Gene: C1S

716
EDSPD2
complement C1s
protein-coding
12p13.31
Ensembl:ENSG00000182326 MIM:120580 Vega:OTTHUMG00000150305 UniprotKB:P09871
NG_011694.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.886e-1 (AD)  8.693e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1R0.933
SERPING10.861
IL18BP0.839
OSMR0.837
STAT30.833
LIMK20.828
MYD880.823
IL1R10.817
PARP90.816
ANO60.816

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPLX3-0.436
CRH-0.424
KCNIP3-0.379
CYP1A1-0.372
WNT7A-0.37
KIT-0.366
ATP2C2-0.356
ADRA1D-0.353
ACY3-0.348
MARCH4-0.344

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00002CetuximabBiotechDrug205923-56-4ApprovedTarget
DB00005EtanerceptBiotechDrug185243-69-0Approved|InvestigationalTarget
DB00051AdalimumabBiotechDrug331731-18-1ApprovedTarget
DB00054AbciximabBiotechDrug143653-53-6ApprovedTarget
DB00056Gemtuzumab ozogamicinBiotechDrug220578-59-6Approved|InvestigationalTarget
DB00072TrastuzumabBiotechDrug180288-69-1Approved|InvestigationalTarget
DB00073RituximabBiotechDrug174722-31-7ApprovedTarget
DB00074BasiliximabBiotechDrug179045-86-4Approved|InvestigationalTarget
DB00075MuromonabBiotechDrug140608-64-6Approved|InvestigationalTarget
DB00078Ibritumomab tiuxetanBiotechDrug206181-63-7Approved|InvestigationalTarget
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB023712-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic AcidSmall Molecule7365-44-8ExperimentalTarget
DB06404Human C1-esterase inhibitorBiotechDrugApprovedTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
DB09228Conestat alfaBiotechDrug80295-38-1Approved|InvestigationalTarget
DB12831GabexateSmall Molecule39492-01-8InvestigationalEnzyme
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of C1S mRNA"19162173
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of C1S mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of C1S mRNA"19114083
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of C1S mRNA"20713471
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of C1S mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of C1S mRNA"21346803
C0054642-aminothiophenol2-aminothiophenol inhibits the reaction [C4A protein binds to C1S protein]8435078
C0054642-aminothiophenol2-aminothiophenol inhibits the reaction [C4B protein binds to C1S protein]8435078
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of C1S mRNA"23196670
C5575053',4'-dimethoxy-alpha-naphthoflavone"3',4'-dimethoxy-alpha-naphthoflavone inhibits the reaction [IL1B protein results in increased expression of C1S mRNA]"21127131
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C1S mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C1S mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C1S mRNA"27188386
C0194984-nitroanilineC1S protein results in increased hydrolysis of 4-nitroaniline analog3495295
C0293704-toluidine4-toluidine results in decreased expression of C1S mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C1S mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C1S mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C1S mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of C1S mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of C1S protein20106945
D000393Air PollutantsAir Pollutants analog results in decreased expression of C1S mRNA21757418
D000447AldehydesAldehydes results in decreased expression of C1S mRNA25014914
D000638AmiodaroneAmiodarone affects the expression of C1S mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of C1S mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of C1S mRNA24449571
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of C1S mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of C1S mRNA23912714
D001151ArsenicArsenic affects the methylation of C1S gene25304211
D001151ArsenicArsenic results in increased expression of C1S mRNA18315880
C547126AZM551248AZM551248 results in increased expression of C1S mRNA22323515
D001553BenzbromaroneBenzbromarone affects the expression of C1S mRNA19483382
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of C1S mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of C1S mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of C1S mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of C1S mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of C1S mRNA22228805|2373587
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of C1S mRNA19619570
D004958EstradiolEstradiol results in increased expression of C1S mRNA19619570
C006780bisphenol Abisphenol A results in increased expression of C1S mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of C1S mRNA28628672
C006780bisphenol Abisphenol A affects the expression of C1S mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of C1S gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of C1S mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of C1S mRNA26079696
D002104CadmiumC1S protein binds to Cadmium23896426
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1S mRNA]"20230807
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of C1S mRNA17484886
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C1S mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of C1S mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of C1S mRNA20938992
C418118CI 1044CI 1044 results in increased expression of C1S mRNA17569694
D002994ClofibrateClofibrate affects the expression of C1S mRNA16081524
D002994ClofibrateClofibrate results in decreased expression of C1S mRNA23811191
D002994ClofibrateClofibrate affects the expression of C1S mRNA19483382
