Gene: TLR5

7100
MELIOS|SLE1|SLEB1|TIL3
toll like receptor 5
protein-coding
1q41
Ensembl:ENSG00000187554 MIM:603031 Vega:OTTHUMG00000037937 UniprotKB:O60602
NG_016244.1
PubMed
0   ANCO-SNPs
CD|ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.020e-1 (AD)  3.117e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SIRPB20.921
TLR60.887
TLR70.87
NFAM10.859
AOAH0.859
RGS180.857
TLR80.854
CD840.854
CD330.853
VENTX0.853

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZSCAN1-0.4
ATOH7-0.379
KCNIP3-0.366
CRH-0.357
NEUROD6-0.354
KREMEN2-0.353
CPLX3-0.349
GSG1-0.348
MARCH4-0.348
ST6GAL2-0.342

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TLR5 mRNA"22698814|2890350
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one[Lipopolysaccharides co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in increased expression of TLR5 mRNA23405061
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of TLR5 mRNA"20406850
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of TLR5 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of TLR5 mRNA17562736
D000119Acetylmuramyl-Alanyl-IsoglutamineAcetylmuramyl-Alanyl-Isoglutamine results in increased expression of TLR5 mRNA17087994
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of TLR5 mRNA"23195993
D000942Antigens, Bacterial"Antigens, Bacterial results in increased activity of TLR5 protein"28003376
D001151ArsenicArsenic results in increased expression of TLR5 mRNA27838757
C012768benzanthronebenzanthrone results in increased expression of TLR5 mRNA28495615
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TLR5 mRNA20064835
C006780bisphenol Abisphenol A affects the expression of TLR5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TLR5 gene28505145
C528306CBLB502CBLB502 binds to TLR5 protein24602561
D002994ClofibrateClofibrate results in increased expression of TLR5 mRNA23811191
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of TLR5 mRNA23405061
C007262deoxynivalenoldeoxynivalenol results in increased expression of TLR5 mRNA22968694
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of TLR5 mRNA28962523
C039281furanfuran results in decreased expression of TLR5 mRNA24183702
C008261lead acetatelead acetate results in decreased expression of TLR5 mRNA22609695
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in increased expression of TLR5 mRNA23405061
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with U 0126] results in increased expression of TLR5 mRNA23405061
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of TLR5 mRNA23405061
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TLR5 mRNA23405061
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Titanium] results in decreased expression of TLR5 mRNA21308757
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of TLR5 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon inhibits the reaction [TLR5 protein results in increased secretion of IL12B protein]"23266719
D037742Nanotubes, Carbon"Nanotubes, Carbon promotes the reaction [TLR5 protein results in increased secretion of TNF protein]"23266719
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TLR5 mRNA"25620056
D009532NickelNickel results in decreased expression of TLR5 mRNA23195993|2476865
C508075Pam(3)CSK(4) peptidePam(3)CSK(4) peptide results in decreased expression of TLR5 mRNA23405061
C508075Pam(3)CSK(4) peptidePam(3)CSK(4) peptide results in increased expression of TLR5 mRNA23405061
C002669parthenolideparthenolide results in decreased expression of TLR5 mRNA16921510
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of TLR5 mRNA23948077
D010416PentachlorophenolPentachlorophenol results in increased expression of TLR5 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of TLR5 mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of TLR5 mRNA18301758
D011070Poly I-CPoly I-C results in decreased expression of TLR5 mRNA23405061
D011070Poly I-CPoly I-C results in increased expression of TLR5 mRNA17087994
D011374ProgesteroneProgesterone results in decreased expression of TLR5 mRNA21540246
D011374ProgesteroneProgesterone results in increased expression of TLR5 mRNA17701593
C059514resveratrol[resveratrol co-treated with TLR5 protein] results in increased secretion of IL1B protein24035785
C059514resveratrol[resveratrol co-treated with TLR5 protein] results in increased secretion of IL6 protein24035785
C059514resveratrol[resveratrol co-treated with TLR5 protein] results in increased secretion of TNF protein24035785
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TLR5 mRNA25895662
D013629TamoxifenTamoxifen results in decreased expression of TLR5 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TLR5 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TLR5 mRNA26290441
D014025Titanium[Lipopolysaccharides co-treated with Titanium] results in decreased expression of TLR5 mRNA21308757
D014241TrichloroethyleneTrichloroethylene results in increased methylation of TLR5 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of TLR5 mRNA24935251
C113580U 0126[Lipopolysaccharides co-treated with U 0126] results in increased expression of TLR5 mRNA23405061
D014635Valproic AcidValproic Acid results in decreased expression of TLR5 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TLR5 gene25560391
C025643vinclozolinvinclozolin results in increased expression of TLR5 mRNA18629315
C088658zoledronic acidzoledronic acid results in increased expression of TLR5 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0005149interleukin-1 receptor binding-IPI12925853  
GO ID GO Term Qualifier Evidence PubMed
GO:0002755MyD88-dependent toll-like receptor signaling pathway-TAS-  
GO:0006954inflammatory response-IEA-  
GO:0032757positive regulation of interleukin-8 production-IDA17128265  
GO:0034123positive regulation of toll-like receptor signaling pathway-IDA17128265  
GO:0034146toll-like receptor 5 signaling pathway-TAS-  
GO:0042742defense response to bacterium-IEA-  
GO:0045087innate immune response-IEA-  
GO:0050707regulation of cytokine secretion-IEA-  
GO:0071260cellular response to mechanical stimulus-IEP19593445  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04620Toll-like receptor signaling pathway
hsa05130Pathogenic Escherichia coli infection
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-168142Toll Like Receptor 10 (TLR10) CascadeTAS
R-HSA-168176Toll Like Receptor 5 (TLR5) CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-5260271Diseases of Immune SystemTAS
R-HSA-5602358Diseases associated with the TLR signaling cascadeTAS
R-HSA-5602680MyD88 deficiency (TLR5)TAS
R-HSA-5603037IRAK4 deficiency (TLR5)TAS
R-HSA-975871MyD88 cascade initiated on plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26061394Expression of Toll-like receptors in nasal epithelium in allergic rhinitis. (2015 Aug)Renkonen JAPMIS
27717287Cocaine Vaccine Development: Evaluation of Carrier and Adjuvant Combinations That Activate Multiple Toll-Like Receptors. (2016 Nov 7)Kimishima AMol Pharm
25531528Flagellin as carrier and adjuvant in cocaine vaccine development. (2015 Feb 2)Lockner JWMol Pharm
22855713Airway epithelial expression of TLR5 is downregulated in healthy smokers and smokers with chronic obstructive pulmonary disease. (2012 Sep 1)Wang RJ Immunol