Gene info: ID 7101

Gene: NR2E1

GENE ID: 7101

Synonyms: TLL|TLX|XTLL

Description: nuclear receptor subfamily 2 group E member 1

Gene type: protein-coding

Location: 6q21

dbXrefs: Ensembl:ENSG00000112333 MIM:603849 Vega:OTTHUMG00000015319 UniprotKB:Q9Y466

RefSeq: NG_042807.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.361e-1 (AD) 8.072e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EZR	0.905
STOX1	0.897
ARHGEF26	0.893
SLC1A3	0.892
OAF	0.886
SLC4A4	0.884
EMX2	0.883
FAM167A	0.879
TP53BP2	0.878
CLDN10	0.875

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NRG1	-0.466
ADTRP	-0.448
TRABD2A	-0.436
THEMIS	-0.433
FOXP2	-0.432
ENPP6	-0.43
NPFFR2	-0.426
QRFPR	-0.425
POSTN	-0.422
SAMD5	-0.415

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2E1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2E1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2E1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2E1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2E1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2E1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of NR2E1 mRNA	25064622
D000638	Amiodarone	Amiodarone affects the expression of NR2E1 mRNA	25064622
D001151	Arsenic	Arsenic affects the methylation of NR2E1 gene	25304211
C015001	arsenite	arsenite results in increased methylation of NR2E1 promoter	23974009
C006780	bisphenol A	bisphenol A affects the methylation of NR2E1 promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of NR2E1 mRNA	25181051
D002746	Chlorpromazine	Chlorpromazine affects the expression of NR2E1 mRNA	25064622
D019327	Copper Sulfate	Copper Sulfate results in increased expression of NR2E1 mRNA	19549813
D016572	Cyclosporine	Cyclosporine affects the expression of NR2E1 mRNA	25064622
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of NR2E1 mRNA	25064622
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of NR2E1 mRNA	28001369
D010269	Paraquat	Paraquat affects the expression of NR2E1 mRNA	25064622
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of NR2E1 mRNA	25895662
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NR2E1 mRNA	21570461\|2405805
D013752	Tetracycline	Tetracycline affects the expression of NR2E1 mRNA	25064622
D013853	Thioacetamide	Thioacetamide affects the expression of NR2E1 mRNA	25064622
C012589	trichostatin A	trichostatin A results in decreased expression of NR2E1 mRNA	15901671
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2E1 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of NR2E1 mRNA	24935251\|2627250
D014635	Valproic Acid	Valproic Acid affects the expression of NR2E1 mRNA	25064622
D014635	Valproic Acid	Valproic Acid results in decreased expression of NR2E1 mRNA	15901671
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2E1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of NR2E1 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased expression of NR2E1 mRNA	19101580\|2317975
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of NR2E1 gene	25560391
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2E1 mRNA"	27188386
C111237	vorinostat	vorinostat results in decreased expression of NR2E1 mRNA	26272509

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0003707	steroid hormone receptor activity	-	IEA	-
GO:0005515	protein binding	-	IPI	28420882
GO:0008270	zinc ion binding	-	IEA	-
GO:0042826	histone deacetylase binding	-	IEA	-
GO:0043565	sequence-specific DNA binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0001662	behavioral fear response	-	IEA	-
GO:0002118	aggressive behavior	-	IEA	-
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	-
GO:0007399	nervous system development	-	TAS	9628820
GO:0007601	visual perception	-	IEA	-
GO:0021542	dentate gyrus development	-	IEA	-
GO:0021764	amygdala development	-	IEA	-
GO:0021772	olfactory bulb development	-	IEA	-
GO:0021819	layer formation in cerebral cortex	-	IEA	-
GO:0021872	forebrain generation of neurons	-	IEA	-
GO:0021895	cerebral cortex neuron differentiation	-	IEA	-
GO:0021960	anterior commissure morphogenesis	-	IEA	-
GO:0030198	extracellular matrix organization	-	IEA	-
GO:0035019	somatic stem cell population maintenance	-	IEA	-
GO:0035176	social behavior	-	IEA	-
GO:0043066	negative regulation of apoptotic process	-	IEA	-
GO:0043401	steroid hormone mediated signaling pathway	-	IEA	-
GO:0045165	cell fate commitment	-	IEA	-
GO:0045665	negative regulation of neuron differentiation	-	IEA	-
GO:0045766	positive regulation of angiogenesis	-	IEA	-
GO:0045787	positive regulation of cell cycle	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	-
GO:0048712	negative regulation of astrocyte differentiation	-	IEA	-
GO:0048814	regulation of dendrite morphogenesis	-	IEA	-
GO:0060041	retina development in camera-type eye	-	IEA	-
GO:0060164	regulation of timing of neuron differentiation	-	IEA	-
GO:0060291	long-term synaptic potentiation	-	IEA	-
GO:0090049	regulation of cell migration involved in sprouting angiogenesis	-	IEA	-
GO:2000178	negative regulation of neural precursor cell proliferation	-	IEA	-
GO:2000179	positive regulation of neural precursor cell proliferation	-	IEA	-
GO:2000648	positive regulation of stem cell proliferation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1257604	PIP3 activates AKT signaling	IEA
R-HSA-162582	Signal Transduction	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-383280	Nuclear Receptor transcription pathway	TAS
R-HSA-6807070	PTEN Regulation	IEA
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8943724	Regulation of PTEN gene transcription	IEA
R-HSA-9006925	Intracellular signaling by second messengers	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24847019	In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling. (2014 Jul)	Fowler PA	Hum Reprod