| C471674 | 10'(Z),13'(E),15'(E)-heptadecatrienylhydroquinone | "10'(Z),13'(E),15'(E)-heptadecatrienylhydroquinone binds to TOP2A protein" | 23088786 |
| C447943 | 11-keto-boswellic acid | 11-keto-boswellic acid analog results in decreased activity of TOP2A protein | 21056033 |
| C049325 | 1,2-dithiol-3-thione | "1,2-dithiol-3-thione results in increased expression of TOP2A mRNA" | 19162173 |
| C040756 | 1,2-naphthoquinone | "1,2-naphthoquinone binds to and results in decreased activity of TOP2A protein" | 22218491 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TOP2A mRNA" | 22698814|2890350 |
| C035342 | 1,4-naphthoquinone | "1,4-naphthoquinone binds to and results in decreased activity of TOP2A protein" | 22218491 |
| C029790 | 2,2',3',4,4',5-hexachlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TOP2A mRNA" | 25510870 |
| C511295 | 2,2',4,4'-tetrabromodiphenyl ether | "2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TOP2A mRNA" | 25614096 |
| C511295 | 2,2',4,4'-tetrabromodiphenyl ether | "2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TOP2A mRNA" | 20566336 |
| C111118 | 2',3,3',4',5-pentachloro-4-hydroxybiphenyl | "2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TOP2A mRNA" | 19114083 |
| C029497 | 2,3-bis(3'-hydroxybenzyl)butyrolactone | "[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TOP2A mRNA" | 19167446 |
| C081766 | 2,4,4'-trichlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TOP2A mRNA" | 25510870 |
| C014024 | 2,4,5,2',4',5'-hexachlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TOP2A mRNA" | 25510870 |
| C009828 | 2,4,5,2',5'-pentachlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TOP2A mRNA" | 25510870 |
| C010914 | 2,4-diaminotoluene | "2,4-diaminotoluene results in increased expression of TOP2A mRNA" | 20713471 |
| C009407 | 2,5,2',5'-tetrachlorobiphenyl | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TOP2A mRNA" | 25510870 |
| C049584 | 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | "2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of TOP2A mRNA" | 20816883 |
| C006551 | 2-amino-2-methyl-1-propanol | 2-amino-2-methyl-1-propanol results in increased expression of TOP2A mRNA | 25088246 |
| C036990 | 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline | "2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TOP2A mRNA" | 20816883 |
| C019499 | 2-nitrofluorene | 2-nitrofluorene results in increased expression of TOP2A mRNA | 15890375 |
| C054649 | 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol | "3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in decreased expression of TOP2A mRNA" | 12734338 |
| C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOP2A mRNA" | 27188386 |
| C517041 | (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) | "(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of TOP2A mRNA" | 19561079 |
| C027576 | 4-hydroxy-2-nonenal | 4-hydroxy-2-nonenal results in decreased expression of TOP2A mRNA | 12419474 |
| C027576 | 4-hydroxy-2-nonenal | 4-hydroxy-2-nonenal results in decreased expression of TOP2A mRNA | 19191707 |
| C027576 | 4-hydroxy-2-nonenal | 4-hydroxy-2-nonenal results in increased expression of TOP2A mRNA | 19191707 |
| C406734 | 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid | 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid results in decreased expression of TOP2A protein | 17089011 |
| C016583 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of TOP2A mRNA | 15890375 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOP2A mRNA" | 27188386 |
| C052026 | 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole | "[6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole results in decreased phosphorylation of MAPK14 protein] which results in decreased expression of TOP2A protein" | 15753397 |
| C005399 | 9,10-phenanthrenequinone | "9,10-phenanthrenequinone binds to and results in decreased activity of TOP2A protein" | 22218491 |
| C008009 | 9-hydroxyellipticine | TOP2A protein affects the susceptibility to 9-hydroxyellipticine | 23293027 |
| C008009 | 9-hydroxyellipticine | 9-hydroxyellipticine results in decreased activity of TOP2A protein | 23293027 |
| D000082 | Acetaminophen | Acetaminophen results in decreased expression of TOP2A mRNA | 29067470 |
| D000082 | Acetaminophen | Acetaminophen results in increased expression of TOP2A mRNA | 22230336 |
| D000082 | Acetaminophen | Acetaminophen affects the expression of TOP2A mRNA | 17562736 |
| D000082 | Acetaminophen | Acetaminophen results in decreased expression of TOP2A protein | 26011634 |
| C094432 | acetyl-11-ketoboswellic acid | acetyl-11-ketoboswellic acid results in decreased activity of TOP2A protein | 10860928 |
| D000111 | Acetylcysteine | Acetylcysteine inhibits the reaction [wedelolactone results in decreased activity of TOP2A protein] | 22733624 |
| D020106 | Acrylamide | Acrylamide inhibits the reaction [Etoposide results in decreased expression of TOP2A protein] | 20006698 |
| D020106 | Acrylamide | Acrylamide results in decreased expression of TOP2A mRNA | 28606764 |
| D020106 | Acrylamide | Acrylamide results in increased expression of TOP2A mRNA | 28959563 |
| D000255 | Adenosine Triphosphate | copper-thiosemicarbazone complex analog inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate] | 26982206 |
| D000255 | Adenosine Triphosphate | Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate] | 20855424 |
| D000255 | Adenosine Triphosphate | Etoposide metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate] | 27533850 |
| D000255 | Adenosine Triphosphate | Thiosemicarbazones analog inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate] | 26982206 |
| D000255 | Adenosine Triphosphate | TOP2A protein results in increased hydrolysis of Adenosine Triphosphate | 26982206|2753385 |
| D000255 | Adenosine Triphosphate | TOP2A results in increased hydrolysis of Adenosine Triphosphate | 20855424 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 affects the expression of TOP2A protein | 20106945 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased methylation of TOP2A gene | 27153756 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased expression of TOP2A mRNA | 19770486 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased expression of TOP2A mRNA | 15890375 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in increased expression of TOP2A mRNA | 23630614 |
| C000188 | alachlor | alachlor results in increased expression of TOP2A mRNA | 12419858 |
| C095643 | altenusin | altenusin results in decreased activity of TOP2A protein | 27682608 |
| C005197 | alternariol | alternariol metabolite results in decreased activity of TOP2A protein | 27422292 |
| C005197 | alternariol | alternariol results in decreased activity of TOP2A protein | 27422292|2768260 |
| C018206 | alternariol monomethyl ether | alternariol monomethyl ether metabolite results in decreased activity of TOP2A protein | 27422292 |
| C018206 | alternariol monomethyl ether | alternariol monomethyl ether results in decreased activity of TOP2A protein | 27422292|2768260 |
| C120102 | alterperylenol | alterperylenol results in decreased activity of TOP2A protein | 27682608 |
