Gene: TNFRSF1B

7133
CD120b|TBPII|TNF-R-II|TNF-R75|TNFBR|TNFR1B|TNFR2|TNFR80|p75|p75TNFR
TNF receptor superfamily member 1B
protein-coding
1p36.22
Ensembl:ENSG00000028137 MIM:191191 Vega:OTTHUMG00000001829 UniprotKB:P20333
NG_029791.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.636e-2 (AD)  2.522e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09557991chr1:12227927TNFRSF1B1.000e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPSM30.917
SPI10.915
CMTM70.914
FPR10.913
RHBDF20.912
FCGR2A0.911
HCK0.906
PTPN60.903
ARHGAP300.9
B4GALT10.899

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.516
MARCH4-0.498
SLC7A4-0.48
KCNB2-0.478
KCNIP3-0.475
PPEF1-0.473
ABCC12-0.472
ATOH7-0.472
WNT7A-0.467
CPLX3-0.462

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00005EtanerceptBiotechDrug185243-69-0Approved|InvestigationalTarget
DB11626TasonerminBiotechDrug94948-59-1ApprovedTarget
ID Drug Name Action PubMed
C50489712-(3-adamantan-1-ylureido)dodecanoic acid12-(3-adamantan-1-ylureido)dodecanoic acid affects the expression of TNFRSF1B mRNA19435785
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of TNFRSF1B mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TNFRSF1B mRNA19933214
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of TNFRSF1B mRNA"20702594
C0430603,3-dimethylallyl pyrophosphate"3,3-dimethylallyl pyrophosphate results in increased expression of TNFRSF1B protein"12932289
C5805985-OH-BDE-475-OH-BDE-47 results in decreased expression of TNFRSF1B mRNA27589474
C5805996-OH-BDE-476-OH-BDE-47 results in decreased expression of TNFRSF1B mRNA27589474
C496492abrineabrine results in increased expression of TNFRSF1B mRNA22595364
D000082AcetaminophenAcetaminophen results in increased expression of TNFRSF1B mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of TNFRSF1B mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of TNFRSF1B mRNA12540782
D000082Acetaminophen"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of TNFRSF1B mRNA]"12540782
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TNFRSF1B mRNA22129741
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of TNFRSF1B mRNA"23195993
C008088alfacalcidolalfacalcidol results in decreased expression of TNFRSF1B protein modified form15044820
C518327aloe emodinaloe emodin results in increased expression of TNFRSF1B protein19928967
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TNFRSF1B mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TNFRSF1B mRNA16483693
D000967Antimony Sodium GluconateAntimony Sodium Gluconate results in decreased expression of TNFRSF1B protein7844400
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TNFRSF1B mRNA24449571
D001151ArsenicArsenic affects the expression of TNFRSF1B protein24675094
D001151ArsenicArsenic affects the methylation of TNFRSF1B gene25304211
D001152ArsenicalsArsenicals results in decreased methylation of TNFRSF1B promoter23315758
C006632arsenic trioxidearsenic trioxide results in decreased expression of TNFRSF1B mRNA15761015
C006632arsenic trioxidearsenic trioxide results in increased expression of TNFRSF1B mRNA24345465
C006632arsenic trioxide[sanguinarine co-treated with arsenic trioxide] results in increased expression of TNFRSF1B mRNA24345465
C006632arsenic trioxidearsenic trioxide results in decreased expression of TNFRSF1B mRNA12243866
C006632arsenic trioxidearsenic trioxide results in decreased expression of TNFRSF1B mRNA19730151
C015001arsenitearsenite results in decreased expression of TNFRSF1B mRNA18191166
D001194AsbestosAsbestos results in decreased expression of TNFRSF1B mRNA22398240
D001194AsbestosAsbestos results in increased expression of TNFRSF1B mRNA22398240
D001374AzacitidineAzacitidine results in increased expression of TNFRSF1B mRNA15547111
C028559bathocuproine sulfonate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF1B mRNA]15477007
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TNFRSF1B mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TNFRSF1B mRNA20713471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNFRSF1B mRNA"20382639
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of TNFRSF1B mRNA20660070
D004958EstradiolEstradiol results in increased expression of TNFRSF1B protein16436532
C006780bisphenol Abisphenol A results in increased expression of TNFRSF1B mRNA25181051
