Gene info: ID 7112

Gene: TMPO

GENE ID: 7112

Synonyms: CMD1T|LAP2|LEMD4|PRO0868|TP

Description: thymopoietin

Gene type: protein-coding

Location: 12q23.1

dbXrefs: Ensembl:ENSG00000120802 MIM:188380 Vega:OTTHUMG00000170210 UniprotKB:P42166

RefSeq: NG_021393.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.446e-1 (AD) 7.998e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZBTB38	0.92
RPE	0.919
CGGBP1	0.907
APPL1	0.906
SACM1L	0.905
FGFR1OP2	0.901
ZBTB11	0.899
CCDC126	0.899
LEPROTL1	0.897
PPP1R12A	0.894

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.525
OR4F29	-0.494
SOX3	-0.308
ENDOU	-0.306
S100A1	-0.306
NXNL1	-0.302
PON1	-0.3
PLA2G5	-0.296
S100A14	-0.294
C22orf31	-0.291

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in decreased phosphorylation of TMPO protein"	27026707
C032668	1-nitropyrene	1-nitropyrene results in increased expression of TMPO mRNA	19041380
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TMPO mRNA"	19114083
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TMPO mRNA"	19167446
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of TMPO mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMPO mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMPO mRNA"	27188386
C075773	4-phenylbutyric acid	4-phenylbutyric acid results in decreased expression of TMPO mRNA	14583596
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMPO mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMPO mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of TMPO mRNA	21420995\|2906747
C016601	afimoxifene	afimoxifene results in decreased expression of TMPO mRNA	16514628
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TMPO mRNA	16483693
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of TMPO mRNA	26705709
C006632	arsenic trioxide	arsenic trioxide results in increased expression of TMPO mRNA	20458559
C015001	arsenite	arsenite affects the expression of TMPO mRNA	22959463
D001280	Atrazine	Atrazine results in increased expression of TMPO mRNA	25929836
D001374	Azacitidine	[Azacitidine co-treated with Thalidomide] affects the expression of TMPO mRNA	18720364
D001379	Azathioprine	Azathioprine results in decreased expression of TMPO mRNA	22623647
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TMPO mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TMPO protein	20097212
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TMPO mRNA"	19150397\|2038263
D004958	Estradiol	Estradiol results in decreased phosphorylation of TMPO protein	27026707
D004958	Estradiol	Estradiol results in increased expression of TMPO mRNA	16474171\|1651462
C006780	bisphenol A	bisphenol A results in decreased expression of TMPO mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of TMPO mRNA	16474171
C006780	bisphenol A	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TMPO promoter	23359474
C006780	bisphenol A	bisphenol A results in increased expression of TMPO mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased phosphorylation of TMPO protein	22174045
D000069286	Bortezomib	Bortezomib results in decreased expression of TMPO mRNA	20977926
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of TMPO mRNA	12414654\|1533650
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TMPO protein	24527689
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of TMPO mRNA	23650126
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TMPO mRNA	19320972\|1937684
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TMPO mRNA	24386269
D003042	Cocaine	Cocaine results in increased expression of TMPO mRNA	17898221
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of TMPO mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of TMPO mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TMPO mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of TMPO mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of TMPO mRNA	19167446
D016572	Cyclosporine	Cyclosporine results in decreased expression of TMPO mRNA	20106945\|2163298
D000069439	Dasatinib	Dasatinib results in decreased expression of TMPO mRNA	20579391
D003703	Demecolcine	Demecolcine results in decreased expression of TMPO mRNA	23649840
C007262	deoxynivalenol	deoxynivalenol affects the phosphorylation of TMPO protein	23811945
D003993	Dibutyl Phthalate	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TMPO promoter	23359474
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of TMPO mRNA	21266533
D002945	Cisplatin	Cisplatin inhibits the reaction [Piroxicam results in increased expression of TMPO mRNA]	21858171
D004051	Diethylhexyl Phthalate	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TMPO promoter	23359474
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TMPO mRNA	17854601
