Gene info: ID 7132

Gene: TNFRSF1A

GENE ID: 7132

Description: TNF receptor superfamily member 1A

Gene type: protein-coding

Location: 12p13.31

dbXrefs: Ensembl:ENSG00000067182 MIM:191190 Vega:OTTHUMG00000168267 UniprotKB:P19438

RefSeq: NG_007506.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 5

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.404e-1 (AD) 4.588e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg19567168	chr12:6438502	TNFRSF1A	Gene body	6.546e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PXDC1	0.905
YBX3	0.892
LTBR	0.884
TEAD3	0.883
SLC39A1	0.883
IFITM3	0.879
MSN	0.873
OSMR	0.873
IFITM2	0.872
CEBPD	0.868

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PPEF1	-0.609
SLC7A4	-0.607
ABCC12	-0.598
NEUROD6	-0.583
CALHM1	-0.558
CASC15	-0.535
MARCH4	-0.532
GPR61	-0.529
XKR4	-0.528
NXPH2	-0.526

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB03507	6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One	Small Molecule		Experimental	Target
DB11626	Tasonermin	BiotechDrug	94948-59-1	Approved	Target

ID	Drug Name	Action	PubMed
C504897	12-(3-adamantan-1-ylureido)dodecanoic acid	12-(3-adamantan-1-ylureido)dodecanoic acid affects the expression of TNFRSF1A mRNA	19435785
C038983	1,3-dimethylthiourea	"1,3-dimethylthiourea inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]"	9870925
C038983	1,3-dimethylthiourea	"1,3-dimethylthiourea inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF1A protein]"	9870925
C047948	1'-acetoxychavicol acetate	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]	15905586
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TNFRSF1A mRNA"	25614096
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TNFRSF1A mRNA"	26808241
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TNFRSF1A protein"	27589474
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TNFRSF1A mRNA"	25462306
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TNFRSF1A mRNA"	19114083
C562254	2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione	"2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in decreased expression of TNFRSF1A protein"	21741372
C562254	2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione	"Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in decreased expression of TNFRSF1A protein]"	21741372
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of TNFRSF1A mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of TNFRSF1A mRNA"	21346803
C003898	2-anisidine	2-anisidine results in decreased expression of TNFRSF1A mRNA	28089782
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in increased expression of TNFRSF1A mRNA	21070800
C031278	2-chloroethyl ethyl sulfide	TNFRSF1A gene mutant form inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of CCL2 mRNA]	21070800
C031278	2-chloroethyl ethyl sulfide	TNFRSF1A gene mutant form inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of CHIL3 protein]	21070800
C031278	2-chloroethyl ethyl sulfide	TNFRSF1A gene mutant form inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of NOS2 mRNA]	21070800
C031278	2-chloroethyl ethyl sulfide	TNFRSF1A gene mutant form inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of PTGS2 mRNA]	21070800
C031278	2-chloroethyl ethyl sulfide	TNFRSF1A gene mutant form inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of PTGS2 protein]	21070800
C031278	2-chloroethyl ethyl sulfide	TNFRSF1A gene mutant form inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of SOD1 mRNA]	21070800
C031278	2-chloroethyl ethyl sulfide	TNFRSF1A gene mutant form inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of SOD1 protein]	21070800
C031278	2-chloroethyl ethyl sulfide	TNFRSF1A gene mutant form inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of SOD2 mRNA]	21070800
C031278	2-chloroethyl ethyl sulfide	TNFRSF1A gene mutant form inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of SOD2 protein]	21070800
C031278	2-chloroethyl ethyl sulfide	TNFRSF1A protein results in increased susceptibility to 2-chloroethyl ethyl sulfide	21070800
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane results in increased expression of TNFRSF1A mRNA"	22514694
C524042	3,5-bis(2-fluorobenzylidene)piperidin-4-one	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF1A mRNA]"	23452621
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of TNFRSF1A mRNA	22841810
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of TNFRSF1A mRNA"	18648102
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of TNFRSF1A mRNA	12419474
C580598	5-OH-BDE-47	5-OH-BDE-47 results in decreased expression of TNFRSF1A mRNA	27589474
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A protein]"	22025971
C053876	6-isopropoxy-9-oxoxanthene-2-carboxylic acid	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to TNFRSF1A protein]	19407222
C053876	6-isopropoxy-9-oxoxanthene-2-carboxylic acid	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of TNFRSF1A protein	19407222
C580599	6-OH-BDE-47	6-OH-BDE-47 results in decreased expression of TNFRSF1A mRNA	27589474
C580599	6-OH-BDE-47	6-OH-BDE-47 results in decreased expression of TNFRSF1A protein	27589474
C016276	8-bromocyclic GMP	8-bromocyclic GMP inhibits the reaction [TNF protein promotes the reaction [TNFRSF1A protein binds to TRADD protein]]	10792026
D000082	Acetaminophen	Acetaminophen results in decreased expression of TNFRSF1A mRNA	21420995\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of TNFRSF1A mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of TNFRSF1A mRNA	12540782\|1455738
D000082	Acetaminophen	Acetaminophen results in increased expression of TNFRSF1A protein	22575169
D000082	Acetaminophen	LGALS3 protein affects the reaction [Acetaminophen results in increased expression of TNFRSF1A mRNA]	22461450
D000082	Acetaminophen	MST1R protein affects the reaction [Acetaminophen results in increased expression of TNFRSF1A protein]	22575169
D000082	Acetaminophen	"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of TNFRSF1A mRNA]"	12540782
D000082	Acetaminophen	TNFRSF1A protein affects the reaction [Acetaminophen results in increased expression of CTGF mRNA]	14550746
D000082	Acetaminophen	TNFRSF1A protein affects the reaction [Acetaminophen results in increased expression of LGALS3 mRNA]	22461450
D000082	Acetaminophen	TNFRSF1A protein affects the reaction [Acetaminophen results in increased expression of MMP9 mRNA]	14550746
D000082	Acetaminophen	TNFRSF1A protein affects the reaction [Acetaminophen results in increased expression of SLC3A2 mRNA]	22461450
D000082	Acetaminophen	TNFRSF1A protein affects the reaction [Acetaminophen results in increased expression of TNF mRNA]	14557383
D000082	Acetaminophen	TNFRSF1A protein affects the reaction [Acetaminophen results in increased expression of TNF protein]	14557383
