Gene: TNS1

7145
MST091|MST122|MST127|MSTP091|MSTP122|MSTP127|MXRA6|PPP1R155|TNS
tensin 1
protein-coding
2q35
Ensembl:ENSG00000079308 MIM:600076 Vega:OTTHUMG00000133056 UniprotKB:Q9HBL0
NC_000002.12
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.590e-2 (AD)  1.386e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PHF100.818
CALD10.802
ITGB10.795
ZNF6210.791
TLN10.778
ROCK10.775
CFLAR0.767
PEAR10.762
TJP10.755
KANK20.755

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GSG1-0.478
CRH-0.471
SMIM18-0.466
SPEF1-0.431
ABCC12-0.43
ATOH7-0.427
MUC12-0.418
ADRA1D-0.409
DLK2-0.402
CORT-0.402

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of TNS1 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of TNS1 mRNA"25270620
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of TNS1 mRNA"20702594
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of TNS1 mRNA"20406850
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of TNS1 mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNS1 mRNA"27188386
C496492abrineabrine results in increased expression of TNS1 mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of TNS1 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of TNS1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TNS1 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TNS1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TNS1 mRNA19770486
C068073Am 580Am 580 results in decreased expression of TNS1 mRNA16982809
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TNS1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TNS1 mRNA24449571
D001151ArsenicArsenic affects the methylation of TNS1 gene25304211
D001280AtrazineAtrazine results in increased expression of TNS1 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of TNS1 mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of TNS1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of TNS1 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TNS1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TNS1 mRNA21871943
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TNS1 mRNA19770486|2171566
D004958EstradiolEstradiol results in decreased expression of TNS1 mRNA20106945|2163298
D004958EstradiolEstradiol inhibits the reaction [Lipopolysaccharides results in increased expression of TNS1 mRNA]16977382
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in decreased expression of TNS1 mRNA25270620
C095105bexarotenebexarotene results in increased expression of TNS1 mRNA16648578
C006780bisphenol Abisphenol A affects the expression of TNS1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of TNS1 mRNA29275510
C006780bisphenol A[potassium bromate co-treated with bisphenol A] affects the expression of TNS1 mRNA27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of TNS1 mRNA]27082013
C006780bisphenol Abisphenol A affects the expression of TNS1 mRNA25181051
C006780bisphenol Abisphenol A results in decreased methylation of TNS1 gene28505145
C006780bisphenol Abisphenol A results in increased expression of TNS1 mRNA29097150
C018475butyraldehydebutyraldehyde results in decreased expression of TNS1 mRNA26079696
C059041calyculin Acalyculin A results in decreased expression of TNS1 mRNA25270620
D002509CephaloridineCephaloridine results in decreased expression of TNS1 mRNA18500788
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TNS1 mRNA25270620
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of TNS1 mRNA16197558
D002922CiguatoxinsCiguatoxins affects the expression of TNS1 mRNA18353800
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of TNS1 mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of TNS1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of TNS1 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of TNS1 mRNA19770486
C007262deoxynivalenoldeoxynivalenol results in decreased phosphorylation of TNS1 protein23811945
D003907DexamethasoneDexamethasone results in increased expression of TNS1 mRNA23946490
D003907DexamethasoneValproic Acid inhibits the reaction [Dexamethasone results in increased expression of TNS1 mRNA]23946490
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TNS1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TNS1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TNS1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TNS1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TNS1 mRNA22023808
D004041Dietary FatsDietary Fats results in decreased expression of TNS1 mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of TNS1 mRNA20920545
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TNS1 mRNA19638242
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of TNS1 mRNA"22485181
D004237DiuronDiuron results in decreased expression of TNS1 mRNA25152437
D004237DiuronDiuron results in increased expression of TNS1 mRNA21551480
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of TNS1 mRNA"23811387
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TNS1 mRNA17942748
C540355fenamidonefenamidone results in increased expression of TNS1 mRNA27029645
C069837fullerene C60fullerene C60 results in increased expression of TNS1 mRNA19167457
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of TNS1 mRNA25270620
