Gene: C1QB

713
-
complement C1q B chain
protein-coding
1p36.12
Ensembl:ENSG00000173369 MIM:120570 Vega:OTTHUMG00000002896 UniprotKB:P02746
NG_007283.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.612e-2 (AD)  7.551e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1QC0.993
C1QA0.986
FCGR3A0.945
LAPTM50.94
VSIG40.94
FCER1G0.94
ITGB20.936
ALOX5AP0.931
TYROBP0.927
LAT20.924

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZSCAN1-0.468
HES5-0.446
KCNIP3-0.431
CPLX3-0.421
ATP2C2-0.419
ST6GAL2-0.415
NEUROD6-0.409
ABCC12-0.408
MARCH4-0.404
WNT7A-0.39

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00002CetuximabBiotechDrug205923-56-4ApprovedTarget
DB00005EtanerceptBiotechDrug185243-69-0Approved|InvestigationalTarget
DB00051AdalimumabBiotechDrug331731-18-1ApprovedTarget
DB00054AbciximabBiotechDrug143653-53-6ApprovedTarget
DB00056Gemtuzumab ozogamicinBiotechDrug220578-59-6Approved|InvestigationalTarget
DB00072TrastuzumabBiotechDrug180288-69-1Approved|InvestigationalTarget
DB00073RituximabBiotechDrug174722-31-7ApprovedTarget
DB00074BasiliximabBiotechDrug179045-86-4Approved|InvestigationalTarget
DB00075MuromonabBiotechDrug140608-64-6Approved|InvestigationalTarget
DB00078Ibritumomab tiuxetanBiotechDrug206181-63-7Approved|InvestigationalTarget
DB00081TositumomabBiotechDrug208921-02-2Approved|InvestigationalTarget
DB00087AlemtuzumabBiotechDrug216503-57-0Approved|InvestigationalTarget
DB00092AlefaceptBiotechDrug222535-22-0Approved|Investigational|WithdrawnTarget
DB00095EfalizumabBiotechDrug214745-43-4Approved|InvestigationalTarget
DB00108NatalizumabBiotechDrug189261-10-7Approved|InvestigationalTarget
DB00110PalivizumabBiotechDrug188039-54-5Approved|InvestigationalTarget
DB00111DaclizumabBiotechDrug152923-56-3Investigational|WithdrawnTarget
DB00112BevacizumabBiotechDrug216974-75-3Approved|InvestigationalTarget
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of C1QB mRNA"26377693
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of C1QB mRNA"19162173
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of C1QB mRNA"21920950
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of C1QB mRNA"28973690
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of C1QB mRNA"23146750
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of C1QB mRNA21983209
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of C1QB mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of C1QB mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of C1QB mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of C1QB mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of C1QB mRNA24449571
D001104ArbutinArbutin results in decreased expression of C1QB mRNA17103032
C006632arsenic trioxidearsenic trioxide results in increased expression of C1QB mRNA19128835
D001372Aza CompoundsAza Compounds results in decreased expression of C1QB mRNA20521778
D001372Aza CompoundsAza Compounds results in increased expression of C1QB mRNA20521778
C547126AZM551248AZM551248 results in increased expression of C1QB mRNA22323515
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of C1QB mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of C1QB mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of C1QB mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of C1QB mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of C1QB mRNA]25566086
D004958EstradiolEstradiol affects the expression of C1QB mRNA15598610
D004958EstradiolEstradiol results in increased expression of C1QB mRNA19484750
C095105bexarotene[bexarotene co-treated with Tamoxifen] results in decreased expression of C1QB mRNA17630414
C095105bexarotenebexarotene results in increased expression of C1QB mRNA16648578
C452139BIRB 796BIRB 796 results in decreased expression of C1QB mRNA21328587
C006780bisphenol Abisphenol A affects the expression of C1QB mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of C1QB mRNA25594700
C006780bisphenol Abisphenol A results in decreased methylation of C1QB promoter27312807
C006780bisphenol Abisphenol A affects the expression of C1QB mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of C1QB mRNA25181051
D001761BleomycinBleomycin results in increased expression of C1QB mRNA26345256
D002065BuspironeBuspirone results in decreased expression of C1QB mRNA24136188
D002104CadmiumC1QB protein binds to Cadmium23896426
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of C1QB mRNA25993096
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of C1QB promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of C1QB mRNA27339419
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of C1QB mRNA19395590
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of C1QB mRNA27344345
D002793Cholic Acids[Cyclosporine co-treated with Cholic Acids] affects the expression of C1QB mRNA27344345
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of C1QB mRNA20938992
C418118CI 1044CI 1044 results in increased expression of C1QB mRNA17569694
