Gene: TOP3A

7156
TOP3|ZGRF7
DNA topoisomerase III alpha
protein-coding
17p11.2
Ensembl:ENSG00000177302 MIM:601243 Vega:OTTHUMG00000059391 UniprotKB:Q13472
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.826e-1 (AD)  5.370e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HMGXB30.931
SUGP20.93
QRICH10.927
MBD10.925
GBF10.923
SART30.922
NAT100.922
LRRC410.919
DDX510.917
SIN3B0.916

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.549
OR4F29-0.51
MTRNR2L6-0.388
MTRNR2L9-0.385
MTRNR2L10-0.379
TRDN-0.336
KLRC2-0.334
SH2D1A-0.323
OR4F16-0.316
KLRB1-0.315

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TOP3A mRNA"18648102
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of TOP3A mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TOP3A mRNA24449571
D001280AtrazineAtrazine results in decreased expression of TOP3A mRNA22378314
C044887beta-methylcholinebeta-methylcholine affects the expression of TOP3A mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TOP3A mRNA28628672
C006780bisphenol Abisphenol A affects the expression of TOP3A mRNA21786754
C006780bisphenol Abisphenol A affects the expression of TOP3A mRNA21786754
C006780bisphenol Abisphenol A affects the expression of TOP3A mRNA25181051
C584509C646 compoundC646 compound results in increased expression of TOP3A mRNA26191083
D003078ColchicineColchicine results in decreased expression of TOP3A mRNA24211769
D003300CopperCopper results in decreased expression of TOP3A mRNA22641096
D016572CyclosporineCyclosporine results in increased methylation of TOP3A promoter27989131
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TOP3A mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TOP3A mRNA28628672
D002945CisplatinCisplatin results in decreased expression of TOP3A mRNA24211769
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of TOP3A mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of TOP3A mRNA26924002
D005047EtoposideEtoposide results in decreased expression of TOP3A mRNA24211769
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TOP3A mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TOP3A mRNA28628672
D007854LeadLead affects the expression of TOP3A mRNA22313790
D007854LeadLead results in decreased expression of TOP3A mRNA22641096
D018021Lithium ChlorideLithium Chloride results in decreased expression of TOP3A mRNA23527032
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TOP3A mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TOP3A mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased methylation of TOP3A promoter"26251327
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of TOP3A protein24625837
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TOP3A mRNA26924002
D009532NickelNickel results in decreased expression of TOP3A mRNA23195993
D010126OzoneOzone results in increased expression of TOP3A mRNA28652203
D052638Particulate MatterParticulate Matter results in increased expression of TOP3A mRNA24769257
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TOP3A mRNA21570461
C483909torcetrapibtorcetrapib results in increased expression of TOP3A mRNA23228038
D014635Valproic AcidValproic Acid affects the expression of TOP3A mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TOP3A gene25560391
D000225AdenineAdenine results in decreased expression of TOP3A mRNA24211769

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003916DNA topoisomerase activity-IBA21873635  
GO:0003917DNA topoisomerase type I activity-IDA20445207  
GO:0005515protein binding-IPI10728666  15775963  16537486  20360068  20711169  20826342  
23509288  24509834  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006260DNA replication-TAS-  
GO:0006265DNA topological change-IBA21873635  
GO:0006265DNA topological change-IDA20445207  
GO:0051321meiotic cell cycle-TAS8622991  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-TAS8622991  
GO:0005654nucleoplasm-TAS-  
GO:0005694chromosome-IEA-  
GO:0016605PML body-IDA10728666  
KEGG ID KEGG Term
hsa03440Homologous recombination
Reactome ID Reactome Term Evidence
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5685938HDR through Single Strand Annealing (SSA)TAS
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693537Resolution of D-Loop StructuresTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)TAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693568Resolution of D-loop Structures through Holliday Junction IntermediatesTAS
R-HSA-5693579Homologous DNA Pairing and Strand ExchangeTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchangeTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-912446Meiotic recombinationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28355294Mining expression and prognosis of topoisomerase isoforms in non-small-cell lung cancer by using Oncomine and Kaplan-Meier plotter. (2017)Hou GXPLoS One