Gene: TP73

7161
P73
tumor protein p73
protein-coding
1p36.32
Ensembl:ENSG00000078900 MIM:601990 Vega:OTTHUMG00000000610 UniprotKB:O15350
NG_017035.2
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.572e-1 (AD)  3.679e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26055950chr1:3600852TP735.700e-13Smoking27651444
cg26105278chr1:3624054TP733.400e-12Smoking27651444
cg27055894chr1:3590920TP735.000e-11Smoking27651444
cg17471939chr1:3600879TP731.100e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EFS0.638
COL9A20.625
SNX220.625
OLIG20.623
TPPP30.616
NKX2-20.602
GAL3ST10.602
MUTYH0.598
SMIM50.596
PSTPIP10.595

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNTN5-0.436
HS6ST3-0.432
PIP5K1B-0.426
CDH7-0.426
GPR26-0.419
PLS1-0.418
HTR3B-0.416
KCNH5-0.414
ANKRD34C-0.411
LANCL3-0.409

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C50489712-(3-adamantan-1-ylureido)dodecanoic acid12-(3-adamantan-1-ylureido)dodecanoic acid affects the expression of TP73 mRNA19435785
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased expression of TP73 mRNA15031205
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased phosphorylation of and results in increased activity of TP73 protein15031205
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one[arsenic trioxide co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] promotes the reaction [TP73 protein binds to TP53AIP1 promoter]15031205
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one[arsenic trioxide co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in increased activity of TP73 protein15031205
C4512192,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one"2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one inhibits the reaction [TP53 protein mutant form binds to TP73 protein]"21647879
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide affects the expression of TP73 protein alternative form"16467208
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [arsenic trioxide results in increased expression of TP73 protein alternative form]"16467208
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide results in increased expression of TP73 mRNA"15031205
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide results in increased phosphorylation of and results in increased activity of TP73 protein"15031205
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"[arsenic trioxide co-treated with 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide] promotes the reaction [TP73 protein binds to TP53AIP1 promoter]"15031205
C5290612-(4,5-dihydro-1,3-thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanone"2-(4,5-dihydro-1,3-thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanone inhibits the reaction [TP53 protein mutant form binds to TP73 protein]"18424558
C5290612-(4,5-dihydro-1,3-thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanone"TP53 protein mutant form affects the reaction [2-(4,5-dihydro-1,3-thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanone results in increased expression of TP73 mRNA]"18424558
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in decreased expression of BCL2 mRNA"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in decreased expression of BCL2 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of BAX mRNA"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of BAX protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of FAS mRNA"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of FAS protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of PMAIP1 mRNA"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B mRNA"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in decreased expression of BCL2 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of BAX protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of FAS protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in decreased expression of BCL2 mRNA"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in decreased expression of BCL2 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of BAX mRNA"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of BAX protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of FAS mRNA"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of FAS protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of PMAIP1 mRNA"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B mRNA"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in decreased expression of BCL2 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of BAX protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of FAS protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in decreased expression of BCL2 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of BAX protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of FAS protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of PMAIP1 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of TNFRSF10B protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in decreased expression of BCL2 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of BAX protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of FAS protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of PMAIP1 protein"21214929
C4882882,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of TNFRSF10B protein"21214929
C0067574-biphenylamine4-biphenylamine results in decreased expression of TP73 mRNA24857880