D000082	Acetaminophen	TNFRSF1A protein affects the reaction [pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]]	14550746
D000082	Acetaminophen	TNFRSF1A protein affects the susceptibility to Acetaminophen	22461450
D000082	Acetaminophen	TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of CCL2 mRNA]	14550746\|1455738
D000082	Acetaminophen	TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of CCL2 protein]	14557383
D000082	Acetaminophen	TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of CCL3 mRNA]	14557383
D000082	Acetaminophen	TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of CCL3 protein]	14557383
D000082	Acetaminophen	TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of CXCL2 mRNA]	14557383
D000082	Acetaminophen	TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of CXCL2 protein]	14557383
D000082	Acetaminophen	TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of ICAM1 mRNA]	14557383
D000082	Acetaminophen	TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of IFNG mRNA]	14557383
D000082	Acetaminophen	TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of IL10 mRNA]	14550746
D000082	Acetaminophen	TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of IL1A mRNA]	14557383
D000082	Acetaminophen	TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of IL1B mRNA]	14550746\|1455738
D000082	Acetaminophen	TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of IL6 mRNA]	14557383
D000082	Acetaminophen	TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of NOS2 mRNA]	14557383
D000082	Acetaminophen	TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of SELE mRNA]	14557383
D000082	Acetaminophen	TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of VCAM1 mRNA]	14557383
D000082	Acetaminophen	TNFRSF1A protein results in decreased susceptibility to Acetaminophen	14550746
D000082	Acetaminophen	TNFRSF1A protein results in decreased susceptibility to [Acetaminophen results in increased expression of NOS2 protein]	14550746
D000082	Acetaminophen	TNFRSF1A protein results in increased susceptibility to Acetaminophen	14557383
D000111	Acetylcysteine	"Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in decreased expression of TNFRSF1A protein]"	21741372
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Mimosine results in increased cleavage of TNFRSF1A protein]	15550384
C046926	AH 23848	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to TNFRSF1A protein]	19407222
C046926	AH 23848	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of TNFRSF1A protein	19407222
C031143	AICA ribonucleotide	AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A protein]	22025971
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of TNFRSF1A mRNA"	23195993
C068582	almond oil	almond oil inhibits the reaction [Carbon Tetrachloride results in increased expression of TNFRSF1A mRNA]	27623180
C518327	aloe emodin	aloe emodin results in increased expression of TNFRSF1A protein	19928967
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of TNFRSF1A mRNA	28070108
D015081	2-Naphthylamine	2-Naphthylamine results in decreased expression of TNFRSF1A mRNA	18247414
D000967	Antimony Sodium Gluconate	Antimony Sodium Gluconate results in decreased expression of TNFRSF1A protein	7844400
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of TNFRSF1A mRNA	24449571
D016718	Arachidonic Acid	TNFRSF1A protein affects the reaction [Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Arachidonic Acid]]	10588948
D001151	Arsenic	Arsenic results in decreased expression of TNFRSF1A mRNA	11134558
C006632	arsenic trioxide	[arsenic trioxide co-treated with TNF protein] results in increased expression of TNFRSF1A protein	17673311
C006632	arsenic trioxide	arsenic trioxide results in increased expression of TNFRSF1A mRNA	20458559
C006632	arsenic trioxide	arsenic trioxide results in increased expression of TNFRSF1A protein	17673311
C015001	arsenite	arsenite results in increased expression of TNFRSF1A mRNA	18585952
C015001	arsenite	XPA protein affects the reaction [arsenite results in increased expression of TNFRSF1A mRNA]	18585952
D001194	Asbestos	Asbestos results in increased expression of TNFRSF1A	18709470
D017636	Asbestos, Amphibole	"Asbestos, Amphibole affects the expression of TNFRSF1A protein"	20855422
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of TNFRSF1A mRNA"	16798876
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of TNFRSF1A protein"	16798876
D001241	Aspirin	Aspirin results in increased expression of TNFRSF1A mRNA	20457246
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in decreased expression of TNFRSF1A protein	16360360
D001379	Azathioprine	Azathioprine results in increased expression of TNFRSF1A mRNA	22623647
C051597	Bandrowski's base	Bandrowski's base affects the expression of TNFRSF1A mRNA	18202158
D001554	Benzene	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of TNFRSF1A mRNA	17905399
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNFRSF1A protein	21295105
D019324	beta-Naphthoflavone	isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNFRSF1A protein]	21295105
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TNFRSF1A mRNA	18247414
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TNFRSF1A mRNA	15735009\|2623829
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TNFRSF1A mRNA	21964900\|2261060
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of TNFRSF1A mRNA"	20382639
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNFRSF1A mRNA"	19150397
D004958	Estradiol	Estradiol results in increased expression of TNFRSF1A mRNA	12469912
D004958	Estradiol	[Estradiol co-treated with Testosterone] results in increased expression of TNFRSF1A mRNA	11375906
C044887	beta-methylcholine	beta-methylcholine affects the expression of TNFRSF1A mRNA	21179406
C026609	beta-solamarine	beta-solamarine results in increased expression of TNFRSF1A protein	17619073
C095105	bexarotene	bexarotene results in increased expression of TNFRSF1A mRNA	16648578
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TNFRSF1A mRNA	28628672
C006780	bisphenol A	bisphenol A results in increased expression of TNFRSF1A mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TNFRSF1A mRNA	28628672
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of TNFRSF1A mRNA	24247028
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of TNFRSF1A mRNA	18958704
D001761	Bleomycin	TNFRSF1A results in increased susceptibility to Bleomycin	12003776
C032688	boric acid	boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of TNFRSF1A protein]	28285642
C024626	bradykinin, des-Arg(9)-	"TNFRSF1A protein promotes the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein]"	16039549
C006794	brevianamide A	brevianamide A results in increased expression of TNFRSF1A mRNA	19818335
