Gene: TNNT2

7139
CMD1D|CMH2|CMPD2|LVNC6|RCM3|TnTC|cTnT
troponin T2, cardiac type
protein-coding
1q32.1
Ensembl:ENSG00000118194 MIM:191045 Vega:OTTHUMG00000035733 UniprotKB:P45379
NG_007556.1
PubMed|SNP Mapped
2   ANCO-SNPs
AD
1   
9.763e-1 (AD)  5.689e-1 (ND)   (Frontal_Cortex)
4.046e-1 (AD)  4.406e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2799686chr1:201378187 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2275863chr1:201359696 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC6A70.856
CHGA0.846
CABP10.84
RHBDL30.83
CHRD0.821
EMX10.821
TBR10.82
ADAM110.817
HAPLN40.816
SLC9A10.814

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EVA1A-0.528
IRX1-0.518
SLITRK6-0.501
IRX2-0.497
SH2D1A-0.496
HAS2-0.491
RAI14-0.489
CRNDE-0.488
LRAT-0.485
ISL1-0.482

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0152621,6-hexamethylene diisocyanate"1,6-hexamethylene diisocyanate results in decreased expression of TNNT2 mRNA"24211530
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TNNT2 mRNA"19114083
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of TNNT2 mRNA"20713471
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of TNNT2 mRNA"25912373
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNNT2 mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to TNNT2 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TNNT2 protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNNT2 mRNA"27188386
C0307357-aminocephalosporanic acid7-aminocephalosporanic acid results in decreased expression of TNNT2 mRNA24211530
D000171AcroleinAcrolein results in decreased expression of TNNT2 mRNA24211530
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TNNT2 mRNA16483693
C018453ammonium hexachloroplatinateammonium hexachloroplatinate results in decreased expression of TNNT2 mRNA24211530
D001151ArsenicArsenic affects the methylation of TNNT2 gene25304211
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TNNT2 protein]26598702
D001374AzacitidineAzacitidine results in increased expression of TNNT2 protein22496879
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with fluoranthene] results in decreased expression of TNNT2 mRNA25412620
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TNNT2 mRNA21839799
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of TNNT2 mRNA26496021
C495703bis(2-chloroethoxy)methanebis(2-chloroethoxy)methane results in decreased expression of TNNT2 protein15204972
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of TNNT2 mRNA25912373
C006780bisphenol Abisphenol A results in decreased expression of TNNT2 mRNA25912373
C006780bisphenol Abisphenol A results in decreased methylation of TNNT2 promoter27312807
C006780bisphenol Abisphenol A affects the expression of TNNT2 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of TNNT2 mRNA26496021
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of TNNT2 mRNA22079614
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of TNNT2 mRNA14729362
C005563captaxcaptax results in decreased expression of TNNT2 mRNA24211530
D002235CarbofuranCarbofuran results in increased expression of TNNT2 protein19854236
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TNNT2 mRNA17484886
C016299chelerythrinechelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of TNNT2 protein]12003851
C100187chloropicrinchloropicrin results in decreased expression of TNNT2 mRNA24211530
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNNT2 mRNA20938992
C012843cinnamic aldehydecinnamic aldehyde results in decreased expression of TNNT2 mRNA24211530
D019327Copper SulfateCopper Sulfate results in increased expression of TNNT2 mRNA19549813
C029036crocincrocin inhibits the reaction [Doxorubicin results in increased expression of TNNT2 protein]26807765
D003561CytarabineCytarabine results in decreased expression of TNNT2 mRNA21198554
D003630DaunorubicinDaunorubicin results in increased secretion of TNNT2 protein14618274
D003630DaunorubicinDaunorubicin results in increased secretion of TNNT2 protein17587482|2104636
D003630DaunorubicinDaunorubicin results in increased secretion of TNNT2 protein18194856
D003630DaunorubicinNebivolol inhibits the reaction [Daunorubicin results in increased expression of TNNT2 protein]18194856
D064730DexrazoxaneDexrazoxane inhibits the reaction [Doxorubicin results in increased secretion of TNNT2 protein]26873546
D003976DiazinonDiazinon results in increased methylation of TNNT2 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TNNT2 mRNA21266533
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of TNNT2 mRNA17394237
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of TNNT2 mRNA"22485181
D004237DiuronDiuron results in increased expression of TNNT2 mRNA21551480
D004317DoxorubicinDoxorubicin affects the expression of TNNT2 protein12322705
D004317DoxorubicinDoxorubicin affects the expression of TNNT2 protein29385562
D004317DoxorubicinDexrazoxane inhibits the reaction [Doxorubicin results in increased secretion of TNNT2 protein]26873546
