]"	23692848
C020748	ferrous sulfate	"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]"	23692848
C004999	ferulic acid	ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]	21291945
C004999	ferulic acid	ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein]	21291945
D004397	Fonofos	Fonofos results in increased methylation of TLR2 promoter	22847954
C460864	FSL-1 lipoprotein, synthetic	"FSL-1 lipoprotein, synthetic binds to and results in increased activity of TLR2 protein"	17938187
C460864	FSL-1 lipoprotein, synthetic	"[FSL-1 lipoprotein, synthetic binds to and results in increased activity of TLR2 protein] which affects the localization of and affects the activity of RELA protein"	17938187
C460864	FSL-1 lipoprotein, synthetic	"TLR2 protein affects the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]"	25200491
C460864	FSL-1 lipoprotein, synthetic	"TLR2 protein affects the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein]"	25200491
C460864	FSL-1 lipoprotein, synthetic	"FSL-1 lipoprotein, synthetic binds to and results in increased activity of TLR2 protein"	17938187
C460864	FSL-1 lipoprotein, synthetic	"FSL-1 lipoprotein, synthetic binds to and results in increased activity of TLR2 protein"	23266719
D062610	Fungal Polysaccharides	[Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of TLR2 mRNA	27181935
C039281	furan	furan results in increased methylation of TLR2 gene	22079235
D019833	Genistein	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]	23452621
D005947	Glucose	Glucose results in decreased expression of TLR2 protein	20200188
D005978	Glutathione	Glutathione results in decreased expression of TLR2 mRNA	22385246
D006052	Gold Sodium Thiomalate	Gold Sodium Thiomalate results in decreased expression of TLR2 mRNA	19192274
D006632	Histamine	Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]	20040740
D006632	Histamine	Histamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone]	20040740
D006632	Histamine	HRH1 affects the reaction [Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]]	20040740
D017313	Fenretinide	Fenretinide results in increased expression of TLR2 mRNA	28973697
D006820	Hyaluronic Acid	Hyaluronic Acid metabolite results in increased expression of TLR2 mRNA	23692848
D006820	Hyaluronic Acid	Hyaluronic Acid metabolite results in increased expression of TLR2 protein	23692848
D006820	Hyaluronic Acid	"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Hyaluronic Acid metabolite results in increased expression of TLR2 mRNA]"	23692848
D006820	Hyaluronic Acid	"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Hyaluronic Acid metabolite results in increased expression of TLR2 protein]"	23692848
D006854	Hydrocortisone	Hydrocortisone results in increased expression of TLR2 mRNA	17033190
C020755	hydroxycitronellal	hydroxycitronellal results in increased expression of TLR2 mRNA	17936526
C082585	iberin	Acetylcysteine inhibits the reaction [iberin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]]	25294874
C082585	iberin	Dithiothreitol inhibits the reaction [iberin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]]	25294874
C082585	iberin	iberin analog binds to TLR2 protein	25294874
C082585	iberin	iberin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR2 protein]]	25294874
C082585	iberin	iberin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR6 protein binds to TLR2 protein]]	25294874
C082585	iberin	iberin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]	25294874
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TLR2 mRNA	25613284
C036643	isoeugenol	isoeugenol results in increased expression of TLR2 mRNA	17936526
C561695	(+)-JQ1 compound	"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR2 mRNA]"	24799421
C561695	(+)-JQ1 compound	"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR2 protein]"	24799421
C064309	kaempferol 3-O-sophoroside	kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein]	22178603
D008055	Lipids	[Methotrexate analog binds to Lipids] which results in decreased expression of TLR2 mRNA	24065615
C014643	lipopeptidophosphoglycan	CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR2 protein]	15910421
C014643	lipopeptidophosphoglycan	lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein	15910421
C014643	lipopeptidophosphoglycan	[lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] results in increased activity of [NFKB1 protein binds to RELA protein]	15910421
C014643	lipopeptidophosphoglycan	[lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of CXCL8 protein	15910421
C014643	lipopeptidophosphoglycan	[lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL10 protein	15910421
C014643	lipopeptidophosphoglycan	[lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL12B protein	15910421
C014643	lipopeptidophosphoglycan	[lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of TNF protein	15910421
C014643	lipopeptidophosphoglycan	lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein	15910421
C014643	lipopeptidophosphoglycan	TLR2 protein results in increased susceptibility to lipopeptidophosphoglycan	15910421
C433788	lipopolysaccharide, E. coli O26-B6	"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TLR2 mRNA]"	21474333
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in decreased expression of TLR2 mRNA"	23090859
