Gene: TOP1

7150
TOPI
DNA topoisomerase I
protein-coding
20q12
Ensembl:ENSG00000198900 MIM:126420 Vega:OTTHUMG00000033057 UniprotKB:P11387
NG_012262.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.369e-1 (AD)  3.453e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ELAVL10.952
CAPRIN10.944
TMED20.941
AKIRIN10.935
UBE2D30.935
RNF40.934
KPNB10.934
ADNP0.933
GSPT10.928
CLIP10.926

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.728
OR4F29-0.685
OR6C74-0.229
AKR1B15-0.228
VNN3-0.22
CTNNA3-0.218
TNFRSF13B-0.21
HMHB1-0.209
FCRL1-0.205
RSPO1-0.2

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00762IrinotecanSmall Molecule97682-44-5Approved|InvestigationalTarget
DB01030TopotecanSmall Molecule123948-87-8Approved|InvestigationalTarget
DB04690CamptothecinSmall Molecule7689-03-4ExperimentalTarget
DB04882EdotecarinSmall Molecule174402-32-5InvestigationalTarget
DB04967LucanthoneSmall Molecule479-50-5Approved|InvestigationalTarget
DB05129ElsamitrucinSmall Molecule97068-30-9InvestigationalTarget
DB054827-ethyl-10-hydroxycamptothecinSmall Molecule86639-52-3InvestigationalTarget
DB05630Sodium stibogluconateSmall Molecule16037-91-5Approved|InvestigationalTarget
DB05806CositecanSmall Molecule203923-89-1InvestigationalTarget
DB06069XMT-1001Small Molecule-InvestigationalTarget
DB06159RubitecanSmall Molecule91421-42-0InvestigationalTarget
DB073542,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUMSmall MoleculeExperimentalTarget
DB081594-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C44794311-keto-boswellic acid11-keto-boswellic acid analog results in decreased activity of TOP1 protein21056033
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in increased expression of TOP1 mRNA20566314
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of TOP1 mRNA28329830
C0326681-nitropyrene1-nitropyrene results in increased expression of TOP1 mRNA19041380
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in decreased expression of TOP1 mRNA"12734338
C0191323-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole"3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in decreased activity of TOP1 protein"8600349
C0191333-amino-1-methyl-5H-pyrido(4,3-b)indole"3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of TOP1 protein"8600349
C0385553'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin results in increased activity of TOP1 protein2164630
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of TOP1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOP1 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of TOP1 mRNA"19561079
C0138134-anisidine4-anisidine results in decreased expression of TOP1 mRNA12929121
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of TOP1 mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOP1 mRNA"27188386
C094432acetyl-11-ketoboswellic acidacetyl-11-ketoboswellic acid results in decreased activity of TOP1 protein10860928
C016601afimoxifeneafimoxifene results in decreased expression of TOP1 mRNA16514628
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of TOP1 protein16483693
D000873AnthracenesAnthracenes results in decreased activity of TOP1 protein7598737
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TOP1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased activity of TOP1 protein15178684
C006632arsenic trioxideBCL2 protein inhibits the reaction [arsenic trioxide results in increased activity of TOP1 protein]15178684
C006632arsenic trioxideCaspase Inhibitors inhibits the reaction [arsenic trioxide results in increased activity of TOP1 protein]15178684
C006632arsenic trioxideReactive Oxygen Species promotes the reaction [arsenic trioxide results in increased activity of TOP1 protein]15178684
D001280AtrazineAtrazine results in increased expression of TOP1 mRNA25929836
C057924batracylinbatracylin results in decreased activity of TOP1 protein21388138
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TOP1 mRNA"19150397
D001599BerberineBerberine results in decreased activity of TOP1 protein23747414
D004958EstradiolEstradiol affects the expression of TOP1 mRNA22574217
D004958EstradiolEstradiol results in increased expression of TOP1 mRNA16514628
C002070betulinic acidbetulinic acid results in decreased activity of TOP1 protein10860928
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in decreased expression of TOP1 mRNA"20162321
C006780bisphenol Abisphenol A results in increased expression of TOP1 mRNA26063408
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of TOP1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of TOP1 mRNA25181051
C054625boswellic acidboswellic acid analog binds to and results in decreased activity of TOP1 protein10860928
