Gene info: ID 7128

Gene: TNFAIP3

GENE ID: 7128

Synonyms: A20|AISBL|OTUD7C|TNFA1P2

Description: TNF alpha induced protein 3

Gene type: protein-coding

Location: 6q23.3

dbXrefs: Ensembl:ENSG00000118503 MIM:191163 Vega:OTTHUMG00000015664 UniprotKB:P21580

RefSeq: NG_032761.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.790e-1 (AD) 6.847e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ICAM1	0.893
STX11	0.867
B4GALT1	0.862
NFKB2	0.849
PLAUR	0.841
CLEC1A	0.831
TNFRSF10B	0.8
ITPRIP	0.796
TNFRSF10A	0.793
ITGA5	0.793

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
AMER3	-0.54
ASIC2	-0.534
TMEM179	-0.526
MYADML2	-0.518
CHRNB2	-0.51
MARCH4	-0.507
KCNB2	-0.504
SVOP	-0.502
CDK5R2	-0.5
SLC7A4	-0.5

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of TNFAIP3 mRNA	28329830
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TNFAIP3 mRNA"	17547211
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of TNFAIP3 protein	21173233
C003898	2-anisidine	2-anisidine affects the expression of TNFAIP3 mRNA	28089782
C012796	2-butenal	2-butenal results in decreased expression of TNFAIP3 mRNA	20471460
C019499	2-nitrofluorene	2-nitrofluorene results in decreased expression of TNFAIP3 mRNA	21873647
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of TNFAIP3 mRNA	21873647
C026114	2-xylene	2-xylene results in increased expression of TNFAIP3 mRNA	20359517
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of TNFAIP3 mRNA	19191707
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TNFAIP3 mRNA	21873647
C029728	4-phenylenediamine	4-phenylenediamine results in increased expression of TNFAIP3 mRNA	20713136
C094782	5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone	"5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]"	20438634
C553817	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of TNFAIP3 mRNA"	19936915
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNFAIP3 mRNA]	16137721
D020106	Acrylamide	Acrylamide results in decreased expression of TNFAIP3 mRNA	28959563
D000241	Adenosine	[Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]	24224954
D000241	Adenosine	[Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]	24224954
D000241	Adenosine	[Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 mRNA	24224954
D000241	Adenosine	[Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 protein	24224954
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of TNFAIP3 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of TNFAIP3 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TNFAIP3 mRNA	21873647\|2210060
D000447	Aldehydes	Aldehydes results in increased expression of TNFAIP3 mRNA	25014914
D006710	Homocysteine	[Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]	24224954
D006710	Homocysteine	[Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]	24224954
D006710	Homocysteine	[Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 mRNA	24224954
D006710	Homocysteine	[Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 protein	24224954
D000638	Amiodarone	Amiodarone results in increased expression of TNFAIP3 mRNA	19774075
D003913	Dextroamphetamine	Dextroamphetamine results in decreased expression of TNFAIP3 mRNA	12205029
D003913	Dextroamphetamine	SOD1 inhibits the reaction [Dextroamphetamine results in decreased expression of TNFAIP3 mRNA]	12205029
D039741	Antigens, Dermatophagoides	"TNFAIP3 gene mutant form results in increased susceptibility to Antigens, Dermatophagoides"	24453940
D000965	Antimony	Antimony results in increased expression of TNFAIP3 mRNA	17547211
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in increased expression of TNFAIP3 mRNA	17547211
D000968	Antimycin A	Antimycin A inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]	24316229
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of TNFAIP3 mRNA	24449571
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of TNFAIP3 mRNA	17696278
D001151	Arsenic	Arsenic results in decreased expression of TNFAIP3 mRNA	27838757
C058317	arsenic disulfide	arsenic disulfide results in increased expression of TNFAIP3 mRNA	16918137
C006632	arsenic trioxide	arsenic trioxide results in increased expression of TNFAIP3 mRNA	17547211\|1823173
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of TNFAIP3 mRNA"	24160326\|2575705
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of TNFAIP3 mRNA"	18687144\|2535159
D001280	Atrazine	Atrazine results in decreased expression of TNFAIP3 mRNA	25929836
D001554	Benzene	Benzene results in decreased expression of TNFAIP3 mRNA	19162166
D001554	Benzene	Benzene results in increased expression of TNFAIP3 mRNA	20359517
