Gene: TLR3

7098
CD283|IIAE2
toll like receptor 3
protein-coding
4q35.1
Ensembl:ENSG00000164342 MIM:603029 Vega:OTTHUMG00000160345 UniprotKB:O15455
NG_007278.1
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
18   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.882e-1 (AD)  4.357e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SAMD9L0.883
PARP90.861
DDX600.853
SAMD90.851
DDX60L0.846
PARP140.841
APOBEC3G0.839
APOBEC3F0.832
SP140L0.83
TRIM210.829

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGIX-0.462
MYADML2-0.46
KCNIP3-0.455
CHRNA4-0.455
ADRA1D-0.452
TMEM179-0.448
ABCC12-0.443
ZSCAN1-0.432
DLK2-0.43
BCL11A-0.43

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0044821-aminopyrene[Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-aminopyrene23458896
C0326681-nitropyrene[Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-nitropyrene23458896
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one[Lipopolysaccharides co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in increased expression of TLR3 mRNA23405061
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TLR3 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one[Poly I-C co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TLR3 mRNA23405061
C0235052',5'-oligoadenylate"[2',5'-oligoadenylate binds to and results in increased activity of RNASEL protein] which results in increased expression of TLR3 mRNA"24651439
C0038982-anisidine2-anisidine results in decreased expression of TLR3 mRNA28089782
C0354193,4-dihydroxybenzohydroxamic acid"3,4-dihydroxybenzohydroxamic acid affects the reaction [Lipopolysaccharides results in increased expression of TLR3 mRNA]"25843059
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of TLR3 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLR3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLR3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLR3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLR3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TLR3 mRNA21420995|2776149
D000082AcetaminophenAcetaminophen results in increased expression of TLR3 protein26079055
D000082AcetaminophenChlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR3 protein]26079055
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TLR3 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TLR3 mRNA22100608
D000393Air PollutantsAir Pollutants analog results in decreased expression of TLR3 mRNA21757418
D000517alpha-Chlorohydrinalpha-Chlorohydrin affects the expression of TLR3 mRNA28522335
D0150752-Aminopurine[Poly I-C co-treated with 2-Aminopurine] results in decreased expression of TLR3 mRNA23405061
C006632arsenic trioxidearsenic trioxide results in increased expression of TLR3 mRNA20458559
D001241AspirinTLR3 polymorphism affects the susceptibility to Aspirin21461252
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to TLR3 promoter]19654925
C034786bis(4-hydroxycinnamoyl)methane[bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of TLR3 mRNA22029407
C034786bis(4-hydroxycinnamoyl)methane[bis(4-hydroxycinnamoyl)methane co-treated with APP protein] results in increased expression of TLR3 mRNA22029407
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of TLR3 mRNA28806546
C543008bis(4-hydroxyphenyl)sulfone[Pam(3)CSK(4) peptide co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TLR3 mRNA28806546
C543008bis(4-hydroxyphenyl)sulfone[Poly I-C co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TLR3 mRNA28806546
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TLR3 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of TLR3 mRNA28806546
C006780bisphenol Abisphenol A results in increased expression of TLR3 mRNA23606268
C006780bisphenol A[nonylphenol co-treated with bisphenol A] results in increased expression of TLR3 mRNA23606268
C006780bisphenol A[Pam(3)CSK(4) peptide co-treated with bisphenol A] results in decreased expression of TLR3 mRNA28806546
C006780bisphenol A[Poly I-C co-treated with bisphenol A] results in decreased expression of TLR3 mRNA28806546
C006780bisphenol Abisphenol A results in decreased expression of TLR3 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of TLR3 gene22576693
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TLR3 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of TLR3 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of TLR3 mRNA25181051
C000611646bisphenol Fbisphenol F results in decreased expression of TLR3 mRNA28806546
C000611646bisphenol F[Pam(3)CSK(4) peptide co-treated with bisphenol F] results in decreased expression of TLR3 mRNA28806546
C000611646bisphenol F[Poly I-C co-treated with bisphenol F] results in decreased expression of TLR3 mRNA28806546
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TLR3 mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of TLR3 promoter22457795
C058667cadmium selenide[cadmium selenide co-treated with zinc sulfide] results in increased expression of TLR3 mRNA22342292
