Gene: TMPRSS2

7113
PP9284|PRSS10
transmembrane serine protease 2
protein-coding
21q22.3
Ensembl:ENSG00000184012 MIM:602060 Vega:OTTHUMG00000086762 UniprotKB:O15393
NG_047085.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.775e-1 (AD)  8.875e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRAC10.681
REG3G0.655
KLK20.65
MSMB0.648
TGM40.644
KLK30.617
ACPP0.604
MS4A30.595
BPI0.595
CEACAM80.586

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KHDC1-0.331
OMG-0.308
FBXO15-0.306
SIRT5-0.305
NME9-0.304
ENPP5-0.303
BCAS3-0.3
LRRC27-0.298
VTN-0.298
TMEM56-0.297

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of TMPRSS2 mRNA"26377693
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of TMPRSS2 mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of TMPRSS2 mRNA]"27071940
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TMPRSS2 mRNA"22698814
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TMPRSS2 mRNA"25510870
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of TMPRSS2 mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TMPRSS2 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TMPRSS2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TMPRSS2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TMPRSS2 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TMPRSS2 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TMPRSS2 mRNA"25510870
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of TMPRSS2 mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMPRSS2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMPRSS2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMPRSS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMPRSS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMPRSS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMPRSS2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TMPRSS2 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of TMPRSS2 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [SOD2 protein affects the expression of TMPRSS2 mRNA]18829485
C109238acylineacyline results in decreased expression of TMPRSS2 mRNA17510436
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TMPRSS2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TMPRSS2 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TMPRSS2 mRNA19770486
D013196Dihydrotestosteronebicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA]23708653|2875713
D013196DihydrotestosteroneCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to TMPRSS2 enhancer]]22258452
D013196DihydrotestosteroneCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]]22258452
D013196DihydrotestosteroneCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to TMPRSS2 enhancer]]22258452
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [AR protein binds to TMPRSS2 enhancer]22258452
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]22258452
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [GATA2 protein binds to TMPRSS2 enhancer]22258452
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of TMPRSS2 mRNA12711008
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of TMPRSS2 mRNA20601956|2370865
D013196DihydrotestosteroneEtoposide inhibits the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA]20601956
D013196Dihydrotestosteronemerbarone inhibits the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA]20601956
D013196Dihydrotestosteronepalbociclib promotes the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA]23708653
D013196DihydrotestosteroneTOP2B protein promotes the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA]20601956
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TMPRSS2 mRNA16483693
D000728AndrogensAndrogens promotes the reaction [TOP2B protein results in increased mutagenesis of TMPRSS2 gene]20601956
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TMPRSS2 mRNA21802500
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of TMPRSS2 mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TMPRSS2 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TMPRSS2 mRNA19770486
D004958EstradiolEGF protein promotes the reaction [Estradiol results in decreased expression of TMPRSS2 mRNA]24758408
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TMPRSS2 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of TMPRSS2 mRNA24758408
D004958EstradiolEstradiol results in increased expression of TMPRSS2 mRNA19619570
D004958Estradiol[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TMPRSS2 mRNA21185374
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of TMPRSS2 mRNA26496021
C053541bicalutamidebicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA]23708653|2875713
C053541bicalutamide[Goserelin co-treated with bicalutamide] results in decreased expression of TMPRSS2 protein24323034
C053541bicalutamide[Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of TMPRSS2 protein24323034
C053541bicalutamide[Goserelin co-treated with Dutasteride co-treated with bicalutamide] results in decreased expression of TMPRSS2 protein24323034
C006780bisphenol Abisphenol A affects the expression of TMPRSS2 mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of TMPRSS2 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of TMPRSS2 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of TMPRSS2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of TMPRSS2 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of TMPRSS2 mRNA26794494
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TMPRSS2 mRNA18804290
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of TMPRSS220938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TMPRSS2 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMPRSS2 mRNA20938992
D003474CurcuminCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to TMPRSS2 enhancer]]22258452
D003474CurcuminCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]]22258452
D003474CurcuminCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to TMPRSS2 enhancer]]22258452
D003474CurcuminCurcumin results in decreased expression of TMPRSS2 mRNA18719366|2225845
D016572CyclosporineCyclosporine results in decreased expression of TMPRSS2 mRNA20106945
D003622DapsoneDapsone analog inhibits the reaction [Metribolone results in increased expression of TMPRSS2 mRNA]21440447
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of TMPRSS2 mRNA23914054
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TMPRSS2 mRNA]27941970
D003976DiazinonDiazinon results in increased methylation of TMPRSS2 gene22964155
C000944dicrotophosdicrotophos results in decreased expression of TMPRSS2 mRNA28302478
D002117CalcitriolCalcitriol results in increased expression of TMPRSS2 mRNA21592394|2648566
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of TMPRSS2 mRNA21592394
D000068538Dutasteride[Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of TMPRSS2 protein24323034