D001761BleomycinTNFRSF1B results in increased susceptibility to Bleomycin12003776
D001761BleomycinBleomycin results in increased expression of TNFRSF1B protein15371238
C006794brevianamide Abrevianamide A results in increased expression of TNFRSF1B mRNA19818335
C006862butylphenbutylphen results in increased expression of TNFRSF1B protein15816839
C584509C646 compoundC646 compound results in increased expression of TNFRSF1B mRNA26191083
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TNFRSF1B mRNA12634122
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TNFRSF1B mRNA15501611
D002248Carbon MonoxideCarbon Monoxide results in increased expression of TNFRSF1B protein modified form18629312
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TNFRSF1B mRNA17484886
D002251Carbon TetrachlorideTNFRSF1B gene mutant form results in decreased susceptibility to Carbon Tetrachloride15760680
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TNFRSF1B protein24389507
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of TNFRSF1B mRNA27344345
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TNFRSF1B mRNA12634122
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TNFRSF1B mRNA12634122
D002922CiguatoxinsCiguatoxins affects the expression of TNFRSF1B mRNA18353800
D003042CocaineCocaine affects the expression of TNFRSF1B mRNA15681117
C029892cupric chloridecupric chloride results in decreased expression of TNFRSF1B mRNA24650576
D003471CuprizoneCuprizone affects the expression of TNFRSF1B mRNA27523638
D003471CuprizoneCuprizone results in decreased expression of TNFRSF1B mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B mRNA]17666914
D003474CurcuminCurcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B protein]17666914
C038459curdlancurdlan affects the expression of TNFRSF1B mRNA19904525
C014347decitabinedecitabine affects the expression of TNFRSF1B mRNA23300844
C014347decitabinedecitabine results in increased expression of TNFRSF1B protein19117987
D003911Dextrans[Dextrans co-treated with ferrite analog] results in decreased expression of TNFRSF1B mRNA26576301
D016264Dextran SulfateDextran Sulfate results in increased expression of TNFRSF1B mRNA20824662
D002945CisplatinCisplatin affects the expression of TNFRSF1B mRNA23300844
D002945CisplatinCisplatin results in increased expression of TNFRSF1B mRNA24975837|2654657
D002945CisplatinCisplatin results in increased expression of TNFRSF1B protein15701814
D002945CisplatinSB 203580 inhibits the reaction [Cisplatin results in increased expression of TNFRSF1B protein]15701814
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene affects the expression of TNFRSF1B mRNA24576310
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TNFRSF1B mRNA22129741
D004317DoxorubicinTNFRSF1B protein affects the reaction [Doxorubicin affects the expression of PLCD1 mRNA]16618758
D004317DoxorubicinTNFRSF1B protein affects the reaction [Doxorubicin affects the expression of PLCD1 protein]16618758
D004317DoxorubicinTNFRSF1B protein affects the reaction [Doxorubicin results in decreased expression of FAS protein]16505099
D004317DoxorubicinTNFRSF1B protein affects the susceptibility to Doxorubicin16618758
D004317DoxorubicinDoxorubicin results in decreased expression of TNFRSF1B protein17651020
D004391DustDust results in increased expression of TNFRSF1B mRNA17805423
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of TNFRSF1B mRNA19118595
D000431EthanolEthanol inhibits the reaction [FOXO3 protein results in increased expression of TNFRSF1B mRNA]26470730
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TNFRSF1B mRNA17557909
C001215ferrite[Dextrans co-treated with ferrite analog] results in decreased expression of TNFRSF1B mRNA26576301
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of TNFRSF1B mRNA28329830
D005472FluorouracilTNFRSF1B protein affects the susceptibility to Fluorouracil16477629
D005665FurosemideFurosemide affects the expression of TNFRSF1B mRNA17497460
C002469fusarenon-Xfusarenon-X results in increased expression of TNFRSF1B mRNA24983900
C419708gefitinibgefitinib results in decreased expression of TNFRSF1B mRNA16685379
D005944GlucosamineGlucosamine analog inhibits the reaction [TNF results in increased expression of TNFRSF1B mRNA]18173918