C018021cobaltous chloridecobaltous chloride results in increased expression of C1S mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of C1S mRNA24386269
D003300CopperC1S protein binds to Copper23896426
D003300Copper[Disulfiram binds to Copper] which results in increased expression of C1S mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of C1S mRNA20971185
D003300CopperCopper results in decreased expression of C1S mRNA22465980
D019327Copper SulfateCopper Sulfate results in increased expression of C1S mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of C1S mRNA22077320
D016572CyclosporineCyclosporine results in decreased expression of C1S mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of C1S mRNA19770486
D000069439DasatinibDasatinib results in increased expression of C1S mRNA20579391
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of C1S mRNA]21095227
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of C1S mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of C1S mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of C1S mRNA27392435
D002945CisplatinCisplatin results in increased expression of C1S mRNA27392435
D004026DieldrinDieldrin results in increased expression of C1S mRNA20438755
D004041Dietary FatsDietary Fats results in decreased expression of C1S mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of C1S mRNA28412506
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of C1S mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of C1S mRNA]19850644
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of C1S mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of C1S mRNA21658437
D002117CalcitriolCalcitriol results in decreased expression of C1S mRNA26485663
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of C1S mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of C1S mRNA"21785161
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of C1S mRNA24690739
D004237DiuronDiuron results in decreased expression of C1S mRNA25152437
C007630estradiol 17 beta-cypionateestradiol 17 beta-cypionate results in increased expression of C1S mRNA22497863
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of C1S mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of C1S mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of C1S mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of C1S mRNA17108234
D005001EthionineEthionine affects the expression of C1S mRNA19483382
D005459FluoridesFluorides results in increased expression of C1S protein25556215
D005485FlutamideFlutamide results in decreased expression of C1S mRNA24136188|2479361
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of C1S mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of C1S mRNA23649840|2893796
C039281furanfuran results in decreased expression of C1S mRNA25539665
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of C1S gene28505145
D005839GentamicinsGentamicins results in increased expression of C1S mRNA21081137
D005947GlucoseGlucose deficiency affects the secretion of C1S protein24802182
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of C1S mRNA15159207
D017313FenretinideFenretinide results in decreased expression of C1S mRNA28973697
C082770IMM 125IMM 125 results in increased expression of C1S mRNA21081137
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of C1S mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of C1S mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of C1S mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of C1S mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of C1S mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of C1S mRNA27392435
C544151jinfukangjinfukang results in increased expression of C1S mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of C1S protein17337753
D007854LeadLead affects the expression of C1S mRNA28903495
C042720mercuric bromidemercuric bromide results in increased expression of C1S mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C1S mRNA"27188386
D008713MethimazoleMethimazole results in increased expression of C1S mRNA22504374
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of C1S mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of C1S mRNA28001369
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of C1S mRNA15120970
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1S mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1S mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1S mRNA]"20230807
C523799MRK 003MRK 003 results in decreased expression of C1S mRNA21169257
C523799MRK 003C1S results in decreased susceptibility to MRK 00319903844
C500085muraglitazarmuraglitazar results in decreased expression of C1S mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of C1S mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of C1S mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of C1S mRNA24136188
D009532NickelC1S protein binds to Nickel23896426
D009532NickelNickel results in increased expression of C1S mRNA25583101
C022838nickel chloridenickel chloride affects the expression of C1S mRNA22110744
C029938nickel sulfatenickel sulfate results in increased expression of C1S mRNA22714537
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1S mRNA]"20230807
C012655nimesulidenimesulide results in decreased expression of C1S mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of C1S mRNA20971185
C024713n-tetradecanen-tetradecane results in decreased expression of C1S protein17337753
D009853OmeprazoleOmeprazole affects the expression of C1S mRNA19483382