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of TP73 protein15607904
D000249Adenosine MonophosphateTP73 protein affects the abundance of Adenosine Monophosphate25554796
D016604Aflatoxin B1[Zearalenone co-treated with Aflatoxin B1] results in increased expression of TP73 mRNA28965971
D000393Air PollutantsAir Pollutants results in decreased expression of TP73 mRNA23649983
D047310ApigeninApigenin results in increased expression of TP73 protein19397994
D001151ArsenicArsenic affects the methylation of TP73 gene25304211
C006632arsenic trioxide"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [arsenic trioxide results in increased expression of TP73 protein alternative form]"16467208
C006632arsenic trioxide[arsenic trioxide co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] promotes the reaction [TP73 protein binds to TP53AIP1 promoter]15031205
C006632arsenic trioxide[arsenic trioxide co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in increased activity of TP73 protein15031205
C006632arsenic trioxide"[arsenic trioxide co-treated with 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide] promotes the reaction [TP73 protein binds to TP53AIP1 promoter]"15031205
C006632arsenic trioxidearsenic trioxide promotes the reaction [EP300 protein binds to and results in increased acetylation of TP73 protein]15031205
C006632arsenic trioxidearsenic trioxide results in increased expression of TP73 mRNA19763917|2045855
D001194AsbestosAsbestos affects the localization of TP73 protein25466987
D001280AtrazineAtrazine results in increased expression of TP73 mRNA25929836
D001374AzacitidineTP73 protein promotes the reaction [Azacitidine results in increased expression of FAM129A mRNA]21245298
D001374AzacitidineTP73 protein promotes the reaction [Azacitidine results in increased expression of HMGA2 mRNA]21245298
D001374AzacitidineTP73 protein promotes the reaction [Azacitidine results in increased expression of KLF6 mRNA]21245298
D053119BenzophenanthridinesBenzophenanthridines analog results in decreased expression of TP73 mRNA23117580
D001564Benzo(a)pyreneBenzo(a)pyrene affects the activity of TP73 protein20624995
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TP73 mRNA20862736
C095105bexarotenebexarotene results in increased expression of TP73 protein19067706
C006780bisphenol Abisphenol A results in decreased expression of TP73 mRNA25181051
C546611brevetoxin 2brevetoxin 2 results in increased expression of TP73 mRNA20498034
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of TP73 mRNA27509014
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased methylation of TP73 gene27509014
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of TP73 protein25446071
D019256Cadmium Chloride[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]25446071
D019256Cadmium ChlorideEdetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]]25446071
D002118Calcium[Calcium co-treated with CAPN1 protein] results in increased degradation of TP73 protein modified form21516125
C071482calpeptincalpeptin inhibits the reaction [Cisplatin results in decreased expression of TP73 protein modified form]21516125
C043561chrysinchrysin results in increased expression of TP73 protein18331776|1939799
C018021cobaltous chloridecobaltous chloride results in decreased activity of TP73 protein25446071
C018021cobaltous chloride[cobaltous chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]25446071
D003300CopperCopper results in decreased expression of TP73 mRNA16391388
C000543cyclopiazonic acidcyclopiazonic acid results in increased degradation of TP73 protein modified form21516125
D016572CyclosporineCyclosporine results in decreased methylation of TP73 promoter27989131
C014347decitabinedecitabine results in decreased methylation of TP73 promoter19194470
D003976DiazinonDiazinon results in increased methylation of TP73 gene22964155
D002945Cisplatincalpeptin inhibits the reaction [Cisplatin results in decreased expression of TP73 protein modified form]21516125
D002945CisplatinCisplatin affects the localization of TP73 protein modified form21516125
D002945Cisplatin"[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein"21214929
D002945Cisplatin"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in decreased expression of BCL2 mRNA"21214929
D002945Cisplatin"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in decreased expression of BCL2 protein"21214929
D002945Cisplatin"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of BAX mRNA"21214929
D002945Cisplatin"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of BAX protein"21214929
D002945Cisplatin"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of FAS mRNA"21214929
D002945Cisplatin"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of FAS protein"21214929
D002945Cisplatin"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of PMAIP1 mRNA"21214929
D002945Cisplatin"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein"21214929
D002945Cisplatin"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B mRNA"21214929
D002945Cisplatin"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B protein"21214929
D002945Cisplatin"[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein"21214929
D002945Cisplatin"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in decreased expression of BCL2 protein"21214929
D002945Cisplatin"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of BAX protein"21214929