D005944GlucosamineGlucosamine inhibits the reaction [TNF results in increased expression of TNFRSF1B mRNA]18173918
C025206hopanehopane results in increased expression of TNFRSF1B20123637
D017313FenretinideFenretinide results in increased expression of TNFRSF1B mRNA28973697
D006861Hydrogen PeroxideTNFRSF1B protein results in decreased susceptibility to Hydrogen Peroxide22110694
D000068877Imatinib Mesylate[tetraarsenic tetrasulfide co-treated with Imatinib Mesylate] results in decreased expression of TNFRSF1B mRNA19208803
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TNFRSF1B mRNA22129741
D015759Ionomycin[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF1B mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF1B mRNA15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF1B mRNA25613284
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of TNFRSF1B protein27169980
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TNFRSF1B mRNA23086925|2675264
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1B mRNA]25890327
D007654KetoconazoleKetoconazole results in increased expression of TNFRSF1B mRNA25808816
D007654KetoconazoleKetoconazole results in increased expression of TNFRSF1B mRNA25808816
D007854LeadLead results in increased expression of TNFRSF1B protein22142875
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TNFRSF1B mRNA12634122
C008261lead acetatelead acetate results in increased expression of TNFRSF1B mRNA21829687
C017461lead nitratelead nitrate affects the reaction [TNFRSF1B affects the expression of MT1 mRNA]11891201
C017461lead nitratelead nitrate affects the reaction [TNFRSF1B affects the expression of MT2 mRNA]11891201
C467567lenalidomidelenalidomide results in decreased expression of TNFRSF1B mRNA15618473
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TNFRSF1B protein10072544
D008070LipopolysaccharidesNFKBIA protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1B protein]10072544
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1B mRNA]25890327
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TNFRSF1B mRNA10975854|2216911
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TNFRSF1B protein19133137
D008070Lipopolysaccharidesprocyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1B mRNA]22169119
D008070Lipopolysaccharidesterameprocol inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1B protein]19133137
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TNFRSF1B mRNA25613284
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TNFRSF1B mRNA21641980
D008550MelatoninTNFRSF1B protein results in increased susceptibility to Melatonin21342247
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TNFRSF1B mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TNFRSF1B mRNA"20188158
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TNFRSF1B mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of TNFRSF1B mRNA24810058
D009151Mustard GasTNF protein affects the reaction [Mustard Gas affects the expression of TNFRSF1B mRNA]16173061
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of TNFRSF1B mRNA19818335
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of TNFRSF1B mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of TNFRSF1B mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TNFRSF1B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TNFRSF1B mRNA"25554681
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of TNFRSF1B mRNA27344345
C017096n-butoxyethanoln-butoxyethanol results in increased expression of TNFRSF1B mRNA19812364
C015380neoechinulinneoechinulin results in decreased expression of TNFRSF1B mRNA19818335
C015380neoechinulinneoechinulin results in increased expression of TNFRSF1B mRNA19818335
D009532NickelNickel results in decreased expression of TNFRSF1B mRNA23195993
D009532NickelNickel results in increased expression of TNFRSF1B mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of TNFRSF1B mRNA16780908
D009585Nitrogen DioxideNitrogen Dioxide results in increased expression of TNFRSF1B protein modified form18629312
C107010O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of TNFRSF1B mRNA]"12540782
C464660obeticholic acidobeticholic acid results in increased expression of TNFRSF1B mRNA27939613
D015282OctreotideOctreotide results in increased expression of TNFRSF1B mRNA21692635
