Gene: CLDN5

7122
AWAL|BEC1|CPETRL1|TMDVCF|TMVCF
claudin 5
protein-coding
22q11.21
Ensembl:ENSG00000184113 MIM:602101 Vega:OTTHUMG00000150441 UniprotKB:O00501
NC_000022.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.473e-1 (AD)  6.169e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GIMAP50.856
HLA-E0.848
ICAM20.841
SRGN0.838
NFKBIA0.837
TAGLN20.832
KANK30.82
LRRC320.801
ESAM0.8
FXYD50.796

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XKR4-0.459
PPEF1-0.442
GRIN3A-0.436
EPHA5-0.434
KIT-0.43
GABRG3-0.43
PTPRR-0.43
NDST3-0.428
GLRA3-0.425
FSTL5-0.423

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of CLDN5 protein]24200059
C0700552,3',4,4',5-pentachlorobiphenyl"2,3',4,4',5-pentachlorobiphenyl results in decreased expression of CLDN5 protein"20064788
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of CLDN5 protein"20064788
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of CLDN5 mRNA]20525806
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of CLDN5 protein]24200059
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL6 protein results in decreased expression of CLDN5 protein]26025059
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in decreased expression of CLDN5 protein]26025059
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of CLDN5 mRNA25088246
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of CLDN5 mRNA16142770
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of CLDN5 mRNA17011747
D000082AcetaminophenAcetaminophen affects the expression of CLDN5 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of CLDN5 protein]28115242
D000171Acrolein2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of CLDN5 mRNA]20525806
D000171AcroleinAcrolein results in decreased expression of CLDN5 mRNA20525806
D000171AcroleinAcrolein results in increased expression of CLDN5 mRNA20525806
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CLDN5 mRNA16483693
D000068180AripiprazoleAripiprazole results in decreased expression of CLDN5 mRNA17868501
C006632arsenic trioxideAcetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of CLDN5 protein]28115242
C006632arsenic trioxidearsenic trioxide results in decreased expression of CLDN5 protein28115242
C547126AZM551248AZM551248 results in decreased expression of CLDN5 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CLDN5 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CLDN5 mRNA19770486|2171566
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of CLDN5 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of CLDN5 mRNA15289156|1948475
C006780bisphenol Abisphenol A results in decreased expression of CLDN5 mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of CLDN5 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CLDN5 mRNA20711499
D004390ChlorpyrifosChlorpyrifos affects the expression of CLDN5 mRNA22611033
D002922CiguatoxinsCiguatoxins affects the expression of CLDN5 mRNA18353800
C011730clay[clay analog co-treated with deoxynivalenol] results in increased expression of CLDN5 mRNA23922676
C011730clayclay analog results in increased expression of CLDN5 mRNA23922676
C107676deguelindeguelin results in increased expression of CLDN5 mRNA19861542
C007262deoxynivalenol[clay analog co-treated with deoxynivalenol] results in increased expression of CLDN5 mRNA23922676
C007262deoxynivalenoldeoxynivalenol results in increased expression of CLDN5 mRNA23922676
C028009diallyl disulfidediallyl disulfide results in decreased expression of CLDN5 mRNA20600798
C028009diallyl disulfidediallyl disulfide results in decreased expression of CLDN5 protein20600798
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of CLDN5 mRNA24084732
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of CLDN5 protein24084732
D003994BucladesineBucladesine results in increased expression of CLDN5 mRNA20711499
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CLDN5 mRNA15289156
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CLDN5 mRNA17011747
D004176DipyridamoleDipyridamole results in increased expression of CLDN5 mRNA20711499
D004317DoxorubicinDoxorubicin results in increased expression of CLDN5 mRNA19277126
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CLDN5 mRNA17557909
C039281furanfuran results in increased expression of CLDN5 mRNA27387713
D017965gamma-Linolenic Acid[gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of CLDN5 protein16514648
D017965gamma-Linolenic Acid[gamma-Linolenic Acid co-treated with Iodine] results in increased expression of and results in increased localization of CLDN5 protein16514648
D017965gamma-Linolenic Acidgamma-Linolenic Acid results in increased expression of and results in increased localization of CLDN5 protein16514648
D017965gamma-Linolenic Acid[Selenium co-treated with gamma-Linolenic Acid] results in increased expression of and results in increased localization of CLDN5 protein16514648
D019833GenisteinGenistein results in decreased expression of CLDN5 mRNA15289156
D005839GentamicinsGentamicins results in decreased expression of CLDN5 mRNA22061828
D007455Iodine[gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of CLDN5 protein16514648
D007455Iodine[gamma-Linolenic Acid co-treated with Iodine] results in increased expression of and results in increased localization of CLDN5 protein16514648
D007455IodineIodine results in increased expression of and results in increased localization of CLDN5 protein16514648
D007455Iodine[Selenium co-treated with Iodine] results in increased expression of and results in increased localization of CLDN5 protein16514648
D048628KetolidesKetolides analog affects the expression of CLDN5 mRNA24967691
D007854LeadLead results in decreased expression of CLDN5 protein20970449
D007854Lead[malaoxon co-treated with Lead] results in decreased expression of CLDN5 protein20970449