| C050233 | altertoxin I | altertoxin I results in decreased activity of TOP2A protein | 27682608 |
| C050234 | altertoxin II | altertoxin II results in decreased activity of TOP2A protein | 27682608 |
| C059765 | amphotericin B, deoxycholate drug combination | "amphotericin B, deoxycholate drug combination results in increased expression of TOP2A mRNA" | 22863853 |
| D000677 | Amsacrine | [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Amsacrine | 16969495 |
| D000677 | Amsacrine | [MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Amsacrine | 21878638 |
| D000677 | Amsacrine | [MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Amsacrine | 21878638 |
| D000677 | Amsacrine | TOP2A gene mutant form results in decreased susceptibility to Amsacrine | 11676865|1651812 |
| D000677 | Amsacrine | TOP2A protein modified form affects the susceptibility to Amsacrine | 12569090 |
| D000677 | Amsacrine | TOP2A protein mutant form results in decreased susceptibility to Amsacrine | 10727526|1147051 |
| D000677 | Amsacrine | Amsacrine results in decreased activity of TOP2A protein | 16549872|1736802 |
| D000873 | Anthracenes | Anthracenes results in decreased activity of TOP2A protein | 20561793 |
| D016718 | Arachidonic Acid | Arachidonic Acid results in decreased expression of TOP2A mRNA | 16704987 |
| D001151 | Arsenic | Arsenic results in increased expression of TOP2A mRNA | 11134558 |
| C006632 | arsenic trioxide | arsenic trioxide results in decreased expression of TOP2A protein | 16884364 |
| D001205 | Ascorbic Acid | Ascorbic Acid inhibits the reaction [wedelolactone results in decreased activity of TOP2A protein] | 22733624 |
| D001280 | Atrazine | Atrazine results in increased expression of TOP2A mRNA | 25929836 |
| C083578 | aurofusarin | aurofusarin results in decreased activity of TOP2A protein | 29248571 |
| D001374 | Azacitidine | [Azacitidine co-treated with Thalidomide] affects the expression of TOP2A mRNA | 18720364 |
| D001374 | Azacitidine | [Curcumin co-treated with Azacitidine] results in decreased expression of TOP2A mRNA | 18348204 |
| D001379 | Azathioprine | Azathioprine results in decreased expression of TOP2A mRNA | 22623647 |
| C547126 | AZM551248 | AZM551248 results in increased expression of TOP2A mRNA | 22323515 |
| C057924 | batracylin | batracylin results in decreased activity of TOP2A protein | 21388138 |
| D001554 | Benzene | Benzene results in decreased expression of TOP2A mRNA | 21382456 |
| D001554 | Benzene | Benzene results in decreased expression of TOP2A protein | 21382456 |
| D001562 | Benzimidazoles | Benzimidazoles results in decreased activity of TOP2A protein | 20884089 |
| C006703 | benzo(b)fluoranthene | benzo(b)fluoranthene results in increased expression of TOP2A mRNA | 26377693 |
| D019324 | beta-Naphthoflavone | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TOP2A mRNA | 18164116 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of TOP2A mRNA | 20064835|2180250 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of TOP2A mRNA | 20106945 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of TOP2A mRNA | 19770486 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of TOP2A mRNA | 20713471 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of TOP2A mRNA | 21839799 |
| D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TOP2A mRNA" | 20018196|2038263 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]] | 17575151 |
| D001599 | Berberine | TOP2A protein affects the reaction [Berberine results in increased expression of H2AFX protein modified form] | 23747414 |
| D001599 | Berberine | TOP2A protein affects the susceptibility to Berberine | 23747414 |
| D004958 | Estradiol | Estradiol results in increased expression of TOP2A mRNA | 16474171|1831028 |
| D004958 | Estradiol | [Estradiol results in increased expression of TOP2A mRNA] which results in increased susceptibility to Cisplatin | 28323900 |
| D004958 | Estradiol | [Estradiol results in increased expression of TOP2A mRNA] which results in increased susceptibility to Doxorubicin | 28323900 |
| D004958 | Estradiol | ESR1 protein promotes the reaction [Estradiol results in increased expression of TOP2A mRNA] | 25210133 |
| D004958 | Estradiol | Estradiol results in increased expression of TOP2A mRNA | 19484750|1969329 |
| D004958 | Estradiol | Estradiol results in increased expression of TOP2A mRNA | 26372666 |
| D004958 | Estradiol | Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of TOP2A mRNA] | 26372666 |
| C044887 | beta-methylcholine | beta-methylcholine affects the expression of TOP2A mRNA | 21179406 |
| C002070 | betulinic acid | betulinic acid results in decreased activity of TOP2A protein | 10860928 |
| C002070 | betulinic acid | betulinic acid analog results in decreased activity of TOP2A protein | 28254521 |
| C551172 | bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) | "bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in decreased expression of TOP2A mRNA" | 20162321 |
| C006780 | bisphenol A | bisphenol A affects the expression of TOP2A mRNA | 21786754 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of TOP2A mRNA | 29275510 |
| C006780 | bisphenol A | bisphenol A results in increased expression of TOP2A mRNA | 16474171 |
| C006780 | bisphenol A | bisphenol A affects the expression of TOP2A mRNA | 21786754 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of TOP2A mRNA | 25181051 |
| C054625 | boswellic acid | boswellic acid analog binds to and results in decreased activity of TOP2A protein | 10860928 |
| D002085 | Butylhydroxybutylnitrosamine | [Butylhydroxybutylnitrosamine co-treated with Propolis analog] results in increased expression of TOP2A mRNA | 26111810 |
| C018475 | butyraldehyde | butyraldehyde results in decreased expression of TOP2A mRNA | 26079696 |
| D002101 | Cacodylic Acid | Cacodylic Acid results in increased expression of TOP2A mRNA | 17441966 |
| D002101 | Cacodylic Acid | Cacodylic Acid results in decreased expression of TOP2A mRNA | 17720352 |
| D019256 | Cadmium Chloride | Cadmium Chloride results in decreased activity of TOP2A protein | 21497582 |
| D019256 | Cadmium Chloride | Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of TOP2A protein] | 21497582 |
| D019256 | Cadmium Chloride | [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of TOP2A mRNA | 19840844 |
| D019256 | Cadmium Chloride | Cadmium Chloride results in decreased expression of TOP2A mRNA | 25993096 |
| C073718 | cannabidiol hydroxyquinone | cannabidiol hydroxyquinone results in decreased activity of TOP2A protein | 17237277 |
| C073718 | cannabidiol hydroxyquinone | cannabidiol hydroxyquinone results in decreased activity of TOP2A protein | 25409338 |
| C073718 | cannabidiol hydroxyquinone | Dithiothreitol affects the reaction [cannabidiol hydroxyquinone results in decreased activity of TOP2A protein] | 25409338 |
| C001614 | captafol | captafol results in decreased activity of TOP2A protein | 12113771 |
| D002215 | Captan | Captan results in decreased activity of TOP2A protein | 12113771 |
| D002218 | Carbadox | Carbadox results in decreased expression of TOP2A protein | 26558467 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride results in increased expression of TOP2A mRNA | 27339419 |