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TNS1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TNS1 mRNA24435446|2479639
C008261lead acetatelead acetate results in decreased expression of TNS1 mRNA25270620
C045463leflunomideleflunomide results in increased expression of TNS1 mRNA28988120
D008070LipopolysaccharidesEstradiol inhibits the reaction [Lipopolysaccharides results in increased expression of TNS1 mRNA]16977382
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TNS1 mRNA16977382
D008694MethamphetamineMethamphetamine results in increased expression of TNS1 mRNA26307267
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TNS1 mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TNS1 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of TNS1 mRNA24810058
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of TNS1 protein24625837
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of TNS1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of TNS1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TNS1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TNS1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TNS1 mRNA"25620056
D009285NaphthoquinonesNaphthoquinones results in increased expression of TNS1 mRNA23811387
D009532NickelNickel results in decreased expression of TNS1 mRNA25583101
C022838nickel chloridenickel chloride results in increased expression of TNS1 mRNA21455298
C029938nickel sulfatenickel sulfate results in decreased expression of TNS1 mRNA22714537
D009966OrphenadrineOrphenadrine affects the expression of TNS1 mRNA23665939
D010100OxygenOxygen deficiency results in increased expression of TNS1 mRNA26516004
C016030pantogabpantogab results in increased expression of TNS1 mRNA17379144
D010416PentachlorophenolPentachlorophenol results in increased expression of TNS1 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TNS1 protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of TNS1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of TNS1 mRNA25270620
D010634PhenobarbitalPhenobarbital results in increased expression of TNS1 mRNA19162173
D010795Phthalic AcidsPhthalic Acids results in increased expression of TNS1 mRNA21061450
C019536potassium bromate[potassium bromate co-treated with bisphenol A] affects the expression of TNS1 mRNA27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of TNS1 mRNA]27082013
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TNS1 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of TNS1 mRNA20726854
C045950propiconazolepropiconazole results in decreased expression of TNS1 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of TNS1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TNS1 mRNA27029645
D011794QuercetinQuercetin results in decreased expression of TNS1 mRNA21632981
C059514resveratrolresveratrol results in increased expression of and affects the localization of TNS1 protein15735708
C059514resveratrolresveratrol results in increased expression of TNS1 mRNA15735708
C089730rosiglitazonerosiglitazone results in decreased expression of TNS1 mRNA16982809
C016104sodium bichromatesodium bichromate results in decreased expression of TNS1 mRNA17685462
D053260SootSoot affects the expression of TNS1 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNS1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNS1 mRNA20702594
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TNS1 mRNA19770486|2527062
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNS1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TNS1 mRNA21215274
C009495titanium dioxidetitanium dioxide affects the expression of TNS1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TNS1 mRNA28065790
D014050TolueneToluene results in increased expression of TNS1 mRNA22967744
C012589trichostatin Atrichostatin A results in increased expression of TNS1 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of TNS1 mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNS1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of TNS1 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of TNS1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of TNS1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid inhibits the reaction [Dexamethasone results in increased expression of TNS1 mRNA]23946490
D014640VancomycinVancomycin results in increased expression of TNS1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TNS1 gene25560391
C025643vinclozolinvinclozolin affects the expression of TNS1 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of TNS1 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of TNS1 mRNA26682919
D014810Vitamin EVitamin E results in increased expression of TNS1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0003779actin binding-IEA-  
GO:0005515protein binding-IPI17190795  24728074  
GO ID GO Term Qualifier Evidence PubMed
GO:0007044cell-substrate junction assembly-IEA-  
GO:0010761fibroblast migration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005856cytoskeleton-IEA-  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IDA11023826  
GO:0009986cell surface-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26986948An Interleukin 13 Polymorphism Is Associated with Symptom Severity in Adult Subjects with Ever Asthma. (2016)Accordini SPLoS One