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in increased expression of TLR2 mRNA"	21474333
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in increased expression of TLR2 protein"	21474333
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of TLR2 protein"	17630318
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of TLR2 mRNA"	11991888\|1283267
C482199	lipopolysaccharide, E coli O55-B5	"Particulate Matter analog promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TLR2 mRNA]"	12832678
C482199	lipopolysaccharide, E coli O55-B5	"Vehicle Emissions analog promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TLR2 mRNA]"	12832678
C482199	lipopolysaccharide, E coli O55-B5	"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of TLR2 mRNA"	20371263
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR2 mRNA"	23840549
C440499	lipopolysaccharide, Escherichia coli O111 B4	"[Pam(3)CSK(4) peptide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR2 mRNA"	23840549
C440499	lipopolysaccharide, Escherichia coli O111 B4	"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR2 mRNA]"	24799421
C440499	lipopolysaccharide, Escherichia coli O111 B4	"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR2 protein]"	24799421
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR2 mRNA"	24799421
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR2 protein"	24799421
C442865	lipopolysaccharide, Helicobacter pylori	"DDIT3 protein inhibits the reaction [TLR2 protein promotes the reaction [lipopolysaccharide, Helicobacter pylori results in increased expression of CCL20 mRNA]]"	21220698
C442865	lipopolysaccharide, Helicobacter pylori	"DDIT3 protein inhibits the reaction [TLR2 protein promotes the reaction [lipopolysaccharide, Helicobacter pylori results in increased expression of CXCL8 mRNA]]"	21220698
C442865	lipopolysaccharide, Helicobacter pylori	"lipopolysaccharide, Helicobacter pylori binds to and results in increased activity of TLR2 protein"	21220698
C442865	lipopolysaccharide, Helicobacter pylori	"TLR2 protein promotes the reaction [lipopolysaccharide, Helicobacter pylori results in increased expression of CXCL8 mRNA]"	21220698
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TLR2 mRNA	19336472
D008070	Lipopolysaccharides	"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]"	20174873
D008070	Lipopolysaccharides	Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA]	21329777
D008070	Lipopolysaccharides	curdlan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA]	21329777
D008070	Lipopolysaccharides	Lipopolysaccharides binds to and results in increased activity of TLR2 protein	12734376
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of TLR2 mRNA	21329777
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TLR2 mRNA	16443229\|1971273
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TLR2 protein	12176910\|1644322
D008070	Lipopolysaccharides	lycopene inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]	22429818
D008070	Lipopolysaccharides	Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]	16443229
D008070	Lipopolysaccharides	TLR2 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAP2K4 protein]	21112663
D008070	Lipopolysaccharides	TLR2 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]	21112663
D008070	Lipopolysaccharides	Zymosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA]	21329777
D008070	Lipopolysaccharides	aflatoxin B2 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]	22445859
D008070	Lipopolysaccharides	aflatoxin G1 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]	22445859
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Ozone] results in increased expression of TLR2 mRNA	16864405
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TLR2 mRNA	12888452\|1686440
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TLR2 protein	10823826\|2244585
D008070	Lipopolysaccharides	Polysaccharides inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]	21875662
D008070	Lipopolysaccharides	SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]	12888452
D008070	Lipopolysaccharides	SN50 peptide inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]	12888452
D008070	Lipopolysaccharides	Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]	12888452
D008070	Lipopolysaccharides	TLR2 affects the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]	22905218
D008070	Lipopolysaccharides	TLR2 protein affects the susceptibility to Lipopolysaccharides	15593098
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Titanium] results in increased expression of TLR2 mRNA	21308757
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TLR2 mRNA	21051124
D008070	Lipopolysaccharides	tributyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]	21051124
D008070	Lipopolysaccharides	iberin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR2 protein]]	25294874
D008070	Lipopolysaccharides	iberin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR6 protein binds to TLR2 protein]]	25294874
C009900	lipoteichoic acid	lipoteichoic acid results in increased activity of TLR2 protein	28003376
C009900	lipoteichoic acid	lipoteichoic acid binds to and results in increased activity of TLR2 protein	18845389
