Gene: TNFAIP2

7127
B94|EXOC3L3
TNF alpha induced protein 2
protein-coding
14q32.32
Ensembl:ENSG00000185215 MIM:603300 Vega:OTTHUMG00000171890 UniprotKB:Q03169
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.126e-2 (AD)  8.661e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WARS0.75
TAP20.741
RAB430.711
SOD20.706
CTSL0.702
SLC25A370.699
CD2740.697
IPO40.694
TRIM250.692
ARF60.691

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.392
OR4F29-0.359
KLRC2-0.217
P2RY14-0.196
DIAPH3-0.193
HPR-0.179
SNX22-0.166
MTRNR2L6-0.163
KCNJ16-0.158
OR4F16-0.151

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TNFAIP2 mRNA"21354444|2269881
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TNFAIP2 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TNFAIP2 mRNA"27291303
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of TNFAIP2 mRNA"18343893
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TNFAIP2 mRNA"19692669
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TNFAIP2 mRNA"23994337
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFAIP2 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of TNFAIP2 mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFAIP2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of TNFAIP2 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TNFAIP2 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of TNFAIP2 mRNA"24160326|2575705
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of TNFAIP2 mRNA"25351596
D001280AtrazineAtrazine results in increased expression of TNFAIP2 mRNA22378314
D001379AzathioprineAzathioprine results in decreased expression of TNFAIP2 mRNA19192274
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of TNFAIP2 mRNA23994337
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TNFAIP2 mRNA22316170
D001564Benzo(a)pyreneAHR affects the reaction [Benzo(a)pyrene results in increased expression of TNFAIP2 mRNA]21995607
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to TNFAIP2 promoter]21995607
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TNFAIP2 mRNA14625279|1977048
D001564Benzo(a)pyrene[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of TNFAIP2 mRNA]14625279
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TNFAIP2 mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNFAIP2 mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of TNFAIP2 mRNA25181051
D002104CadmiumCadmium results in decreased expression of TNFAIP2 mRNA24067728
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TNFAIP2 mRNA12760830
D002185CannabidiolCannabidiol results in increased expression of TNFAIP2 mRNA21542829
C023676chloroquine diphosphatechloroquine diphosphate results in decreased expression of TNFAIP2 mRNA19192274
D002994ClofibrateClofibrate results in decreased expression of TNFAIP2 mRNA23811191
C423222cotylenin Acotylenin A results in increased expression of TNFAIP2 mRNA16129123
D016572CyclosporineCyclosporine results in increased expression of TNFAIP2 mRNA20106945
D013759DronabinolDronabinol results in increased expression of TNFAIP2 mRNA21542829
D003976DiazinonDiazinon results in decreased methylation of TNFAIP2 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TNFAIP2 mRNA21266533
D002945CisplatinCisplatin results in increased expression of TNFAIP2 mRNA27594783
D002117CalcitriolCalcitriol results in increased expression of TNFAIP2 mRNA16129123
D004237DiuronDiuron results in decreased expression of TNFAIP2 mRNA25152437
D004317DoxorubicinDoxorubicin results in increased expression of TNFAIP2 mRNA19277126
D004391DustDust results in increased expression of TNFAIP2 mRNA17805423
C118739entinostatentinostat results in increased expression of TNFAIP2 mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TNFAIP2 mRNA22079256
D000431EthanolEthanol results in decreased expression of TNFAIP2 mRNA16098508
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TNFAIP2 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TNFAIP2 mRNA17942748
D005557FormaldehydeFormaldehyde results in decreased expression of TNFAIP2 mRNA17938736
C039281furanfuran results in decreased expression of TNFAIP2 mRNA26194646
D005897GlafenineGlafenine results in increased expression of TNFAIP2 mRNA24136188
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in decreased expression of TNFAIP2 mRNA19192274
D017313FenretinideFenretinide results in increased expression of TNFAIP2 mRNA28973697
C075954indolo(3,2-b)carbazole"indolo(3,2-b)carbazole results in increased expression of TNFAIP2 mRNA"23994337
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TNFAIP2 mRNA24297863
C045463leflunomideleflunomide results in increased expression of TNFAIP2 mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TNFAIP2 mRNA25890327|2658214
C106335macrophage stimulatory lipopeptide 2macrophage stimulatory lipopeptide 2 results in increased expression of TNFAIP2 mRNA18832182
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TNFAIP2 mRNA21641980
D008727MethotrexateMethotrexate results in decreased expression of TNFAIP2 mRNA19192274
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TNFAIP2 mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of TNFAIP2 mRNA24810058
D008775MethylprednisoloneMethylprednisolone results in decreased expression of TNFAIP2 mRNA19192274
C523799MRK 003TNFAIP2 results in increased susceptibility to MRK 00319903844
C500085muraglitazarmuraglitazar results in decreased expression of TNFAIP2 mRNA21515302
D009151Mustard GasMustard Gas results in increased expression of TNFAIP2 mRNA15674844
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of TNFAIP2 mRNA"29244179
C001478N(6)-(delta(2)-isopentenyl)adenineN(6)-(delta(2)-isopentenyl)adenine results in increased expression of TNFAIP2 mRNA16129123