D002726Chlorogenic AcidChlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR3 protein]26079055
C012843cinnamic aldehydecinnamic aldehyde inhibits the reaction [Poly I-C results in increased expression of TLR3 mRNA]18306459
D002953CitrininCitrinin results in decreased expression of TLR3 mRNA22771370
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of TLR3 mRNA23405061
C029892cupric chloridecupric chloride results in decreased expression of TLR3 mRNA24650576
D016572CyclosporineCyclosporine results in increased expression of TLR3 mRNA20106945|2214713
C007262deoxynivalenoldeoxynivalenol results in decreased expression of TLR3 mRNA22968694
D003907DexamethasoneDexamethasone results in decreased expression of TLR3 mRNA12732289
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TLR3 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TLR3 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TLR3 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TLR3 mRNA27392435
D002945CisplatinCisplatin results in increased expression of TLR3 mRNA27392435
D002945CisplatinCisplatin results in increased expression of TLR3 mRNA21151649|2654657
D004041Dietary FatsDietary Fats results in increased expression of TLR3 mRNA25016146
D002117CalcitriolCalcitriol results in increased expression of TLR3 mRNA19918113|2159239
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of TLR3 mRNA21592394
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TLR3 mRNA22079256
D015025ZearalenoneZearalenone results in increased expression of TLR3 mRNA27757495
D015025ZearalenoneZearalenone results in decreased expression of TLR3 mRNA25455459
D005472FluorouracilFluorouracil results in increased expression of TLR3 mRNA18779317|2036764
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in increased expression of TLR3 mRNA]18779317
D037741FullerenesFullerenes analog results in increased expression of TLR3 mRNA22342292
D012971Gold Sodium ThiosulfateTLR3 protein affects the reaction [Gold Sodium Thiosulfate results in increased secretion of CXCL8 protein]25458486
C412815GW 4064GW 4064 promotes the reaction [NR1H4 protein binds to TLR3 gene]20091679
C540383INCB018424INCB018424 inhibits the reaction [IFNB1 protein results in increased expression of TLR3 mRNA]28365849
C016517indole-3-carbinolindole-3-carbinol affects the expression of TLR3 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TLR3 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TLR3 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TLR3 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of TLR3 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TLR3 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TLR3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TLR3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TLR3 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TLR3 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TLR3 mRNA24796395|2675264
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in increased expression of TLR3 mRNA23405061
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with pyrazolanthrone] results in increased expression of TLR3 mRNA23405061
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with SB 203580] results in increased expression of TLR3 mRNA23405061
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with U 0126] results in increased expression of TLR3 mRNA23405061
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of TLR3 mRNA23405061
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TLR3 mRNA23405061
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TLR3 mRNA15191912
D008070Lipopolysaccharides"3,4-dihydroxybenzohydroxamic acid affects the reaction [Lipopolysaccharides results in increased expression of TLR3 mRNA]"25843059
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TLR3 mRNA24056979|2584305
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of TLR3 mRNA]24056979
D008727MethotrexateMethotrexate results in increased expression of TLR3 mRNA21678067
D008727MethotrexateMethotrexate inhibits the reaction [pristane results in increased expression of TLR3 mRNA]24423102
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of TLR3 mRNA]24056979
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of TLR3 mRNA22108045
D009151Mustard GasMustard Gas results in increased expression of TLR3 mRNA18955075
D037742Nanotubes, Carbon"[[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of IL12B protein"23266719
D037742Nanotubes, Carbon"[[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of TNF protein"23266719
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TLR3 mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of TLR3 mRNA22714537
C025256nonylphenol[nonylphenol co-treated with bisphenol A] results in increased expression of TLR3 mRNA23606268