C009900	lipoteichoic acid	[lipoteichoic acid binds to and results in increased activity of TLR2 protein] which results in increased expression of TNF mRNA	18845389
C009900	lipoteichoic acid	lipoteichoic acid results in increased activity of TLR2 protein	28003376
C009900	lipoteichoic acid	TLR2 protein affects the reaction [lipoteichoic acid results in increased abundance of Nitrites]	19573522
C009900	lipoteichoic acid	TLR2 protein affects the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]	19573522
C009900	lipoteichoic acid	TLR2 protein affects the reaction [lipoteichoic acid results in increased phosphorylation of RAF1 protein]	19573522
C015329	lycopene	lycopene inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein]	22429818
C015329	lycopene	lycopene inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]	22429818
C106335	macrophage stimulatory lipopeptide 2	macrophage stimulatory lipopeptide 2 binds to and results in increased activity of TLR2 protein	18096868\|2060021
D058185	Magnetite Nanoparticles	Magnetite Nanoparticles results in increased expression of TLR2 mRNA	24525745
D008694	Methamphetamine	[Methamphetamine co-treated with SCH 23390] results in decreased expression of TLR2 mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in decreased expression of TLR2 mRNA	19564919
D008727	Methotrexate	[Methotrexate analog binds to Lipids] which results in decreased expression of TLR2 mRNA	24065615
D008727	Methotrexate	Methotrexate results in decreased expression of TLR2 mRNA	19192274
D008727	Methotrexate	Methotrexate results in increased expression of TLR2 mRNA	21678067
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of TLR2 mRNA	26011545
D008775	Methylprednisolone	Methylprednisolone results in decreased expression of TLR2 mRNA	19192274
C008493	methylselenic acid	methylselenic acid results in increased expression of TLR2 mRNA	12517777
C502230	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin	"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]"	23692848
C502230	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin	"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]"	23692848
C502230	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin	"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Hyaluronic Acid metabolite results in increased expression of TLR2 mRNA]"	23692848
C502230	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin	"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Hyaluronic Acid metabolite results in increased expression of TLR2 protein]"	23692848
C523799	MRK 003	TLR2 results in increased susceptibility to MRK 003	19903844
D009151	Mustard Gas	Mustard Gas results in increased expression of TLR2 mRNA	18955075
D009151	Mustard Gas	Mustard Gas results in increased expression of TLR2 mRNA	18988085
D037742	Nanotubes, Carbon	"Nanotubes, Carbon inhibits the reaction [TLR2 protein results in increased secretion of IL10 protein]"	23266719
D037742	Nanotubes, Carbon	"Nanotubes, Carbon promotes the reaction [TLR2 protein results in increased secretion of IL6 protein]"	23266719
D037742	Nanotubes, Carbon	"Nanotubes, Carbon promotes the reaction [TLR2 protein results in increased secretion of TNF protein]"	23266719
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of TLR2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TLR2 mRNA"	25554681
D009532	Nickel	Nickel results in increased expression of TLR2 mRNA	25583101
D009573	Nitrites	TLR2 protein affects the reaction [lipoteichoic acid results in increased abundance of Nitrites]	19573522
D009599	Nitroprusside	[Nitroprusside co-treated with TNF co-treated with IFNG] results in increased expression of TLR2 mRNA	15153526
D010047	Ovalbumin	TLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein]	26882889
D010047	Ovalbumin	TLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL2 protein]	26882889
D010047	Ovalbumin	TLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL7 protein]	26882889
D010047	Ovalbumin	TLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein]	26882889
D010047	Ovalbumin	TLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL4 protein]	26882889
D010047	Ovalbumin	TLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL5 protein]	26882889
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of TLR2 mRNA	25729387
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine binds to and results in decreased activity of TLR2 protein	23500011
D010100	Oxygen	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]"	23452621
D010100	Oxygen	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]	23452621
D010100	Oxygen	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]	23452621
D010100	Oxygen	Oxygen deficiency results in increased expression of TLR2 mRNA	23452621
D010100	Oxygen	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]	23452621
D010100	Oxygen	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]	23452621
D010126	Ozone	[Lipopolysaccharides co-treated with Ozone] results in increased expression of TLR2 mRNA	16864405
D010126	Ozone	[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of TLR2 mRNA	25658374
D010126	Ozone	Ozone results in increased expression of TLR2 mRNA	17626835
D010126	Ozone	TLR2 gene mutant form inhibits the reaction [Ozone results in increased expression of CXCL1 mRNA]	17626835