D002083	Butylated Hydroxyanisole	TNFRSF1A protein affects the reaction [Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Arachidonic Acid]]	10588948
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of TNFRSF1A mRNA	12419474
C006862	butylphen	butylphen results in increased expression of TNFRSF1A protein	15816839
C584509	C646 compound	C646 compound results in decreased expression of TNFRSF1A mRNA	26191083
D002101	Cacodylic Acid	Cacodylic Acid results in decreased expression of TNFRSF1A mRNA	17481689
D002104	Cadmium	[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of TNFRSF1A mRNA	21481475
C028031	cadmium acetate	cadmium acetate affects the expression of TNFRSF1A mRNA	16249259
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TNFRSF1A mRNA	12160620
C058819	calphostin C	calphostin C inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]	9870925
C058819	calphostin C	calphostin C inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF1A protein]	9870925
D002211	Capsaicin	Capsaicin results in increased expression of TNFRSF1A mRNA	21310942
D002211	Capsaicin	Capsaicin results in increased expression of TNFRSF1A protein	19531269
D002211	Capsaicin	capsazepine inhibits the reaction [Capsaicin results in increased expression of TNFRSF1A protein]	19531269
D002211	Capsaicin	phenyl-N-tert-butylnitrone inhibits the reaction [Capsaicin results in increased expression of TNFRSF1A protein]	19531269
D002211	Capsaicin	TRPV1 gene mutant form inhibits the reaction [Capsaicin results in increased expression of TNFRSF1A protein]	19531269
C071423	capsazepine	capsazepine inhibits the reaction [Capsaicin results in increased expression of TNFRSF1A protein]	19531269
C071423	capsazepine	capsazepine inhibits the reaction [resiniferatoxin results in increased expression of TNFRSF1A protein]	19531269
D002220	Carbamazepine	Carbamazepine affects the expression of TNFRSF1A mRNA	24752500
D002251	Carbon Tetrachloride	almond oil inhibits the reaction [Carbon Tetrachloride results in increased expression of TNFRSF1A mRNA]	27623180
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of TNFRSF1A mRNA	15963342
D002251	Carbon Tetrachloride	[Carbon Tetrachloride co-treated with TM4SF4 protein] results in increased expression of TNFRSF1A mRNA	17069928
D002251	Carbon Tetrachloride	[Carbon Tetrachloride co-treated with TM4SF4 protein] results in increased expression of TNFRSF1A protein	17069928
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TNFRSF1A mRNA	17522070\|2762318
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TNFRSF1A protein	24389507
C010063	carbonyl sulfide	carbonyl sulfide results in increased expression of TNFRSF1A mRNA	19395590
D000068579	Celecoxib	Celecoxib results in decreased expression of TNFRSF1A mRNA	28201806
D002509	Cephaloridine	Cephaloridine results in increased expression of TNFRSF1A mRNA	18500788
D002725	Chloroform	Chloroform results in increased expression of TNFRSF1A mRNA	17522070
D002784	Cholesterol	Cholesterol analog results in increased expression of TNFRSF1A protein	19477266
C000488	cladosporin	cladosporin results in increased expression of TNFRSF1A mRNA	19818335
D002994	Clofibrate	Clofibrate results in decreased expression of TNFRSF1A mRNA	16081524
D002994	Clofibrate	Clofibrate results in decreased expression of TNFRSF1A mRNA	15033592
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to TNFRSF1A protein]]	19608869
C007095	cobaltiprotoporphyrin	zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to TNFRSF1A protein]]]	19608869
C018021	cobaltous chloride	cobaltous chloride results in increased expression of TNFRSF1A mRNA	19320972
D003042	Cocaine	Cocaine affects the expression of TNFRSF1A mRNA	15681117
D003078	Colchicine	TNFRSF1A protein affects the susceptibility to Colchicine	20159942
D019327	Copper Sulfate	Copper Sulfate results in increased expression of TNFRSF1A mRNA	19549813
D003471	Cuprizone	Cuprizone results in increased expression of TNFRSF1A mRNA	27523638
D003474	Curcumin	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF1A mRNA]	23452621
D003474	Curcumin	Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A mRNA]	17666914
D003474	Curcumin	Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]	17666914
D016572	Cyclosporine	Cyclosporine results in increased expression of TNFRSF1A mRNA	25562108
D003634	DDT	DDT results in decreased expression of TNFRSF1A mRNA	11948501
D003634	DDT	DDT results in increased expression of TNFRSF1A mRNA	11948501
C014347	decitabine	decitabine results in increased expression of TNFRSF1A mRNA	27915011
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TNFRSF1A mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TNFRSF1A mRNA	28628672
D003907	Dexamethasone	boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of TNFRSF1A protein]	28285642
D003907	Dexamethasone	[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of TNFRSF1A protein	28285642
D003907	Dexamethasone	Dexamethasone results in increased expression of TNFRSF1A mRNA	21041162
D003907	Dexamethasone	sodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of TNFRSF1A protein]	28285642
D003907	Dexamethasone	Dexamethasone results in decreased expression of TNFRSF1A mRNA	17522070
D003976	Diazinon	Diazinon results in increased expression of TNFRSF1A mRNA	27920530
D003976	Diazinon	Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of TNFRSF1A mRNA]	27920530
D003976	Diazinon	[Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of TNFRSF1A mRNA]	27920530
D003976	Diazinon	Selenium analog inhibits the reaction [Diazinon results in increased expression of TNFRSF1A mRNA]	27920530
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of TNFRSF1A mRNA	21266533
D002945	Cisplatin	Cisplatin results in increased expression of TNFRSF1A mRNA	26546572
D002945	Cisplatin	Cisplatin results in increased expression of TNFRSF1A protein	15701814
D002945	Cisplatin	SB 203580 inhibits the reaction [Cisplatin results in increased expression of TNFRSF1A protein]	15701814
D002945	Cisplatin	TNFRSF1A protein affects the susceptibility to Cisplatin	20159942
D004008	Diclofenac	Diclofenac affects the expression of TNFRSF1A mRNA	24752500
D004008	Diclofenac	Diclofenac results in increased expression of TNFRSF1A mRNA	26934552
D004026	Dieldrin	Dieldrin affects the expression of TNFRSF1A mRNA	22546817
D004040	Dietary Carbohydrates	Dietary Carbohydrates results in decreased expression of TNFRSF1A mRNA	17490981
D004041	Dietary Fats	Dietary Fats results in decreased expression of TNFRSF1A mRNA	18042831
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNFRSF1A protein	21295105
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TNFRSF1A mRNA	27048571
D004052	Diethylnitrosamine	DMU-212 promotes the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TNFRSF1A mRNA]	27048571
D004052	Diethylnitrosamine	isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNFRSF1A protein]	21295105