D000068538Dutasteride[Goserelin co-treated with Dutasteride co-treated with bicalutamide] results in decreased expression of TMPRSS2 protein24323034
D000068538Dutasteride[Goserelin co-treated with Dutasteride] results in decreased expression of TMPRSS2 protein24323034
C118739entinostatentinostat results in increased expression of TMPRSS2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMPRSS2 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TMPRSS2 mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TMPRSS2 mRNA18936297
C024565ethylene dichlorideethylene dichloride results in increased expression of TMPRSS2 mRNA28189721
D005047EtoposideEtoposide inhibits the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA]20601956
D005419FlavonoidsFlavonoids results in increased expression of TMPRSS2 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of TMPRSS220938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TMPRSS2 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMPRSS2 mRNA20938992
C039281furanfuran results in decreased methylation of TMPRSS2 gene27387713
C039281furanfuran results in increased expression of TMPRSS2 mRNA27387713
C106014geduningedunin results in decreased expression of TMPRSS2 mRNA17010675
D019833GenisteinGenistein results in decreased expression of TMPRSS2 mRNA15378649|2686566
C071834glycidamideglycidamide results in decreased expression of TMPRSS2 mRNA17822822
D017273Goserelin[Goserelin co-treated with bicalutamide] results in decreased expression of TMPRSS2 protein24323034
D017273Goserelin[Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of TMPRSS2 protein24323034
D017273Goserelin[Goserelin co-treated with Dutasteride co-treated with bicalutamide] results in decreased expression of TMPRSS2 protein24323034
D017273Goserelin[Goserelin co-treated with Dutasteride] results in decreased expression of TMPRSS2 protein24323034
D017313FenretinideFenretinide results in increased expression of TMPRSS2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TMPRSS2 mRNA20044591
D007213IndomethacinIndomethacin results in decreased expression of TMPRSS2 mRNA28201806
D007654Ketoconazole[Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of TMPRSS2 protein24323034
D018021Lithium ChlorideLithium Chloride results in increased expression of TMPRSS2 mRNA23527032
C045459merbaronemerbarone inhibits the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA]20601956
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of TMPRSS220938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TMPRSS2 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMPRSS2 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TMPRSS2 mRNA23458150
C008493methylselenic acidmethylselenic acid affects the expression of TMPRSS2 mRNA14617803
D015741MetriboloneDapsone analog inhibits the reaction [Metribolone results in increased expression of TMPRSS2 mRNA]21440447
D015741MetriboloneMetribolone results in decreased expression of TMPRSS2 mRNA12711008
D015741MetriboloneMetribolone results in increased expression of TMPRSS2 mRNA17010675|2144044
C028473N-acetyl-4-benzoquinoneimineTMPRSS2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TMPRSS2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TMPRSS2 mRNA"25620056
D009532NickelNickel results in decreased expression of TMPRSS2 mRNA24768652|2558310
C500026palbociclibpalbociclib promotes the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA]23708653
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TMPRSS2 mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of TMPRSS2 mRNA23948077
D010634PhenobarbitalPhenobarbital affects the expression of TMPRSS2 mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of TMPRSS2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of TMPRSS2 mRNA19482888
C011978phentin acetatephentin acetate affects the expression of TMPRSS2 mRNA12711008
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMPRSS2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TMPRSS2 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TMPRSS2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of TMPRSS2 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of TMPRSS2 mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in increased expression of TMPRSS2 mRNA23608068
D011374ProgesteroneProgesterone affects the expression of TMPRSS2 mRNA17251523
C045950propiconazolepropiconazole results in increased expression of TMPRSS2 mRNA21278054
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TMPRSS2 mRNA21185374
C059514resveratrolresveratrol results in decreased expression of TMPRSS2 mRNA18586690
D012643SeleniumSelenium results in increased expression of TMPRSS2 mRNA19244175
D053260SootSoot results in decreased expression of TMPRSS2 mRNA26551751
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of TMPRSS2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of TMPRSS2 mRNA21592394
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of TMPRSS2 mRNA20189893
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TMPRSS2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TMPRSS2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMPRSS2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TMPRSS2 mRNA19770486
C009424tetramethrintetramethrin results in increased expression of TMPRSS2 mRNA12711008
D013853ThioacetamideThioacetamide results in increased expression of TMPRSS2 mRNA23411599
D014212TretinoinTretinoin results in increased expression of TMPRSS2 mRNA23830798
C012589trichostatin Atrichostatin A results in increased expression of TMPRSS2 mRNA24935251
C050414tripterinetripterine results in decreased expression of TMPRSS2 mRNA17010675
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMPRSS2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TMPRSS2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TMPRSS2 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TMPRSS2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of TMPRSS2 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of TMPRSS2 mRNA26682919
C088658zoledronic acidzoledronic acid results in increased expression of TMPRSS2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IEA-  
GO:0005044scavenger receptor activity-IEA-  
GO:0005515protein binding-IPI21068237  
GO:0008236serine-type peptidase activity-TAS9325052  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IDA21068237  24227843  
GO:0006898receptor-mediated endocytosis-IEA-  
GO:0016540protein autoprocessing-IBA21873635  
GO:0016540protein autoprocessing-IMP21068237  
GO:0046598positive regulation of viral entry into host cell-IDA21068237  24227843  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA21068237  
GO:0005887integral component of plasma membrane-TAS9325052  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19147396Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure. (2009 Aug)Cheong SCOral Oncol