| D002264 | Carboxylic Acids | Carboxylic Acids results in decreased activity of TOP2A protein | 20884089 |
| D002392 | Catechin | Catechin results in decreased expression of TOP2A mRNA | 15465739 |
| C099555 | CD 437 | CD 437 results in decreased expression of TOP2A protein | 15059897 |
| C083924 | CEF regimen | TOP2A gene mutant form results in increased susceptibility to CEF regimen | 16234514 |
| D002509 | Cephaloridine | Cephaloridine results in decreased expression of TOP2A mRNA | 18500788 |
| C035377 | chlorendic acid | chlorendic acid results in increased expression of TOP2A mRNA | 22584684 |
| D002713 | Chlorine | [Ozone co-treated with Chlorine] results in decreased expression of TOP2A mRNA | 18636392 |
| C004656 | chloroacetaldehyde | chloroacetaldehyde results in increased activity of TOP2A protein | 15751973 |
| D004390 | Chlorpyrifos | Chlorpyrifos results in decreased expression of TOP2A mRNA | 21356183 |
| D004390 | Chlorpyrifos | Chlorpyrifos results in decreased activity of TOP2A protein | 26198043 |
| D002939 | Ciprofloxacin | Ciprofloxacin binds to TOP2A protein | 21413765 |
| D002939 | Ciprofloxacin | [Ciprofloxacin binds to TOP2A protein] inhibits the reaction [Etoposide binds to TOP2A protein] | 21413765 |
| D002939 | Ciprofloxacin | [Ciprofloxacin binds to TOP2A protein] inhibits the reaction [F14512 binds to TOP2A protein] | 21413765 |
| C057477 | clinafloxacin | clinafloxacin results in decreased activity of TOP2A protein | 23340199 |
| D007464 | Clioquinol | [Clioquinol binds to Copper] which results in increased expression of TOP2A protein | 18346929 |
| C034456 | CMF regimen | TOP2A gene mutant form results in decreased susceptibility to CMF regimen | 22204715 |
| C018021 | cobaltous chloride | cobaltous chloride results in decreased expression of TOP2A mRNA | 19320972|1937684 |
| C018021 | cobaltous chloride | cobaltous chloride results in decreased expression of TOP2A mRNA | 24386269 |
| D003300 | Copper | [Clioquinol binds to Copper] which results in increased expression of TOP2A protein | 18346929 |
| D003300 | Copper | [NSC 689534 binds to Copper] which results in decreased expression of TOP2A mRNA | 20971185 |
| D019327 | Copper Sulfate | Copper Sulfate results in decreased expression of TOP2A mRNA | 19549813 |
| C066363 | copper-thiosemicarbazone complex | copper-thiosemicarbazone complex analog inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate] | 26982206 |
| C066363 | copper-thiosemicarbazone complex | copper-thiosemicarbazone complex analog results in decreased activity of TOP2A protein | 26982206 |
| D003345 | Corticosterone | Corticosterone results in decreased expression of TOP2A mRNA | 15755911 |
| D003375 | Coumestrol | "[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TOP2A mRNA" | 19167446 |
| D003375 | Coumestrol | [Coumestrol co-treated with ESR1 protein] results in increased expression of TOP2A mRNA | 18310284 |
| D003375 | Coumestrol | ESR2 protein promotes the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of TOP2A mRNA] | 18310284 |
| C408982 | CPG-oligonucleotide | CPG-oligonucleotide results in decreased expression of TOP2A mRNA | 21878529 |
| C037886 | cryptotanshinone | cryptotanshinone results in decreased expression of and results in decreased activity of TOP2A protein | 28716507 |
| C037886 | cryptotanshinone | cryptotanshinone results in decreased expression of TOP2A mRNA | 28716507 |
| C029892 | cupric chloride | cupric chloride results in decreased expression of TOP2A mRNA | 19174923 |
| C030973 | cupric oxide | cupric oxide results in decreased expression of TOP2A mRNA | 22077320 |
| D003471 | Cuprizone | Cuprizone results in increased expression of TOP2A mRNA | 26577399 |
| D003474 | Curcumin | Curcumin analog results in decreased expression of TOP2A mRNA | 26409325 |
| D003474 | Curcumin | [Curcumin co-treated with Azacitidine] results in decreased expression of TOP2A mRNA | 18348204 |
| D003474 | Curcumin | Curcumin results in decreased expression of TOP2A mRNA | 18348204|1841405 |
| D003474 | Curcumin | [sulfinosine co-treated with Curcumin] results in decreased expression of TOP2A mRNA | 18414057 |
| D003520 | Cyclophosphamide | TOP2A protein affects the susceptibility to [Cyclophosphamide co-treated with Epirubicin co-treated with Fluorouracil] | 18465341 |
| D003520 | Cyclophosphamide | TOP2A protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] | 16682728 |
| D003520 | Cyclophosphamide | Cyclophosphamide results in increased expression of TOP2A mRNA | 11599041 |
| D016572 | Cyclosporine | Cyclosporine results in decreased expression of TOP2A mRNA | 20106945|2163298 |
| D016572 | Cyclosporine | Cyclosporine results in decreased expression of TOP2A mRNA | 19770486 |
| D016572 | Cyclosporine | Cyclosporine results in decreased expression of TOP2A mRNA | 19224547 |
| D000069439 | Dasatinib | Dasatinib results in decreased expression of TOP2A mRNA | 20579391 |
| D003630 | Daunorubicin | Daunorubicin results in decreased activity of TOP2A protein | 19885609 |
| C014347 | decitabine | decitabine affects the expression of TOP2A mRNA | 23300844 |
| C017185 | delphinidin | delphinidin results in decreased activity of TOP2A protein | 19182879 |
| C017185 | delphinidin | delphinidin results in decreased susceptibility to [Doxorubicin affects the activity of TOP2A protein] | 19182879 |
| C017185 | delphinidin | delphinidin results in decreased susceptibility to [Etoposide affects the activity of TOP2A protein] | 19182879 |
| D013759 | Dronabinol | Dronabinol results in increased expression of TOP2A mRNA | 16597638 |
| D003703 | Demecolcine | Demecolcine results in decreased expression of TOP2A mRNA | 23649840 |
| D003907 | Dexamethasone | Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TOP2A mRNA] | 27941970 |
| D003907 | Dexamethasone | Dexamethasone results in increased expression of TOP2A mRNA | 23137833 |
| D003907 | Dexamethasone | Dexamethasone affects the expression of TOP2A mRNA | 15102944 |
| D064730 | Dexrazoxane | Dexrazoxane analog results in decreased activity of TOP2A protein | 28941780 |
| D064730 | Dexrazoxane | Dexrazoxane results in decreased activity of TOP2A protein | 28941780 |
| C539263 | di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone | "di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone results in decreased activity of TOP2A protein" | 21750178 |
| D016190 | Carboplatin | TOP2A results in decreased susceptibility to [Carboplatin co-treated with Etoposide co-treated with Ifosfamide] | 11325482 |
| C023614 | dibenzofuran | dibenzofuran analog results in decreased expression of TOP2A mRNA | 20566336 |
| D003993 | Dibutyl Phthalate | Dibutyl Phthalate results in decreased expression of TOP2A mRNA | 28973377 |
| D003993 | Dibutyl Phthalate | Dibutyl Phthalate results in decreased expression of TOP2A mRNA | 17361019|2126653 |
| D003993 | Dibutyl Phthalate | Dibutyl Phthalate results in decreased expression of TOP2A mRNA | 21266533 |
| D003999 | Dichloroacetic Acid | Dichloroacetic Acid results in increased expression of TOP2A mRNA | 28962523 |