D004317Doxorubicin[Doxorubicin co-treated with MT2A protein] results in increased expression of TNNT2 protein16144979
D004317DoxorubicinDoxorubicin results in decreased expression of TNNT2 protein16144979|1980149
D004317DoxorubicinDoxorubicin results in increased expression of TNNT2 protein10815931
D004317DoxorubicinDoxorubicin results in increased secretion of TNNT2 protein17382496|2687354
D004317DoxorubicinNRG1 protein affects the reaction [Doxorubicin results in decreased expression of TNNT2 protein]19801490
D004317DoxorubicinZinc inhibits the reaction [Doxorubicin results in increased secretion of TNNT2 protein]17382496
D004317DoxorubicinAKT1 protein promotes the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNT2 protein]]19801490
D004317Doxorubicincrocin inhibits the reaction [Doxorubicin results in increased expression of TNNT2 protein]26807765
D004317DoxorubicinDoxorubicin affects the localization of and results in increased expression of TNNT2 protein9443390
D004317DoxorubicinDoxorubicin results in decreased expression of TNNT2 mRNA19801490
D004317DoxorubicinDoxorubicin results in decreased expression of TNNT2 protein17924179|1980149
D004317DoxorubicinDoxorubicin results in increased expression of TNNT2 protein10561281|1258996
D004317DoxorubicinDoxorubicin results in increased transport of TNNT2 protein10561281
D004317DoxorubicinEPO protein inhibits the reaction [Doxorubicin results in decreased expression of TNNT2 protein]17924179
D004317DoxorubicinERBB2 protein promotes the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNT2 protein]]19801490
D004317DoxorubicinMTOR protein promotes the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNT2 protein]]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNT2 mRNA]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNT2 protein]19801490
D004610Ellagic AcidEllagic Acid inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]21762681
C070609EMD 53998EMD 53998 analog results in decreased expression of TNNT2 mRNA24977338
D004811EpichlorohydrinEpichlorohydrin results in decreased expression of TNNT2 mRNA24211530
C007738fluoranthene[Benzo(a)pyrene co-treated with fluoranthene] results in decreased expression of TNNT2 mRNA25412620
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNNT2 mRNA20938992
D004397FonofosFonofos results in increased methylation of TNNT2 promoter22847954
D008299Maleic AnhydridesMaleic Anhydrides results in decreased expression of TNNT2 mRNA24211530
D005707Gallic AcidGallic Acid inhibits the reaction [Isoproterenol results in increased secretion of TNNT2 protein]19146839
D005947GlucoseGlucose results in increased expression of TNNT2 mRNA17178593
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of TNNT2 mRNA23562911
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of TNNT2 mRNA"26377693
D007545IsoproterenolEllagic Acid inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]21762681
D007545IsoproterenolGallic Acid inhibits the reaction [Isoproterenol results in increased secretion of TNNT2 protein]19146839
D007545IsoproterenolIsoproterenol affects the expression of TNNT2 protein17848144
D007545IsoproterenolIsoproterenol results in increased expression of TNNT2 protein17188415|1765440
D007545IsoproterenolIsoproterenol results in increased secretion of TNNT2 protein19146839|2553713
D007545Isoproterenolnaringin inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]17188415
D007545IsoproterenolQuercetin inhibits the reaction [Isoproterenol results in increased secretion of TNNT2 protein]25537132
D007545IsoproterenolVincristine inhibits the reaction [Isoproterenol results in increased secretion of TNNT2 protein]25537132
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of TNNT2 mRNA15618438
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TNNT2 mRNA26752646
D009921MetaproterenolMetaproterenol results in increased expression of TNNT2 protein22878004
D008713MethimazoleMethimazole results in increased expression of TNNT2 mRNA22504374
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNNT2 mRNA20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of TNNT2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TNNT2 mRNA"25554681
C005274naringinnaringin inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]17188415
D000068577NebivololNebivolol inhibits the reaction [Daunorubicin results in increased expression of TNNT2 protein]18194856
C017557nickel subsulfidenickel subsulfide results in increased expression of TNNT2 mRNA21086188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of TNNT2 mRNA17616710
D010278ParathionParathion results in increased methylation of TNNT2 promoter22847954
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of TNNT2 mRNA23562911
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of TNNT2 mRNA23562911
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of TNNT2 mRNA22237054
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNNT2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TNNT2 mRNA26272509