D010126	Ozone	TLR2 gene mutant form inhibits the reaction [Ozone results in increased expression of IL6 mRNA]	17626835
D010126	Ozone	TLR2 gene mutant form inhibits the reaction [Ozone results in increased expression of IL6 protein]	17626835
D010126	Ozone	TLR2 gene mutant form results in decreased susceptibility to Ozone	17626835
C508075	Pam(3)CSK(4) peptide	[bis(4-hydroxyphenyl)sulfone co-treated with Pam(3)CSK(4) peptide] results in decreased expression of TLR2 mRNA	28806546
C508075	Pam(3)CSK(4) peptide	[bisphenol A co-treated with Pam(3)CSK(4) peptide] results in decreased expression of TLR2 mRNA	28806546
C508075	Pam(3)CSK(4) peptide	[bisphenol F co-treated with Pam(3)CSK(4) peptide] results in decreased expression of TLR2 mRNA	28806546
C508075	Pam(3)CSK(4) peptide	Pam(3)CSK(4) peptide results in increased expression of TLR2 mRNA	28806546
C508075	Pam(3)CSK(4) peptide	"[Pam(3)CSK(4) peptide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR2 mRNA"	23840549
C508075	Pam(3)CSK(4) peptide	Pam(3)CSK(4) peptide results in increased expression of TLR2 mRNA	23840549
C508075	Pam(3)CSK(4) peptide	TLR2 protein promotes the reaction [Pam(3)CSK(4) peptide results in increased metabolism of Eicosanoids]	17369491
C508075	Pam(3)CSK(4) peptide	Acetylcysteine inhibits the reaction [iberin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]]	25294874
C508075	Pam(3)CSK(4) peptide	Dithiothreitol inhibits the reaction [iberin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]]	25294874
C508075	Pam(3)CSK(4) peptide	iberin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]	25294874
C508075	Pam(3)CSK(4) peptide	Pam(3)CSK(4) peptide binds to and results in increased activity of TLR2 protein	23266719
C508075	Pam(3)CSK(4) peptide	Pam(3)CSK(4) peptide results in increased activity of TLR2 protein	25294874
C508075	Pam(3)CSK(4) peptide	Quercetin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]	25294874
C508075	Pam(3)CSK(4) peptide	spiraeoside analog inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]	25294874
D010269	Paraquat	epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR2 protein]	27890776
D010269	Paraquat	Paraquat results in increased expression of TLR2 protein	27890776
D010269	Paraquat	epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR2 protein]	27890776
D010269	Paraquat	Paraquat results in increased expression of TLR2 protein	27890776
D010278	Parathion	Parathion results in increased methylation of TLR2 promoter	22847954
D052638	Particulate Matter	Particulate Matter results in decreased expression of TLR2 protein	17630318
D052638	Particulate Matter	TLR2 protein affects the reaction [Particulate Matter results in increased secretion of IL6 protein]	20549640
D052638	Particulate Matter	"Particulate Matter analog promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TLR2 mRNA]"	12832678
D052638	Particulate Matter	TLR2 gene mutant form inhibits the reaction [Particulate Matter results in increased secretion of CCL3 protein]	23896513
D052638	Particulate Matter	TLR2 gene mutant form inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]	23896513
D052638	Particulate Matter	TLR2 gene mutant form inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]	23896513
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of TLR2 mRNA	23892564
C046012	pentanal	pentanal results in increased expression of TLR2 mRNA	26079696
D010457	Peptidoglycan	Peptidoglycan binds to and results in increased activity of TLR2 protein	12734376
D010457	Peptidoglycan	Peptidoglycan binds to and results in increased activity of TLR2 protein	15593098
D010457	Peptidoglycan	Peptidoglycan results in increased expression of TLR2 mRNA	15593098
D010457	Peptidoglycan	Peptidoglycan results in increased expression of TLR2 protein	15593098
D010457	Peptidoglycan	TLR2 protein affects the susceptibility to Peptidoglycan	15593098
D010457	Peptidoglycan	TLR2 protein promotes the reaction [Peptidoglycan results in increased metabolism of Eicosanoids]	17369491
D015232	Dinoprostone	Histamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone]	20040740
D015232	Dinoprostone	[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone	20040740
D010634	Phenobarbital	Phenobarbital affects the expression of TLR2 mRNA	19159669
D010672	Phenytoin	[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of TLR2 mRNA	23986454
D010672	Phenytoin	Phenytoin results in increased expression of TLR2 mRNA	23986454
D010862	Pilocarpine	Pilocarpine results in increased expression of TLR2 mRNA	15193289
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TLR2 mRNA	19710929
D010894	Piroxicam	Piroxicam results in decreased expression of TLR2 mRNA	19192274
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]	23452621
D011070	Poly I-C	[bis(4-hydroxyphenyl)sulfone co-treated with Poly I-C] results in decreased expression of TLR2 mRNA	28806546
D011070	Poly I-C	[bisphenol A co-treated with Poly I-C] results in decreased expression of TLR2 mRNA	28806546
D011070	Poly I-C	[bisphenol F co-treated with Poly I-C] results in decreased expression of TLR2 mRNA	28806546
D011070	Poly I-C	Poly I-C results in increased expression of TLR2 mRNA	17669408
D011134	Polysaccharides	Polysaccharides inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]	21875662