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of TNFRSF1A mRNA	27638505
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of TNFRSF1A protein	15798949
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]	9870925
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF1A protein]	9870925
D004147	Dioxins	Dioxins affects the expression of TNFRSF1A mRNA	20463971
C521792	DMU-212	DMU-212 promotes the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TNFRSF1A mRNA]	27048571
C521792	DMU-212	DMU-212 results in decreased expression of TNFRSF1A mRNA	27048571
D004317	Doxorubicin	Doxorubicin affects the localization of TNFRSF1A protein	21097524
D004317	Doxorubicin	Doxorubicin results in increased expression of TNFRSF1A mRNA	21097524
D004317	Doxorubicin	Doxorubicin results in increased expression of TNFRSF1A protein	21097524
D004317	Doxorubicin	TNFRSF1A protein affects the reaction [Doxorubicin affects the expression of PLCD1 mRNA]	16618758
D004317	Doxorubicin	TNFRSF1A protein affects the reaction [Doxorubicin affects the expression of PLCD1 protein]	16618758
D004317	Doxorubicin	TNFRSF1A protein affects the reaction [Doxorubicin results in decreased expression of FAS protein]	16505099
D004317	Doxorubicin	TNFRSF1A protein affects the susceptibility to Doxorubicin	16618758
D004317	Doxorubicin	Doxorubicin results in increased expression of TNFRSF1A protein	17651020
D004391	Dust	Dust results in increased expression of TNFRSF1A mRNA	17805423
C509867	E804 bisindole	E804 bisindole results in decreased expression of TNFRSF1A mRNA	23107598
C509867	E804 bisindole	Lipopolysaccharides inhibits the reaction [E804 bisindole results in decreased expression of TNFRSF1A mRNA]	23107598
C007590	emulphogene BC 720	emulphogene BC 720 results in increased expression of TNFRSF1A mRNA	25398874
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of TNFRSF1A mRNA	12655031
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of TNFRSF1A mRNA	20816778
D004918	Erythromycin Estolate	Erythromycin Estolate results in increased expression of TNFRSF1A mRNA	17522070
D000431	Ethanol	[Zinc deficiency co-treated with Ethanol] results in increased expression of TNFRSF1A protein	24155903
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of TNFRSF1A mRNA	23649840
D005047	Etoposide	TNFRSF1A protein affects the susceptibility to Etoposide	20159942
C540355	fenamidone	fenamidone results in increased expression of TNFRSF1A mRNA	27029645
D005290	Ferric Compounds	Ferric Compounds results in decreased expression of TNFRSF1A mRNA	24035972
D005411	Flame Retardants	Flame Retardants results in increased expression of TNFRSF1A mRNA	26808241
D005485	Flutamide	Flutamide results in increased expression of TNFRSF1A mRNA	24136188
C056933	fumonisin B1	fumonisin B1 results in increased expression of TNFRSF1A mRNA	15590129
D005665	Furosemide	Furosemide affects the expression of TNFRSF1A mRNA	17497460
C038958	gadolinium chloride	gadolinium chloride results in increased expression of TNFRSF1A mRNA	15590129
D019833	Genistein	[Genistein co-treated with trichostatin A] results in increased expression of TNFRSF1A mRNA	22626855
D019833	Genistein	[Genistein co-treated with trichostatin A] results in increased expression of TNFRSF1A protein	22626855
D005839	Gentamicins	Gentamicins results in increased expression of TNFRSF1A mRNA	22061828
D005897	Glafenine	Glafenine results in increased expression of TNFRSF1A mRNA	24136188
D005944	Glucosamine	Glucosamine analog inhibits the reaction [TNF results in increased expression of TNFRSF1A mRNA]	18173918
D005944	Glucosamine	Glucosamine inhibits the reaction [TNF results in increased expression of TNFRSF1A mRNA]	18173918
D005978	Glutathione	TNFRSF1A protein affects the abundance of Glutathione	20159942
D006046	Gold	[Polyethyleneimine binds to Gold] which results in decreased expression of TNFRSF1A mRNA	28433809
C103280	goniothalamin	goniothalamin results in decreased expression of TNFRSF1A protein	18771661
C103280	goniothalamin	goniothalamin results in decreased activity of TNFRSF1A protein	23845509
D055768	Halogenated Diphenyl Ethers	Halogenated Diphenyl Ethers results in increased expression of TNFRSF1A mRNA	26808241
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of TNFRSF1A mRNA	15159207
D006861	Hydrogen Peroxide	"1,3-dimethylthiourea inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]"	9870925
D006861	Hydrogen Peroxide	calphostin C inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]	9870925
D006861	Hydrogen Peroxide	CAT protein inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]	9870925
D006861	Hydrogen Peroxide	Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]	9870925
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased cleavage of TNFRSF1A protein	15550384
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of TNFRSF1A protein	9870925
D006861	Hydrogen Peroxide	KB R8301 inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]	9870925
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of TNFRSF1A protein	27494022
D006861	Hydrogen Peroxide	PI103 inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]	27494022
D006861	Hydrogen Peroxide	Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]	27494022
D006861	Hydrogen Peroxide	TNFRSF1A protein affects the susceptibility to Hydrogen Peroxide	20159942
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TNFRSF1A mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TNFRSF1A mRNA	28628672
D007213	Indomethacin	TNFRSF1A protein affects the susceptibility to Indomethacin	15138204
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF1A mRNA	25613284
C051890	irinotecan	irinotecan results in increased expression of TNFRSF1A mRNA	20097248
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TNFRSF1A mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TNFRSF1A mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of TNFRSF1A protein]	28285642
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of TNFRSF1A protein	28285642
D015056	1-Methyl-3-isobutylxanthine	sodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of TNFRSF1A protein]	28285642
D007530	Isoflurane	Isoflurane results in decreased expression of TNFRSF1A mRNA	16978161
D007545	Isoproterenol	Isoproterenol results in decreased expression of TNFRSF1A mRNA	24286936
D007545	Isoproterenol	Isoproterenol results in increased expression of TNFRSF1A mRNA	24286936
C016527	isoquercitrin	isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNFRSF1A protein]	21295105
C410337	K 7174	K 7174 results in increased expression of TNFRSF1A mRNA	24086573
C423012	KB R8301	KB R8301 inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]	9870925
C423012	KB R8301	KB R8301 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF1A protein]	9870925
D007654	Ketoconazole	Ketoconazole results in increased expression of TNFRSF1A mRNA	25808816