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TOP1 mRNA24982889
D002166CamptothecinCiprofloxacin promotes the reaction [Camptothecin results in decreased activity of TOP1 protein]18191106
D002166Camptothecinmoxifloxacin promotes the reaction [Camptothecin results in decreased activity of TOP1 protein]18191106
D002166CamptothecinCamptothecin results in decreased activity of TOP1 protein19201781
D002166Camptothecindecitabine inhibits the reaction [Camptothecin results in decreased activity of TOP1 protein]19201781
D002166CamptothecinCamptothecin analog results in decreased activity of TOP1 protein21056033
D002166CamptothecinCamptothecin results in decreased activity of TOP1 protein12097280|2122792
D002166Camptothecin[Ciprofloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein18191106
D002166Camptothecin[moxifloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein18191106
D002166CamptothecinTOP1 protein mutant form results in decreased susceptibility to Camptothecin12097280
D002166CamptothecinCamptothecin results in decreased activity of TOP1 protein20600288
D002166CamptothecinCamptothecin results in decreased activity of TOP1 protein23451051
D002166CamptothecinCamptothecin results in decreased expression of and affects the localization of TOP1 protein23451051
D002166CamptothecinCamptothecin results in increased expression of TOP1 mRNA23451051
D002166CamptothecinCamptothecin analog results in decreased activity of TOP1 protein7707314
D002166CamptothecinCamptothecin results in decreased activity of TOP1 protein21710981|8383887
C001614captafolcaptafol results in decreased activity of TOP1 protein12113771
D061945Caspase InhibitorsCaspase Inhibitors inhibits the reaction [arsenic trioxide results in increased activity of TOP1 protein]15178684
D002392CatechinCatechin results in decreased expression of TOP1 mRNA15465739
D002392CatechinCatechin results in decreased expression of TOP1 protein15465739
C495817CC-8490CC-8490 results in increased expression of TOP1 mRNA15604281
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of TOP1 mRNA25596134
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TOP1 gene20938992
C059262cidofovircidofovir affects the expression of TOP1 mRNA25596134
D002939CiprofloxacinCiprofloxacin promotes the reaction [Camptothecin results in decreased activity of TOP1 protein]18191106
D002939Ciprofloxacin[Ciprofloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein18191106
D003300Copper[Thiosemicarbazones binds to Copper] which results in increased expression of TOP1 protein20931265
D019327Copper SulfateCopper Sulfate results in increased expression of TOP1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of TOP1 mRNA25562108
D003609DactinomycinDactinomycin results in increased activity of TOP1 protein2164630
C014347decitabinedecitabine inhibits the reaction [Camptothecin results in decreased activity of TOP1 protein]19201781
C017185delphinidindelphinidin results in decreased activity of TOP1 protein19182879
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of TOP1 mRNA"25908611
D002945CisplatinCisplatin results in increased expression of TOP1 mRNA25596134
D002945CisplatinCisplatin results in increased expression of TOP1 mRNA21151649
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of TOP1 mRNA26924002
D004052Diethylnitrosamine[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of TOP1 mRNA18253720
C024629dimethyl phthalatedimethyl phthalate affects the expression of TOP1 mRNA26924002
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TOP1 mRNA17942748
D011345Fenofibrate[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of TOP1 mRNA18253720
D011345FenofibrateFenofibrate results in increased expression of TOP1 mRNA25596134
D005419FlavonoidsFlavonoids results in decreased expression of TOP1 mRNA15465739
D005419FlavonoidsFlavonoids results in decreased expression of TOP1 protein15465739
D005419FlavonoidsFlavonoids results in decreased expression of TOP1 mRNA18035473
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of TOP1 mRNA28329830
D005472FluorouracilFluorouracil results in decreased expression of TOP1 mRNA16709241
D005472FluorouracilTOP1 protein affects the susceptibility to Fluorouracil18509181
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TOP1 gene20938992
C070081fulvestrantfulvestrant results in decreased expression of TOP1 mRNA16514628
C005010harmanharman results in decreased activity of TOP1 protein8600349
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in increased expression of TOP1 mRNA20566314
D017313FenretinideFenretinide results in increased expression of TOP1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TOP1 mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased secretion of TOP1 mRNA21179422