D002945Cisplatin"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of FAS protein"21214929
D002945Cisplatin"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein"21214929
D002945Cisplatin"[[[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B protein"21214929
D002945Cisplatin[Cisplatin co-treated with TP73 protein] results in increased expression of BAX protein20100536
D002945Cisplatin[Cisplatin co-treated with TP73 protein] results in increased expression of CDKN1A protein20100536
D002945CisplatinCisplatin promotes the reaction [[TP73 protein binds to GRAMD4 promoter] which results in increased expression of GRAMD4 mRNA]21127500
D002945CisplatinCisplatin promotes the reaction [[TP73 protein binds to IL4R intron] which results in increased expression of IL4R mRNA]14678968
D002945CisplatinCisplatin results in decreased expression of TP73 mRNA21737676
D002945CisplatinCisplatin results in decreased expression of TP73 protein modified form21516125
D002945CisplatinCisplatin results in increased activity of TP73 protein14678968
D002945CisplatinCisplatin results in increased expression of TP73 protein17076661|2065588
D002945CisplatinCisplatin results in increased localization of [PLK1 protein co-treated with TP73 protein]20655883
D002945CisplatinPLK1 protein inhibits the reaction [Cisplatin results in increased expression of TP73 protein]20655883
D002945CisplatinRELA protein mutant form inhibits the reaction [Cisplatin results in decreased expression of TP73 mRNA]21737676
D002945Cisplatin[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein20686837
D002945Cisplatin[[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein] which results in increased expression of BBC3 protein20686837
D002945Cisplatin[[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein20686837
D002945CisplatinTP73 mutant form inhibits the reaction [RELA promotes the reaction [Cisplatin results in increased expression of PMAIP1 mRNA]]21737676
D002945CisplatinTP73 protein modified form promotes the reaction [Cisplatin results in increased expression of BBC3 protein]21516125
D002945CisplatinTP73 protein modified form promotes the reaction [Cisplatin results in increased expression of PMAIP1 protein]21516125
D002945CisplatinTP73 protein modified form results in increased susceptibility to Cisplatin21516125
D002945CisplatinTP73 protein promotes the reaction [Cisplatin results in increased expression of GRAMD4 mRNA]21127500
D002945CisplatinTP73 protein results in increased susceptibility to [Sirolimus co-treated with Cisplatin]20686837
D002945CisplatinTP73 results in increased susceptibility to Cisplatin20100536
D002945Cisplatinwortmannin promotes the reaction [Cisplatin results in increased expression of TP73 protein]21214929
D002945Cisplatin"YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]"21214929
D002945Cisplatin"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in decreased expression of BCL2 protein"21214929
D002945Cisplatin"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of BAX protein"21214929
D002945Cisplatin"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of FAS protein"21214929
D002945Cisplatin"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of PMAIP1 protein"21214929
D002945Cisplatin"[YAP1 protein promotes the reaction [[Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of TNFRSF10B protein"21214929
D002945CisplatinCisplatin results in decreased expression of and results in increased degradation of TP73 protein alternative form21837762
D002945CisplatinCisplatin results in increased expression of TP73 protein21837762
D002117Calcitriol[[Etoposide results in increased expression of TP73 protein] which results in increased expression of VDR protein] which results in increased susceptibility to Calcitriol17716971
D004317Doxorubicin"[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein"21214929
D004317Doxorubicin"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in decreased expression of BCL2 mRNA"21214929
D004317Doxorubicin"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in decreased expression of BCL2 protein"21214929
D004317Doxorubicin"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of BAX mRNA"21214929
D004317Doxorubicin"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of BAX protein"21214929
D004317Doxorubicin"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of FAS mRNA"21214929
D004317Doxorubicin"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of FAS protein"21214929
D004317Doxorubicin"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of PMAIP1 mRNA"21214929
D004317Doxorubicin"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein"21214929
D004317Doxorubicin"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B mRNA"21214929
D004317Doxorubicin"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B protein"21214929
D004317Doxorubicin"[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein"21214929
D004317Doxorubicin"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in decreased expression of BCL2 protein"21214929
D004317Doxorubicin"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of BAX protein"21214929
D004317Doxorubicin"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of FAS protein"21214929
D004317Doxorubicin"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein"21214929
D004317Doxorubicin"[[[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of ABL1 protein] which results in increased expression of TP73 protein] which results in increased expression of TNFRSF10B protein"21214929