C017461	lead nitrate	lead nitrate affects the reaction [TNFRSF1A affects the expression of MT1 mRNA]	11891201
C017461	lead nitrate	lead nitrate affects the reaction [TNFRSF1A affects the expression of MT2 mRNA]	11891201
C045463	leflunomide	leflunomide results in increased expression of TNFRSF1A mRNA	28988120
C467567	lenalidomide	lenalidomide results in decreased expression of TNFRSF1A mRNA	15618473
D017705	Lignans	Lignans analog results in increased expression of TNFRSF1A protein	26620693
D017705	Lignans	Lignans results in increased expression of TNFRSF1A protein	26620693
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in decreased expression of TNFRSF1A mRNA"	23090859
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TNFRSF1A protein	10072544
D008070	Lipopolysaccharides	NFKBIA protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A protein]	10072544
D008070	Lipopolysaccharides	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A protein]"	22025971
D008070	Lipopolysaccharides	AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A protein]	22025971
D008070	Lipopolysaccharides	Lipopolysaccharides inhibits the reaction [E804 bisindole results in decreased expression of TNFRSF1A mRNA]	23107598
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TNFRSF1A mRNA	10975854\|2317083
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TNFRSF1A protein	22025971
D008070	Lipopolysaccharides	notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A mRNA]	23170834
D008070	Lipopolysaccharides	resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A protein]	22025971
D008070	Lipopolysaccharides	Magnesium deficiency promotes the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A mRNA]	13679239
C018091	maduramicin	maduramicin results in decreased expression of TNFRSF1A mRNA	29128925
D008274	Magnesium	Magnesium deficiency promotes the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A mRNA]	13679239
D008277	Magnesium Oxide	Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of TNFRSF1A mRNA]	27920530
D008277	Magnesium Oxide	[Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of TNFRSF1A mRNA]	27920530
D058185	Magnetite Nanoparticles	Magnetite Nanoparticles affects the expression of TNFRSF1A mRNA	25532727
D008628	Mercury	Mercury results in increased expression of TNFRSF1A mRNA	12730625
D008628	Mercury	Mercury results in increased expression of TNFRSF1A protein	12730625
D016210	Methacholine Chloride	TNFRSF1A protein results in increased susceptibility to Methacholine Chloride	21070800
D008727	Methotrexate	Methotrexate results in decreased expression of TNFRSF1A mRNA	24449571
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of TNFRSF1A mRNA	23458150
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of TNFRSF1A mRNA	23179753\|2800136
C030957	methylmercury II	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of TNFRSF1A mRNA	17905399
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of TNFRSF1A mRNA	23649840
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of TNFRSF1A mRNA	24810058
D015735	Mifepristone	Mifepristone results in increased expression of TNFRSF1A mRNA	17584828
D008898	Mimosine	Acetylcysteine inhibits the reaction [Mimosine results in increased cleavage of TNFRSF1A protein]	15550384
D008898	Mimosine	Mimosine results in increased cleavage of TNFRSF1A protein	15550384
D016686	Monocrotaline	TNFRSF1A protein inhibits the reaction [Monocrotaline results in increased expression of PSMA3 mRNA]	18801959
C020300	monomethylarsonic acid	monomethylarsonic acid results in decreased expression of TNFRSF1A mRNA	17481689
C437683	motexafin gadolinium	motexafin gadolinium results in increased expression of TNFRSF1A mRNA	16357179
C437683	motexafin gadolinium	[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TNFRSF1A mRNA	16357179
D009151	Mustard Gas	TNF protein affects the reaction [Mustard Gas affects the expression of TNFRSF1A mRNA]	16173061
D009173	Mycophenolic Acid	Mycophenolic Acid results in increased expression of TNFRSF1A mRNA	19818335
D009183	Mycotoxins	Mycotoxins results in increased expression of TNFRSF1A mRNA	19818335
C064769	N-acetylsphingosine	N-acetylsphingosine promotes the reaction [TNF protein promotes the reaction [TNFRSF1A protein binds to TRADD protein]]	10792026
D009270	Naloxone	Naloxone results in decreased expression of TNFRSF1A mRNA	17522070
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of TNFRSF1A mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TNFRSF1A mRNA"	25554681\|2562005
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of TNFRSF1A mRNA	15913567
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of TNFRSF1A mRNA	17522070
C066471	NCS 382	NCS 382 results in increased expression of TNFRSF1A mRNA	28119166
C051752	nefazodone	nefazodone results in increased expression of TNFRSF1A mRNA	24136188
C015380	neoechinulin	neoechinulin results in increased expression of TNFRSF1A mRNA	19818335
C490266	neoechinulin A	neoechinulin A results in increased expression of TNFRSF1A mRNA	19818335
D009532	Nickel	Nickel results in decreased expression of TNFRSF1A mRNA	23195993
C022838	nickel chloride	nickel chloride affects the expression of TNFRSF1A mRNA	22546817
C029938	nickel sulfate	nickel sulfate affects the expression of TNFRSF1A mRNA	18202158
D009538	Nicotine	Nicotine results in decreased expression of TNFRSF1A mRNA	18247414
D009538	Nicotine	Nicotine results in increased expression of TNFRSF1A mRNA	20426880
C012655	nimesulide	nimesulide results in increased expression of TNFRSF1A mRNA	24136188
D009569	Nitric Oxide	[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [TNF protein promotes the reaction [TNFRSF1A protein binds to TRADD protein]]	10792026
D026423	S-Nitroso-N-Acetylpenicillamine	[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [TNF protein promotes the reaction [TNFRSF1A protein binds to TRADD protein]]	10792026
C010615	Nonidet P-40	Nonidet P-40 results in decreased expression of TNFRSF1A mRNA	26552463
C072936	notoginsenoside R1	notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A mRNA]	23170834
C107010	O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate	"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of TNFRSF1A mRNA]"	12540782
C025589	ochratoxin A	ochratoxin A results in decreased expression of TNFRSF1A mRNA	17316727
C025589	ochratoxin A	ochratoxin A results in increased expression of TNFRSF1A mRNA	19562491
D015282	Octreotide	Octreotide results in increased expression of TNFRSF1A mRNA	21692635
D015242	Ofloxacin	Ofloxacin results in increased expression of TNFRSF1A mRNA	24582689
D015242	Ofloxacin	Ofloxacin results in increased expression of TNFRSF1A protein	24582689
D015242	Ofloxacin	TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA]	24582689
D015242	Ofloxacin	TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA]	24582689