D011239	Prednisolone	Prednisolone results in decreased expression of TLR2 mRNA	19192274
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of TLR2 mRNA	17404688
D011374	Progesterone	Progesterone results in increased expression of TLR2 mRNA	17404688
D011374	Progesterone	Progesterone results in increased expression of TLR2 mRNA	21549006
D011374	Progesterone	Progesterone results in increased expression of TLR2 protein	21549006
C045950	propiconazole	propiconazole results in increased expression of TLR2 mRNA	21278054\|2233456
C005556	propionaldehyde	propionaldehyde results in increased expression of TLR2 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of TLR2 mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of TLR2 mRNA	27029645
D011794	Quercetin	Quercetin results in decreased expression of TLR2 mRNA	20828867
D011794	Quercetin	Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]	27601294
D011794	Quercetin	Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein]	26218279\|2760129
D011794	Quercetin	Quercetin inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]	25294874
D017382	Reactive Oxygen Species	Reactive Oxygen Species results in decreased expression of TLR2 mRNA	25800948
C059514	resveratrol	[resveratrol co-treated with TLR2 protein] results in decreased secretion of IL10 protein	24035785
C059514	resveratrol	[resveratrol co-treated with TLR2 protein] results in increased secretion of IL6 protein	24035785
C059514	resveratrol	[resveratrol co-treated with TLR2 protein] results in increased secretion of TNF protein	24035785
C059514	resveratrol	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]	23452621
C059514	resveratrol	resveratrol results in decreased activity of TLR2 protein	24617573
C059514	resveratrol	resveratrol results in decreased expression of TLR2 protein	23661603
C059514	resveratrol	resveratrol results in increased expression of TLR2 mRNA	25905778
C034206	Ribomunyl	Ribomunyl results in increased activity of TLR2 protein	21817197
C034206	Ribomunyl	Ribomunyl results in increased expression of TLR2 mRNA	21817197
C089730	rosiglitazone	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 protein]]"	24612634
C089730	rosiglitazone	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone promotes the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 mRNA]]"	24612634
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 protein]	24612634
C089730	rosiglitazone	rosiglitazone promotes the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 mRNA]	24612634
C093642	SB 203580	SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]	12888452
C534628	SCH 23390	[Methamphetamine co-treated with SCH 23390] results in decreased expression of TLR2 mRNA	19564919
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of TLR2 mRNA	25351596
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of TLR2 mRNA	23221170
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of TLR2 mRNA	21602193
D019821	Simvastatin	Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein]	16443229
D019821	Simvastatin	Simvastatin results in increased expression of TLR2 protein	16387846
C118258	SN50 peptide	SN50 peptide inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]	12888452
C016104	sodium bichromate	sodium bichromate results in decreased expression of TLR2 mRNA	22561333
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in increased expression of TLR2 mRNA	17936526
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of TLR2 mRNA	23274088
D053260	Soot	Soot results in increased expression of TLR2 mRNA	22461453
C080613	spiraeoside	spiraeoside analog inhibits the reaction [Pam(3)CSK(4) peptide results in increased activity of TLR2 protein]	25294874
C025971	staphylococcal delta toxin	staphylococcal delta toxin binds to and results in increased activity of TLR2 protein	15388451
D012460	Sulfasalazine	Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]	12888452
D013467	Sulindac	"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of TLR2 mRNA"	20371263
C490727	T 91825	T 91825 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 protein]	27397760
C012568	terbufos	terbufos results in increased methylation of TLR2 promoter	22847954
D013739	Testosterone	Testosterone inhibits the reaction [Dietary Fats results in increased expression of TLR2 mRNA]	22010203
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of TLR2 mRNA	25461914
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone promotes the reaction [HMGB1 protein binds to TLR2 protein]	27413111
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone results in increased expression of TLR2 mRNA	27413111
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone results in increased expression of TLR2 protein	27413111
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TLR2 mRNA	21570461
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of TLR2 protein	28720485
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TLR2 mRNA	25613284
D014025	Titanium	[Lipopolysaccharides co-treated with Titanium] results in increased expression of TLR2 mRNA	21308757
C009495	titanium dioxide	titanium dioxide results in increased expression of TLR2 mRNA	23409001\|2355797
D014028	Tobacco Smoke Pollution	T 91825 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 protein]	27397760