C025256nonylphenolnonylphenol results in increased expression of TLR3 mRNA23606268
C508075Pam(3)CSK(4) peptide[Pam(3)CSK(4) peptide co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TLR3 mRNA28806546
C508075Pam(3)CSK(4) peptide[Pam(3)CSK(4) peptide co-treated with bisphenol A] results in decreased expression of TLR3 mRNA28806546
C508075Pam(3)CSK(4) peptide[Pam(3)CSK(4) peptide co-treated with bisphenol F] results in decreased expression of TLR3 mRNA28806546
C508075Pam(3)CSK(4) peptidePam(3)CSK(4) peptide results in decreased expression of TLR3 mRNA23405061
D052638Particulate MatterParticulate Matter results in increased expression of TLR3 mRNA22178795
D010416PentachlorophenolPentachlorophenol results in increased expression of TLR3 mRNA23892564
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLR3 mRNA"27188386
C006253pirinixic acidpirinixic acid results in decreased expression of TLR3 mRNA20813756
D011070Poly I-C[Poly I-C co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TLR3 mRNA28806546
D011070Poly I-C[Poly I-C co-treated with bisphenol A] results in decreased expression of TLR3 mRNA28806546
D011070Poly I-C[Poly I-C co-treated with bisphenol F] results in decreased expression of TLR3 mRNA28806546
D011070Poly I-CPoly I-C results in increased expression of TLR3 mRNA28806546
D011070Poly I-C[Poly I-C binds to and results in increased activity of TLR3 protein] which results in increased expression of IFNW1 mRNA23405061
D011070Poly I-C[Poly I-C co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TLR3 mRNA23405061
D011070Poly I-C[Poly I-C co-treated with 2-Aminopurine] results in decreased expression of TLR3 mRNA23405061
D011070Poly I-C[Poly I-C co-treated with SB 203580] results in decreased expression of TLR3 mRNA23405061
D011070Poly I-C[Poly I-C co-treated with wortmannin] results in decreased expression of TLR3 mRNA23405061
D011070Poly I-C"[[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of IL12B protein"23266719
D011070Poly I-C"[[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of TNF protein"23266719
D011070Poly I-C[Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-aminopyrene23458896
D011070Poly I-C[Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-nitropyrene23458896
D011070Poly I-C[Poly I-C binds to TLR3 protein] which affects the susceptibility to pyrene23458896
D011070Poly I-CPoly I-C results in increased activity of TLR3 protein28003376
D011070Poly I-CPoly I-C results in increased expression of TLR3 mRNA17669408|2141803
D011070Poly I-CTLR3 protein affects the reaction [Poly I-C results in increased expression of CXCL8 mRNA]18779317
D011070Poly I-CTLR3 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]18779317
D011070Poly I-C[Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of TLR3 mRNA16399790
D011070Poly I-C[Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of TLR3 protein16399790
D011070Poly I-Ccinnamic aldehyde inhibits the reaction [Poly I-C results in increased expression of TLR3 mRNA]18306459
D011070Poly I-CPoly I-C results in increased expression of TLR3 mRNA18306459
D011070Poly I-CMIR26A mRNA inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]24423102
D011070Poly I-CPoly I-C results in increased activity of TLR3 protein24423102
D011070Poly I-CPoly I-C binds to and results in increased activity of TLR3 protein17345100|1942667
D011070Poly I-CPoly I-C binds to TLR3 protein23458896
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TLR3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TLR3 mRNA22079256|2271453
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of TLR3 mRNA28903501
C009042pristaneMethotrexate inhibits the reaction [pristane results in increased expression of TLR3 mRNA]24423102
C009042pristaneMIR26A mRNA inhibits the reaction [pristane results in increased expression of TLR3 mRNA]24423102
C009042pristaneMIR26A mRNA inhibits the reaction [pristane results in increased expression of TLR3 protein]24423102
C009042pristanepristane results in increased expression of TLR3 mRNA24423102
C009042pristanepristane results in increased expression of TLR3 protein24423102
C432165pyrazolanthrone[Lipopolysaccharides co-treated with pyrazolanthrone] results in increased expression of TLR3 mRNA23405061
C030984pyrene[Poly I-C binds to TLR3 protein] which affects the susceptibility to pyrene23458896
C402365resiquimodresiquimod results in decreased expression of TLR3 mRNA23405061
C059514resveratrolresveratrol results in decreased expression of TLR3 mRNA21937650
C093642SB 203580[Lipopolysaccharides co-treated with SB 203580] results in increased expression of TLR3 mRNA23405061
C093642SB 203580[Poly I-C co-treated with SB 203580] results in decreased expression of TLR3 mRNA23405061
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of TLR3 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TLR3 mRNA25895662
D012834SilverSilver analog results in increased expression of TLR3 mRNA24462830