D004317DoxorubicinDoxorubicin promotes the reaction [E2F1 protein binds to TP73 promoter]25124555
D004317DoxorubicinDoxorubicin promotes the reaction [HDAC2 protein binds to TP73 promoter]25124555
D004317DoxorubicinDoxorubicin results in increased expression of TP73 mRNA17716971|2512455
D004317DoxorubicinDoxorubicin results in increased expression of TP73 protein17716971|2121492
D004317DoxorubicinE2F1 protein promotes the reaction [Doxorubicin results in increased expression of TP73 protein]25124555
D004317DoxorubicinSETD7 protein inhibits the reaction [Doxorubicin results in increased expression of TP73 mRNA]25124555
D004317DoxorubicinSETD7 protein inhibits the reaction [Doxorubicin results in increased expression of TP73 protein]25124555
D004317DoxorubicinSETD7 protein promotes the reaction [Doxorubicin promotes the reaction [E2F1 protein binds to TP73 promoter]]25124555
D004317DoxorubicinSETD7 protein promotes the reaction [Doxorubicin promotes the reaction [HDAC2 protein binds to TP73 promoter]]25124555
D004317Doxorubicinwortmannin promotes the reaction [Doxorubicin results in increased expression of TP73 protein]21214929
D004317Doxorubicin"YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]"21214929
D004317Doxorubicin"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in decreased expression of BCL2 protein"21214929
D004317Doxorubicin"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of BAX protein"21214929
D004317Doxorubicin"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of FAS protein"21214929
D004317Doxorubicin"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of PMAIP1 protein"21214929
D004317Doxorubicin"[YAP1 protein promotes the reaction [[Doxorubicin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased expression of TP73 protein]] which results in increased expression of TNFRSF10B protein"21214929
D004492Edetic AcidEdetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]]25446071
D005047EtoposideEtoposide results in increased expression of TP73 mRNA17716971
D005047EtoposideEtoposide results in increased expression of TP73 protein17716971|2180144
D005047Etoposide[[Etoposide results in increased expression of TP73 protein] which results in increased expression of VDR protein] which results in increased susceptibility to Calcitriol17716971
D005047EtoposideTP73 mutant form inhibits the reaction [Etoposide results in increased activity of CASP3 protein]21801448
D005047EtoposideTP73 mutant form inhibits the reaction [Etoposide results in increased activity of CASP7 protein]21801448
D005047EtoposideTP73 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]21801448
D005047EtoposideTP73 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP8 protein]21801448
D005047EtoposideTP73 protein affects the reaction [Etoposide results in increased expression of VDR mRNA]17716971
D015025Zearalenone[Zearalenone co-treated with Aflatoxin B1] results in increased expression of TP73 mRNA28965971
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of TP73 mRNA22213190
D005472FluorouracilTP73 protein affects the susceptibility to Fluorouracil18714155
D005472FluorouracilTP73 protein promotes the reaction [Fluorouracil results in increased expression of GRAMD4 mRNA]21127500
C039281furanfuran results in decreased expression of TP73 mRNA25539665
D007291Inosine MonophosphateTP73 protein affects the abundance of Inosine Monophosphate25554796
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TP73 mRNA24796395
C006552kaempferolkaempferol results in increased expression of TP73 protein18331776|1939799
D007654KetoconazoleKetoconazole results in decreased expression of TP73 mRNA25808816
D047311LuteolinLuteolin results in increased expression of TP73 protein18331776|1939799
C025340manganese chloridemanganese chloride results in decreased expression of TP73 mRNA27107493
C025340manganese chloridemanganese chloride results in decreased expression of TP73 protein modified form27107493
C025340manganese chlorideTP73 protein modified form results in decreased susceptibility to manganese chloride27107493
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TP73 mRNA23649840
D0156551-Methyl-4-phenylpyridiniumU 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of TP73 mRNA]12710931
C040015myricetinmyricetin results in increased expression of TP73 protein19397994
C005246myristicinmyristicin results in decreased expression of TP73 mRNA24792648
C022838nickel chloridenickel chloride results in decreased activity of TP73 protein25446071
C022838nickel chloride[nickel chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]25446071
C022838nickel chloridenickel chloride results in increased phosphorylation of TP73 protein21466819
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of TP73 protein14587038
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TP73 mRNA"18778698
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TP73 mRNA]"18778698
C482205nutlin 3nutlin 3 inhibits the reaction [TP73 binds to MDM2]20422343
C016340o,p'-DDT"o,p'-DDT analog results in decreased expression of TP73 mRNA"22937105
C016340o,p'-DDT"o,p'-DDT results in increased expression of TP73 mRNA"22937105
C046012pentanalpentanal results in increased expression of TP73 mRNA26079696
C030090phosphoramide mustardphosphoramide mustard results in increased expression of TP73 mRNA26708502