D015282OctreotideOctreotide results in increased expression of TNFRSF1B protein21692635
D016627OxidopamineTNFRSF1B protein results in decreased susceptibility to Oxidopamine22110694
D009828Oleanolic AcidOleanolic Acid results in increased expression of TNFRSF1B mRNA18706400
C016340o,p'-DDT"o,p'-DDT analog results in decreased expression of TNFRSF1B mRNA"22937105
C016340o,p'-DDT"o,p'-DDT analog results in increased expression of TNFRSF1B mRNA"22937105
C016340o,p'-DDT"o,p'-DDT results in increased expression of TNFRSF1B mRNA"22937105
D008939MitotaneMitotane analog results in increased expression of TNFRSF1B mRNA23485034
D008939MitotaneMitotane results in increased expression of TNFRSF1B mRNA23485034
D010126OzoneIL6 gene mutant form inhibits the reaction [Ozone results in increased expression of TNFRSF1B protein]15516495
D010126OzoneOzone affects the expression of TNFRSF1B mRNA11159038
D010126OzoneOzone results in increased expression of TNFRSF1B protein15516495|1600255
D010126OzoneTNFRSF1A protein affects the reaction [Ozone affects the expression of TNFRSF1B mRNA]11159038
D010126OzoneTNFRSF1B affects the reaction [CPE affects the susceptibility to Ozone]23434795
D010126OzoneTNFRSF1B affects the reaction [[CPE affects the susceptibility to Ozone] which affects the expression of IL5 mRNA]23434795
D010126OzoneTNFRSF1B affects the reaction [Ozone results in increased expression of CCL20 protein]23434795
D010126OzoneTNFRSF1B protein affects the reaction [Ozone affects the expression of TNFRSF1A mRNA]11159038
C016030pantogabpantogab results in increased expression of TNFRSF1B mRNA17379144
D052638Particulate MatterParticulate Matter results in decreased expression of TNFRSF1B mRNA17450221
D052638Particulate MatterParticulate Matter results in increased expression of TNFRSF1B mRNA15046786
D052638Particulate MatterParticulate Matter results in increased expression of TNFRSF1B protein modified form18629312
D052638Particulate MatterTNFRSF1B results in increased susceptibility to Particulate Matter22634322
D010416PentachlorophenolPentachlorophenol results in increased expression of TNFRSF1B mRNA23892564
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TNFRSF1B mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of TNFRSF1B mRNA18445702
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons results in increased expression of TNFRSF1B20123637
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TNFRSF1B mRNA28903501
C479581procyanidin B3procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1B mRNA]22169119
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of TNFRSF1B mRNA20660070
D011441PropylthiouracilPropylthiouracil results in increased expression of TNFRSF1B mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TNFRSF1B mRNA27029645
C020972pyrrolidine dithiocarbamic acid[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF1B mRNA]15477007
D011794QuercetinQuercetin results in increased expression of TNFRSF1B mRNA15309432
C012526quercitrinquercitrin results in decreased expression of TNFRSF1B mRNA25193878
C059514resveratrolTNFRSF1B protein results in increased susceptibility to resveratrol21342247
C005705sanguinarine[sanguinarine co-treated with arsenic trioxide] results in increased expression of TNFRSF1B mRNA24345465
C093642SB 203580SB 203580 inhibits the reaction [Cisplatin results in increased expression of TNFRSF1B protein]15701814
D019821SimvastatinSimvastatin results in decreased expression of TNFRSF1B mRNA18310456
C017947sodium arsenitesodium arsenite affects the methylation of TNFRSF1B gene28589171
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TNFRSF1B mRNA12634122
D013311StreptozocinTNF protein inhibits the reaction [Streptozocin results in increased expression of TNFRSF1B mRNA]20446767
D013311StreptozocinStreptozocin results in increased expression of TNFRSF1B mRNA20446767
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TNFRSF1B mRNA21641980
C076852terameprocolterameprocol inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1B protein]19133137
C534735tetraarsenic tetrasulfide[tetraarsenic tetrasulfide co-treated with Imatinib Mesylate] results in decreased expression of TNFRSF1B mRNA19208803
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNFRSF1B mRNA22298810
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of TNFRSF1B mRNA]16891777