D002994ClofibrateClofibrate results in decreased expression of C1QB mRNA23811191
D003471CuprizoneCuprizone results in increased expression of C1QB mRNA27523638
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C1QB mRNA]18200517
C009160cyclonitecyclonite results in increased expression of C1QB mRNA25559034
D016572Cyclosporine[Cyclosporine co-treated with Cholic Acids] affects the expression of C1QB mRNA27344345
D016572CyclosporineCyclosporine results in increased expression of C1QB mRNA21865292
D004008DiclofenacDiclofenac results in increased expression of C1QB mRNA26934552
D004041Dietary FatsDietary Fats results in decreased expression of C1QB mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of C1QB mRNA22609946
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of C1QB mRNA28943392
D002117CalcitriolCalcitriol results in decreased expression of C1QB mRNA26485663
C042080diisodecyl phthalatediisodecyl phthalate results in increased expression of C1QB mRNA25270620
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of C1QB mRNA"21785161
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of C1QB mRNA25380136
D004237DiuronDiuron results in decreased expression of C1QB mRNA25152437
D000431EthanolEthanol results in decreased expression of C1QB mRNA17920746
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with IL1B protein] results in increased expression of C1QB mRNA12072388
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of C1QB mRNA12072388
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of C1QB mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of C1QB mRNA15834898
C061365flusilazoleflusilazole results in decreased expression of C1QB mRNA22382673
C061365flusilazoleflusilazole results in increased expression of C1QB mRNA22382673
D005485FlutamideFlutamide results in decreased expression of C1QB mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of C1QB mRNA20938992
C056933fumonisin B1fumonisin B1 results in increased expression of C1QB mRNA16221962
D005839GentamicinsGentamicins results in increased expression of C1QB mRNA21081137
C010974glyphosateglyphosate results in increased expression of C1QB mRNA26302742
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of C1QB mRNA15159207
C082770IMM 125IMM 125 results in increased expression of C1QB mRNA21081137
D007211IndolesIndoles results in decreased expression of C1QB mRNA20521778
D007211IndolesIndoles results in increased expression of C1QB mRNA20521778
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of C1QB mRNA25613284
D007608Kainic AcidKainic Acid results in increased expression of C1QB mRNA17997037
D007649KetamineKetamine results in increased expression of C1QB mRNA20080153
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of C1QB mRNA"24972896
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of C1QB mRNA"23306164
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of C1QB mRNA27339419
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of C1QB mRNA20843944
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of C1QB mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of C1QB mRNA17400583
D008727MethotrexateMethotrexate affects the expression of C1QB mRNA18502557
C030589methylmercury cysteinemethylmercury cysteine results in decreased expression of C1QB mRNA19465457
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of C1QB mRNA15120970
C047806monomethylpropionmonomethylpropion results in increased expression of C1QB mRNA22303338
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of C1QB mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of C1QB mRNA"25554681
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of C1QB mRNA27344345
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of C1QB mRNA25380136
C017096n-butoxyethanoln-butoxyethanol results in increased expression of C1QB mRNA19812364
D009532NickelC1QB protein binds to Nickel23896426
D009532NickelNickel results in increased expression of C1QB mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in decreased expression of C1QB mRNA16780908
C012655nimesulidenimesulide inhibits the reaction [PTGS2 results in increased expression of C1QB mRNA]11810182
C012655nimesulidenimesulide results in decreased expression of C1QB mRNA24136188
C025589ochratoxin Aochratoxin A results in increased expression of C1QB mRNA16251485
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of C1QB mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of C1QB mRNA25729387
D010100OxygenOxygen results in increased expression of C1QB mRNA22911455
D017239PaclitaxelPaclitaxel results in increased expression of C1QB mRNA18754875
D000073878Palm OilPalm Oil results in decreased expression of C1QB mRNA18042831
D052638Particulate MatterParticulate Matter results in increased expression of C1QB mRNA24769257
C008814perobenperoben results in increased activity of [C1QA protein binds to C1QB protein binds to C1QC protein]157301