| D002945 | Cisplatin | Cisplatin affects the expression of TOP2A mRNA | 23300844 |
| D002945 | Cisplatin | Cisplatin results in decreased expression of TOP2A mRNA | 27594783 |
| D002945 | Cisplatin | [Estradiol results in increased expression of TOP2A mRNA] which results in increased susceptibility to Cisplatin | 28323900 |
| D002945 | Cisplatin | TOP2A results in decreased susceptibility to [Cisplatin co-treated with Etoposide] | 11325482 |
| D002945 | Cisplatin | TOP2A results in decreased susceptibility to [Cisplatin co-treated with Paclitaxel] | 11325482 |
| D002945 | Cisplatin | TOP2A results in decreased susceptibility to [Cisplatin co-treated with Teniposide] | 11325482 |
| D002945 | Cisplatin | Cisplatin results in increased expression of TOP2A mRNA | 21151649 |
| D002945 | Cisplatin | Cisplatin results in decreased expression of TOP2A mRNA | 22023808 |
| C000944 | dicrotophos | dicrotophos results in decreased expression of TOP2A mRNA | 28302478 |
| D004041 | Dietary Fats | Dietary Fats results in increased expression of TOP2A mRNA | 25016146 |
| D004041 | Dietary Fats | [Dietary Fats co-treated with resveratrol] results in decreased expression of TOP2A mRNA | 21852083 |
| D004052 | Diethylnitrosamine | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TOP2A mRNA | 24535843 |
| D004052 | Diethylnitrosamine | Diethylnitrosamine results in increased expression of TOP2A mRNA | 17854601 |
| D004052 | Diethylnitrosamine | RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TOP2A mRNA] | 17854601 |
| D004052 | Diethylnitrosamine | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TOP2A mRNA | 18164116 |
| D004052 | Diethylnitrosamine | Diethylnitrosamine results in increased expression of TOP2A mRNA | 25242409 |
| D004052 | Diethylnitrosamine | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TOP2A mRNA | 22129741 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in increased expression of TOP2A mRNA | 15890375 |
| C035318 | diethylthiourea | diethylthiourea results in increased expression of TOP2A mRNA | 22584684 |
| D002117 | Calcitriol | Calcitriol results in decreased expression of TOP2A mRNA | 21592394 |
| D002117 | Calcitriol | [Testosterone co-treated with Calcitriol] results in decreased expression of TOP2A mRNA | 21592394 |
| D004128 | Dimethylnitrosamine | Dimethylnitrosamine results in increased expression of TOP2A mRNA | 15890375 |
| D004229 | Dithiothreitol | Dithiothreitol affects the reaction [cannabidiol hydroxyquinone results in decreased activity of TOP2A protein] | 25409338 |
| D004317 | Doxorubicin | delphinidin results in decreased susceptibility to [Doxorubicin affects the activity of TOP2A protein] | 19182879 |
| D004317 | Doxorubicin | Doxorubicin affects the activity of TOP2A protein | 19182879 |
| D004317 | Doxorubicin | Doxorubicin results in decreased expression of TOP2A mRNA | 15205334|1602661 |
| D004317 | Doxorubicin | Doxorubicin results in increased expression of TOP2A protein | 17351394|2275143 |
| D004317 | Doxorubicin | [DPP4 protein results in increased expression of TOP2A protein] which results in increased susceptibility to Doxorubicin | 15753397 |
| D004317 | Doxorubicin | [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Doxorubicin | 16969495 |
| D004317 | Doxorubicin | [Estradiol results in increased expression of TOP2A mRNA] which results in increased susceptibility to Doxorubicin | 28323900 |
| D004317 | Doxorubicin | palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein] | 22751436 |
| D004317 | Doxorubicin | RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]] | 22751436 |
| D004317 | Doxorubicin | TOP2A mRNA results in decreased susceptibility to Doxorubicin | 15765123 |
| D004317 | Doxorubicin | TOP2A mRNA results in increased susceptibility to Doxorubicin | 15239142 |
| D004317 | Doxorubicin | TOP2A protein affects the susceptibility to Doxorubicin | 16217747 |
| D004317 | Doxorubicin | [TOP2A protein co-treated with ERBB2 protein] results in increased susceptibility to Doxorubicin | 15486187 |
| D004317 | Doxorubicin | TOP2A protein mutant form results in decreased susceptibility to Doxorubicin | 11470519 |
| D004317 | Doxorubicin | TOP2A protein results in decreased susceptibility to Doxorubicin | 15765123 |
| D004317 | Doxorubicin | TOP2A results in increased susceptibility to Doxorubicin | 9862568 |
| D004317 | Doxorubicin | Doxorubicin results in decreased expression of TOP2A mRNA | 25896364 |
| D004317 | Doxorubicin | Doxorubicin results in increased expression of TOP2A mRNA | 22712078 |
| D004317 | Doxorubicin | Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TOP2A mRNA] | 22712078 |
| D004317 | Doxorubicin | Doxorubicin results in decreased activity of TOP2A protein | 15688034|9505340 |
| C479799 | (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide | (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide results in decreased expression of TOP2A mRNA | 15528975 |
| C034192 | ellipticine | ellipticine results in decreased activity of TOP2A protein | 16027529 |
| D004642 | Emodin | Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate] | 20855424 |
| D004642 | Emodin | Emodin results in increased activity of TOP2A protein | 20855424 |
| D004642 | Emodin | TOP2A affects the reaction [Emodin results in increased expression of H2AFX protein modified form] | 20855424 |
| D004785 | Environmental Pollutants | Environmental Pollutants results in increased expression of TOP2A mRNA | 12655031 |
| D015251 | Epirubicin | TOP2A protein affects the susceptibility to [Cyclophosphamide co-treated with Epirubicin co-treated with Fluorouracil] | 18465341 |
| D015251 | Epirubicin | TOP2A protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] | 16682728 |
| C062669 | epicatechin gallate | epicatechin gallate results in decreased activity of TOP2A protein | 16536579 |
| C045651 | epigallocatechin gallate | epigallocatechin gallate results in increased expression of TOP2A mRNA | 18851785 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased expression of TOP2A mRNA | 17942748 |
| D004997 | Ethinyl Estradiol | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TOP2A mRNA | 17942748 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol affects the expression of TOP2A mRNA | 17351261 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in decreased expression of TOP2A mRNA | 12655037 |
| C004912 | ethylbenzene | ethylbenzene results in increased methylation of TOP2A promoter | 29217486 |
| D005047 | Etoposide | Acrylamide inhibits the reaction [Etoposide results in decreased expression of TOP2A protein] | 20006698 |
| D005047 | Etoposide | Etoposide results in decreased expression of TOP2A protein | 20006698 |
| D005047 | Etoposide | benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]] | 17575151 |
| D005047 | Etoposide | [Ciprofloxacin binds to TOP2A protein] inhibits the reaction [Etoposide binds to TOP2A protein] | 21413765 |
| D005047 | Etoposide | delphinidin results in decreased susceptibility to [Etoposide affects the activity of TOP2A protein] | 19182879 |
| D005047 | Etoposide | [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Etoposide | 16969495 |
| D005047 | Etoposide | Etoposide affects the activity of TOP2A protein | 19182879|2465015 |