C030090phosphoramide mustardphosphoramide mustard results in increased expression of TP73 protein26708502
C121565pifithrinpifithrin results in decreased activity of TP73 protein18418056
C498077piperlongumininepiperlonguminine inhibits the reaction [TP73 protein binds to XPO1 protein]26026911
D010936Plant ExtractsPlant Extracts results in decreased expression of TP73 mRNA23557933
D011794QuercetinQuercetin results in increased expression of TP73 protein18331776|1939799
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of TP73 mRNA19429434
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased expression of TP73 protein11517458
C059514resveratrolresveratrol results in increased expression of TP73 mRNA18347188
C059514resveratrolresveratrol results in increased expression of TP73 protein18347188
D012176RetinoidsRetinoids results in increased expression of TP73 protein19067706
D020123Sirolimus[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein20686837
D020123Sirolimus[[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein] which results in increased expression of BBC3 protein20686837
D020123Sirolimus[[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein20686837
D020123SirolimusSirolimus inhibits the reaction [TP73 protein affects the activity of HEN1 protein]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein affects the activity of HOXA9 protein]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein affects the activity of TAL1 protein]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein affects the activity of ZIC2 protein]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in decreased expression of ACER2 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in decreased expression of JMY mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in decreased expression of MIR181A2 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in decreased expression of NR1H4 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in decreased expression of RPL7P26 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in decreased expression of SCD mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in decreased expression of SERPINE1 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in decreased expression of YPEL1 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of BTBD11 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of C9ORF3 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of CAV3 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of CCNG2 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of CHRNB3 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of DEPDC6 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of FAXDC2 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of FBXO32 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of FGF7 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of FOLR1 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of FTL mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of ING4 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of MBNL2 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of MTURN mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of MYLK mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of MYOF mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of NMU mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of OXA1L mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of SEMA3C mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of SIRT2 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of SMIM14 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of STARD10 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of SYT1 mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of TMEM14C mRNA]21245298
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of ZNRD1 mRNA]21245298
D020123SirolimusSirolimus promotes the reaction [TP73 protein affects the activity of GCM2 protein]21245298
D020123SirolimusSirolimus promotes the reaction [TP73 protein affects the activity of PAX8 protein]21245298
D020123SirolimusSirolimus promotes the reaction [TP73 protein affects the activity of REST protein]21245298
D020123SirolimusSirolimus promotes the reaction [TP73 protein affects the activity of TEAD1 protein]21245298
D020123SirolimusSirolimus promotes the reaction [TP73 protein binds to MDM2 promoter]21245298
D020123SirolimusSirolimus promotes the reaction [TP73 protein binds to RPS27L promoter]21245298
D020123SirolimusSirolimus promotes the reaction [TP73 protein binds to RRAD promoter]21245298
D020123SirolimusSirolimus results in increased expression of TP73 protein21245298
D020123SirolimusTP73 protein promotes the reaction [Sirolimus results in increased expression of MIR151 mRNA]21245298
D020123SirolimusTP73 protein promotes the reaction [Sirolimus results in increased expression of MIR190A mRNA]21245298
D020123SirolimusTP73 protein promotes the reaction [Sirolimus results in increased expression of MIR29C mRNA]21245298
D020123SirolimusTP73 protein promotes the reaction [Sirolimus results in increased expression of MIR324 mRNA]21245298
D020123SirolimusTP73 protein promotes the reaction [Sirolimus results in increased expression of MIR379 mRNA]21245298
D020123SirolimusTP73 protein promotes the reaction [Sirolimus results in increased expression of MIR433 mRNA]21245298
D020123SirolimusTP73 protein promotes the reaction [Sirolimus results in increased expression of MIR503 mRNA]21245298