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of TNFRSF1A mRNA"	22937105
D008939	Mitotane	Mitotane results in increased expression of TNFRSF1A mRNA	23485034
D010100	Oxygen	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF1A mRNA]"	23452621
D010100	Oxygen	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF1A mRNA]	23452621
D010100	Oxygen	Oxygen deficiency results in increased expression of TNFRSF1A mRNA	23452621
D010100	Oxygen	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF1A mRNA]	23452621
D010100	Oxygen	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF1A mRNA]	23452621
D010100	Oxygen	Oxygen deficiency results in decreased expression of TNFRSF1A mRNA	24205000
D010100	Oxygen	TNFRSF1A protein affects the reaction [Oxygen results in increased expression of ICAM1 mRNA]	10781441
D010100	Oxygen	TNFRSF1A protein affects the reaction [Oxygen results in increased expression of SOD2 mRNA]	10781441
D010100	Oxygen	TNFRSF1A protein affects the susceptibility to Oxygen	10781441
D010126	Ozone	Ozone results in increased expression of TNFRSF1A mRNA	27206323
D010126	Ozone	IL1R1 gene mutant form inhibits the reaction [Ozone results in increased expression of TNFRSF1A protein]	17575079
D010126	Ozone	IL6 gene mutant form inhibits the reaction [Ozone results in increased expression of TNFRSF1A protein]	15516495
D010126	Ozone	Ozone affects the expression of TNFRSF1A mRNA	11159038
D010126	Ozone	Ozone results in increased expression of TNFRSF1A protein	15516495\|1600255
D010126	Ozone	TNFRSF1A protein affects the reaction [Ozone affects the expression of TNFRSF1B mRNA]	11159038
D010126	Ozone	TNFRSF1B protein affects the reaction [Ozone affects the expression of TNFRSF1A mRNA]	11159038
D017239	Paclitaxel	TNFRSF1A protein affects the susceptibility to Paclitaxel	20159942
D000073878	Palm Oil	Palm Oil results in decreased expression of TNFRSF1A mRNA	18042831
D010269	Paraquat	Paraquat results in decreased expression of TNFRSF1A mRNA	18836921
D052638	Particulate Matter	TNFRSF1A results in increased susceptibility to Particulate Matter	22634322
D052638	Particulate Matter	TNFRSF1A protein affects the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]	18474546
D010424	Pentobarbital	Pentobarbital results in decreased expression of TNFRSF1A mRNA	16978161
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in increased expression of TNFRSF1A protein	19878704
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of TNFRSF1A mRNA	19162173
D015232	Dinoprostone	Dinoprostone results in increased activity of TNFRSF1A protein	19407222
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TNFRSF1A mRNA	27048571
D010634	Phenobarbital	DMU-212 promotes the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TNFRSF1A mRNA]	27048571
C029217	phenyl-N-tert-butylnitrone	phenyl-N-tert-butylnitrone inhibits the reaction [Capsaicin results in increased expression of TNFRSF1A protein]	19531269
C029217	phenyl-N-tert-butylnitrone	phenyl-N-tert-butylnitrone inhibits the reaction [resiniferatoxin results in increased expression of TNFRSF1A protein]	19531269
C030090	phosphoramide mustard	phosphoramide mustard results in increased expression of TNFRSF1A mRNA	27888070
C522973	PI103	PI103 inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]	27494022
D010862	Pilocarpine	Pilocarpine results in increased expression of TNFRSF1A mRNA	17971868
C004479	pimagedine	TNFRSF1A protein affects the reaction [pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]]	14550746
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF1A mRNA]	23452621
D010936	Plant Extracts	Plant Extracts results in increased expression of TNFRSF1A protein	18070620\|2060080
D011094	Polyethyleneimine	[Polyethyleneimine binds to Gold] which results in decreased expression of TNFRSF1A mRNA	28433809
C045362	prochloraz	prochloraz results in increased expression of TNFRSF1A mRNA	29038839
D011374	Progesterone	Progesterone results in increased expression of TNFRSF1A mRNA	21549006
D011374	Progesterone	Progesterone results in increased expression of TNFRSF1A mRNA	21770760
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of TNFRSF1A mRNA	27029645
D011794	Quercetin	Quercetin results in increased expression of TNFRSF1A mRNA	23727915
D011794	Quercetin	Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]	27494022
D011794	Quercetin	Quercetin results in decreased expression of and affects the localization of TNFRSF1A protein	26076811
C012526	quercitrin	quercitrin results in decreased expression of TNFRSF1A mRNA	25193878
D011802	Quinidine	Quinidine results in decreased expression of TNFRSF1A mRNA	17522070
C024353	resiniferatoxin	capsazepine inhibits the reaction [resiniferatoxin results in increased expression of TNFRSF1A protein]	19531269
C024353	resiniferatoxin	phenyl-N-tert-butylnitrone inhibits the reaction [resiniferatoxin results in increased expression of TNFRSF1A protein]	19531269
C024353	resiniferatoxin	resiniferatoxin results in increased expression of TNFRSF1A protein	19531269
C024353	resiniferatoxin	TRPV1 gene mutant form inhibits the reaction [resiniferatoxin results in increased expression of TNFRSF1A protein]	19531269
C059514	resveratrol	resveratrol analog results in decreased expression of TNFRSF1A mRNA	24044363
C059514	resveratrol	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF1A mRNA]	23452621
C059514	resveratrol	resveratrol results in decreased expression of TNFRSF1A mRNA	24044363
C059514	resveratrol	resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A protein]	22025971
D012402	Rotenone	Rotenone results in increased expression of TNFRSF1A mRNA	23186747
C093642	SB 203580	SB 203580 inhibits the reaction [Cisplatin results in increased expression of TNFRSF1A protein]	15701814
D012643	Selenium	[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of TNFRSF1A mRNA	21481475
D012643	Selenium	[Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of TNFRSF1A mRNA]	27920530
D012643	Selenium	Selenium analog inhibits the reaction [Diazinon results in increased expression of TNFRSF1A mRNA]	27920530
D012717	Sesquiterpenes	Sesquiterpenes results in increased expression of TNFRSF1A protein	18070620
D019821	Simvastatin	Simvastatin results in decreased expression of TNFRSF1A mRNA	18310456
D012906	Smoke	Smoke results in increased expression of TNFRSF1A mRNA	21095227
C017947	sodium arsenite	sodium arsenite results in increased expression of TNFRSF1A mRNA	20886546
C017947	sodium arsenite	sodium arsenite results in decreased expression of TNFRSF1A mRNA	16014739
C017947	sodium arsenite	sodium arsenite results in increased expression of TNFRSF1A mRNA	14691202
C538809	sodium pentaborate	sodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of TNFRSF1A protein]	28285642
D012999	Soman	Soman results in increased expression of TNFRSF1A mRNA	19281266