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of TLR2 mRNA	27404394
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of TLR2 mRNA	27480279\|2786577
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of TLR2 protein	27397760\|2872048
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of TLR2 mRNA	20133372
D014028	Tobacco Smoke Pollution	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 protein]]"	24612634
D014028	Tobacco Smoke Pollution	"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [rosiglitazone promotes the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 mRNA]]"	24612634
D014028	Tobacco Smoke Pollution	rosiglitazone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 protein]	24612634
D014028	Tobacco Smoke Pollution	rosiglitazone promotes the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 mRNA]	24612634
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of TLR2 mRNA	24612634
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of TLR2 protein	24612634
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of TLR2 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of TLR2 mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of TLR2 mRNA"	19682533
C005830	tributyrin	tributyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]	21051124
C015559	trimellitic anhydride	trimellitic anhydride affects the expression of TLR2 mRNA	19110044
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of TLR2	16891783
D010853	Picryl Chloride	TLR2 protein affects the reaction [TLR4 protein results in increased susceptibility to Picryl Chloride]	18725520
C002802	tungsten carbide	[tungsten carbide co-treated with Cobalt] results in decreased expression of TLR2 mRNA	18078969
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of TLR2 protein	17630318
D001335	Vehicle Emissions	"Vehicle Emissions analog promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TLR2 mRNA]"	12832678
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of TLR2 gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of TLR2 mRNA	18629315
C029297	vinylidene chloride	vinylidene chloride results in increased expression of TLR2 mRNA	26682919
D014801	Vitamin A	Vitamin A results in increased expression of TLR2 mRNA	17033190
D014807	Vitamin D	Vitamin D results in decreased expression of TLR2 mRNA	23281135
D014807	Vitamin D	Vitamin D results in decreased expression of TLR2 protein	23281135
D014807	Vitamin D	Vitamin D inhibits the reaction [Dust results in increased expression of TLR2 mRNA]	23281135
D015034	Zinc Oxide	[Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TLR2 protein	25127755
D015034	Zinc Oxide	Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR2 mRNA]	25127755
C017803	zinc protoporphyrin	zinc protoporphyrin promotes the reaction [TLR2 protein binds to MYD88 protein]	25780291
D015054	Zymosan	Zymosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA]	21329777
D015054	Zymosan	Zymosan results in decreased expression of TLR2 mRNA	21329777
D015054	Zymosan	TLR2 protein promotes the reaction [Zymosan affects the activity of IFNG protein]	17257219
D015054	Zymosan	TLR2 protein promotes the reaction [Zymosan results in increased expression of IL10 protein]	17312158
D015054	Zymosan	TLR2 protein promotes the reaction [Zymosan results in increased expression of [IL12A protein binds to IL12B protein]]	17312158
D015054	Zymosan	TLR2 protein promotes the reaction [Zymosan results in increased expression of IL2 protein]	17312158
D015054	Zymosan	Zymosan results in decreased expression of TLR2 mRNA	14726497
D015054	Zymosan	Zymosan results in increased expression of TLR2 protein	10823826\|1732146

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001530	lipopolysaccharide binding	-	IDA	11274165
GO:0001540	amyloid-beta binding	-	IDA	22198949
GO:0001540	amyloid-beta binding	-	ISS	-
GO:0001875	lipopolysaccharide receptor activity	-	TAS	11518816
GO:0005515	protein binding	-	IPI	10854325 11441107 12594264 15657077 16622205 16880211 17095513 17126326 18765807 19509286 19880448 20802527 23155421 23376921 24658140
GO:0008329	signaling pattern recognition receptor activity	-	IDA	10384090
GO:0035325	Toll-like receptor binding	-	IPI	16880211
GO:0038023	signaling receptor activity	-	TAS	10426995
GO:0042497	triacyl lipopeptide binding	-	IDA	17889651
GO:0042802	identical protein binding	-	IPI	23155421
GO:0042834	peptidoglycan binding	-	IDA	11986301
GO:0044877	protein-containing complex binding	-	IPI	22198949
GO:0046982	protein heterodimerization activity	-	IDA	17889651

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001666	response to hypoxia	-	IEA	-
GO:0001774	microglial cell activation	-	IEA	-
GO:0001775	cell activation	-	IDA	15294986
GO:0002224	toll-like receptor signaling pathway	-	IBA	21873635
GO:0002224	toll-like receptor signaling pathway	-	TAS	-
GO:0002374	cytokine secretion involved in immune response	-	IMP	20441518
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	-	TAS	-
GO:0006691	leukotriene metabolic process	-	IEA	-
GO:0006915	apoptotic process	-	TAS	10426996
GO:0006954	inflammatory response	-	IBA	21873635
GO:0006954	inflammatory response	-	IEA	-
GO:0006955	immune response	-	TAS	10426995
GO:0007165	signal transduction	-	TAS	11044375
GO:0007252	I-kappaB phosphorylation	-	IDA	19740627
GO:0007612	learning	-	ISS	-