D012834SilverSilver results in decreased expression of TLR3 mRNA22342292
D012834SilverSilver results in decreased expression of TLR3 mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of TLR3 mRNA28595984
C017947sodium arsenitesodium arsenite results in increased expression of TLR3 mRNA17879257
D013311StreptozocinTNF protein inhibits the reaction [Streptozocin results in increased expression of TLR3 mRNA]20446767
D013311StreptozocinStreptozocin results in increased expression of TLR3 mRNA20446767
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of TLR3 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of TLR3 mRNA21592394
C004648testosterone enanthatetestosterone enanthate affects the expression of TLR3 mRNA17440010
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TLR3 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of TLR3 mRNA22342292
D014212TretinoinTretinoin results in increased expression of TLR3 mRNA23830798
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of TLR3 mRNA19042947
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of TLR3 mRNA29024780
C113580U 0126[Lipopolysaccharides co-treated with U 0126] results in increased expression of TLR3 mRNA23405061
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLR3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of TLR3 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of TLR3 mRNA24383497|2493525
D001335Vehicle Emissions[Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of TLR3 mRNA16399790
D001335Vehicle Emissions[Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of TLR3 protein16399790
C025643vinclozolinvinclozolin results in increased expression of TLR3 mRNA18629315
C009687wortmannin[Poly I-C co-treated with wortmannin] results in decreased expression of TLR3 mRNA23405061
C031238zinc sulfide[cadmium selenide co-treated with zinc sulfide] results in increased expression of TLR3 mRNA22342292
D015054ZymosanZymosan results in increased expression of TLR3 protein17321468

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003725double-stranded RNA binding-IBA21873635  
GO:0003725double-stranded RNA binding-IDA16111635  
GO:0003725double-stranded RNA binding-NAS12054664  
GO:0004888transmembrane signaling receptor activity-NAS12054664  
GO:0005515protein binding-IPI16858407  25736436  
GO:0038023signaling receptor activity-TAS10426995  
GO:0042802identical protein binding-IPI18172197  23155421  25217833  
GO ID GO Term Qualifier Evidence PubMed
GO:0001774microglial cell activation-IEA-  
GO:0002224toll-like receptor signaling pathway-IBA21873635  
GO:0002224toll-like receptor signaling pathway-TAS-  
GO:0002730regulation of dendritic cell cytokine production-IEA-  
GO:0002756MyD88-independent toll-like receptor signaling pathway-TAS-  
GO:0006954inflammatory response-IEA-  
GO:0006972hyperosmotic response-NAS12054664  
GO:0007165signal transduction-TAS9435236  10426995  
GO:0007249I-kappaB kinase/NF-kappaB signaling-TAS-  
GO:0007250activation of NF-kappaB-inducing kinase activity-NAS12054664  
GO:0007252I-kappaB phosphorylation-IDA19740627  
GO:0008584male gonad development-IEA-  
GO:0009597detection of virus-NAS12054664  
GO:0010628positive regulation of gene expression-IMP23817958  25754930  
GO:0032722positive regulation of chemokine production-IDA19740627  
GO:0032728positive regulation of interferon-beta production-ISS-  
GO:0032735positive regulation of interleukin-12 production-ISS-  
GO:0032755positive regulation of interleukin-6 production-IDA19740627  
GO:0032757positive regulation of interleukin-8 production-IDA17128265  
GO:0032760positive regulation of tumor necrosis factor production-ISS-  
GO:0034123positive regulation of toll-like receptor signaling pathway-IDA17128265  
GO:0034128negative regulation of MyD88-independent toll-like receptor signaling pathway-TAS-  
GO:0034138toll-like receptor 3 signaling pathway-TAS-  
GO:0034346positive regulation of type III interferon production-IEA-  
GO:0035458cellular response to interferon-beta-IEA-  
GO:0035666TRIF-dependent toll-like receptor signaling pathway-TAS-  
GO:0035690cellular response to drug-IEA-  
GO:0042742defense response to bacterium-TAS10426995  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IEA-  
GO:0043330response to exogenous dsRNA-IDA21266579  
GO:0043331response to dsRNA-IBA21873635  
GO:0045078positive regulation of interferon-gamma biosynthetic process-IDA16286015  
GO:0045080positive regulation of chemokine biosynthetic process-IEA-  
GO:0045087innate immune response-TAS15356140  
GO:0045356positive regulation of interferon-alpha biosynthetic process-IDA16286015  
GO:0045359positive regulation of interferon-beta biosynthetic process-IDA16286015  
GO:0045359positive regulation of interferon-beta biosynthetic process-IMP12054664  
GO:0045671negative regulation of osteoclast differentiation-NAS12133979  