D006918HydroxyureaHydroxyurea results in decreased expression of TOP1 mRNA12929121
C492448ICG 001ICG 001 results in decreased expression of TOP1 mRNA26191083
D007069IfosfamideIfosfamide results in increased expression of TOP1 mRNA25596134
C027185indirubinindirubin results in decreased expression of TOP1 mRNA15056799
C051890irinotecanirinotecan binds to TOP1 protein15655543
C051890irinotecanirinotecan results in decreased activity of TOP1 protein11914913
C051890irinotecanTOP1 protein affects the susceptibility to irinotecan15041737|1850918
C051890irinotecanirinotecan results in decreased activity of TOP1 protein15292932|2171098
D007854LeadLead affects the expression of TOP1 mRNA28903495
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of TOP1 mRNA26667767
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TOP1 mRNA10975854
D047311LuteolinLuteolin binds to and results in decreased activity of TOP1 protein12027807
C034244matrinematrine analog results in decreased activity of TOP1 protein21194615
D008610MentholMenthol results in decreased activity of TOP1 protein16158947
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TOP1 gene20938992
D008727MethotrexateMethotrexate results in decreased expression of TOP1 mRNA24449571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TOP1 mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of TOP1 protein26558463
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TOP1 mRNA26924002
C104727moxifloxacinmoxifloxacin promotes the reaction [Camptothecin results in decreased activity of TOP1 protein]18191106
C104727moxifloxacin[moxifloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein18191106
C010262norharmannorharman results in decreased activity of TOP1 protein8600349
C048396NSC 354646NSC 354646 results in increased activity of TOP1 protein2164630
D009828Oleanolic AcidOleanolic Acid analog results in decreased expression of TOP1 protein26612655
D009828Oleanolic AcidOleanolic Acid results in decreased activity of TOP1 protein10860928
D009942Organometallic CompoundsOrganometallic Compounds analog results in decreased activity of TOP1 protein21194615
C030110oxaliplatinTOP1 protein affects the susceptibility to oxaliplatin18509181
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TOP1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of TOP1 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of TOP1 mRNA25596134
D017239PaclitaxelPaclitaxel results in decreased expression of TOP1 mRNA12929121
C500026palbociclibpalbociclib results in decreased expression of TOP1 mRNA24549232
C005413palmatinepalmatine results in decreased activity of TOP1 protein23747414
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of TOP1 mRNA18593933
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of TOP1 mRNA18692542
C006253pirinixic acidpirinixic acid results in decreased expression of TOP1 mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of TOP1 mRNA15465739
D010936Plant ExtractsPlant Extracts results in decreased expression of TOP1 protein15465739
D010936Plant ExtractsPlant Extracts results in increased expression of TOP1 mRNA23557933
D059808PolyphenolsPolyphenols results in decreased expression of TOP1 mRNA15465739
D059808PolyphenolsPolyphenols results in decreased expression of TOP1 protein15465739
C432165pyrazolanthrone[pyrazolanthrone results in decreased phosphorylation of JUN protein] inhibits the reaction [JUN protein binds to TOP1 protein]15923621
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of TOP1 mRNA16514628
D017382Reactive Oxygen SpeciesReactive Oxygen Species promotes the reaction [arsenic trioxide results in increased activity of TOP1 protein]15178684
C053339rebeccamycinrebeccamycin results in decreased activity of TOP1 protein21710981
C059514resveratrol[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of TOP1 mRNA26667767
C059514resveratrolresveratrol results in decreased expression of TOP1 protein25505154
C104586roscovitineroscovitine results in increased expression of TOP1 mRNA24549232
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of TOP1 mRNA19244175
D012643SeleniumSelenium results in decreased expression of TOP1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TOP1 mRNA25895662
C016104sodium bichromatesodium bichromate affects the expression of TOP1 mRNA11960910
D012969Sodium FluorideSodium Fluoride results in decreased expression of TOP1 mRNA27862939
C061133tamibarotenetamibarotene results in decreased expression of TOP1 mRNA15498508
D013629TamoxifenTamoxifen results in increased expression of TOP1 mRNA15604281
