Gene: TOP2B

7155
TOPIIB|top2beta
DNA topoisomerase II beta
protein-coding
3p24.2
Ensembl:ENSG00000077097 MIM:126431 Vega:OTTHUMG00000155596 UniprotKB:Q02880
NG_052961.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.432e-1 (AD)  2.861e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM30A0.946
BTBD10.938
SERINC10.936
EIF2AK10.935
MATR30.933
PSIP10.931
STARD70.929
PEX190.929
PRKAR1A0.927
STX120.927

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.802
OR4F29-0.796
MTRNR2L6-0.29
MTRNR2L10-0.281
MTRNR2L9-0.275
MTRNR2L3-0.252
TTLL10-0.232
C8orf74-0.228
MTRNR2L2-0.225
MTRNR2L8-0.212

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00380DexrazoxaneSmall Molecule24584-09-6Approved|WithdrawnTarget
DB00694DaunorubicinSmall Molecule20830-81-3ApprovedTarget
DB00773EtoposideSmall Molecule33419-42-0ApprovedTarget
DB04395Phosphoaminophosphonic Acid-Adenylate EsterSmall MoleculeExperimentalTarget
DB05022AmonafideSmall Molecule69408-81-7InvestigationalTarget
DB05488Technetium Tc-99m ciprofloxacinSmall Molecule374107-43-4InvestigationalTarget
DB06042ZEN-012Small Molecule-InvestigationalTarget
DB06362BecatecarinSmall Molecule119673-08-4InvestigationalTarget
DB06421DeclopramideSmall Molecule891-60-1InvestigationalTarget
DB086513'-THIO-THYMIDINE-5'-PHOSPHATESmall MoleculeExperimentalTarget
DB00970DactinomycinSmall Molecule50-76-0Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in decreased expression of TOP2B mRNA"23826121
C02017516 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione"16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in decreased expression of TOP2B mRNA"20519331
C0326681-nitropyrene1-nitropyrene results in increased expression of TOP2B mRNA19041380
C0312853-xylene3-xylene results in decreased expression of TOP2B mRNA12815608
C0708994,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione"4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione results in increased degradation of and results in decreased expression of TOP2B protein"17875725
C0708994,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione"Bortezomib inhibits the reaction [4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione results in increased degradation of and results in decreased expression of TOP2B protein]"17875725
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of TOP2B mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOP2B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOP2B mRNA"27188386
D000079AcetaldehydeAcetaldehyde affects the expression of TOP2B mRNA22634333
D000082AcetaminophenAcetaminophen results in decreased expression of TOP2B mRNA22230336
C016601afimoxifeneafimoxifene results in decreased expression of TOP2B mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TOP2B mRNA19770486
D013196DihydrotestosteroneTOP2B protein promotes the reaction [Dihydrotestosterone results in increased expression of KLK2 mRNA]20601956
D013196DihydrotestosteroneTOP2B protein promotes the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]20601956
D013196DihydrotestosteroneTOP2B protein promotes the reaction [Dihydrotestosterone results in increased expression of SLC45A3 mRNA]20601956
D013196DihydrotestosteroneTOP2B protein promotes the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA]20601956
C005197alternariolalternariol metabolite results in decreased activity of TOP2B protein27422292
C005197alternariolalternariol results in decreased activity of TOP2B protein27422292
C018206alternariol monomethyl etheralternariol monomethyl ether metabolite results in decreased activity of TOP2B protein27422292
C018206alternariol monomethyl etheralternariol monomethyl ether results in decreased activity of TOP2B protein27422292
D006710HomocysteineHomocysteine results in decreased expression of TOP2B mRNA17326132
D000677AmsacrineTOP2B protein mutant form results in decreased susceptibility to Amsacrine15322234|1623960
D000677AmsacrineAmsacrine results in decreased activity of TOP2B protein16549872
D000728AndrogensAndrogens promotes the reaction [TOP2B protein results in increased mutagenesis of ERG gene]20601956
D000728AndrogensAndrogens promotes the reaction [TOP2B protein results in increased mutagenesis of TMPRSS2 gene]20601956
D001151ArsenicArsenic results in decreased expression of TOP2B mRNA21332098
D001151ArsenicArsenic results in decreased expression of TOP2B protein21332098
D001151ArsenicCurcumin inhibits the reaction [Arsenic results in decreased expression of TOP2B mRNA]21332098
D001151ArsenicCurcumin inhibits the reaction [Arsenic results in decreased expression of TOP2B protein]21332098