D004052	Diethylnitrosamine	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TMPO mRNA]	17854601
D002117	Calcitriol	Calcitriol results in decreased expression of TMPO mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of TMPO mRNA	21592394
D015127	9,10-Dimethyl-1,2-benzanthracene	"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of TMPO protein"	22248470
D004221	Disulfiram	Disulfiram results in decreased expression of TMPO mRNA	20530235
D004237	Diuron	Diuron results in decreased expression of TMPO mRNA	21551480
D004317	Doxorubicin	TMPO protein affects the susceptibility to Doxorubicin	16217747
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of TMPO mRNA	20064776
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TMPO protein	23301498
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of TMPO mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TMPO mRNA	17942748
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of TMPO mRNA	23649840
D018120	Finasteride	Finasteride results in increased expression of TMPO mRNA	24136188
D005485	Flutamide	Flutamide results in decreased expression of TMPO mRNA	24793618
D005557	Formaldehyde	Formaldehyde results in decreased expression of TMPO mRNA	23649840
C070081	fulvestrant	fulvestrant results in decreased expression of TMPO mRNA	16514628
D019833	Genistein	Genistein results in increased expression of TMPO mRNA	16474171
D005839	Gentamicins	Gentamicins results in increased expression of TMPO mRNA	22061828
D005897	Glafenine	Glafenine results in decreased expression of TMPO mRNA	24136188
D017313	Fenretinide	Fenretinide results in increased expression of TMPO mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of TMPO mRNA	12414654
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of TMPO mRNA	25613284
D007529	Isoflavones	"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of TMPO protein"	22248470
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TMPO mRNA	24796395
C410337	K 7174	K 7174 results in decreased expression of TMPO mRNA	24086573
D007649	Ketamine	Ketamine results in decreased expression of TMPO mRNA	20080153
D007854	Lead	Lead affects the expression of TMPO mRNA	28903495
C045463	leflunomide	leflunomide results in decreased expression of TMPO mRNA	28988120
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TMPO mRNA	21641980
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of TMPO mRNA	23649840
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of TMPO mRNA	23649840
D009151	Mustard Gas	Mustard Gas results in increased phosphorylation of TMPO protein	19845377
D009532	Nickel	Nickel results in decreased expression of TMPO mRNA	18922574
C022838	nickel chloride	nickel chloride results in decreased expression of TMPO mRNA	17312168
D005996	Nitroglycerin	Nitroglycerin results in increased expression of TMPO mRNA	12102619
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of TMPO mRNA	20971185
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of TMPO mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of TMPO mRNA	25729387
C500026	palbociclib	palbociclib results in decreased expression of TMPO mRNA	22869556
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of TMPO mRNA	23892564
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of TMPO protein	26879310
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of TMPO mRNA	17616710
D010634	Phenobarbital	Phenobarbital affects the expression of TMPO mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of TMPO mRNA	19162173
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMPO mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of TMPO mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in decreased expression of TMPO mRNA	17426115
C006253	pirinixic acid	pirinixic acid results in increased expression of TMPO mRNA	23811191
D010894	Piroxicam	Cisplatin inhibits the reaction [Piroxicam results in increased expression of TMPO mRNA]	21858171
D010894	Piroxicam	Piroxicam results in increased expression of TMPO mRNA	21858171
D010936	Plant Extracts	Plant Extracts results in increased expression of TMPO mRNA	23557933
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog results in increased expression of TMPO mRNA	16474171
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of TMPO mRNA	23608068
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of TMPO mRNA	19162173
D011374	Progesterone	Progesterone affects the expression of TMPO mRNA	17251523
D011374	Progesterone	Progesterone results in decreased expression of TMPO mRNA	20726854
C045950	propiconazole	propiconazole results in increased expression of TMPO mRNA	19363144\|2127805
C005556	propionaldehyde	propionaldehyde results in decreased expression of TMPO mRNA	26079696
