Gene: TMOD1

7111
D9S57E|ETMOD|TMOD
tropomodulin 1
protein-coding
9q22.33
Ensembl:ENSG00000136842 MIM:190930 Vega:OTTHUMG00000020325 UniprotKB:P28289
NC_000009.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.689e-2 (AD)  8.490e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXO340.915
NDEL10.914
DIAPH10.908
UBP10.904
ARHGEF30.899
ATP1A10.898
CDR20.897
CNST0.895
BTBD100.894
SLC25A120.894

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.5
OR4F29-0.479
HEY2-0.394
MYL3-0.368
CTNNA3-0.366
MBNL3-0.358
CPM-0.348
LRAT-0.343
COPZ2-0.34
OLAH-0.338

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TMOD1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of TMOD1 mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TMOD1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TMOD1 mRNA"19692669
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMOD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMOD1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TMOD1 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of TMOD1 mRNA17562736
D020106AcrylamideAcrylamide affects the expression of TMOD1 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TMOD1 mRNA16483693
D016589AstemizoleAstemizole results in increased expression of TMOD1 mRNA20221588
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TMOD1 mRNA21715664|2222880
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TMOD1 mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TMOD1 mRNA]25566086
D004958EstradiolEstradiol affects the expression of TMOD1 mRNA14699072
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of TMOD1 mRNA20660070
C044887beta-methylcholinebeta-methylcholine affects the expression of TMOD1 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of TMOD1 mRNA26063408
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of TMOD1 mRNA20147733
C018021cobaltous chloridecobaltous chloride results in increased expression of TMOD1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of TMOD1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of TMOD1 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of TMOD1 mRNA27989131
C017160cypermethrincypermethrin results in increased expression of TMOD1 mRNA21142847
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TMOD1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of TMOD1 mRNA22023808
D004041Dietary FatsDietary Fats results in increased expression of TMOD1 mRNA25016146
D002117CalcitriolCalcitriol results in increased expression of TMOD1 mRNA16002434
C118739entinostatentinostat results in increased expression of TMOD1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMOD1 mRNA"27188386
C017461lead nitratelead nitrate results in decreased expression of TMOD1 mRNA21628963
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TMOD1 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of TMOD1 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of TMOD1 mRNA19812364
C029938nickel sulfatenickel sulfate results in increased expression of TMOD1 mRNA22714537
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TMOD1 mRNA27935865
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TMOD1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of TMOD1 mRNA25729387
C030110oxaliplatin[Topotecan co-treated with oxaliplatin] results in decreased expression of TMOD1 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of TMOD1 mRNA26516004
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of TMOD1 mRNA22237054
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TMOD1 mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of TMOD1 mRNA18301758
C006253pirinixic acidpirinixic acid results in increased expression of TMOD1 mRNA12832660
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of TMOD1 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of TMOD1 mRNA20726854
D011441PropylthiouracilPropylthiouracil results in decreased expression of TMOD1 mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of TMOD1 mRNA14699072
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of TMOD1 mRNA19059307
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TMOD1 mRNA19059307
C089730rosiglitazonerosiglitazone results in decreased expression of TMOD1 mRNA21515302
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TMOD1 mRNA25351596
D012834SilverSilver results in decreased expression of TMOD1 mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of TMOD1 gene28589171
D012969Sodium FluorideSodium Fluoride results in increased expression of TMOD1 protein28918527
D013629TamoxifenTamoxifen affects the expression of TMOD1 mRNA14699072
D013629Tamoxifen[Tamoxifen co-treated with ESR1 protein] results in increased expression of TMOD1 mRNA19059307
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of TMOD1 mRNA19059307
C501413tesaglitazartesaglitazar results in decreased expression of TMOD1 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMOD1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TMOD1 mRNA19692669
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMOD1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMOD1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TMOD1 mRNA21724226
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TMOD1 mRNA25729387
D019772Topotecan[Topotecan co-treated with oxaliplatin] results in decreased expression of TMOD1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of TMOD1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of TMOD1 mRNA21934132
C011559tributyltintributyltin results in increased expression of TMOD1 mRNA21683754
C012589trichostatin Atrichostatin A affects the expression of TMOD1 mRNA28542535
C057693troglitazonetroglitazone results in increased expression of TMOD1 mRNA19140230
D017973Tungsten CompoundsTungsten Compounds results in decreased expression of TMOD1 mRNA28666766
D014415TunicamycinTunicamycin results in increased expression of TMOD1 mRNA17127020
D014635Valproic AcidValproic Acid affects the expression of TMOD1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TMOD1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of TMOD1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TMOD1 gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of TMOD1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IDA26370058  
GO:0005523tropomyosin binding-IBA21873635  
GO:0051015actin filament binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-IBA21873635  
GO:0007015actin filament organization-IBA21873635  
GO:0008344adult locomotory behavior-IEA-  
GO:0030049muscle filament sliding-TAS-  
GO:0030239myofibril assembly-IBA21873635  
GO:0051694pointed-end actin filament capping-IEA-  
GO:0070307lens fiber cell development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IBA21873635  
GO:0005865striated muscle thin filament-IBA21873635  
GO:0005865striated muscle thin filament-IDA25250574  
GO:0005884actin filament-IDA26370058  
GO:0008180COP9 signalosomecolocalizes_withIDA18850735  
GO:0016020membrane-IEA-  
GO:0030016myofibril-IBA21873635  
GO:0030016myofibril-IDA26370058  
GO:0030017sarcomere-IDA26370058  
GO:0030863cortical cytoskeleton-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-390522Striated Muscle ContractionTAS
R-HSA-397014Muscle contractionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25110502Effects of smoking cessation on gene expression in human leukocytes of chronic smoker. (2014 Jul)Kim SJPsychiatry Investig