GO:0008285	negative regulation of cell proliferation	-	IEA	-
GO:0009636	response to toxic substance	-	IEA	-
GO:0010628	positive regulation of gene expression	-	IMP	23817958 26649771
GO:0014005	microglia development	-	ISS	-
GO:0030177	positive regulation of Wnt signaling pathway	-	IMP	16601243
GO:0031663	lipopolysaccharide-mediated signaling pathway	-	IEA	-
GO:0032289	central nervous system myelin formation	-	IEA	-
GO:0032570	response to progesterone	-	IEA	-
GO:0032613	interleukin-10 production	-	IDA	23826189
GO:0032640	tumor necrosis factor production	-	ISS	-
GO:0032722	positive regulation of chemokine production	-	IDA	19740627
GO:0032728	positive regulation of interferon-beta production	-	ISS	-
GO:0032733	positive regulation of interleukin-10 production	-	IEA	-
GO:0032735	positive regulation of interleukin-12 production	-	ISS	-
GO:0032741	positive regulation of interleukin-18 production	-	ISS	-
GO:0032755	positive regulation of interleukin-6 production	-	IDA	19740627
GO:0032757	positive regulation of interleukin-8 production	-	IDA	17128265 19740627
GO:0032760	positive regulation of tumor necrosis factor production	-	ISS	-
GO:0032868	response to insulin	-	IEA	-
GO:0034123	positive regulation of toll-like receptor signaling pathway	-	IDA	17128265
GO:0034134	toll-like receptor 2 signaling pathway	-	IEA	-
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway	-	TAS	-
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	-	TAS	-
GO:0042495	detection of triacyl bacterial lipopeptide	-	IDA	19931471
GO:0042496	detection of diacyl bacterial lipopeptide	-	IDA	19931471
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0045087	innate immune response	-	TAS	15356140
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	-
GO:0046209	nitric oxide metabolic process	-	IEA	-
GO:0048714	positive regulation of oligodendrocyte differentiation	-	IEA	-
GO:0050729	positive regulation of inflammatory response	-	IC	19740627
GO:0050765	negative regulation of phagocytosis	-	ISS	-
GO:0050830	defense response to Gram-positive bacterium	-	IDA	11521063
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IDA	12594207 21618349
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	-	ISS	-
GO:0051964	negative regulation of synapse assembly	-	ISS	-
GO:0070542	response to fatty acid	-	IEA	-
GO:0071221	cellular response to bacterial lipopeptide	-	TAS	15356140
GO:0071223	cellular response to lipoteichoic acid	-	IDA	12594207
GO:0071223	cellular response to lipoteichoic acid	-	IMP	26649771
GO:0071346	cellular response to interferon-gamma	-	IDA	11672593
GO:0071726	cellular response to diacyl bacterial lipopeptide	-	IDA	16880211 19931471
GO:0071727	cellular response to triacyl bacterial lipopeptide	-	IDA	16880211 19931471
GO:1901224	positive regulation of NIK/NF-kappaB signaling	-	IDA	19740627
GO:1903974	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	-	IDA	11672593
GO:2000484	positive regulation of interleukin-8 secretion	-	IGI	22198949

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IDA	19740627
GO:0005794	Golgi apparatus	-	IDA	16880211
GO:0005886	plasma membrane	-	IDA	19740627
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	TAS	9435236
GO:0009986	cell surface	-	IDA	12443841
GO:0030667	secretory granule membrane	-	TAS	-
GO:0030670	phagocytic vesicle membrane	-	IEA	-
GO:0031226	intrinsic component of plasma membrane	-	IBA	21873635
GO:0031226	intrinsic component of plasma membrane	-	IDA	11274165
GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex	-	IDA	17889651
GO:0042995	cell projection	-	IEA	-
GO:0044297	cell body	-	IEA	-
GO:0045121	membrane raft	-	IDA	16880211

KEGG ID	KEGG Term
hsa04145	Phagosome
hsa04620	Toll-like receptor signaling pathway
hsa05140	Leishmaniasis
hsa05142	Chagas disease (American trypanosomiasis)
hsa05144	Malaria
hsa05145	Toxoplasmosis
hsa05146	Amoebiasis
hsa05323	Rheumatoid arthritis

Reactome ID	Reactome Term	Evidence
R-HSA-1236974	ER-Phagosome pathway	TAS
R-HSA-1236975	Antigen processing-Cross presentation	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1461957	Beta defensins	TAS
R-HSA-1461973	Defensins	TAS
R-HSA-1643685	Disease	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-5260271	Diseases of Immune System	TAS
R-HSA-5602358	Diseases associated with the TLR signaling cascade	TAS
R-HSA-5602498	MyD88 deficiency (TLR2/4)	TAS
R-HSA-5603041	IRAK4 deficiency (TLR2/4)	TAS
R-HSA-5686938	Regulation of TLR by endogenous ligand	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-6803157	Antimicrobial peptides	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23823019	A TLR6 polymorphism is associated with increased risk of Legionnaires' disease. (2013 Oct)	Misch EA	Genes Immun
22251071	Common genetic risk variants of TLR2 are not associated with periodontitis in large European case-control populations. (2012 Apr)	Richter GM	J Clin Periodontol
27274225	Effects of budesonide on toll-like receptor expression in alveolar macrophages from smokers with and without COPD. (2016)	Ji J	Int J Chron Obstruct Pulmon Dis
26846412	Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study. (2016 Feb 5)	Ramos BR	BMC Pregnancy Childbirth
28009434	Gene polymorphisms of TLR2 and TLR3 in HBV clearance and HBV-related hepatocellular carcinoma in a Chinese male population. (2017 May 4)	Chen D	Int J Biol Markers