C010313	pseudocumene	pseudocumene results in decreased expression of TMPO protein	17337753
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of TMPO mRNA	16514628
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of TMPO mRNA	19167446
C059514	resveratrol	resveratrol results in decreased phosphorylation of TMPO protein	25311616
C059514	resveratrol	resveratrol results in decreased expression of TMPO protein	25505154
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of TMPO mRNA	21427059
C017947	sodium arsenite	sodium arsenite affects the methylation of TMPO gene	28589171
C017947	sodium arsenite	sodium arsenite results in decreased expression of TMPO mRNA	17998272
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of TMPO protein	28918527
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of TMPO protein	27548804
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of TMPO mRNA	24383545
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TMPO mRNA	21641980
C025462	sulindac sulfide	sulindac sulfide results in decreased expression of TMPO mRNA	16184548
C061133	tamibarotene	tamibarotene affects the expression of TMPO mRNA	15498508
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of TMPO mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of TMPO mRNA	21592394
C020806	tetrabromobisphenol A	tetrabromobisphenol A affects the expression of TMPO mRNA	18976794
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TMPO mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TMPO mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TMPO mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TMPO mRNA	15328365\|1794274
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of TMPO mRNA	25613284
D013792	Thalidomide	[Azacitidine co-treated with Thalidomide] affects the expression of TMPO mRNA	18720364
D013893	Thiram	Thiram results in decreased expression of TMPO mRNA	20530235
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of TMPO mRNA	28065790
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of TMPO mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of TMPO mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of TMPO mRNA	15498508
C032910	triadimefon	triadimefon results in increased expression of TMPO mRNA	19363144
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMPO mRNA"	27188386
C012589	trichostatin A	trichostatin A affects the expression of TMPO mRNA	28542535
C012589	trichostatin A	trichostatin A results in decreased expression of TMPO mRNA	26272509
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of TMPO mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TMPO mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of TMPO mRNA	28973697
C080163	trovafloxacin	trovafloxacin results in decreased expression of TMPO mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of TMPO mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of TMPO mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid results in decreased methylation of TMPO gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of TMPO mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in decreased expression of TMPO mRNA	21427059
D014747	Vinblastine	TMPO protein affects the susceptibility to Vinblastine	16217747
C025643	vinclozolin	vinclozolin results in increased expression of TMPO mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in increased expression of TMPO mRNA	26682919
D024483	Vitamin K 3	Vitamin K 3 results in decreased expression of TMPO mRNA	12414654
C111237	vorinostat	vorinostat results in decreased expression of TMPO mRNA	22083351

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003677	DNA binding	-	IEA	-
GO:0005515	protein binding	-	IPI	16247757 29568061
GO:0005521	lamin binding	-	TAS	8530026
GO:0045296	cadherin binding	-	HDA	25468996

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006355	regulation of transcription, DNA-templated	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000785	chromatin	-	IDA	17284516
GO:0005634	nucleus	-	IDA	17284516
GO:0005635	nuclear envelope	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1640170	Cell Cycle	TAS
R-HSA-2555396	Mitotic Metaphase and Anaphase	TAS
R-HSA-2980766	Nuclear Envelope Breakdown	TAS
R-HSA-2993913	Clearance of Nuclear Envelope Membranes from Chromatin	TAS
R-HSA-2995383	Initiation of Nuclear Envelope Reformation	TAS
R-HSA-2995410	Nuclear Envelope Reassembly	TAS
R-HSA-4419969	Depolymerisation of the Nuclear Lamina	TAS
R-HSA-68875	Mitotic Prophase	TAS
R-HSA-68882	Mitotic Anaphase	TAS
R-HSA-68886	M Phase	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28587642	Differential expression analysis at the individual level reveals a lncRNA prognostic signature for lung adenocarcinoma. (2017 Jun 6)	Peng F	Mol Cancer