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TNFAIP3 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TNFAIP3 mRNA	20064835\|2187364
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TNFAIP3 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TNFAIP3 mRNA	21569818\|2222880
C027870	berbamine	berbamine results in increased expression of TNFAIP3 protein	19960011
D004958	Estradiol	Estradiol results in increased expression of TNFAIP3 mRNA	19153601\|2337363
D004958	Estradiol	Estradiol results in decreased expression of TNFAIP3 mRNA	22467019
C006780	bisphenol A	bisphenol A results in decreased expression of TNFAIP3 mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of TNFAIP3 mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of TNFAIP3 mRNA	24247028
D000069286	Bortezomib	[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of TNFAIP3 mRNA	25522274
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of TNFAIP3 mRNA	22079614
D015124	8-Bromo Cyclic Adenosine Monophosphate	[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TNFAIP3 mRNA	16997883
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of TNFAIP3 mRNA	15336504
C018475	butyraldehyde	butyraldehyde results in increased expression of TNFAIP3 mRNA	26079696
D002104	Cadmium	Cadmium results in increased expression of TNFAIP3 mRNA	17547211\|2112074
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of TNFAIP3 mRNA	17547211
D002330	Carmustine	TNFAIP3 mRNA results in increased susceptibility to Carmustine	16365179
D020355	Cholates	"[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of TNFAIP3 protein"	25814186
D020355	Cholates	"resveratrol inhibits the reaction [[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of TNFAIP3 protein]"	25814186
D002791	Cholesterol, Dietary	"[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of TNFAIP3 protein"	25814186
D002791	Cholesterol, Dietary	"resveratrol inhibits the reaction [[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of TNFAIP3 protein]"	25814186
D002794	Choline	Choline affects the expression of TNFAIP3 mRNA	17616785
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFAIP3 mRNA	20938992
D002857	Chromium	Chromium results in increased expression of TNFAIP3 mRNA	17547211
D002922	Ciguatoxins	Ciguatoxins affects the expression of TNFAIP3 mRNA	18353800
D003000	Clonidine	Clonidine results in increased expression of TNFAIP3 mRNA	21873647
D003035	Cobalt	[tungsten carbide co-treated with Cobalt] results in increased expression of TNFAIP3 mRNA	18078969
C026305	cobalt sulfate	cobalt sulfate results in increased expression of TNFAIP3 mRNA	20713136
C052387	cocoa butter	"[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of TNFAIP3 protein"	25814186
C052387	cocoa butter	"resveratrol inhibits the reaction [[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of TNFAIP3 protein]"	25814186
D019327	Copper Sulfate	Copper Sulfate results in increased expression of TNFAIP3 mRNA	19549813
D003513	Cycloheximide	[TNF protein co-treated with Cycloheximide] results in increased expression of TNFAIP3 mRNA	21146893
D003513	Cycloheximide	Ursodeoxycholic Acid analog promotes the reaction [[TNF protein co-treated with Cycloheximide] results in increased expression of TNFAIP3 mRNA]	21146893
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of TNFAIP3 mRNA	21873647
D016572	Cyclosporine	Cyclosporine results in decreased expression of TNFAIP3 mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in increased expression of TNFAIP3 mRNA	20106945\|2798913
D016572	Cyclosporine	Cyclosporine results in decreased expression of TNFAIP3 mRNA	19770486
D016572	Cyclosporine	Cyclosporine results in increased expression of TNFAIP3 mRNA	23958496
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of TNFAIP3 mRNA	23726867\|2492166
D003561	Cytarabine	Cytarabine results in decreased expression of TNFAIP3 mRNA	21198554
D003609	Dactinomycin	TNFAIP3 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]	11880364
D003703	Demecolcine	Demecolcine results in increased expression of TNFAIP3 mRNA	23649840
D003907	Dexamethasone	[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TNFAIP3 mRNA	16997883
D002945	Cisplatin	[Cisplatin co-treated with panobinostat] affects the expression of TNFAIP3 mRNA	21791302
D002945	Cisplatin	Cisplatin results in decreased expression of TNFAIP3 protein	16803524
D002945	Cisplatin	Cisplatin results in increased expression of TNFAIP3 mRNA	27594783
D002945	Cisplatin	Cisplatin results in increased expression of TNFAIP3 mRNA	21151649\|2654657
D004008	Diclofenac	Diclofenac results in decreased expression of TNFAIP3 mRNA	21873647
D004041	Dietary Fats	Dietary Fats results in increased expression of TNFAIP3 mRNA	18042831