D053260	Soot	Soot results in decreased expression of TNFRSF1A mRNA	21914721
D013241	Sterigmatocystin	Sterigmatocystin results in increased expression of TNFRSF1A mRNA	19818335
D013739	Testosterone	[Estradiol co-treated with Testosterone] results in increased expression of TNFRSF1A mRNA	11375906
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TNFRSF1A mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TNFRSF1A promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TNFRSF1A mRNA	12167310\|1471864
D013749	Tetrachlorodibenzodioxin	TNFRSF1A gene mutant form results in decreased susceptibility to Tetrachlorodibenzodioxin	24718703
D013749	Tetrachlorodibenzodioxin	TNFRSF1A protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]	20181658
D013749	Tetrachlorodibenzodioxin	TNFRSF1A protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein]	20181658
D013749	Tetrachlorodibenzodioxin	TNFRSF1A protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC2A4 protein]	20181658
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TNFRSF1A mRNA	16054898
D013752	Tetracycline	Tetracycline results in increased expression of TNFRSF1A mRNA	17522070
D013755	Tetradecanoylphorbol Acetate	"1,3-dimethylthiourea inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF1A protein]"	9870925
D013755	Tetradecanoylphorbol Acetate	calphostin C inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF1A protein]	9870925
D013755	Tetradecanoylphorbol Acetate	Dimethyl Sulfoxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF1A protein]	9870925
D013755	Tetradecanoylphorbol Acetate	KB R8301 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF1A protein]	9870925
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased expression of TNFRSF1A protein	11882518
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of TNFRSF1A protein	9870925
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF1A mRNA	25613284
D013792	Thalidomide	Thalidomide results in decreased expression of TNFRSF1A mRNA	15618473
D013792	Thalidomide	Thalidomide results in decreased expression of TNFRSF1A protein	16344495
C009495	titanium dioxide	titanium dioxide results in decreased expression of TNFRSF1A mRNA	19695317\|2234229
C402696	TMC 120A	TMC 120A results in increased expression of TNFRSF1A mRNA	19818335
D014028	Tobacco Smoke Pollution	MIR218-2 mRNA inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNFRSF1A protein]	28864214
D014028	Tobacco Smoke Pollution	TNFRSF1A protein inhibits the reaction [MIR218-2 mRNA inhibits the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased secretion of MUC5AC protein]]	28864214
D014028	Tobacco Smoke Pollution	TNFRSF1A protein inhibits the reaction [MIR218-2 mRNA inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CXCL8 mRNA]]	28864214
D014028	Tobacco Smoke Pollution	TNFRSF1A protein inhibits the reaction [MIR218-2 mRNA inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]]	28864214
D014028	Tobacco Smoke Pollution	TNFRSF1A protein inhibits the reaction [MIR218-2 mRNA inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of RELA protein]]	28864214
D014028	Tobacco Smoke Pollution	TNFRSF1A protein inhibits the reaction [MIR218-2 mRNA inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of CXCL8 protein]]	28864214
D014028	Tobacco Smoke Pollution	TNFRSF1A protein inhibits the reaction [MIR218-2 mRNA inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]]	28864214
D014028	Tobacco Smoke Pollution	TNFRSF1A protein promotes the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased secretion of MUC5AC protein]	28864214
D014028	Tobacco Smoke Pollution	TNFRSF1A protein promotes the reaction [Tobacco Smoke Pollution results in increased expression of CXCL8 mRNA]	28864214
D014028	Tobacco Smoke Pollution	TNFRSF1A protein promotes the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]	28864214
D014028	Tobacco Smoke Pollution	TNFRSF1A protein promotes the reaction [Tobacco Smoke Pollution results in increased phosphorylation of RELA protein]	28864214
D014028	Tobacco Smoke Pollution	TNFRSF1A protein promotes the reaction [Tobacco Smoke Pollution results in increased secretion of CXCL8 protein]	28864214
D014028	Tobacco Smoke Pollution	TNFRSF1A protein promotes the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]	28864214
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of TNFRSF1A mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of TNFRSF1A protein	28864214
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of TNFRSF1A mRNA	28111298
C066340	tolcapone	tolcapone results in increased expression of TNFRSF1A mRNA	24136188
D014212	Tretinoin	Tretinoin results in increased expression of TNFRSF1A mRNA	18230668
D014212	Tretinoin	[Tretinoin co-treated with zoledronic acid] results in increased expression of TNFRSF1A mRNA	20349282
D014212	Tretinoin	Tretinoin results in increased expression of TNFRSF1A mRNA	16166294
D014241	Trichloroethylene	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of TNFRSF1A mRNA	17905399
C012589	trichostatin A	[Genistein co-treated with trichostatin A] results in increased expression of TNFRSF1A mRNA	22626855
C012589	trichostatin A	[Genistein co-treated with trichostatin A] results in increased expression of TNFRSF1A protein	22626855
C012589	trichostatin A	trichostatin A results in decreased expression of TNFRSF1A mRNA	23558232
C046498	tricyclodecane-9-yl-xanthogenate	tricyclodecane-9-yl-xanthogenate inhibits the reaction [TNF protein promotes the reaction [TNFRSF1A protein binds to TRADD protein]]	10792026
C046488	trimethyltin	trimethyltin results in increased expression of TNFRSF1A mRNA	21435392\|2400288
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TNFRSF1A mRNA"	26179874
C406224	valdecoxib	valdecoxib results in increased expression of TNFRSF1A mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of TNFRSF1A mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of TNFRSF1A mRNA	29154799
D014640	Vancomycin	Vancomycin results in decreased expression of TNFRSF1A mRNA	18930951
D001335	Vehicle Emissions	TNFRSF1A protein affects the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein]	18474546
C025643	vinclozolin	vinclozolin results in decreased expression of TNFRSF1A mRNA	23034163
C025643	vinclozolin	vinclozolin results in increased expression of TNFRSF1A mRNA	18629315
C111237	vorinostat	vorinostat inhibits the reaction [TNF protein results in increased activity of TNFRSF1A protein]	16377638
C020174	WR 1065	TNFRSF1A protein affects the reaction [WR 1065 results in increased activity of SOD2]	21945096
C020174	WR 1065	[TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [WR 1065 results in increased activity of SOD2]	21945096
C403304	zerumbone	zerumbone inhibits the reaction [TNFRSF1A protein results in increased activity of [NFKB1 protein binds to RELA protein]]	16007145