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of C1QB mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of C1QB mRNA19482888
D010634PhenobarbitalPhenobarbital results in increased expression of C1QB mRNA19162173
C006253pirinixic acidpirinixic acid results in decreased expression of C1QB mRNA17426115|2381119
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of C1QB mRNA27989595
D017035PravastatinPravastatin results in decreased expression of C1QB mRNA27225895
D017035PravastatinPravastatin results in decreased expression of C1QB mRNA27225895
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of C1QB mRNA19162173
C005556propionaldehydepropionaldehyde results in decreased expression of C1QB mRNA26079696
C513428pyrachlostrobinpyrachlostrobin results in increased expression of C1QB mRNA27029645
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of C1QB mRNA16079270
C059514resveratrol[resveratrol co-treated with Streptozocin] results in increased expression of C1QB mRNA25905778
C059514resveratrolresveratrol results in increased expression of C1QB mRNA25905778
D012643SeleniumSelenium results in increased expression of C1QB mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in decreased expression of C1QB mRNA23221170
C009277sodium arsenatesodium arsenate results in decreased expression of C1QB mRNA23922661
D012999SomanSoman results in increased expression of C1QB mRNA19281266
D053260SootSoot results in increased expression of C1QB mRNA26551751
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in increased expression of C1QB mRNA25905778
D013311StreptozocinStreptozocin results in increased expression of C1QB mRNA16684804
D013311Streptozocinvanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of C1QB mRNA]16684804
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in decreased expression of C1QB mRNA16214533
D013629Tamoxifen[bexarotene co-treated with Tamoxifen] results in decreased expression of C1QB mRNA17630414
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of C1QB mRNA24680724|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of C1QB mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of C1QB mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of C1QB mRNA16960034
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of C1QB mRNA21215274|2280813
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of C1QB mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of C1QB mRNA28943392
C009495titanium dioxidetitanium dioxide results in increased expression of C1QB mRNA21259345|2355797
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of C1QB mRNA24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of C1QB mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of C1QB mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of C1QB mRNA"19682533
D014241TrichloroethyleneTrichloroethylene results in decreased expression of C1QB mRNA19448997
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of C1QB mRNA16141432
C046488trimethyltintrimethyltin results in increased expression of C1QB mRNA21435392|2400288
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C1QB mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of C1QB mRNA17982090|1820051
C057693troglitazonetroglitazone results in increased expression of C1QB mRNA28973697
C034028vanadyl sulfatevanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of C1QB mRNA]16684804
D014640VancomycinVancomycin results in decreased expression of C1QB mRNA18930951
C025643vinclozolinvinclozolin results in decreased expression of C1QB mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of C1QB mRNA26682919
D015032ZincC1QB protein binds to Zinc23896426
D015032ZincZinc deficiency results in increased expression of C1QB mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005515protein binding-IPI7240  12960167  21054788  28018340  
GO:0042803protein homodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0006956complement activation-TAS-  
GO:0006958complement activation, classical pathway-TAS-  
GO:0030449regulation of complement activation-TAS-  
GO:0045087innate immune response-IEA-  
GO:0048839inner ear development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005581collagen trimer-IEA-  
GO:0005602complement component C1 complex-TAS1706597  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
hsa05020Prion diseases
hsa05142Chagas disease (American trypanosomiasis)
hsa05150Staphylococcus aureus infection
hsa05322Systemic lupus erythematosus
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-166663Initial triggering of complementTAS
R-HSA-166786Creation of C4 and C2 activatorsTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-173623Classical antibody-mediated complement activationTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28434814Novel protein biomarkers associated with coronary artery disease in statin-treated patients with familial hypercholesterolemia. (2017 May - Jun)Bos SJ Clin Lipidol