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TNFAIP2 mRNA"15585362
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TNFAIP2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TNFAIP2 mRNA"25554681|2562005
D009532NickelNickel results in increased expression of TNFAIP2 mRNA25583101
C022838nickel chloridenickel chloride results in increased expression of TNFAIP2 mRNA17312168
C028007nickel monoxidenickel monoxide results in increased expression of TNFAIP2 mRNA19167457
C017557nickel subsulfidenickel subsulfide results in decreased expression of TNFAIP2 mRNA12760830
C029938nickel sulfatenickel sulfate results in increased expression of TNFAIP2 mRNA22714537
D009966OrphenadrineOrphenadrine affects the expression of TNFAIP2 mRNA23665939
D010076OxazepamOxazepam results in increased expression of TNFAIP2 mRNA12727805
D010076OxazepamOxazepam results in increased expression of TNFAIP2 protein12727805
D052638Particulate MatterParticulate Matter results in increased expression of TNFAIP2 mRNA28341207|2841250
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of TNFAIP2 mRNA23948077
D010634PhenobarbitalPhenobarbital affects the expression of TNFAIP2 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of TNFAIP2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of TNFAIP2 mRNA19270015
D010634PhenobarbitalPhenobarbital results in increased expression of TNFAIP2 mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFAIP2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TNFAIP2 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TNFAIP2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of TNFAIP2 mRNA18445702
D010936Plant ExtractsPlant Extracts results in increased expression of TNFAIP2 mRNA21297082
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TNFAIP2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TNFAIP2 mRNA22079256
C027373potassium chromate(VI)[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of TNFAIP2 mRNA]14625279
D011192Potassium Dichromate[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of TNFAIP2 mRNA]14625279
D011239PrednisolonePrednisolone results in decreased expression of TNFAIP2 mRNA19192274
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of TNFAIP2 mRNA28903501
D011374ProgesteroneProgesterone affects the expression of TNFAIP2 mRNA17251523
C089730rosiglitazonerosiglitazone results in decreased expression of TNFAIP2 mRNA21515302
D012643SeleniumSelenium results in increased expression of TNFAIP2 mRNA19244175
D017632Asbestos, Serpentine"Asbestos, Serpentine affects the expression of TNFAIP2 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TNFAIP2 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of TNFAIP2 mRNA25351596
D012834SilverSilver results in increased expression of TNFAIP2 mRNA27131904
C009277sodium arsenatesodium arsenate results in decreased expression of TNFAIP2 mRNA12727804
C017947sodium arsenitesodium arsenite results in decreased expression of TNFAIP2 mRNA12727804|1276083
C017947sodium arsenitesodium arsenite results in increased expression of TNFAIP2 mRNA16014739
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TNFAIP2 mRNA21641980
C016766sulforafansulforafan results in increased expression of TNFAIP2 mRNA26833863
C061133tamibarotenetamibarotene results in increased expression of TNFAIP2 mRNA15498508
D013629TamoxifenTamoxifen affects the expression of TNFAIP2 mRNA17555576|2093736
D013629TamoxifenTamoxifen results in decreased expression of TNFAIP2 mRNA25123088
C501413tesaglitazartesaglitazar results in decreased expression of TNFAIP2 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNFAIP2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNFAIP2 mRNA19692669
D013749TetrachlorodibenzodioxinAHR affects the reaction [Tetrachlorodibenzodioxin results in increased expression of TNFAIP2 mRNA]21995607
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNFAIP2 mRNA18343893|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of TNFAIP2 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TNFAIP2 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of TNFAIP2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNFAIP2 mRNA15328365|1580003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNFAIP2 mRNA22298810
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TNFAIP2 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TNFAIP2 mRNA22363418
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TNFAIP2 mRNA20133372
D024505TocopherolsTocopherols results in increased expression of TNFAIP2 mRNA17056531
D014212TretinoinTretinoin results in increased expression of TNFAIP2 mRNA15498508|1612912
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TNFAIP2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of TNFAIP2 mRNA21515302
D014635Valproic AcidValproic Acid results in decreased expression of TNFAIP2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of TNFAIP2 mRNA20546886
D014638VanadatesVanadates results in decreased expression of TNFAIP2 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TNFAIP2 gene25560391
D002762CholecalciferolCholecalciferol results in increased expression of TNFAIP2 mRNA17170073
C088658zoledronic acidzoledronic acid results in increased expression of TNFAIP2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000149SNARE binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0006887exocytosis-IBA21873635  
GO:0030154cell differentiation-IEA-  
GO:0051601exocyst localization-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000145exocyst-IBA21873635  
GO:0005615extracellular space-TAS1374453  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28416970DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD. (2017)Sundar IKClin Epigenetics