| D005047 | Etoposide | Etoposide analog results in decreased activity of TOP2A protein | 21056033 |
| D005047 | Etoposide | Etoposide binds to TOP2A protein | 21413765 |
| D005047 | Etoposide | "Etoposide metabolite inhibits the reaction [TOP2A protein binds to Nucleic Acids, Nucleotides, and Nucleosides]" | 27533850 |
| D005047 | Etoposide | Etoposide metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate] | 27533850 |
| D005047 | Etoposide | Etoposide metabolite results in decreased activity of TOP2A protein | 27533850 |
| D005047 | Etoposide | Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein] | 17575151 |
| D005047 | Etoposide | Etoposide results in decreased activity of TOP2A protein | 26198043|2742229 |
| D005047 | Etoposide | [MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Etoposide | 21878638 |
| D005047 | Etoposide | [MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Etoposide | 21878638 |
| D005047 | Etoposide | TOP2A gene mutant form results in decreased susceptibility to Etoposide | 11676865 |
| D005047 | Etoposide | TOP2A protein modified form affects the susceptibility to Etoposide | 12569090 |
| D005047 | Etoposide | TOP2A protein mutant form results in decreased susceptibility to Etoposide | 11470519 |
| D005047 | Etoposide | TOP2A protein results in increased susceptibility to Etoposide | 11531262 |
| D005047 | Etoposide | TOP2A results in decreased susceptibility to [Carboplatin co-treated with Etoposide co-treated with Ifosfamide] | 11325482 |
| D005047 | Etoposide | TOP2A results in decreased susceptibility to [Cisplatin co-treated with Etoposide] | 11325482 |
| D005047 | Etoposide | Etoposide results in decreased activity of TOP2A protein | 15211611 |
| D005047 | Etoposide | Etoposide results in decreased expression of TOP2A protein | 10856430 |
| D005047 | Etoposide | Etoposide results in decreased activity of TOP2A protein | 17368022 |
| C534191 | F14512 | [Ciprofloxacin binds to TOP2A protein] inhibits the reaction [F14512 binds to TOP2A protein] | 21413765 |
| C534191 | F14512 | F14512 binds to and affects the activity of TOP2A protein | 21413765 |
| C052498 | FEC protocol | ERBB2 protein promotes the reaction [TOP2A protein results in increased susceptibility to FEC protocol] | 16682728 |
| D005419 | Flavonoids | Flavonoids results in decreased expression of TOP2A mRNA | 15465739 |
| D015073 | 2-Acetylaminofluorene | 2-Acetylaminofluorene results in increased expression of TOP2A mRNA | 22584684 |
| D005472 | Fluorouracil | Fluorouracil results in decreased expression of TOP2A mRNA | 15205334|1655759 |
| D005472 | Fluorouracil | TOP2A protein affects the susceptibility to [Cyclophosphamide co-treated with Epirubicin co-treated with Fluorouracil] | 18465341 |
| D005472 | Fluorouracil | TOP2A protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide] | 16682728 |
| D005472 | Fluorouracil | TP53 protein affects the reaction [Fluorouracil results in decreased expression of TOP2A mRNA] | 15016801 |
| D005472 | Fluorouracil | Fluorouracil results in decreased expression of TOP2A mRNA | 19272435 |
| D005492 | Folic Acid | [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of TOP2A mRNA | 24657277 |
| C070081 | fulvestrant | fulvestrant results in increased expression of TOP2A mRNA | 12154049 |
| C039281 | furan | furan results in increased expression of TOP2A mRNA | 25539665 |
| D019833 | Genistein | Genistein results in increased expression of TOP2A mRNA | 16474171 |
| D019833 | Genistein | Genistein affects the activity of TOP2A protein | 26723871 |
| D005944 | Glucosamine | Glucosamine results in decreased expression of TOP2A mRNA | 17109745 |
| D005947 | Glucose | [INS protein co-treated with Glucose] results in increased expression of TOP2A mRNA | 22634610 |
| D005978 | Glutathione | Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of TOP2A protein] | 21497582 |
| D005978 | Glutathione | Glutathione inhibits the reaction [wedelolactone results in decreased activity of TOP2A protein] | 22733624 |
| C401858 | GW 7604 | GW 7604 results in increased expression of TOP2A mRNA | 12154049 |
| D017313 | Fenretinide | Fenretinide results in increased expression of TOP2A mRNA | 28973697 |
| D006861 | Hydrogen Peroxide | [MPO protein co-treated with Hydrogen Peroxide] promotes the reaction [hydroquinone results in decreased activity of TOP2A protein] | 15935818 |
| C031927 | hydroquinone | hydroquinone affects the activity of TOP2A protein | 15833037 |
| C031927 | hydroquinone | hydroquinone results in decreased activity of TOP2A protein | 11468185|1593581 |
| C031927 | hydroquinone | [MPO protein co-treated with Hydrogen Peroxide] promotes the reaction [hydroquinone results in decreased activity of TOP2A protein] | 15935818 |
| C031927 | hydroquinone | hydroquinone results in decreased activity of TOP2A protein | 15211611 |
| C013038 | hydroxyhydroquinone | hydroxyhydroquinone results in decreased activity of TOP2A protein | 7586126 |
| C004965 | hypericin | hypericin results in decreased activity of TOP2A protein | 11597574 |
| C492448 | ICG 001 | ICG 001 results in decreased expression of TOP2A mRNA | 26191083 |
| D007069 | Ifosfamide | TOP2A results in decreased susceptibility to [Carboplatin co-treated with Etoposide co-treated with Ifosfamide] | 11325482 |
| C027185 | indirubin | indirubin results in decreased expression of TOP2A mRNA | 15056799 |
| C016517 | indole-3-carbinol | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TOP2A mRNA | 22129741 |
| D015759 | Ionomycin | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TOP2A mRNA | 25613284 |
| C051890 | irinotecan | irinotecan metabolite results in decreased expression of TOP2A mRNA | 15956246 |
| C051890 | irinotecan | irinotecan results in decreased expression of TOP2A mRNA | 15956246 |
| C051890 | irinotecan | TOP2A mRNA results in increased susceptibility to irinotecan | 15239142 |
| D007529 | Isoflavones | Isoflavones results in decreased expression of TOP2A mRNA | 17374662 |
| C544151 | jinfukang | jinfukang results in increased expression of TOP2A mRNA | 27392435 |
| C561695 | (+)-JQ1 compound | (+)-JQ1 compound results in decreased expression of TOP2A mRNA | 25961927|2683047 |
| C410337 | K 7174 | K 7174 results in decreased expression of TOP2A mRNA | 24086573 |
| C099406 | L 742694 | L 742694 affects the expression of TOP2A mRNA | 15102944 |
| D007840 | Latex | Latex analog results in increased expression of TOP2A mRNA | 24768652 |
| C008261 | lead acetate | lead acetate results in decreased expression of TOP2A mRNA | 22613225 |
| C045463 | leflunomide | leflunomide results in decreased expression of TOP2A mRNA | 28988120 |
| C045463 | leflunomide | leflunomide results in decreased expression of TOP2A mRNA | 24136188 |
| D008070 | Lipopolysaccharides | Lipopolysaccharides affects the expression of TOP2A mRNA | 28070326 |
| D008070 | Lipopolysaccharides | Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of TOP2A mRNA] | 28070326 |
| D008070 | Lipopolysaccharides | Lipopolysaccharides results in increased expression of TOP2A mRNA | 10975854 |
| D008094 | Lithium | Lithium results in increased expression of TOP2A mRNA | 21711903 |