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of TOP1 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TOP1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TOP1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TOP1 protein16548065
C014215tetrahydropalmatinetetrahydropalmatine results in increased expression of TOP1 protein20109541
D013882Thiosemicarbazones[Thiosemicarbazones binds to Copper] which results in increased expression of TOP1 protein20931265
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TOP1 mRNA15289447
D019772TopotecanTopotecan results in decreased activity of TOP1 protein24549232
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TOP1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of TOP1 mRNA25729387
D019772TopotecanTopotecan results in decreased activity of TOP1 protein15292932|2171098
D014212TretinoinTretinoin results in decreased expression of TOP1 mRNA15498508
D014241TrichloroethyleneTrichloroethylene results in increased methylation of TOP1 gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOP1 mRNA"27188386
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TOP1 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of TOP1 mRNA17127020
D014520UrethaneUrethane results in increased expression of TOP1 mRNA28818685
C005466ursolic acidursolic acid results in decreased activity of TOP1 protein10860928
D014635Valproic AcidValproic Acid results in decreased expression of TOP1 mRNA19101580
D014635Valproic AcidValproic Acid results in decreased expression of TOP1 mRNA20546886
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of TOP1 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of TOP1 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of TOP1 mRNA20044591
C111237vorinostatvorinostat results in decreased expression of TOP1 mRNA27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of TOP1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA22904072  
GO:0003677DNA binding-IDA17355975  
GO:0003677DNA binding-IMP10497031  
GO:0003682chromatin binding-IDA9049244  
GO:0003690double-stranded DNA binding-IMP8631794  
GO:0003697single-stranded DNA binding-IMP8631794  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003917DNA topoisomerase type I activity-IBA21873635  
GO:0003917DNA topoisomerase type I activity-IDA14594810  
GO:0003917DNA topoisomerase type I activity-IMP8567649  8631793  8631794  9611241  14654701  17355975  
GO:0004674protein serine/threonine kinase activity-IMP9611241  
GO:0005515protein binding-IPI8567649  9188637  9512561  10352183  12878161  15448168  
15848144  17234752  17314511  20195357  
GO:0005524ATP binding-IMP8631793  9611241  
GO:0019904protein domain specific binding-IPI9611241  
GO:0097100supercoiled DNA binding-IMP8631793  9611241  14654701  
GO ID GO Term Qualifier Evidence PubMed
GO:0006260DNA replication-IBA21873635  
GO:0006265DNA topological change-IBA21873635  
GO:0006265DNA topological change-IDA14594810  
GO:0006265DNA topological change-IMP8567649  8631793  8631794  9611241  14654701  
GO:0006338chromatin remodeling-IBA21873635  
GO:0006338chromatin remodeling-IMP22904072  
GO:0007059chromosome segregation-IBA21873635  
GO:0007623circadian rhythm-IEP22904072  
GO:0012501programmed cell death-NAS17172417  
GO:0016032viral process-IEA-  
GO:0016310phosphorylation-NAS17481653  
GO:0018105peptidyl-serine phosphorylation-IMP9611241  
GO:0032922circadian regulation of gene expression-IMP22904072  
GO:0040016embryonic cleavage-IEA-  
GO:0042493response to drug-IEP16127745  
GO ID GO Term Qualifier Evidence PubMed
GO:0000228nuclear chromosomecolocalizes_withIDA9049244  
GO:0000932P-body-IDA12878161  
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-HDA16791210  
GO:0005634nucleus-IDA9049244  11016921  
GO:0005654nucleoplasm-IDA9049244  
GO:0005654nucleoplasm-IMP14654701  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IBA21873635  
GO:0005730nucleolus-IDA9049244  
GO:0005730nucleolus-IMP14654701  
GO:0009330DNA topoisomerase complex (ATP-hydrolyzing)-IMP8567649  8631793  8631794  9611241  14654701  
GO:0031298replication fork protection complex-IBA21873635  
GO:0032993protein-DNA complex-IMP10497031  
GO:0043204perikaryon-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2990846SUMOylationTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4615885SUMOylation of DNA replication proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28355294Mining expression and prognosis of topoisomerase isoforms in non-small-cell lung cancer by using Oncomine and Kaplan-Meier plotter. (2017)Hou GXPLoS One
27859136KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer. (2017 Feb 15)Nagy AInt J Cancer