D020123SirolimusTP73 protein promotes the reaction [Sirolimus results in increased expression of MIR508 mRNA]21245298
D020123SirolimusTP73 protein promotes the reaction [Sirolimus results in increased expression of MIR650 mRNA]21245298
D020123SirolimusTP73 protein promotes the reaction [Sirolimus results in increased expression of MIR654 mRNA]21245298
D020123SirolimusTP73 protein promotes the reaction [Sirolimus results in increased expression of MIR758 mRNA]21245298
D020123SirolimusTP73 protein promotes the reaction [Sirolimus results in increased expression of MIR760 mRNA]21245298
D020123SirolimusTP73 protein results in increased susceptibility to [Sirolimus co-treated with Cisplatin]20686837
C017947sodium arsenitesodium arsenite affects the expression of TP73 mRNA29319823
C017947sodium arsenitesodium arsenite affects the methylation of TP73 gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of TP73 mRNA28595984
C525423SRT2183SRT2183 results in increased expression of TP73 mRNA23681230
C113580U 0126U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of TP73 mRNA]12710931
D014520UrethaneUrethane results in decreased expression of TP73 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of TP73 gene28853863|2915479
D014800VitalliumVitallium analog results in increased expression of TP73 mRNA23825117
C009687wortmanninwortmannin promotes the reaction [Cisplatin results in increased expression of TP73 protein]21214929
C009687wortmanninwortmannin promotes the reaction [Doxorubicin results in increased expression of TP73 protein]21214929
D015032ZincZinc binds to and affects the folding of and affects the activity of TP73 protein17170001
D015032ZincZinc deficiency results in decreased expression of TP73 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA16343436  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IDA24652652  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA16343436  
GO:0002039p53 binding-IPI25417702  
GO:0003700DNA-binding transcription factor activity-IDA15678106  
GO:0003700DNA-binding transcription factor activity-IMP25417702  
GO:0005515protein binding-IPI10469568  11706030  11804596  14729977  15070730  15678106  
16998810  17592138  18275817  18280240  18768816  19218448  
19581926  20615966  22340593  25283809  25331851  
GO:0008134transcription factor binding-IPI18421303  
GO:0019901protein kinase binding-IPI18174154  19490146  
GO:0042802identical protein binding-IPI19815500  22340593  22474346  
GO:0044212transcription regulatory region DNA binding-IDA16343436  
GO:0046872metal ion binding-IEA-  
GO:0097371MDM2/MDM4 family protein binding-IPI25417702  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IEA-  
GO:0001822kidney development-IEA-  
GO:0006298mismatch repair-TAS10391249  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006974cellular response to DNA damage stimulus-IDA18174154  
GO:0007050cell cycle arrest-IEA-  
GO:0007346regulation of mitotic cell cycle-IMP18634800  
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage-TAS10391251  
GO:0010243response to organonitrogen compound-IEA-  
GO:0010468regulation of gene expression-IMP18634800  
GO:0016032viral process-IEA-  
GO:0042493response to drug-IEA-  
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator-IDA18174154  19490146  
GO:0042981regulation of apoptotic process-TAS-  
GO:0045665negative regulation of neuron differentiation-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA15678106  16343436  
GO:0045893positive regulation of transcription, DNA-templated-IMP25417702  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16343436  18174154  18421303  19490146  24652652  
GO:0048714positive regulation of oligodendrocyte differentiation-IEA-  
GO:0051262protein tetramerization-IEA-  
GO:0060044negative regulation of cardiac muscle cell proliferation-IMP18634800  
GO:0071158positive regulation of cell cycle arrest-IDA18421303  
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway-TAS-  
GO:1901796regulation of signal transduction by p53 class mediator-TAS-  
GO:1902036regulation of hematopoietic stem cell differentiation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA19490146  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005739mitochondrion-IEA-  
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-TAS-  
GO:0030054cell junction-IDA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa04115p53 signaling pathway
hsa04722Neurotrophin signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-109606Intrinsic Pathway for ApoptosisTAS
R-HSA-114452Activation of BH3-only proteinsTAS
R-HSA-139915Activation of PUMA and translocation to mitochondriaTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5633008TP53 Regulates Transcription of Cell Death GenesTAS
R-HSA-6803204TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseTAS
R-HSA-6803205TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertainTAS
R-HSA-6803207TP53 Regulates Transcription of Caspase Activators and CaspasesTAS
R-HSA-6803211TP53 Regulates Transcription of Death Receptors and LigandsTAS
R-HSA-6804759Regulation of TP53 Activity through Association with Co-factorsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28927526Putative biomarkers for cervical cancer: SNVs, methylation and expression profiles. (2017 Jul)Cardoso MFSMutat Res
25218545Interaction between TP63 and MDM2 genes and the risk of recurrent pregnancy loss. (2014 Nov)Fraga LREur J Obstet Gynecol Reprod Biol