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNFRSF1B mRNA20702594
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNFRSF1B mRNA12167310|1531085
D013749TetrachlorodibenzodioxinTNFRSF1B gene mutant form results in decreased susceptibility to Tetrachlorodibenzodioxin24718703
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNFRSF1B mRNA19520675
D013755Tetradecanoylphorbol Acetate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF1B mRNA]15477007
D013755Tetradecanoylphorbol AcetateNFKBIA protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF1B protein]10072544
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF1B mRNA15477007
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of TNFRSF1B protein10072544
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF1B mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of TNFRSF1B mRNA15618473
C009495titanium dioxidetitanium dioxide results in increased expression of TNFRSF1B mRNA23557971
C402696TMC 120ATMC 120A results in decreased expression of TNFRSF1B mRNA19818335
D014118Toxins, Biological"Toxins, Biological affects the expression of TNFRSF1B mRNA"19682533
D014501UraniumUranium affects the expression of TNFRSF1B mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of TNFRSF1B mRNA15672453
D014635Valproic AcidValproic Acid affects the expression of TNFRSF1B mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TNFRSF1B mRNA28001369|2915479
D001335Vehicle EmissionsVehicle Emissions results in increased expression of TNFRSF1B mRNA15046786
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TNFRSF1B gene25560391
C551177vemurafenib[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of TNFRSF1B protein27169980
C025643vinclozolinvinclozolin results in increased expression of TNFRSF1B mRNA18629315
C029297vinylidene chloridevinylidene chloride results in increased expression of TNFRSF1B mRNA26682919
C020174WR 1065[TNFRSF1A protein co-treated with TNFRSF1B protein] affects the reaction [WR 1065 results in increased activity of SOD2]21945096
C088658zoledronic acidzoledronic acid results in increased expression of TNFRSF1B mRNA24714768
D015054ZymosanZymosan results in increased expression of TNFRSF1B protein10072544

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI8069916  10848577  11244088  14743216  24070898  25609706  
GO:0031625ubiquitin protein ligase binding-IPI11279055  
GO ID GO Term Qualifier Evidence PubMed
GO:0003176aortic valve development-ISS-  
GO:0003177pulmonary valve development-ISS-  
GO:0003332negative regulation of extracellular matrix constituent secretion-ISS-  
GO:0007568aging-IEA-  
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage-IEA-  
GO:0010614negative regulation of cardiac muscle hypertrophy-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0050728negative regulation of inflammatory response-IEA-  
GO:0050779RNA destabilization-IEA-  
GO:0051044positive regulation of membrane protein ectodomain proteolysis-IMP22480688  
GO:0071222cellular response to lipopolysaccharide-IMP22480688  
GO:0071363cellular response to growth factor stimulus-IEA-  
GO:0097191extrinsic apoptotic signaling pathway-IEA-  
GO:1902339positive regulation of apoptotic process involved in morphogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005634nucleus-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0035579specific granule membrane-TAS-  
GO:0043025neuronal cell body-IEA-  
GO:0043196varicosity-IEA-  
GO:0045121membrane raft-IDA17010968  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04920Adipocytokine signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5669034TNFs bind their physiological receptorsTAS
R-HSA-6783783Interleukin-10 signalingTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24121042Role of TNFRSF1B polymorphisms in the response of Crohn's disease patients to infliximab. (2014 Jan)Medrano LMHum Immunol
19684152Cigarette smoking, STAT4 and TNFRSF1B polymorphisms, and systemic lupus erythematosus in a Japanese population. (2009 Oct)Kiyohara CJ Rheumatol
23935829Serum uric acid and non-alcoholic fatty liver disease in non-diabetic Chinese men. (2013)Xie YPLoS One
17634906Polymorphisms in 33 inflammatory genes and risk of myocardial infarction--a system genetics approach. (2007 Nov)Barbaux SJ Mol Med (Berl)