D007854Lead[Malathion co-treated with Lead] results in decreased expression of CLDN5 protein20970449
C008261lead acetate2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of CLDN5 protein]24200059
C008261lead acetate2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of CLDN5 protein]24200059
C008261lead acetatelead acetate results in decreased expression of CLDN5 protein24200059
C100082malaoxon[malaoxon co-treated with Lead] results in decreased expression of CLDN5 protein20970449
C100082malaoxonmalaoxon results in decreased expression of CLDN5 protein20970449
D008294Malathion[Malathion co-treated with Lead] results in decreased expression of CLDN5 protein20970449
D008294MalathionMalathion results in decreased expression of CLDN5 protein20970449
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of CLDN5 mRNA20843944
D008694MethamphetamineMethamphetamine results in decreased expression of CLDN5 mRNA19564919
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of CLDN5 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CLDN5 mRNA"25620056
D009532NickelNickel affects the expression of CLDN5 mRNA14575637
D009532NickelNickel results in decreased expression of CLDN5 mRNA25583101
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of CLDN5 mRNA]14575637
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CLDN5 mRNA25729387
C016030pantogabpantogab results in decreased expression of CLDN5 mRNA17379144
D010208PapaverinePapaverine results in decreased expression of CLDN5 protein20728510
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of CLDN5 mRNA23602845
D010634PhenobarbitalPhenobarbital affects the expression of CLDN5 mRNA19136022
D010798PhycocyaninPhycocyanin inhibits the reaction [tributyltin results in decreased expression of CLDN5 protein]26079211
C006253pirinixic acidpirinixic acid affects the expression of CLDN5 mRNA19136022
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of CLDN5 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of CLDN5 mRNA17404688
C005705sanguinarinesanguinarine results in decreased expression of CLDN5 protein19063874
D012643Selenium[gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of CLDN5 protein16514648
D012643Selenium[Selenium co-treated with gamma-Linolenic Acid] results in increased expression of and results in increased localization of CLDN5 protein16514648
D012643Selenium[Selenium co-treated with Iodine] results in increased expression of and results in increased localization of CLDN5 protein16514648
D012643SeleniumSelenium results in increased expression of and results in increased localization of CLDN5 protein16514648
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CLDN5 mRNA23806026
D012906SmokeSmoke results in decreased expression of CLDN5 mRNA23693141
C009277sodium arsenatesodium arsenate results in decreased expression of CLDN5 mRNA21795629
D013739TestosteroneTestosterone affects the expression of CLDN5 mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLDN5 mRNA24680724
D013749TetrachlorodibenzodioxinGDNF protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CLDN5 protein]26582458
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CLDN5 protein26582458
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CLDN5 mRNA27404394
C024746tobacco tartobacco tar results in decreased expression of CLDN5 mRNA19559774
D014050TolueneToluene results in increased expression of CLDN5 mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CLDN5 mRNA25729387
C011559tributyltinPhycocyanin inhibits the reaction [tributyltin results in decreased expression of CLDN5 protein]26079211
C011559tributyltintributyltin results in decreased expression of CLDN5 protein26079211
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of CLDN5 mRNA]14575637
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of CLDN5 mRNA19042947
C057693troglitazonetroglitazone results in increased expression of CLDN5 mRNA28973697
D014520UrethaneUrethane results in decreased expression of CLDN5 mRNA28818685
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CLDN5 gene25560391
C025643vinclozolinvinclozolin affects the expression of CLDN5 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-IEA-  
GO:0042802identical protein binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003151outflow tract morphogenesis-TAS9192844  
GO:0007043cell-cell junction assembly-IMP23288152  
GO:0007179transforming growth factor beta receptor signaling pathway-IDA21168935  
GO:0007612learning-TAS9192844  
GO:0016338calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules-ISS-  
GO:0060021roof of mouth development-TAS9192844  
GO:0060325face morphogenesis-TAS9192844  
GO:1903142positive regulation of establishment of endothelial barrier-IMP23288152  
GO:2000810regulation of bicellular tight junction assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA25978380  
GO:0005911cell-cell junction-IDA18065521  21168935  23288152  23626836  
GO:0005923bicellular tight junction-IDA9892664  25816133  
GO:0005923bicellular tight junction-ISS-  
GO:0016021integral component of membrane-NAS9892664  
GO:0016021integral component of membrane-TAS9192844  
GO:0016327apicolateral plasma membrane-IDA9892664  
GO:0030054cell junction-TAS-  
GO:0030864cortical actin cytoskeletoncolocalizes_withIDA25816133  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-420029Tight junction interactionsIEA
R-HSA-421270Cell-cell junction organizationIEA
R-HSA-446728Cell junction organizationIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8935964RUNX1 regulates expression of components of tight junctionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27142338Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes. (2016 Jul 15)Shui IMCancer