Gene: TP53BP1

7158
53BP1|TDRD30|TP53|p202|p53BP1
tumor protein p53 binding protein 1
protein-coding
15q15.3
Ensembl:ENSG00000067369 MIM:605230 Vega:OTTHUMG00000059757 UniprotKB:Q12888
NC_000015.10
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.110e-1 (AD)  7.743e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNPO30.958
TUBGCP40.947
KPNA60.947
TCF200.947
RALGAPB0.942
KLHL180.94
RNF1110.938
KIAA01000.934
SBNO10.933
FITM20.932

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.502
OR4F29-0.459
COPZ2-0.398
HEY2-0.39
MYL3-0.38
ASB4-0.377
CTNNA3-0.354
CSAG1-0.351
APOM-0.347
IL18RAP-0.34

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TP53BP1 protein26231820
D000393Air PollutantsAir Pollutants results in increased expression of TP53BP1 protein28389379
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of TP53BP1 mRNA"17331233
D001280AtrazineAtrazine results in increased expression of TP53BP1 mRNA22378314
C006780bisphenol Abisphenol A results in increased expression of TP53BP1 mRNA29027980
C006780bisphenol Abisphenol A results in increased expression of TP53BP1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of TP53BP1 protein29275510
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TP53BP1 mRNA28628672
D000069286BortezomibTP53BP1 protein affects the reaction [[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased cleavage of PARP1 protein]25522274
D000069286BortezomibTP53BP1 protein affects the reaction [[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased phosphorylation of RB1 protein]25522274
D020126Brefeldin ABrefeldin A results in increased expression of TP53BP1 protein27358234
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of TP53BP1 mRNA27509014
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased methylation of TP53BP1 gene27509014
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of TP53BP1 mRNA27793765
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of TP53BP1 mRNA21878529
C029892cupric chloridecupric chloride results in decreased expression of TP53BP1 mRNA24650576
D016572CyclosporineCyclosporine results in increased expression of TP53BP1 mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TP53BP1 mRNA28628672
D002945CisplatinCisplatin results in increased expression of TP53BP1 protein24743697
D002945CisplatinCisplatin results in increased expression of TP53BP1 protein27358234
C070609EMD 53998EMD 53998 analog results in decreased expression of TP53BP1 mRNA24977338
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TP53BP1 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TP53BP1 mRNA22079256
D005047EtoposideEtoposide results in increased expression of TP53BP1 protein26259609|2735823
D005047Etoposidepifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of TP53BP1 protein]26259609
C001277geldanamycingeldanamycin results in increased expression of TP53BP1 mRNA26705709
C056507gemcitabinegemcitabine results in increased expression of TP53BP1 mRNA17039268
D017313FenretinideFenretinide results in increased expression of TP53BP1 mRNA16570282
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TP53BP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TP53BP1 mRNA28628672
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of TP53BP1 mRNA27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TP53BP1 mRNA28001369
D009151Mustard GasMustard Gas results in increased phosphorylation of TP53BP1 protein19845377
C030110oxaliplatinMSH3 protein promotes the reaction [oxaliplatin results in increased expression of TP53BP1 protein]21285347
C030110oxaliplatinoxaliplatin results in increased expression of TP53BP1 protein21285347
C121565pifithrinpifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of TP53BP1 protein]26259609
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TP53BP1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TP53BP1 mRNA22079256
C004765propylene dichloridepropylene dichloride affects the localization of TP53BP1 protein28300663
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TP53BP1 mRNA16714409
D013849ThimerosalThimerosal results in decreased expression of TP53BP1 mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of TP53BP1 mRNA23411599
C483909torcetrapibtorcetrapib results in increased expression of TP53BP1 mRNA23228038
D014212TretinoinTretinoin results in decreased expression of TP53BP1 mRNA24977338
C012589trichostatin Atrichostatin A results in decreased expression of TP53BP1 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of TP53BP1 mRNA24935251
C111237vorinostatvorinostat results in decreased expression of TP53BP1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001102RNA polymerase II activating transcription factor binding-IPI17805299  
GO:0002039p53 binding-IPI14985081  17805299  
GO:0003684damaged DNA binding-IEA-  
GO:0003712transcription coregulator activity-IMP17805299  
GO:0005515protein binding-IPI11877378  12607005  14576432  15456759  16415788  16901786  
17024177  17380123  17500065  17805299  17925232  18001824  
18001825  19124460  19433796  20075863  20126263  20347427  
21317870  22373579  22621922  22653443  23333306  23377543  
25416956  25837623  28241136  
GO:0035064methylated histone binding-IDA22373579  23760478  28241136  
GO:0042162telomeric DNA binding-IEA-  
GO:0042393histone binding-IBA21873635  
GO:0061649ubiquitin modification-dependent histone binding-IDA23760478  
GO ID GO Term Qualifier Evidence PubMed
GO:0000077DNA damage checkpoint-IBA21873635  
GO:0006303double-strand break repair via nonhomologous end joining-IDA23333306  23760478  28241136  
GO:0006303double-strand break repair via nonhomologous end joining-TAS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006974cellular response to DNA damage stimulus-IDA17500065  28241136  
GO:0045830positive regulation of isotype switching-IDA23345425  
GO:0045830positive regulation of isotype switching-IMP23760478  
GO:0045893positive regulation of transcription, DNA-templated-NAS9748285  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP17805299  
GO:0051091positive regulation of DNA-binding transcription factor activity-IC17805299  
GO:0051260protein homooligomerization-IDA23345425  
GO:0071481cellular response to X-ray-IEA-  
GO:2000042negative regulation of double-strand break repair via homologous recombination-IDA23333306  23345425  
GO ID GO Term Qualifier Evidence PubMed
GO:0000777condensed chromosome kinetochore-IEA-  
GO:0000781chromosome, telomeric regioncolocalizes_withIDA15149599  
GO:0000784nuclear chromosome, telomeric region-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA28241136  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005657replication fork-IEA-  
GO:0005737cytoplasm-IDA9748285  
GO:0016604nuclear body-IDA-  
GO:0035861site of double-strand break-IDA23333306  23760478  28241136  
GO:1990391DNA repair complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-2990846SUMOylationTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-3232118SUMOylation of transcription factorsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693571Nonhomologous End-Joining (NHEJ)TAS
R-HSA-5693606DNA Double Strand Break ResponseTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20106900International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants. (2010 Apr)Truong TCarcinogenesis
20372852Cigarette smoking, TP53 Arg72Pro, TP53BP1 Asp353Glu and the risk of lung cancer in a Japanese population. (2010 May)Kiyohara COncol Rep
21212151Interactions between genetic polymorphisms in the apoptotic pathway and environmental factors on esophageal adenocarcinoma risk. (2011 Apr)Wu ICCarcinogenesis
21368091Comprehensive pathway-based association study of DNA repair gene variants and the risk of nasopharyngeal carcinoma. (2011 Apr 15)Qin HDCancer Res