D010795Phthalic AcidsPhthalic Acids affects the expression of TNNT2 mRNA15728792
D010938Plant OilsPlant Oils results in increased expression of TNNT2 mRNA23370395
D017035PravastatinPravastatin results in increased expression of TNNT2 mRNA27225895
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TNNT2 mRNA19162173
D011441PropylthiouracilPropylthiouracil results in increased expression of TNNT2 mRNA22504374|2478091
C428725pyridabenpyridaben results in increased expression of TNNT2 mRNA22563483
D011794QuercetinQuercetin inhibits the reaction [Isoproterenol results in increased secretion of TNNT2 protein]25537132
C059514resveratrolresveratrol results in increased expression of TNNT2 mRNA25888808
C059514resveratrolresveratrol results in decreased expression of TNNT2 mRNA22610192
D012402RotenoneRotenone results in decreased expression of TNNT2 mRNA27900601
D012402RotenoneRotenone results in increased expression of TNNT2 mRNA27979718
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of TNNT2 mRNA"23917077
C009277sodium arsenatesodium arsenate results in decreased expression of TNNT2 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of TNNT2 mRNA21795629
C075117squalestatin 1squalestatin 1 affects the expression of TNNT2 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of TNNT2 mRNA27225895
D016559TacrolimusTacrolimus results in increased expression of TNNT2 protein12975596
C012568terbufosterbufos results in increased methylation of TNNT2 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNNT2 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TNNT2 protein20130022|2135428
D013755Tetradecanoylphorbol Acetatechelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of TNNT2 protein]12003851
D013893ThiramThiram results in decreased expression of TNNT2 mRNA24211530
C009495titanium dioxidetitanium dioxide affects the expression of TNNT2 mRNA17656681
C009495titanium dioxidetitanium dioxide results in decreased expression of TNNT2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TNNT2 mRNA20133372
D014212TretinoinTretinoin results in decreased expression of TNNT2 mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in decreased expression of TNNT2 mRNA25847060
D014635Valproic AcidValproic Acid affects the expression of TNNT2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TNNT2 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TNNT2 gene25560391
C025643vinclozolinvinclozolin affects the expression of TNNT2 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of TNNT2 mRNA20566332
D014750VincristineVincristine inhibits the reaction [Isoproterenol results in increased secretion of TNNT2 protein]25537132
D019820Xanthine[Xanthine co-treated with XDH protein] results in increased expression of TNNT2 protein19464573
D015032ZincZinc inhibits the reaction [Doxorubicin results in increased secretion of TNNT2 protein]17382496

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IDA8205619  
GO:0005509calcium ion binding-IBA21873635  
GO:0005515protein bindingCONTRIBUTES_TOIBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0005523tropomyosin bindingCONTRIBUTES_TOIBA21873635  
GO:0005523tropomyosin binding-IDA10850966  
GO:0030172troponin C binding-IBA21873635  
GO:0030172troponin C binding-IPI8205619  15542288  
GO:0030674protein binding, bridging-IEA-  
GO:0030899calcium-dependent ATPase activityCONTRIBUTES_TOIBA21873635  
GO:0031013troponin I binding-IBA21873635  
GO:0031013troponin I binding-IPI15542288  
GO ID GO Term Qualifier Evidence PubMed
GO:0003009skeletal muscle contraction-IBA21873635  
GO:0006936muscle contraction-IBA21873635  
GO:0008016regulation of heart contraction-IMP15542288  
GO:0030049muscle filament sliding-IDA12186860  15923195  
GO:0030049muscle filament sliding-TAS-  
GO:0032780negative regulation of ATPase activity-IDA10850966  
GO:0032781positive regulation of ATPase activity-IDA10850966  12186860  
GO:0032972regulation of muscle filament sliding speed-IEA-  
GO:0045214sarcomere organization-IBA21873635  
GO:0051291protein heterooligomerization-IEA-  
GO:0051592response to calcium ion-IMP8205619  
GO:0051764actin crosslink formation-IEA-  
GO:0055010ventricular cardiac muscle tissue morphogenesis-IMP16754800  
GO:0060048cardiac muscle contraction-IBA21873635  
GO:0060048cardiac muscle contraction-IDA25771144  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005861troponin complex-IBA21873635  
GO:0005861troponin complex-IDA12186860  
GO:0005865striated muscle thin filament-IDA12186860  
GO:0030017sarcomere-TAS16754800  
GO:0097512cardiac myofibril-IDA25771144  
GO:1990584cardiac Troponin complex-IDA25771144  
KEGG ID KEGG Term
hsa04260Cardiac muscle contraction
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-390522Striated Muscle ContractionTAS
R-HSA-397014Muscle contractionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24037902The genetics of dilated cardiomyopathy: a prioritized candidate gene study of LMNA, TNNT2, TCAP, and PLN. (2013 Oct)Hirtle-Lewis MClin Cardiol