D015032	Zinc	Zinc results in increased expression of TNFRSF1A protein	18842795
D015032	Zinc	[Zinc deficiency co-treated with Ethanol] results in increased expression of TNFRSF1A protein	24155903
D015032	Zinc	Zinc deficiency results in increased expression of TNFRSF1A protein	24155903
D019345	Zinc Acetate	[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TNFRSF1A mRNA	16357179
D019345	Zinc Acetate	Zinc Acetate results in increased expression of TNFRSF1A mRNA	16357179
D017967	Zinc Compounds	Zinc Compounds results in decreased expression of TNFRSF1A mRNA	24035972
C017803	zinc protoporphyrin	zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to TNFRSF1A protein]]]	19608869
C031238	zinc sulfide	[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of TNFRSF1A mRNA	21481475
C088658	zoledronic acid	[Tretinoin co-treated with zoledronic acid] results in increased expression of TNFRSF1A mRNA	20349282
C088658	zoledronic acid	zoledronic acid results in increased expression of TNFRSF1A mRNA	19036117
D015054	Zymosan	Zymosan results in increased expression of TNFRSF1A protein	10072544
D015054	Zymosan	TNFRSF1A gene mutant form inhibits the reaction [Zymosan results in decreased expression of BCL2 protein]	17724436
D015054	Zymosan	TNFRSF1A gene mutant form inhibits the reaction [Zymosan results in increased activity of MPO protein]	17724436
D015054	Zymosan	TNFRSF1A gene mutant form inhibits the reaction [Zymosan results in increased expression of BAX protein]	17724436
D015054	Zymosan	TNFRSF1A gene mutant form inhibits the reaction [Zymosan results in increased expression of FASL protein]	17724436
D015054	Zymosan	TNFRSF1A gene mutant form inhibits the reaction [Zymosan results in increased expression of IL1B protein]	17724436
D015054	Zymosan	TNFRSF1A gene mutant form inhibits the reaction [Zymosan results in increased expression of IL6 protein]	17724436
D015054	Zymosan	TNFRSF1A gene mutant form inhibits the reaction [Zymosan results in increased expression of NOS2 protein]	17724436
D015054	Zymosan	TNFRSF1A gene mutant form inhibits the reaction [Zymosan results in increased expression of TGFB1 protein]	17724436
D015054	Zymosan	TNFRSF1A gene mutant form inhibits the reaction [Zymosan results in increased expression of TNF protein]	17724436
D015054	Zymosan	TNFRSF1A gene mutant form inhibits the reaction [Zymosan results in increased expression of VEGFA protein]	17724436
D015054	Zymosan	TNFRSF1A protein affects the susceptibility to Zymosan	10890648

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005031	tumor necrosis factor-activated receptor activity	-	TAS	2158863
GO:0005515	protein binding	-	IPI	1087798 2848815 7758105 8565075 8621670 8943045 9115275 10848577 11684708 12887920 14743216 15465831 16611992 18022363 19524513 19641494 19781631 20080539 20103630 22028622 22817896 23955153 24070898 24440909 25241761 25911380
GO:0042802	identical protein binding	-	IPI	7758105 14743216 21988832
GO:0043120	tumor necrosis factor binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003176	aortic valve development	-	ISS	-
GO:0003177	pulmonary valve development	-	ISS	-
GO:0003332	negative regulation of extracellular matrix constituent secretion	-	ISS	-
GO:0006693	prostaglandin metabolic process	-	IEA	-
GO:0006954	inflammatory response	-	ISS	-
GO:0007249	I-kappaB kinase/NF-kappaB signaling	-	TAS	-
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	-	TAS	8612133
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	-	IEA	-
GO:0010614	negative regulation of cardiac muscle hypertrophy	-	IEA	-
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	-	TAS	-
GO:0016032	viral process	-	IEA	-
GO:0019221	cytokine-mediated signaling pathway	-	ISS	-
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	IMP	25816133
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	-
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	-	IMP	21410936
GO:0042742	defense response to bacterium	-	IEA	-
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IEP	12761501
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IMP	21410936
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	-
GO:0050728	negative regulation of inflammatory response	-	IMP	13130484
GO:0050729	positive regulation of inflammatory response	-	ISS	-
GO:0071260	cellular response to mechanical stimulus	-	IEP	19593445
GO:0071550	death-inducing signaling complex assembly	-	TAS	-
GO:0072659	protein localization to plasma membrane	-	IMP	25816133
GO:1902339	positive regulation of apoptotic process involved in morphogenesis	-	ISS	-
GO:1903140	regulation of establishment of endothelial barrier	-	IMP	25816133
GO:2000304	positive regulation of ceramide biosynthetic process	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000139	Golgi membrane	-	IDA	22801493
GO:0005576	extracellular region	-	NAS	12189246
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IDA	13130484
GO:0005739	mitochondrion	-	IBA	21873635
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	1698610
GO:0009986	cell surface	-	IEA	-
GO:0043235	receptor complex	-	IDA	23382219
GO:0045121	membrane raft	-	IDA	17010968

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04210	Apoptosis
hsa04380	Osteoclast differentiation
hsa04920	Adipocytokine signaling pathway
hsa05010	Alzheimer's disease
hsa05014	Amyotrophic lateral sclerosis (ALS)
hsa05142	Chagas disease (American trypanosomiasis)
hsa05145	Toxoplasmosis
hsa05160	Hepatitis C

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-168256	Immune System	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-5357786	TNFR1-induced proapoptotic signaling	TAS
R-HSA-5357905	Regulation of TNFR1 signaling	TAS
R-HSA-5357956	TNFR1-induced NFkappaB signaling pathway	TAS
R-HSA-5626978	TNFR1-mediated ceramide production	TAS
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	TAS
R-HSA-5669034	TNFs bind their physiological receptors	TAS
R-HSA-6783783	Interleukin-10 signaling	TAS
R-HSA-73887	Death Receptor Signalling	TAS
R-HSA-75893	TNF signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25332681	Diet and lifestyle factors modify immune/inflammation response genes to alter breast cancer risk and prognosis: the Breast Cancer Health Disparities Study. (2014 Dec)	Slattery ML	Mutat Res
24121042	Role of TNFRSF1B polymorphisms in the response of Crohn's disease patients to infliximab. (2014 Jan)	Medrano LM	Hum Immunol
22199996	Tumor necrosis factor-related genes and colon and rectal cancer. (2011)	Slattery ML	Int J Mol Epidemiol Genet
24776844	Associations between functional polymorphisms in the NFkappaB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease. (2014 Dec)	Bank S	Pharmacogenomics J
21212151	Interactions between genetic polymorphisms in the apoptotic pathway and environmental factors on esophageal adenocarcinoma risk. (2011 Apr)	Wu IC	Carcinogenesis