C006632arsenic trioxideTOP2B protein results in increased susceptibility to arsenic trioxide20707922
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TOP2B mRNA"26238291
D004958EstradiolEstradiol results in increased expression of TOP2B mRNA16514628
C006780bisphenol Abisphenol A results in decreased expression of TOP2B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TOP2B gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased phosphorylation of TOP2B protein22174045
D000069286Bortezomib"Bortezomib inhibits the reaction [4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione results in increased degradation of and results in decreased expression of TOP2B protein]"17875725
D000069286BortezomibBortezomib inhibits the reaction [Razoxane results in increased degradation of and results in decreased expression of TOP2B protein]17875725
D019328Buthionine SulfoximineButhionine Sulfoximine results in decreased expression of TOP2B mRNA15707499
C584509C646 compoundC646 compound results in decreased expression of TOP2B mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TOP2B mRNA24982889
D002220CarbamazepineCarbamazepine affects the expression of TOP2B mRNA22634333
D004390ChlorpyrifosChlorpyrifos results in decreased activity of TOP2B protein26198043
D004390ChlorpyrifosChlorpyrifos results in decreased expression of TOP2B mRNA20350560
C037886cryptotanshinonecryptotanshinone results in decreased expression of TOP2B mRNA28716507
D003474CurcuminCurcumin analog results in decreased expression of TOP2B mRNA26409325
D003474CurcuminCurcumin inhibits the reaction [Arsenic results in decreased expression of TOP2B mRNA]21332098
D003474CurcuminCurcumin inhibits the reaction [Arsenic results in decreased expression of TOP2B protein]21332098
D003687DehydroepiandrosteroneDehydroepiandrosterone results in decreased expression of TOP2B mRNA16940010
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of TOP2B protein23811945
D064730DexrazoxaneDexrazoxane analog results in decreased expression of TOP2B protein28941780
D064730DexrazoxaneDexrazoxane results in decreased expression of TOP2B protein28941780
D002945CisplatinCisplatin results in increased phosphorylation of TOP2B protein22006019
C000944dicrotophosdicrotophos results in decreased expression of TOP2B mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of TOP2B mRNA26924002
C024629dimethyl phthalatedimethyl phthalate results in increased expression of TOP2B mRNA26924002
D004221DisulfiramDisulfiram results in decreased expression of TOP2B mRNA20530235
D004317DoxorubicinTOP2B affects the susceptibility to Doxorubicin16957942
D004317DoxorubicinTOP2B protein mutant form results in decreased susceptibility to Doxorubicin16239602
D004317DoxorubicinTOP2B protein results in decreased susceptibility to Doxorubicin17523305
D004317DoxorubicinTOP2B protein affects the reaction [Doxorubicin results in increased expression of H2AFX protein]17875725
D004317DoxorubicinTOP2B protein affects the susceptibility to Doxorubicin17875725
C034192ellipticineTOP2B protein mutant form results in decreased susceptibility to ellipticine16239602
C034192ellipticineTOP2B protein mutant form results in increased susceptibility to ellipticine15322234
C070609EMD 53998EMD 53998 analog results in decreased expression of TOP2B mRNA24977338
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TOP2B protein23301498
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of TOP2B mRNA18851785
D005047EtoposideEtoposide results in decreased activity of TOP2B protein26198043|2742229
D005047EtoposideTOP2B protein mutant form results in decreased susceptibility to Etoposide16239602
D005047EtoposideTOP2B protein mutant form results in increased susceptibility to Etoposide15322234
D005047EtoposideEtoposide results in decreased expression of TOP2B protein10856430
D005047EtoposideTOP2B protein affects the reaction [Etoposide results in increased expression of H2AFX protein]17875725
D005047EtoposideTOP2B protein affects the susceptibility to Etoposide17875725
C534191F14512F14512 binds to and affects the activity of TOP2B protein21413765
C061365flusilazoleflusilazole affects the expression of TOP2B mRNA22634333
C070081fulvestrantfulvestrant results in decreased expression of TOP2B mRNA16514628
D019833GenisteinESR2 promotes the reaction [Genistein results in decreased expression of TOP2B protein]20884965
D019833GenisteinGenistein results in decreased expression of TOP2B protein20884965
D005897GlafenineGlafenine results in decreased expression of TOP2B mRNA24136188
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TOP2B mRNA25613284