| C053091 | lomefloxacin | lomefloxacin results in decreased activity of TOP2A protein | 23340199 |
| D008148 | Lovastatin | Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TOP2A mRNA] | 22712078 |
| D008154 | Lucanthone | Lucanthone results in decreased expression of TOP2A mRNA | 21148553 |
| C058810 | macrosporin | macrosporin results in decreased activity of TOP2A protein | 27682608 |
| D058185 | Magnetite Nanoparticles | [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TOP2A mRNA | 26378955 |
| D008610 | Menthol | Menthol results in decreased activity of TOP2A protein | 16158947 |
| D008627 | Mercuric Chloride | Mercuric Chloride affects the expression of TOP2A mRNA | 20353558 |
| D008694 | Methamphetamine | Methamphetamine results in decreased expression of TOP2A mRNA | 25290377 |
| D008694 | Methamphetamine | Methamphetamine results in decreased expression of TOP2A mRNA | 28341135 |
| D008694 | Methamphetamine | Methamphetamine results in decreased expression of TOP2A protein | 28341135 |
| D008701 | Methapyrilene | Methapyrilene results in increased expression of TOP2A mRNA | 15890375|2258468 |
| D008701 | Methapyrilene | Methapyrilene results in increased expression of TOP2A protein | 26558467 |
| D008727 | Methotrexate | [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of TOP2A mRNA | 24657277 |
| D008727 | Methotrexate | Methotrexate results in decreased expression of TOP2A mRNA | 24657277 |
| D008748 | Methylcholanthrene | Methylcholanthrene results in increased expression of TOP2A mRNA | 20713471 |
| D008748 | Methylcholanthrene | Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of TOP2A mRNA] | 26372666 |
| C005223 | methyleugenol | methyleugenol affects the expression of TOP2A protein | 26011634 |
| C004925 | methylmercuric chloride | methylmercuric chloride results in decreased expression of TOP2A mRNA | 20061341 |
| D008741 | Methyl Methanesulfonate | Methyl Methanesulfonate results in decreased expression of TOP2A mRNA | 26011545 |
| D008769 | Methylnitronitrosoguanidine | [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of TOP2A mRNA | 19840844 |
| D008769 | Methylnitronitrosoguanidine | [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of TOP2A mRNA | 19840844 |
| D008769 | Methylnitronitrosoguanidine | [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TOP2A mRNA | 19840844 |
| D008770 | Methylnitrosourea | Methylnitrosourea results in increased expression of TOP2A mRNA | 25270620 |
| D015655 | 1-Methyl-4-phenylpyridinium | 1-Methyl-4-phenylpyridinium results in decreased expression of TOP2A mRNA | 24810058 |
| D015655 | 1-Methyl-4-phenylpyridinium | 1-Methyl-4-phenylpyridinium results in increased expression of TOP2A protein | 26558463 |
| C008493 | methylselenic acid | methylselenic acid affects the expression of TOP2A mRNA | 14617803 |
| D008777 | Methyltestosterone | Methyltestosterone results in decreased expression of TOP2A mRNA | 29191790 |
| D009151 | Mustard Gas | Mustard Gas results in decreased expression of TOP2A mRNA | 25102026 |
| D009151 | Mustard Gas | Mustard Gas affects the expression of TOP2A mRNA | 15651846 |
| C044361 | M-VAC protocol | TOP2A protein results in increased susceptibility to M-VAC protocol | 15814643 |
| D009183 | Mycotoxins | [Mycotoxins co-treated with Oxidants] results in decreased activity of TOP2A protein | 26894873 |
| D009183 | Mycotoxins | Mycotoxins results in decreased activity of TOP2A protein | 26894873 |
| C040015 | myricetin | myricetin results in decreased activity of TOP2A protein | 16536579 |
| C028473 | N-acetyl-4-benzoquinoneimine | N-acetyl-4-benzoquinoneimine results in decreased activity of TOP2A protein | 15035644 |
| D037742 | Nanotubes, Carbon | "Nanotubes, Carbon affects the expression of TOP2A mRNA" | 25554681 |
| D037742 | Nanotubes, Carbon | "Nanotubes, Carbon analog results in increased expression of TOP2A mRNA" | 25554681 |
| D015058 | 1-Naphthylisothiocyanate | 1-Naphthylisothiocyanate affects the expression of TOP2A protein | 26011634 |
| C028007 | nickel monoxide | nickel monoxide results in increased expression of TOP2A mRNA | 19167457 |
| C017557 | nickel subsulfide | nickel subsulfide results in increased expression of TOP2A mRNA | 24952340 |
| C558013 | NSC 689534 | [NSC 689534 binds to Copper] which results in decreased expression of TOP2A mRNA | 20971185 |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides | "Etoposide metabolite inhibits the reaction [TOP2A protein binds to Nucleic Acids, Nucleotides, and Nucleosides]" | 27533850 |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides | "TOP2A protein binds to and results in increased cleavage of Nucleic Acids, Nucleotides, and Nucleosides" | 27533850 |
| C025589 | ochratoxin A | ochratoxin A results in increased expression of TOP2A mRNA | 19237604 |
| C025589 | ochratoxin A | ochratoxin A results in increased expression of TOP2A protein | 19237604 |
| D019319 | Okadaic Acid | [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of TOP2A mRNA | 19840844 |
| D009828 | Oleanolic Acid | Oleanolic Acid analog results in decreased expression of TOP2A protein | 26612655 |
| D009828 | Oleanolic Acid | Oleanolic Acid results in decreased activity of TOP2A protein | 10860928 |
| D009942 | Organometallic Compounds | Organometallic Compounds results in decreased activity of TOP2A protein | 23829568 |
| C030110 | oxaliplatin | [oxaliplatin co-treated with Topotecan] results in decreased expression of TOP2A mRNA | 25729387 |
| C030110 | oxaliplatin | oxaliplatin results in decreased expression of TOP2A mRNA | 25729387 |
| C011030 | oxfendazole | oxfendazole results in decreased expression of TOP2A protein | 26558467 |
| D016877 | Oxidants | [Mycotoxins co-treated with Oxidants] results in decreased activity of TOP2A protein | 26894873 |
| D010100 | Oxygen | Oxygen deficiency results in increased expression of TOP2A mRNA | 26476374 |
| D010100 | Oxygen | Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of TOP2A mRNA] | 26476374 |
| D010126 | Ozone | [Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of TOP2A mRNA | 25658374 |
| D010126 | Ozone | Ozone results in increased expression of TOP2A mRNA | 12763052 |
| D010126 | Ozone | TTPA protein affects the reaction [Ozone results in increased expression of TOP2A mRNA] | 19555225 |
| D010126 | Ozone | [Ozone co-treated with Chlorine] results in decreased expression of TOP2A mRNA | 18636392 |
| D017239 | Paclitaxel | TOP2A mRNA results in increased susceptibility to Paclitaxel | 16322897 |
| D017239 | Paclitaxel | TOP2A results in decreased susceptibility to [Cisplatin co-treated with Paclitaxel] | 11325482 |
| C500026 | palbociclib | palbociclib analog results in decreased expression of TOP2A mRNA | 15542782 |
| C500026 | palbociclib | palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein] | 22751436 |
| C500026 | palbociclib | palbociclib results in decreased expression of TOP2A mRNA | 22869556 |
| C500026 | palbociclib | palbociclib results in decreased expression of TOP2A protein | 20948315|2275143 |
| C500026 | palbociclib | RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of TOP2A protein]] | 22751436 |