28956832	Multiple Gene-Environment Interactions on the Angiogenesis Gene-Pathway Impact Rectal Cancer Risk and Survival. (2017 Sep 28)	Sharafeldin N	Int J Environ Res Public Health
24454004	Effects of polymorphisms of innate immunity genes and environmental factors on the risk of noncardia gastric cancer. (2013 Dec)	Kim J	Cancer Res Treat
16870663	Maternal smoking is associated with impaired neonatal toll-like-receptor-mediated immune responses. (2006 Oct)	Noakes PS	Eur Respir J
21738617	Bone marrow mononuclear cells up-regulate toll-like receptor expression and produce inflammatory mediators in response to cigarette smoke extract. (2011)	Zhou J	PLoS One
23998736	Role of Toll-like receptor 2 (-196 to -174) polymorphism in susceptibility to pulmonary tuberculosis in Pakistani population. (2014 Apr)	Khan AU	Int J Immunogenet
17332447	Toll receptor polymorphisms and carotid artery intima-media thickness. (2007 Apr)	Labrum R	Stroke
20337891	The del/del genotype of the nuclear factor-kappaB -94ATTG polymorphism and its relation to aggressive periodontitis. (2010 Jun)	Schulz S	J Periodontal Res
24612634	PPARgamma agonists regulate tobacco smoke-induced Toll like receptor 4 expression in alveolar macrophages. (2014 Mar 11)	Yin Y	Respir Res
28656364	The critical role of macrophages in the pathogenesis of hidradenitis suppurativa. (2017 Nov)	Shah A	Inflamm Res
26208141	TLR2 and TLR4 Expression and Inflammatory Cytokines are Altered in the Airway Epithelium of Those with Alcohol Use Disorders. (2015 Sep)	Bailey KL	Alcohol Clin Exp Res
26072521	A Candidate-Pathway Approach to Identify Gene-Environment Interactions: Analyses of Colon Cancer Risk and Survival. (2015 Sep)	Sharafeldin N	J Natl Cancer Inst
28518213	Relationship between toll-like receptor 2 R753Q and T16934A polymorphisms and Staphylococcus aureus nasal carriage. (2017)	Zukowski M	Anaesthesiol Intensive Ther
22994343	Toll-like receptors 2, 3 and 4 and thymic stromal lymphopoietin expression in fatal asthma. (2012 Oct)	Ferreira DS	Clin Exp Allergy
21224062	Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFkappaB activation resulting in a microenvironment predisposed to ectopic pregnancy. (2011 Jan)	Shaw JL	Am J Pathol
29066918	Asthma with bronchial hypersecretion: expression of mucins and toll-like receptors in sputum and blood. (2017)	Crespo-Lessmann A	J Asthma Allergy
16844729	Innate immune activation in neutrophilic asthma and bronchiectasis. (2007 Mar)	Simpson JL	Thorax
22878868	Nicotine treatment improves Toll-like receptor 2 and Toll-like receptor 9 responsiveness in active pulmonary sarcoidosis. (2013 Feb 1)	Julian MW	Chest
22999059	Functional polymorphisms of Toll-like receptors 2 and 4 alter the risk for colorectal carcinoma in Europeans. (2013 Jan)	Pimentel-Nunes P	Dig Liver Dis
19766998	High expression level of Toll-like receptor 2 on monocytes is an important risk factor for arteriosclerotic disease. (2010 Mar)	Kuwahata S	Atherosclerosis
26371589	A toll-like receptor 9 (rs352140) variant is associated with placental inflammation in newborn infants. (2016)	Karody V	J Matern Fetal Neonatal Med
28560381	Hypomethylation of the Toll-like receptor-2 gene increases the risk of essential hypertension. (2017 Jul)	Mao S	Mol Med Rep
21439805	Toll-like receptor expression in smokers with and without COPD. (2011 Aug)	von Scheele I	Respir Med
26860188	Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis. (2016 Feb 9)	Liao K	J Neuroinflammation
24776844	Associations between functional polymorphisms in the NFkappaB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease. (2014 Dec)	Bank S	Pharmacogenomics J
18034897	Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke. (2007 Nov 22)	MacRedmond RE	Respir Res
21792899	Toll-like receptor genes and their association with colon and rectal cancer development and prognosis. (2012 Jun 15)	Slattery ML	Int J Cancer
23606791	Influence of age, past smoking, and disease severity on TLR2, neutrophilic inflammation, and MMP-9 levels in COPD. (2013)	Simpson JL	Mediators Inflamm
27920557	Effect of smoking on the genetic makeup of toll-like receptors 2 and 6. (2016)	Kohailan M	Onco Targets Ther
25346143	Expression of nucleic acid-sensing Toll-like receptors predicts HPV16 clearance associated with an E6-directed cell-mediated response. (2015 May 15)	Scott ME	Int J Cancer
26880585	Association of toll-like receptor 2 22 and risk for gastric cancer considering main effects and interactions with smoking: a matched case-control study from Mizoram, India. (2016 Aug)	Mukherjee D	Tumour Biol
23206318	High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence. (2013 Apr 1)	Crews FT	Biol Psychiatry
26617606	Cigarette Smoke Amplifies Inflammatory Response and Atherosclerosis Progression Through Activation of the H1R-TLR2/4-COX2 Axis. (2015)	Barua RS	Front Immunol
19675120	Altered innate immune response in farmers and smokers. (2010 Feb)	Sahlander K	Innate Immun
27397760	Effects of ceftaroline on the innate immune and on the inflammatory responses of bronchial epithelial cells exposed to cigarette smoke. (2016 Sep 6)	Pace E	Toxicol Lett
21425908	Toll-like receptor expression and activation in astroglia: differential regulation by HIV-1 Tat, gp120, and morphine. (2011)	El-Hage N	Immunol Invest