GO:0045766positive regulation of angiogenesis-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0046330positive regulation of JNK cascade-IEA-  
GO:0050729positive regulation of inflammatory response-IC19740627  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IEA-  
GO:0051607defense response to virus-IBA21873635  
GO:0051607defense response to virus-TAS15356140  
GO:0070266necroptotic process-TAS-  
GO:0071260cellular response to mechanical stimulus-IEP19593445  
GO:0071346cellular response to interferon-gamma-IEA-  
GO:0071360cellular response to exogenous dsRNA-IEA-  
GO:0097190apoptotic signaling pathway-TAS-  
GO:0097191extrinsic apoptotic signaling pathway-IDA21737330  
GO:0097527necroptotic signaling pathway-IDA21737330  
GO:1901224positive regulation of NIK/NF-kappaB signaling-IDA19740627  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005622intracellular-IDA25204797  
GO:0005737cytoplasm-IDA19740627  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005769early endosome-IEA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9435236  
GO:0009986cell surfaceNOTIDA19740627  
GO:0010008endosome membrane-TAS-  
GO:0016020membrane-NAS12054664  
GO:0036020endolysosome membrane-TAS-  
KEGG ID KEGG Term
hsa04620Toll-like receptor signaling pathway
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-1606322ZBP1(DAI) mediated induction of type I IFNsTAS
R-HSA-1643685DiseaseTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-1679131Trafficking and processing of endosomal TLRTAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-168927TICAM1, RIP1-mediated IKK complex recruitment TAS
R-HSA-1810476RIP-mediated NFkB activation via ZBP1TAS
R-HSA-1834949Cytosolic sensors of pathogen-associated DNA TAS
R-HSA-5260271Diseases of Immune SystemTAS
R-HSA-5602358Diseases associated with the TLR signaling cascadeTAS
R-HSA-5602410TLR3 deficiency - HSETAS
R-HSA-5602415UNC93B1 deficiency - HSETAS
R-HSA-5602566TICAM1 deficiency - HSETAS
R-HSA-5602571TRAF3 deficiency - HSETAS
R-HSA-9013957TLR3-mediated TICAM1-dependent programmed cell deathTAS
R-HSA-9013973TICAM1-dependent activation of IRF3/IRF7TAS
R-HSA-9014325TICAM1,TRAF6-dependent induction of TAK1 complexTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-937072TRAF6-mediated induction of TAK1 complex within TLR4 complexTAS
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS
R-HSA-975163IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22103307Breastfeeding modulates neonatal innate immune responses: a prospective birth cohort study. (2012 Feb)Belderbos MEPediatr Allergy Immunol
28009434Gene polymorphisms of TLR2 and TLR3 in HBV clearance and HBV-related hepatocellular carcinoma in a Chinese male population. (2017 May 4)Chen DInt J Biol Markers
25434707Protective and pathological roles of tissue factor in the heart. (2015)Bode MFHamostaseologie
16870663Maternal smoking is associated with impaired neonatal toll-like-receptor-mediated immune responses. (2006 Oct)Noakes PSEur Respir J
21738617Bone marrow mononuclear cells up-regulate toll-like receptor expression and produce inflammatory mediators in response to cigarette smoke extract. (2011)Zhou JPLoS One
19769802Cigarette smoke extract enhances rhinovirus-induced toll-like receptor 3 expression and interleukin-8 secretion in A549 cells. (2009 Nov-Dec)Wang JHAm J Rhinol Allergy
29571298Toll-like receptor 3 modulates the behavioral effects of cocaine in mice. (2018 Mar 23)Zhu RJ Neuroinflammation
27604339Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses. (2016 Sep 7)Wu WRespir Res
23348232Toll-like receptor 3 stimulation causes corticosteroid-refractory airway neutrophilia and hyperresponsiveness in mice. (2013 Jul)Kimura GChest
25332681Diet and lifestyle factors modify immune/inflammation response genes to alter breast cancer risk and prognosis: the Breast Cancer Health Disparities Study. (2014 Dec)Slattery MLMutat Res
21425908Toll-like receptor expression and activation in astroglia: differential regulation by HIV-1 Tat, gp120, and morphine. (2011)El-Hage NImmunol Invest
23497334Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression. (2013 Mar 9)Todt JCRespir Res
22591330Cigarette smoke augments the expression and responses of toll-like receptor 3 in human macrophages. (2012 Aug)Koarai ARespirology
22994343Toll-like receptors 2, 3 and 4 and thymic stromal lymphopoietin expression in fatal asthma. (2012 Oct)Ferreira DSClin Exp Allergy
21792899Toll-like receptor genes and their association with colon and rectal cancer development and prognosis. (2012 Jun 15)Slattery MLInt J Cancer
25346143Expression of nucleic acid-sensing Toll-like receptors predicts HPV16 clearance associated with an E6-directed cell-mediated response. (2015 May 15)Scott MEInt J Cancer
23206318High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence. (2013 Apr 1)Crews FTBiol Psychiatry
23941132Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons. (2013 Aug 14)Klaile ERespir Res