| D052638 | Particulate Matter | Particulate Matter results in increased expression of TOP2A mRNA | 24216475 |
| C410127 | PCB 180 | "[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TOP2A mRNA" | 25510870 |
| C023036 | perfluorooctanoic acid | perfluorooctanoic acid results in increased expression of TOP2A mRNA | 23427857 |
| C023036 | perfluorooctanoic acid | perfluorooctanoic acid results in decreased expression of TOP2A mRNA | 25868421 |
| D010634 | Phenobarbital | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TOP2A mRNA | 24535843 |
| D010634 | Phenobarbital | NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TOP2A mRNA] | 19482888 |
| D010634 | Phenobarbital | Phenobarbital results in increased expression of TOP2A mRNA | 19363144|1948288 |
| D010634 | Phenobarbital | Phenobarbital results in increased expression of TOP2A mRNA | 19162173 |
| D010662 | Phenylmercuric Acetate | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOP2A mRNA" | 27188386 |
| D010662 | Phenylmercuric Acetate | Phenylmercuric Acetate results in decreased expression of TOP2A mRNA | 26272509 |
| D016226 | Phosphorus, Dietary | "Phosphorus, Dietary affects the expression of TOP2A mRNA" | 17651324 |
| D048789 | Phytoestrogens | Phytoestrogens results in increased expression of TOP2A mRNA | 18310284 |
| D010882 | Piperonyl Butoxide | Piperonyl Butoxide results in increased expression of TOP2A mRNA | 15890375 |
| C006253 | pirinixic acid | pirinixic acid results in decreased expression of TOP2A mRNA | 17426115 |
| C006253 | pirinixic acid | pirinixic acid results in increased expression of TOP2A mRNA | 18301758 |
| C006253 | pirinixic acid | pirinixic acid results in increased expression of TOP2A mRNA | 12832660|1589037 |
| D010936 | Plant Extracts | Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of TOP2A mRNA] | 28070326 |
| D010936 | Plant Extracts | Plant Extracts results in decreased expression of TOP2A mRNA | 15465739 |
| D028321 | Plant Preparations | Plant Preparations affects the expression of TOP2A mRNA | 16046712|1625160 |
| D011078 | Polychlorinated Biphenyls | Polychlorinated Biphenyls analog results in increased expression of TOP2A mRNA | 16474171 |
| D011078 | Polychlorinated Biphenyls | Polychlorinated Biphenyls metabolite affects the activity of TOP2A protein | 16906772 |
| D059808 | Polyphenols | Polyphenols results in decreased expression of TOP2A mRNA | 15465739 |
| D011285 | Pregnenolone Carbonitrile | Pregnenolone Carbonitrile results in increased expression of TOP2A mRNA | 19162173 |
| C479580 | procyanidin B2 | procyanidin B2 results in decreased activity of TOP2A protein | 16536579 |
| D011374 | Progesterone | Progesterone results in decreased expression of TOP2A mRNA | 23012394|2301818 |
| D011374 | Progesterone | Progesterone results in decreased expression of TOP2A mRNA | 21795739 |
| D011374 | Progesterone | Progesterone results in increased expression of TOP2A mRNA | 18070364|2154024 |
| D011374 | Progesterone | Progesterone results in decreased expression of TOP2A mRNA | 20726854 |
| D011398 | Promethazine | Promethazine affects the expression of TOP2A protein | 26011634 |
| C045950 | propiconazole | propiconazole results in increased expression of TOP2A mRNA | 21278054 |
| C005556 | propionaldehyde | propionaldehyde results in decreased expression of TOP2A mRNA | 26079696 |
| D011429 | Propolis | [Butylhydroxybutylnitrosamine co-treated with Propolis analog] results in increased expression of TOP2A mRNA | 26111810 |
| D011441 | Propylthiouracil | Propylthiouracil results in increased expression of TOP2A mRNA | 24780913 |
| C509954 | pyrenophorol | pyrenophorol results in decreased activity of TOP2A protein | 27682608 |
| D011794 | Quercetin | Quercetin results in decreased expression of TOP2A mRNA | 21632981 |
| D011794 | Quercetin | Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of TOP2A mRNA] | 26476374 |
| C004532 | quinone | MYB protein promotes the reaction [quinone results in increased expression of TOP2A mRNA] | 18778717 |
| C004532 | quinone | quinone binds to and affects the activity of TOP2A protein | 15935817 |
| C004532 | quinone | quinone binds to and results in decreased activity of TOP2A protein | 22218491 |
| C004532 | quinone | quinone metabolite affects the activity of TOP2A protein | 16906772 |
| C004532 | quinone | quinone results in decreased activity of TOP2A protein | 11468185|2003448 |
| C004532 | quinone | quinone results in increased activity of TOP2A protein | 15833037 |
| C004532 | quinone | quinone results in increased expression of TOP2A mRNA | 18778717 |
| D020849 | Raloxifene Hydrochloride | Raloxifene Hydrochloride results in increased expression of TOP2A mRNA | 12154049 |
| D011929 | Razoxane | Razoxane binds to TOP2A protein | 17875725 |
| C052785 | rebamipide | rebamipide results in increased expression of TOP2A mRNA | 18299717 |
| C059514 | resveratrol | resveratrol results in decreased activity of TOP2A protein | 16536579 |
| C059514 | resveratrol | resveratrol results in decreased expression of TOP2A mRNA | 15767336|2313783 |
| C059514 | resveratrol | resveratrol results in decreased expression of TOP2A protein | 25505154 |
| C059514 | resveratrol | resveratrol results in increased expression of TOP2A mRNA | 19228061 |
| C059514 | resveratrol | [Dietary Fats co-treated with resveratrol] results in decreased expression of TOP2A mRNA | 21852083 |
| C064116 | S-(1,1,2,2-tetrafluoroethyl)cysteine | "S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of TOP2A mRNA" | 16678137 |
| D012524 | Sarin | Sarin results in decreased expression of TOP2A mRNA | 19522546 |
| D012715 | Sesame Oil | Sesame Oil results in increased expression of TOP2A mRNA | 29191790 |
| D012822 | Silicon Dioxide | Silicon Dioxide results in increased expression of TOP2A mRNA | 25351596 |
| C017947 | sodium arsenite | sodium arsenite results in decreased expression of TOP2A mRNA | 12760830 |
| C017947 | sodium arsenite | sodium arsenite results in increased expression of TOP2A mRNA | 12016162 |
| C016104 | sodium bichromate | sodium bichromate affects the expression of TOP2A mRNA | 11960910 |
| C016104 | sodium bichromate | sodium bichromate results in increased expression of TOP2A mRNA | 22561333 |
| D018038 | Sodium Selenite | Sodium Selenite results in decreased expression of TOP2A mRNA | 24383545 |
| D053260 | Soot | Soot results in increased expression of TOP2A mRNA | 26551751 |
| C075117 | squalestatin 1 | squalestatin 1 results in decreased expression of TOP2A mRNA | 27225895 |
| C075117 | squalestatin 1 | squalestatin 1 results in decreased expression of TOP2A mRNA | 27225895 |
| C060436 | stemphyltoxin III | stemphyltoxin III results in decreased activity of TOP2A protein | 27682608 |
| D004113 | Succimer | [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TOP2A mRNA | 26378955 |
| C063871 | sulfinosine | [sulfinosine co-treated with Curcumin] results in decreased expression of TOP2A mRNA | 18414057 |
| C063871 | sulfinosine | sulfinosine results in decreased expression of TOP2A mRNA | 18414057 |
| C061133 | tamibarotene | tamibarotene affects the expression of TOP2A mRNA | 15498508 |
| D013629 | Tamoxifen | Tamoxifen results in decreased expression of TOP2A protein | 10785588 |