D002117	Calcitriol	Calcitriol results in increased expression of TNFAIP3 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of TNFAIP3 mRNA	21592394
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of TNFAIP3 mRNA	20146380
C521792	DMU-212	DMU-212 affects the expression of TNFAIP3 mRNA	26428916
D004391	Dust	Dust results in increased expression of TNFAIP3 mRNA	17805423
C007619	eriodictyol	eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]	20438634
D004918	Erythromycin Estolate	Erythromycin Estolate results in decreased expression of TNFAIP3 mRNA	24412560
C004912	ethylbenzene	ethylbenzene results in increased expression of TNFAIP3 mRNA	20359517
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of TNFAIP3 mRNA	23649840
D005054	Eugenol	Eugenol results in increased expression of TNFAIP3 mRNA	20713136
D005284	Fenthion	Fenthion results in increased expression of TNFAIP3 mRNA	21538558
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of TNFAIP3 mRNA	28329830
D005472	Fluorouracil	Fluorouracil results in increased expression of TNFAIP3 mRNA	16557594
D005492	Folic Acid	[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of TNFAIP3 mRNA	22975265
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFAIP3 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of TNFAIP3 mRNA	23649840
C056507	gemcitabine	gemcitabine results in increased expression of TNFAIP3 mRNA	17039268
D005907	Gliclazide	Gliclazide inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFAIP3 mRNA]	12646174
D006046	Gold	[Gold co-treated with Polyethylene Glycols] results in increased expression of TNFAIP3 mRNA	19695318
D006534	Heptachlor Epoxide	Heptachlor Epoxide results in decreased expression of TNFAIP3 mRNA	25270620
D017313	Fenretinide	Fenretinide results in increased expression of TNFAIP3 mRNA	28973697
D006861	Hydrogen Peroxide	Gliclazide inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFAIP3 mRNA]	12646174
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of TNFAIP3 mRNA	12646174
C475919	hydroxytamoxifen	GPER1 protein affects the reaction [hydroxytamoxifen results in increased expression of TNFAIP3 mRNA]	19153601
C475919	hydroxytamoxifen	hydroxytamoxifen results in increased expression of TNFAIP3 mRNA	19153601
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of TNFAIP3 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TNFAIP3 mRNA	16997883
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TNFAIP3 mRNA	23086925\|2479639
C006552	kaempferol	kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]	20438634
C045463	leflunomide	leflunomide results in increased expression of TNFAIP3 mRNA	28988120
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in increased expression of TNFAIP3 mRNA"	23090859
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNFAIP3 mRNA"	18930950
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with TNFSF11 protein] results in increased expression of TNFAIP3 protein	21127049
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased activity of TNFAIP3 protein	15451058
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TNFAIP3 mRNA	15451058\|2372405
D008070	Lipopolysaccharides	phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of TNFAIP3 mRNA]	23724058
D008070	Lipopolysaccharides	TNFAIP3 protein promotes the reaction [Lipopolysaccharides results in increased degradation of TRAF6 protein]	21127049
D008070	Lipopolysaccharides	Zinc deficiency inhibits the reaction [Lipopolysaccharides results in increased activity of TNFAIP3 protein]	15451058
D008070	Lipopolysaccharides	Zinc deficiency inhibits the reaction [Lipopolysaccharides results in increased expression of TNFAIP3 mRNA]	15451058
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TNFAIP3 mRNA	20423518\|2445394
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TNFAIP3 protein	24453940
D008070	Lipopolysaccharides	MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2L1 mRNA]	24453940
D008070	Lipopolysaccharides	MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2L1 protein]	24453940
D008070	Lipopolysaccharides	MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2 mRNA]	24453940
D008070	Lipopolysaccharides	MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of IL13 protein]	24453940
D008070	Lipopolysaccharides	MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of IL6 protein]	24453940
D008070	Lipopolysaccharides	MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of TNF protein]	24453940
D008070	Lipopolysaccharides	phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of TNFAIP3 mRNA]	20423518
D008070	Lipopolysaccharides	TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides	24453940
