Gene info: ID 7148

Gene: TNXB

GENE ID: 7148

Synonyms: EDS3|EDSCLL|HXBL|TENX|TN-X|TNX|TNXB1|TNXB2|TNXBS|VUR8|XB|XBS

Description: tenascin XB

Gene type: protein-coding

Location: 6p21.33-p21.32

dbXrefs: Ensembl:ENSG00000168477 MIM:600985 Vega:OTTHUMG00000031088 UniprotKB:P22105

RefSeq: NG_008337.2

Retrived from: PubMed|SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: ND|AD

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs2071293	chr6:32094910 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs7766862	chr6:32065230 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg04872123	chr6:32049699	TNXB	Gene body	2.054e-4	Alcohol use disorders	26763658
cg26872482	chr6:32051108	TNXB	Gene body	4.563e-4	Alcohol use disorders	26763658
cg27337194	chr6:32036911	TNXB		7.720e-8	Maternal smoking in pregnancy	27040690
cg06580770	chr6:32054790	TNXB		7.100e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EPB41	0.804
LAMA5	0.784
NBEAL2	0.747
MED12	0.738
PIAS3	0.723
UBR4	0.721
MAP3K3	0.716
PHKA2	0.713
EP400	0.713
ZZEF1	0.71

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TSPAN8	-0.315
OR4F5	-0.3
OR4F29	-0.299
UTS2	-0.28
GSDMC	-0.267
FXYD4	-0.265
SH2D1A	-0.259
SPRR2E	-0.257
HOXD1	-0.257
CTNNA3	-0.254

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
D000082	Acetaminophen	Acetaminophen results in decreased expression of TNXB mRNA	29067470
D020106	Acrylamide	Acrylamide results in decreased expression of TNXB mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TNXB mRNA	21641981
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TNXB mRNA	16483693
D000968	Antimycin A	Antimycin A results in decreased expression of TNXB mRNA	19304788
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of TNXB mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of TNXB gene	25304211
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of TNXB mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TNXB mRNA	22300585
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TNXB mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of TNXB mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TNXB mRNA	28628672
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of TNXB mRNA	17484886
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of TNXB mRNA	24763279
C031180	chrysene	chrysene results in increased expression of TNXB mRNA	26377693
C480342	clothianidin	clothianidin results in decreased expression of TNXB mRNA	29044138
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of TNXB mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in increased expression of TNXB mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased methylation of TNXB promoter	27989131
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TNXB mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TNXB mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TNXB mRNA	28628672
C016366	dibenzothiophene	dibenzothiophene results in decreased expression of TNXB mRNA	23656968
C574336	excavatolide B	excavatolide B results in increased expression of TNXB protein	26790859
C010974	glyphosate	glyphosate results in decreased expression of TNXB mRNA	28711546
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of TNXB mRNA	24763279
D006540	Herbicides	Herbicides results in decreased expression of TNXB mRNA	28711546
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TNXB mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TNXB mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TNXB mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TNXB mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TNXB mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TNXB mRNA	28628672
D007840	Latex	Latex analog results in decreased expression of TNXB mRNA	24768652
D008727	Methotrexate	Methotrexate results in increased expression of TNXB mRNA	24449571
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of TNXB mRNA	22401849
D009151	Mustard Gas	Mustard Gas results in decreased expression of TNXB mRNA	18988085
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of TNXB mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of TNXB mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TNXB mRNA"	25620056
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of TNXB mRNA	20971185
D010100	Oxygen	Oxygen deficiency results in increased expression of TNXB mRNA	26516004
C084656	paricalcitol	[Phosphorus co-treated with paricalcitol] results in increased expression of TNXB mRNA	17715259
D010758	Phosphorus	[Phosphorus co-treated with paricalcitol] results in increased expression of TNXB mRNA	17715259
D010936	Plant Extracts	Plant Extracts results in decreased expression of TNXB mRNA	23557933
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of TNXB mRNA	24780913
C043680	ptaquiloside	ptaquiloside results in decreased expression of TNXB mRNA	23274088
D015474	Isotretinoin	Isotretinoin results in increased expression of TNXB mRNA	20436886
D012402	Rotenone	Rotenone results in decreased expression of TNXB mRNA	19304788
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of TNXB mRNA	25895662
C017947	sodium arsenite	sodium arsenite results in increased methylation of TNXB gene	24570342
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of TNXB mRNA	23274088
D053260	Soot	Soot results in decreased expression of TNXB mRNA	26551751
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TNXB mRNA	21998131
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TNXB mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TNXB protein	27105554
C009495	titanium dioxide	titanium dioxide results in decreased expression of TNXB mRNA	23557971\|2776080
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of TNXB mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TNXB mRNA"	26179874
D024483	Vitamin K 3	Vitamin K 3 affects the expression of TNXB mRNA	20044591

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005178	integrin binding	-	ISS	-
GO:0005515	protein binding	-	IPI	21516116 25416956
GO:0008201	heparin binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007155	cell adhesion	-	ISS	-
GO:0030036	actin cytoskeleton organization	-	ISS	-
GO:0030199	collagen fibril organization	-	IEA	-
GO:0032963	collagen metabolic process	-	IMP	15102077
GO:0048251	elastic fiber assembly	-	IMP	15102077

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	HDA	27068509
GO:0005583	fibrillar collagen trimer	colocalizes_with	IDA	16278880
GO:0005615	extracellular space	-	HDA	20551380
GO:0005622	intracellular	-	IDA	15102077
GO:0031012	extracellular matrix	-	NAS	7686164
GO:0062023	collagen-containing extracellular matrix	-	HDA	27559042
GO:0062023	collagen-containing extracellular matrix	colocalizes_with	HDA	20551380
GO:0062023	collagen-containing extracellular matrix	colocalizes_with	ISS	22261194
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term
hsa04510	Focal adhesion
hsa04512	ECM-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-3000178	ECM proteoglycans	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28791728	Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study. (2017 Nov)	Barrow TM	J Pathol
28114305	Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls. (2017)	Artigas MS	PLoS One