Gene: TNR

7143
TN-R
tenascin R
protein-coding
1q25.1
Ensembl:ENSG00000116147 MIM:601995 Vega:OTTHUMG00000034876 UniprotKB:Q92752
NG_050931.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.927e-2 (AD)  5.841e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DSCAM0.77
SULF20.761
NAV10.743
ABHD20.736
XYLT10.735
KIF1B0.715
EPN20.715
USP240.71
CBX50.71
PDGFRA0.703

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.619
OR4F29-0.551
ZCCHC13-0.344
CXCL3-0.304
KRT33A-0.296
FAM170B-0.261
LBP-0.257
CXCL9-0.234
GCM1-0.222
TMEM95-0.222

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TNR mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TNR mRNA"19114083
C0352082-amino-4,6-dinitrotoluene"2-amino-4,6-dinitrotoluene affects the expression of TNR mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TNR gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TNR mRNA16483693
D001151ArsenicArsenic results in decreased expression of TNR mRNA24019935
C006780bisphenol Abisphenol A results in decreased expression of TNR mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of TNR mRNA27178563
C013418bromfenacoumbromfenacoum results in increased expression of TNR protein28903499
D004390ChlorpyrifosChlorpyrifos results in decreased expression of TNR mRNA18668222
D019327Copper SulfateCopper Sulfate results in increased expression of TNR mRNA19549813
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of TNR mRNA23640034
D019422Dietary SucroseDietary Sucrose results in increased expression of TNR mRNA26033743
D007854LeadLead results in decreased expression of TNR mRNA19921347
D008344Maneb[Maneb co-treated with Paraquat] results in decreased expression of TNR mRNA23017109
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of TNR mRNA]"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of TNR mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of TNR mRNA]"21673326
D010269Paraquat[Maneb co-treated with Paraquat] results in decreased expression of TNR mRNA23017109
D010862PilocarpinePilocarpine results in increased expression of TNR protein15120744
D011192Potassium DichromatePotassium Dichromate results in increased expression of TNR mRNA23608068
C005556propionaldehydepropionaldehyde results in decreased expression of TNR mRNA26079696
D012834SilverSilver results in increased expression of TNR mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of TNR mRNA23922661
D013629TamoxifenTamoxifen results in increased expression of TNR mRNA15590111
D014050TolueneToluene results in increased expression of TNR mRNA22967744
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TNR gene25487561
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TNR gene25560391
D015034Zinc OxideZinc Oxide analog results in decreased expression of TNR mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-NAS8940128  
GO:0007158neuron cell-cell adhesion-IEA-  
GO:0007411axon guidance-NAS8940128  
GO:0008306associative learning-IEA-  
GO:0022029telencephalon cell migration-IEA-  
GO:0022408negative regulation of cell-cell adhesion-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO:0035641locomotory exploration behavior-IEA-  
GO:0048692negative regulation of axon extension involved in regeneration-IEA-  
GO:0050805negative regulation of synaptic transmission-IEA-  
GO:0050808synapse organization-IEA-  
GO:0050885neuromuscular process controlling balance-IEA-  
GO:0051968positive regulation of synaptic transmission, glutamatergic-IEA-  
GO:0051971positive regulation of transmission of nerve impulse-IEA-  
GO:0060291long-term synaptic potentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0009986cell surface-IEA-  
GO:0045121membrane raft-IEA-  
GO:0062023collagen-containing extracellular matrix-IEA-  
GO:0072534perineuronal net-IEA-  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-3000178ECM proteoglycansTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18420959Lung function loss, smoking, vitamin C intake, and polymorphisms of the glutamate-cysteine ligase genes. (2008 Jul 1)Siedlinski MAm J Respir Crit Care Med
21956439Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q. (2012 Jan)Zuo LNeuropsychopharmacology