D008070	Lipopolysaccharides	[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2L1 mRNA	24453940
D008070	Lipopolysaccharides	[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2L1 protein	24453940
D008070	Lipopolysaccharides	[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2 mRNA	24453940
D008070	Lipopolysaccharides	[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of IL13 protein	24453940
D008070	Lipopolysaccharides	[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of IL6 protein	24453940
D008070	Lipopolysaccharides	[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of TNF protein	24453940
D008070	Lipopolysaccharides	TNFAIP3 protein affects the reaction [Lipopolysaccharides results in increased degradation of and results in increased phosphorylation of NFKBIA protein]	24453940
D047311	Luteolin	Luteolin inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]	15334063
C018091	maduramicin	maduramicin results in increased expression of TNFAIP3 mRNA	29128925
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TNFAIP3 mRNA	26378955
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TNFAIP3 mRNA	26378955
D008344	Maneb	[Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA	23963992
D008344	Maneb	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA]	23963992
D008353	Mannitol	Mannitol results in increased expression of TNFAIP3 mRNA	21873647
D008550	Melatonin	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA]	23963992
D008628	Mercury	Mercury results in increased expression of TNFAIP3 mRNA	17547211
D008701	Methapyrilene	Methapyrilene results in increased expression of TNFAIP3 mRNA	21873647
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNFAIP3 mRNA	20938992
D008727	Methotrexate	Methotrexate results in decreased expression of TNFAIP3 mRNA	17696278
D008752	Methylene Chloride	Methylene Chloride results in increased expression of TNFAIP3 mRNA	20359517
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of TNFAIP3 mRNA	23179753
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TNFAIP3 mRNA"	26251327
C008493	methylselenic acid	methylselenic acid affects the expression of TNFAIP3 mRNA	14617803
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of TNFAIP3 mRNA	16809437
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of TNFAIP3 mRNA	22108045
D009151	Mustard Gas	Mustard Gas results in increased expression of TNFAIP3 mRNA	25102026
D009151	Mustard Gas	Mustard Gas results in increased expression of TNFAIP3 mRNA	15674843\|1895507
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of TNFAIP3 mRNA"	25102311
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TNFAIP3 mRNA"	24389112
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of TNFAIP3 mRNA"	23845593
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of TNFAIP3 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TNFAIP3 mRNA"	25554681\|2562005
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of TNFAIP3 mRNA	19812364
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of TNFAIP3 mRNA	19812364
D009532	Nickel	Nickel results in increased expression of TNFAIP3 mRNA	25583101
C022838	nickel chloride	nickel chloride results in increased expression of TNFAIP3 mRNA	17312168
C029938	nickel sulfate	nickel sulfate results in increased expression of TNFAIP3 mRNA	16780908\|1865156
D009543	Nifedipine	Nifedipine results in decreased expression of TNFAIP3 mRNA	21873647
D015112	4-Nitroquinoline-1-oxide	4-Nitroquinoline-1-oxide results in increased expression of TNFAIP3 mRNA	22561872
C025589	ochratoxin A	ochratoxin A results in increased acetylation of TNFAIP3 promoter	29098329
C025589	ochratoxin A	[ochratoxin A results in increased acetylation of TNFAIP3 promoter] which results in increased expression of TNFAIP3 mRNA	29098329\|2909832
C025589	ochratoxin A	ochratoxin A results in increased expression of TNFAIP3 mRNA	29098329
D010100	Oxygen	Oxygen deficiency results in increased expression of TNFAIP3 mRNA	26516004
D017239	Paclitaxel	Paclitaxel results in increased expression of TNFAIP3 mRNA	18058816
D000073878	Palm Oil	Palm Oil results in increased expression of TNFAIP3 mRNA	18042831
C496932	panobinostat	[Cisplatin co-treated with panobinostat] affects the expression of TNFAIP3 mRNA	21791302
D010269	Paraquat	[Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA	23963992
D010269	Paraquat	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA]	23963992
D052638	Particulate Matter	Particulate Matter results in increased expression of TNFAIP3 mRNA	21703343\|2834120
C551803	PCI 32765	PCI 32765 results in decreased expression of TNFAIP3 mRNA	26254443