| D013629 | Tamoxifen | Tamoxifen results in decreased expression of TOP2A mRNA | 19224547 |
| D013713 | Teniposide | TOP2A results in decreased susceptibility to [Cisplatin co-treated with Teniposide] | 11325482 |
| D013739 | Testosterone | [Testosterone co-treated with Calcitriol] results in decreased expression of TOP2A mRNA | 21592394 |
| D013739 | Testosterone | Testosterone results in decreased expression of TOP2A mRNA | 21592394 |
| D013739 | Testosterone | Testosterone results in increased expression of TOP2A mRNA | 19693291 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of TOP2A mRNA | 21802500 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of TOP2A mRNA | 21570461|2405805 |
| D013749 | Tetrachlorodibenzodioxin | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TOP2A mRNA | 17942748 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin promotes the reaction [NFE2L2 gene mutant form results in increased expression of TOP2A protein] | 21846477 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of TOP2A mRNA | 25975270 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of TOP2A mRNA | 15667827|2184647 |
| D013752 | Tetracycline | Tetracycline results in decreased expression of TOP2A protein | 23293027 |
| D013752 | Tetracycline | Tetracycline results in decreased expression of TOP2A mRNA | 19224547 |
| D013755 | Tetradecanoylphorbol Acetate | [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TOP2A mRNA | 19840844 |
| D013755 | Tetradecanoylphorbol Acetate | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TOP2A mRNA | 25613284 |
| D013792 | Thalidomide | [Azacitidine co-treated with Thalidomide] affects the expression of TOP2A mRNA | 18720364 |
| D019284 | Thapsigargin | Thapsigargin results in increased expression of TOP2A protein | 24648495 |
| D013849 | Thimerosal | Thimerosal results in decreased activity of TOP2A protein | 18197631 |
| D013853 | Thioacetamide | Thioacetamide results in increased expression of TOP2A mRNA | 22659510|2341159 |
| D013853 | Thioacetamide | Thioacetamide results in increased expression of TOP2A protein | 22659510|2601163 |
| D013882 | Thiosemicarbazones | Thiosemicarbazones analog inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate] | 26982206 |
| D013882 | Thiosemicarbazones | Thiosemicarbazones analog results in decreased activity of TOP2A protein | 26982206 |
| D013882 | Thiosemicarbazones | Thiosemicarbazones results in decreased activity of TOP2A protein | 23829568 |
| C003466 | thymoquinone | thymoquinone affects the activity of TOP2A protein | 24650156 |
| C009495 | titanium dioxide | [Vitallium analog binds to titanium dioxide] which results in decreased expression of TOP2A mRNA | 23825117 |
| C009495 | titanium dioxide | titanium dioxide affects the expression of TOP2A mRNA | 17656681 |
| C009495 | titanium dioxide | titanium dioxide results in increased expression of TOP2A mRNA | 23557971 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in decreased expression of TOP2A mRNA | 28065790 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution affects the expression of TOP2A mRNA | 20133372 |
| D019772 | Topotecan | Topotecan results in decreased expression of TOP2A mRNA | 16026610 |
| D019772 | Topotecan | [oxaliplatin co-treated with Topotecan] results in decreased expression of TOP2A mRNA | 25729387 |
| D019772 | Topotecan | Topotecan results in decreased expression of TOP2A mRNA | 25729387 |
| C496197 | trans-10,cis-12-conjugated linoleic acid | "trans-10,cis-12-conjugated linoleic acid results in decreased expression of TOP2A mRNA" | 17951470 |
| D014212 | Tretinoin | Tretinoin results in decreased expression of TOP2A mRNA | 15498508|1624948 |
| D014212 | Tretinoin | Tretinoin results in increased expression of TOP2A protein | 15059897 |
| C034613 | triacsin C | triacsin C results in decreased expression of TOP2A mRNA | 16704987 |
| C012589 | trichostatin A | trichostatin A results in decreased expression of TOP2A mRNA | 15901671 |
| C012589 | trichostatin A | trichostatin A results in decreased expression of TOP2A mRNA | 15901671 |
| C015559 | trimellitic anhydride | trimellitic anhydride results in increased expression of TOP2A mRNA | 19042947 |
| C016805 | tris(1,3-dichloro-2-propyl)phosphate | "tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TOP2A mRNA" | 26179874 |
| C057693 | troglitazone | troglitazone results in decreased expression of TOP2A mRNA | 19140230 |
| C080163 | trovafloxacin | trovafloxacin results in decreased activity of TOP2A protein | 24817034 |
| C005466 | ursolic acid | ursolic acid results in decreased activity of TOP2A protein | 10860928 |
| D014635 | Valproic Acid | Valproic Acid results in decreased expression of TOP2A mRNA | 15901671 |
| D014635 | Valproic Acid | Valproic Acid results in decreased expression of TOP2A mRNA | 20585447|2800136 |
| D014635 | Valproic Acid | Valproic Acid results in increased expression of TOP2A mRNA | 19224547 |
| D014635 | Valproic Acid | Valproic Acid results in decreased expression of TOP2A mRNA | 15901671 |
| D014638 | Vanadates | Vanadates results in decreased expression of TOP2A mRNA | 22714537 |
| D001335 | Vehicle Emissions | Vehicle Emissions results in increased expression of TOP2A mRNA | 24216475 |
| D014747 | Vinblastine | TOP2A protein affects the susceptibility to Vinblastine | 16217747 |
| D014750 | Vincristine | Vincristine results in decreased expression of TOP2A mRNA | 23649840 |
| D014752 | Vinyl Chloride | Vinyl Chloride metabolite results in increased activity of TOP2A protein | 15751973 |
| C029297 | vinylidene chloride | vinylidene chloride results in increased expression of TOP2A mRNA | 26682919 |
| D014800 | Vitallium | [Vitallium analog binds to titanium dioxide] which results in decreased expression of TOP2A mRNA | 23825117 |
| D014800 | Vitallium | Vitallium analog results in decreased expression of TOP2A mRNA | 23825117 |
| D024483 | Vitamin K 3 | Vitamin K 3 affects the expression of TOP2A mRNA | 20044591 |
| D055549 | Volatile Organic Compounds | Volatile Organic Compounds results in increased methylation of TOP2A promoter | 29217486 |
| C051122 | wedelolactone | Acetylcysteine inhibits the reaction [wedelolactone results in decreased activity of TOP2A protein] | 22733624 |
| C051122 | wedelolactone | Ascorbic Acid inhibits the reaction [wedelolactone results in decreased activity of TOP2A protein] | 22733624 |
| C051122 | wedelolactone | Glutathione inhibits the reaction [wedelolactone results in decreased activity of TOP2A protein] | 22733624 |
| C051122 | wedelolactone | wedelolactone binds to and results in decreased activity of TOP2A protein | 22733624 |
| C022186 | xanthatin | xanthatin results in decreased activity of TOP2A protein | 23313378 |
| C022186 | xanthatin | xanthatin results in decreased expression of TOP2A | 23824011 |
| C022186 | xanthatin | [xanthatin results in decreased expression of TOP2A] which results in increased expression of GADD45G mRNA | 23824011 |
| D015032 | Zinc | Zinc deficiency results in increased expression of TOP2A mRNA | 22171008 |
| C088658 | zoledronic acid | zoledronic acid results in decreased expression of TOP2A mRNA | 24714768 |