C544151jinfukangjinfukang results in decreased expression of TOP2B mRNA27392435
D048628KetolidesKetolides analog results in increased expression of TOP2B mRNA24967691
D007854LeadLead affects the expression of TOP2B mRNA28903495
D008610MentholMenthol results in decreased activity of TOP2B protein16158947
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TOP2B mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TOP2B mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TOP2B mRNA"26251327
C517284monomethyl phthalatemonomethyl phthalate results in increased expression of TOP2B mRNA26924002
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TOP2B mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of TOP2B mRNA26476374
D010100OxygenQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of TOP2B mRNA]26476374
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of TOP2B protein26178269
D010936Plant ExtractsPlant Extracts results in increased expression of TOP2B mRNA23557933
D011794QuercetinQuercetin results in decreased expression of TOP2B mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of TOP2B mRNA]26476374
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of TOP2B mRNA16514628
D011929RazoxaneRazoxane binds to TOP2B protein17875725
D011929RazoxaneBortezomib inhibits the reaction [Razoxane results in increased degradation of and results in decreased expression of TOP2B protein]17875725
D011929RazoxaneRazoxane results in increased degradation of and results in decreased expression of TOP2B protein17875725
C059514resveratrolresveratrol results in decreased expression of TOP2B protein25505154
C016104sodium bichromatesodium bichromate affects the expression of TOP2B mRNA11960910
C061133tamibarotenetamibarotene affects the expression of TOP2B mRNA15498508
D013662TeaTea results in increased expression of TOP2B mRNA22181980
D013662TeaTea results in increased expression of TOP2B protein22181980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TOP2B mRNA24058054|2468072
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of TOP2B mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TOP2B mRNA25613284
D013893ThiramThiram results in decreased expression of TOP2B mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TOP2B mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TOP2B mRNA25729387
D014212TretinoinTretinoin results in decreased expression of TOP2B mRNA15498508
D014212TretinoinTretinoin results in decreased expression of TOP2B mRNA24977338
D014415TunicamycinTunicamycin results in increased expression of TOP2B mRNA17127020
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOP2B mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TOP2B mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TOP2B mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in decreased methylation of TOP2B gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TOP2B gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TOP2B gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of TOP2B mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003682chromatin binding-IDA9049244  
GO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activity-IDA10684600  
GO:0005080protein kinase C binding-IPI16611985  
GO:0005524ATP binding-IEA-  
GO:0008022protein C-terminus binding-IPI10666337  
GO:0019899enzyme binding-IPI17567603  
GO:0042826histone deacetylase binding-IPI11062478  11136718  
GO:0046872metal ion binding-IEA-  
GO:0046982protein heterodimerization activity-IPI10473615  
GO ID GO Term Qualifier Evidence PubMed
GO:0000712resolution of meiotic recombination intermediates-IBA21873635  
GO:0000819sister chromatid segregation-IBA21873635  
GO:0001764neuron migration-IEA-  
GO:0006265DNA topological change-IDA10684600  
GO:0007409axonogenesis-IEA-  
GO:0030900forebrain development-IEA-  
GO:0044774mitotic DNA integrity checkpoint-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000792heterochromatincolocalizes_withIDA9049244  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA9049244  17567603  
GO:0005654nucleoplasm-IDA9049244  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolusNOTIDA9049244  
GO:0005829cytosol-IDA9049244  
GO:1990904ribonucleoprotein complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2990846SUMOylationTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4615885SUMOylation of DNA replication proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28355294Mining expression and prognosis of topoisomerase isoforms in non-small-cell lung cancer by using Oncomine and Kaplan-Meier plotter. (2017)Hou GXPLoS One