D000068437	Pemetrexed	[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of TNFAIP3 mRNA	22975265
C046012	pentanal	pentanal results in increased expression of TNFAIP3 mRNA	26079696
D010575	Pesticides	Pesticides results in increased expression of TNFAIP3 mRNA	21538558
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of TNFAIP3 mRNA]	23724058
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of TNFAIP3 mRNA]	20423518
D010634	Phenobarbital	Phenobarbital affects the expression of TNFAIP3 mRNA	19159669
D010634	Phenobarbital	Phenobarbital results in increased expression of TNFAIP3 mRNA	21873647
D010634	Phenobarbital	Phenobarbital results in decreased expression of TNFAIP3 mRNA	25270620
D019800	Phenol	Phenol results in increased expression of TNFAIP3 mRNA	17547211
D010656	Phenylephrine	Phenylephrine results in increased expression of TNFAIP3 protein	12900338
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of TNFAIP3 mRNA	21873647
C006253	pirinixic acid	pirinixic acid results in decreased expression of TNFAIP3 mRNA	21873647
C006253	pirinixic acid	pirinixic acid results in increased expression of TNFAIP3 mRNA	23811191
D010936	Plant Extracts	Plant Extracts results in increased expression of TNFAIP3 mRNA	21920417
D011092	Polyethylene Glycols	[Gold co-treated with Polyethylene Glycols] results in increased expression of TNFAIP3 mRNA	19695318
D011137	Polystyrenes	Polystyrenes analog results in increased expression of TNFAIP3 mRNA	25102311
D011137	Polystyrenes	Polystyrenes results in increased expression of TNFAIP3 mRNA	25102311
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of TNFAIP3 mRNA	17547211
D011374	Progesterone	Progesterone results in increased expression of TNFAIP3 mRNA	21549006
C045950	propiconazole	propiconazole results in increased expression of TNFAIP3 mRNA	21278054
C005556	propionaldehyde	propionaldehyde results in increased expression of TNFAIP3 mRNA	26079696
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors results in decreased expression of TNFAIP3 protein	21173233
D011753	Pyrones	Pyrones inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]	21296074
D011794	Quercetin	Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]	20438634
D015125	Oxyquinoline	Oxyquinoline results in increased expression of TNFAIP3 mRNA	21632981
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of TNFAIP3 mRNA	19429434
C059514	resveratrol	resveratrol results in increased expression of TNFAIP3 mRNA	15280659
C059514	resveratrol	"resveratrol inhibits the reaction [[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of TNFAIP3 protein]"	25814186
D017632	Asbestos, Serpentine	"Asbestos, Serpentine affects the expression of TNFAIP3 mRNA"	24160326
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of TNFAIP3 mRNA	23806026\|2589566
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of TNFAIP3 mRNA	22300531\|2535159
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of TNFAIP3 mRNA	23221170
D012834	Silver	Silver results in decreased expression of TNFAIP3 mRNA	26014281
C017947	sodium arsenite	sodium arsenite results in decreased expression of TNFAIP3 mRNA	25270620
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in increased expression of TNFAIP3 mRNA	20146380
D053260	Soot	Soot results in increased expression of TNFAIP3 mRNA	22461453\|2655175
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TNFAIP3 mRNA	26378955
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TNFAIP3 mRNA	26378955
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in increased expression of TNFAIP3 mRNA"	26680231
C047246	temozolomide	TNFAIP3 mRNA results in increased susceptibility to temozolomide	16365179
C012568	terbufos	terbufos results in increased expression of TNFAIP3 mRNA	21538558
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of TNFAIP3 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of TNFAIP3 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TNFAIP3 mRNA	16704738
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TNFAIP3 mRNA	21570461
D013755	Tetradecanoylphorbol Acetate	"5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]"	20438634
D013755	Tetradecanoylphorbol Acetate	eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]	20438634
D013755	Tetradecanoylphorbol Acetate	kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]	20438634
D013755	Tetradecanoylphorbol Acetate	Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]	20438634
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased expression of TNFAIP3 mRNA	21873647
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased activity of TNFAIP3 protein	15451058
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA	15451058\|2043863