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of C1S mRNA25729387
D017239PaclitaxelPaclitaxel results in increased expression of C1S mRNA18754875
D000073878Palm OilPalm Oil results in decreased expression of C1S mRNA18042831
D010396PenicillaminePenicillamine inhibits the reaction [C4A protein binds to C1S protein]8435078
D010396PenicillaminePenicillamine inhibits the reaction [C4B protein binds to C1S protein]8435078
C046012pentanalpentanal results in decreased expression of C1S mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of C1S mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of C1S mRNA20936131
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of C1S mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of C1S mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of C1S mRNA18467677|2093613
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of C1S mRNA]18467677
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of C1S mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C1S mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of C1S mRNA26272509
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of C1S mRNA22484513
C006253pirinixic acidpirinixic acid results in decreased expression of C1S mRNA17426115|1795077
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of C1S mRNA]17950772|1846767
C006253pirinixic acidpirinixic acid affects the expression of C1S mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of C1S mRNA12832660|1916217
C005556propionaldehydepropionaldehyde results in decreased expression of C1S mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of C1S mRNA19483382
D011441PropylthiouracilPropylthiouracil results in increased expression of C1S mRNA22504374|2478091
D011748PyrogallolPyrogallol results in increased expression of C1S mRNA20362636
D011794QuercetinQuercetin results in increased expression of C1S mRNA21565894
C059514resveratrolresveratrol results in decreased expression of C1S mRNA23419489
D015474IsotretinoinIsotretinoin results in increased expression of C1S mRNA20436886
C089730rosiglitazonerosiglitazone results in decreased expression of C1S mRNA21515302
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of C1S mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of C1S mRNA23806026
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of C1S mRNA]21095227
C017947sodium arsenitesodium arsenite results in increased expression of and affects the splicing of C1S mRNA25879800
C017947sodium arsenitesodium arsenite results in increased expression of C1S mRNA22714537|2587980
D013629TamoxifenTamoxifen affects the expression of C1S mRNA17555576
C501413tesaglitazartesaglitazar results in decreased expression of C1S mRNA21515302
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of C1S mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of C1S mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of C1S mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of C1S mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of C1S mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of C1S mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of C1S mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of C1S mRNA11752688|1605489
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of C1S mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of C1S mRNA19483382
C009495titanium dioxidetitanium dioxide results in increased expression of C1S mRNA21259345
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of C1S mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of C1S mRNA25729387
D014212TretinoinTretinoin results in increased expression of C1S mRNA23830798
C057693troglitazonetroglitazone results in increased expression of C1S mRNA28973697
C057693troglitazonetroglitazone results in decreased expression of C1S mRNA21515302
C022884undecaneundecane results in increased expression of C1S protein17337753
D014635Valproic AcidValproic Acid affects the expression of C1S mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of C1S mRNA23179753|2915479
D014640VancomycinVancomycin results in decreased expression of C1S mRNA18930951
D014810Vitamin EVitamin E results in increased expression of C1S mRNA19244175
D015032ZincC1S protein binds to Zinc23896426
C088658zoledronic acidzoledronic acid results in increased expression of C1S mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IBA21873635  
GO:0004252serine-type endopeptidase activity-IDA11527969  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI2387866  12788922  17996945  25910212  
GO:0042802identical protein binding-IPI2387866  12788922  
GO ID GO Term Qualifier Evidence PubMed
GO:0001867complement activation, lectin pathway-IBA21873635  
GO:0006508proteolysis-IEA-  
GO:0006956complement activation-TAS-  
GO:0006958complement activation, classical pathway-TAS-  
GO:0030449regulation of complement activation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
hsa05150Staphylococcus aureus infection
hsa05322Systemic lupus erythematosus
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-166663Initial triggering of complementTAS
R-HSA-166786Creation of C4 and C2 activatorsTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-173623Classical antibody-mediated complement activationTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
9508360Genotoxicological monitoring of 175 subjects living in the green belts, inner town or near chemical industrial estates in Greater Budapest agglomeration, Hungary. (1998 Jan 13)Major JMutat Res