D013755	Tetradecanoylphorbol Acetate	withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]	20438634
D013755	Tetradecanoylphorbol Acetate	Zinc deficiency inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of TNFAIP3 protein]	15451058
D013755	Tetradecanoylphorbol Acetate	Zinc deficiency inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]	15451058
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of TNFAIP3 mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in increased expression of TNFAIP3 mRNA	23557971\|2776080
D014028	Tobacco Smoke Pollution	Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNFAIP3 mRNA]	16137721
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of TNFAIP3 mRNA	16137721
D014044	Tolbutamide	Tolbutamide results in decreased expression of TNFAIP3 mRNA	21873647
D014050	Toluene	Toluene results in increased expression of TNFAIP3 mRNA	20359517\|2824598
D014118	Toxins, Biological	"Toxins, Biological affects the expression of TNFAIP3 mRNA"	19682533
D014241	Trichloroethylene	Trichloroethylene results in increased expression of TNFAIP3 mRNA	20359517
C046488	trimethyltin	trimethyltin results in increased expression of TNFAIP3 mRNA	24002884
C057693	troglitazone	troglitazone results in increased expression of TNFAIP3 mRNA	19140230
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNFAIP3 mRNA"	18930950
C002802	tungsten carbide	[tungsten carbide co-treated with Cobalt] results in increased expression of TNFAIP3 mRNA	18078969
D014520	Urethane	Urethane results in decreased expression of TNFAIP3 mRNA	28818685
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid analog promotes the reaction [[TNF protein co-treated with Cycloheximide] results in increased expression of TNFAIP3 mRNA]	21146893
D014635	Valproic Acid	Valproic Acid affects the expression of TNFAIP3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of TNFAIP3 mRNA	23179753\|2438349
D014638	Vanadates	Vanadates results in decreased expression of TNFAIP3 mRNA	22714537
C034028	vanadyl sulfate	vanadyl sulfate results in increased expression of TNFAIP3 mRNA	16330358
D014750	Vincristine	Vincristine results in increased expression of TNFAIP3 mRNA	23649840
C029297	vinylidene chloride	vinylidene chloride results in increased expression of TNFAIP3 mRNA	26682919
C009684	withaferin A	withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]	20438634
D015032	Zinc	Zinc affects the expression of TNFAIP3	21035309
D015032	Zinc	[Zinc affects the expression of TNFAIP3] which affects the expression of IL1	21035309
D015032	Zinc	[Zinc affects the expression of TNFAIP3] which affects the expression of TNF	21035309
D015032	Zinc	Zinc deficiency inhibits the reaction [Lipopolysaccharides results in increased activity of TNFAIP3 protein]	15451058
D015032	Zinc	Zinc deficiency inhibits the reaction [Lipopolysaccharides results in increased expression of TNFAIP3 mRNA]	15451058
D015032	Zinc	Zinc deficiency inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of TNFAIP3 protein]	15451058
D015032	Zinc	Zinc deficiency inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]	15451058
D015032	Zinc	Zinc results in increased expression of TNFAIP3 protein	20427734
C088658	zoledronic acid	zoledronic acid results in increased expression of TNFAIP3 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002020	protease binding	-	IPI	18223652
GO:0003677	DNA binding	-	IEA	-
GO:0004842	ubiquitin-protein transferase activity	-	IDA	15258597
GO:0004843	thiol-dependent ubiquitin-specific protease activity	-	IBA	21873635
GO:0004843	thiol-dependent ubiquitin-specific protease activity	-	IDA	15258597 23827681
GO:0004843	thiol-dependent ubiquitin-specific protease activity	-	TAS	20392859
GO:0005515	protein binding	-	IPI	9299557 11389905 11463333 15142865 15169888 15231748 15474016 19060883 19131965 20392859 21988832 23032186 25416956
GO:0008270	zinc ion binding	-	IEA	-
GO:0019900	kinase binding	-	IEA	-
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	-	IMP	15258597
GO:0042802	identical protein binding	-	IPI	11389905 25416956
GO:0043130	ubiquitin binding	-	IPI	19285159
GO:0043621	protein self-association	-	IDA	8797804 15474016
GO:0061578	Lys63-specific deubiquitinase activity	-	EXP	14748687
GO:0061578	Lys63-specific deubiquitinase activity	-	TAS	-
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001922	B-1 B cell homeostasis	-	ISS	-
GO:0002237	response to molecule of bacterial origin	-	IDA	19912257
GO:0002634	regulation of germinal center formation	-	ISS	-
GO:0002677	negative regulation of chronic inflammatory response	-	IEA	-
GO:0006915	apoptotic process	-	IEA	-
GO:0006954	inflammatory response	-	IEA	-
GO:0007010	cytoskeleton organization	-	IBA	21873635
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	-	TAS	-
GO:0016477	cell migration	-	IBA	21873635
GO:0016579	protein deubiquitination	-	TAS	20392859
GO:0030177	positive regulation of Wnt signaling pathway	-	IBA	21873635
GO:0031397	negative regulation of protein ubiquitination	-	IDA	20392859
GO:0032088	negative regulation of NF-kappaB transcription factor activity	-	IDA	18223652
GO:0032480	negative regulation of type I interferon production	-	TAS	-
GO:0032495	response to muramyl dipeptide	-	IEA	-
GO:0032691	negative regulation of interleukin-1 beta production	-	IEA	-
GO:0032703	negative regulation of interleukin-2 production	-	IMP	18223652
GO:0032715	negative regulation of interleukin-6 production	-	ISS	-
GO:0032720	negative regulation of tumor necrosis factor production	-	ISS	-
GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	-	NAS	15142865
GO:0034140	negative regulation of toll-like receptor 3 signaling pathway	-	IDA	15474016
GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	-	NAS	15142865
GO:0034148	negative regulation of toll-like receptor 5 signaling pathway	-	IEA	-
GO:0035523	protein K29-linked deubiquitination	-	IBA	21873635
GO:0035871	protein K11-linked deubiquitination	-	IDA	23827681
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	-	IDA	11463333 15258597 21127049
GO:0045732	positive regulation of protein catabolic process	-	IDA	21127049
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	-	IEA	-
GO:0045779	negative regulation of bone resorption	-	NAS	21127049
GO:0045824	negative regulation of innate immune response	-	ISS	-
GO:0048662	negative regulation of smooth muscle cell proliferation	-	IDA	16816117
GO:0050691	regulation of defense response to virus by host	-	NAS	15142865
GO:0050728	negative regulation of inflammatory response	-	ISS	-
GO:0050869	negative regulation of B cell activation	-	ISS	-
GO:0051259	protein complex oligomerization	-	NAS	15474016
GO:0061043	regulation of vascular wound healing	-	NAS	16816117
GO:0070301	cellular response to hydrogen peroxide	-	ISS	-
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	-	TAS	-
GO:0070429	negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	-	IEA	-
GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	-	IEA	-
GO:0070536	protein K63-linked deubiquitination	-	IDA	15258597
GO:0070936	protein K48-linked ubiquitination	-	IDA	15258597
GO:0071108	protein K48-linked deubiquitination	-	IDA	23827681
GO:0071222	cellular response to lipopolysaccharide	-	IDA	19912257 21127049 21220427
GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process	-	IBA	21873635
GO:0072573	tolerance induction to lipopolysaccharide	-	IMP	21220427
GO:0072666	establishment of protein localization to vacuole	-	IEA	-
GO:0090291	negative regulation of osteoclast proliferation	-	NAS	21127049
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	-	IDA	12167698
GO:1903364	positive regulation of cellular protein catabolic process	-	IEA	-
GO:1990168	protein K33-linked deubiquitination	-	IBA	21873635
GO:2000347	positive regulation of hepatocyte proliferation	-	IEA	-
GO:2000349	negative regulation of CD40 signaling pathway	-	IMP	12885753
GO:2000352	negative regulation of endothelial cell apoptotic process	-	IDA	12885753

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	11463333
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005764	lysosome	-	IEA	-
GO:0005829	cytosol	-	TAS	-
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-
GO:0070062	extracellular exosome	-	HDA	20458337

KEGG ID	KEGG Term
hsa04621	NOD-like receptor signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168638	NOD1/2 Signaling Pathway	TAS
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	TAS
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5357786	TNFR1-induced proapoptotic signaling	TAS
R-HSA-5357905	Regulation of TNFR1 signaling	TAS
R-HSA-5357956	TNFR1-induced NFkappaB signaling pathway	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689896	Ovarian tumor domain proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-73887	Death Receptor Signalling	TAS
R-HSA-75893	TNF signaling	TAS
R-HSA-936440	Negative regulators of DDX58/IFIH1 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23577190	PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study. (2013)	Suzuki T	PLoS One
20439292	Genetic variants in the prediction of rheumatoid arthritis. (2010 Sep)	van der Helm-van Mil AH	Ann Rheum Dis
24776844	Associations between functional polymorphisms in the NFkappaB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease. (2014 Dec)	Bank S	Pharmacogenomics J