Gene: TPH1

7166
TPRH|TRPH
tryptophan hydroxylase 1
protein-coding
11p15.1
Ensembl:ENSG00000129167 MIM:191060 Vega:OTTHUMG00000166421 UniprotKB:P17752
NG_011947.1
PubMed
0   ANCO-SNPs
OD|ND|AD
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.121e-1 (AD)  5.028e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEPSECS0.69
NUP1070.681
RBM30.678
ZNF6620.676
RSPH4A0.674
EOGT0.649
LIMA10.637
FZD60.634
FBXO40.627
TMEM1680.617

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC151-0.431
CTU1-0.422
ZNF771-0.418
ASPDH-0.413
KLRG1-0.407
SPR-0.4
FAM43B-0.399
PSPN-0.385
ADRA2C-0.385
MESP1-0.375

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00360SapropterinSmall Molecule62989-33-7Approved|InvestigationalTarget
DB05199LX1031Small Molecule-InvestigationalTarget
DB12095Telotristat ethylSmall Molecule1033805-22-9Approved|InvestigationalTarget
DB00150L-TryptophanSmall Molecule73-22-3Approved|Nutraceutical|WithdrawnEnzyme
ID Drug Name Action PubMed
C0299552-nitrotoluene2-nitrotoluene results in increased expression of TPH1 mRNA15612046
C0191323-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole"3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in decreased activity of TPH1 protein"1989631
C0191323-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole"3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in decreased activity of TPH1 protein"7931246
C0191333-amino-1-methyl-5H-pyrido(4,3-b)indole"3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of TPH1 protein"1989631
C0191333-amino-1-methyl-5H-pyrido(4,3-b)indole"3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of TPH1 protein"7931246
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of TPH1 mRNA"26186136
D020106AcrylamideAcrylamide results in decreased expression of TPH1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TPH1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TPH1 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of TPH1 protein16483693
D001151Arsenic[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TPH1 protein]22704994
C006632arsenic trioxidearsenic trioxide results in decreased expression of TPH1 mRNA23392890|2351822
C006632arsenic trioxideTaurine inhibits the reaction [arsenic trioxide results in decreased expression of TPH1 mRNA]23392890
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TPH1 mRNA22316170
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of TPH1 mRNA26186136
C006780bisphenol Abisphenol A results in decreased expression of TPH1 mRNA25181051|2618613
D002509CephaloridineCephaloridine results in increased expression of TPH1 mRNA18500788
D048271Chitosan[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TPH1 protein]22704994
D004390ChlorpyrifosChlorpyrifos results in increased expression of TPH1 mRNA17452286|1883540
D002994ClofibrateClofibrate results in increased expression of TPH1 mRNA21318169
D003474Curcumin[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TPH1 protein]22704994
C009160cyclonitecyclonite results in decreased expression of TPH1 mRNA25559034
D003976DiazinonDiazinon affects the expression of TPH1 mRNA18835401
D003976DiazinonDiazinon results in increased expression of TPH1 mRNA17452286
D015946Ethylene DibromideEthylene Dibromide results in increased expression of TPH1 mRNA15612046
D004026DieldrinDieldrin results in increased expression of TPH1 mRNA18835401
D004041Dietary FatsDietary Fats results in decreased expression of TPH1 mRNA18042831
D004726Endosulfan[Endosulfan co-treated with Flutamide] results in decreased expression of TPH1 mRNA22227439
D004726EndosulfanEndosulfan results in decreased expression of TPH1 mRNA22227439
D004726EndosulfanEndosulfan results in decreased expression of TPH1 mRNA26615145
D005473FluoxetineFluoxetine results in increased expression of TPH1 mRNA21083617
D005473FluoxetineFluoxetine results in increased expression of TPH1 mRNA15631896
D005485Flutamide[Endosulfan co-treated with Flutamide] results in decreased expression of TPH1 mRNA22227439
D005485FlutamideFlutamide results in decreased expression of TPH1 mRNA22227439
D005492Folic AcidFolic Acid results in increased expression of TPH1 mRNA25006883
C039281furanfuran results in increased expression of TPH1 mRNA27387713
C004312glycidolglycidol results in increased expression of TPH1 mRNA15612046
D012701SerotoninTPH1 mRNA inhibits the reaction [TH2 gene mutant form results in decreased abundance of Serotonin]23754283
D012701SerotoninTPH1 gene polymorphism affects the abundance of Serotonin17203304
D012701SerotoninTPH1 gene polymorphism results in increased abundance of Serotonin18405062
D012701SerotoninTPH1 protein results in increased chemical synthesis of Serotonin18506000
D012701SerotoninTPH1 protein results in increased chemical synthesis of Serotonin20204739
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TPH1 protein21179406
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of TPH1 mRNA"24972896
C036868methyl carbamatemethyl carbamate results in increased expression of TPH1 mRNA15612046
D009151Mustard GasMustard Gas results in increased expression of TPH1 mRNA15674843
D009532NickelNickel results in decreased expression of TPH1 mRNA18835401
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of TPH1 protein19716841
D000073878Palm OilPalm Oil results in decreased expression of TPH1 mRNA18042831
D028321Plant PreparationsPlant Preparations affects the expression of TPH1 mRNA16046712
D012110ReserpineReserpine results in decreased activity of TPH1 protein8369965
D012110ReserpineReserpine results in increased activity of TPH1 protein8369965
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TPH1 mRNA25895662
D013654TaurineTaurine inhibits the reaction [arsenic trioxide results in decreased expression of TPH1 mRNA]23392890
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TPH1 gene]20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TPH1 mRNA21354282
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TPH1 mRNA20819909
D014635Valproic AcidValproic Acid results in decreased expression of TPH1 mRNA21318169

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004510tryptophan 5-monooxygenase activity-IEA-  
GO:0005506iron ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007623circadian rhythm-IEA-  
GO:0009072aromatic amino acid family metabolic process-IEA-  
GO:0030279negative regulation of ossification-IEA-  
GO:0035902response to immobilization stress-IEA-  
GO:0042427serotonin biosynthetic process-IEA-  
GO:0045600positive regulation of fat cell differentiation-IEA-  
GO:0046849bone remodeling-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO:0060749mammary gland alveolus development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0043005neuron projection-IEA-  
KEGG ID KEGG Term
hsa00380Tryptophan metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-209776Amine-derived hormonesTAS
R-HSA-209931Serotonin and melatonin biosynthesisTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15654285A functional polymorphism in the promoter region of the tryptophan hydroxylase gene is associated with alcohol dependence in one aboriginal group in Taiwan. (2005 Jan)Sun HSAlcohol Clin Exp Res
18405071Alcohol dependence and polymorphisms of serotonin-related genes: association studies. (2008 Jan)Mokrovic GColl Antropol
16257348Tryptophan hydroxylase polymorphism is associated with age of onset of alcoholism related behaviors. (2005 May)Chung IWAlcohol
15635702Pleiotropic effect of the TPH A779C polymorphism on nicotine dependence and personality. (2005 Apr 5)Reuter MAm J Med Genet B Neuropsychiatr Genet
23177301[Genetic polymorphisms as tool indicators for individual vulnerability to smoking behaviour]. (2013 Jan 19)Barrot CMed Clin (Barc)
17986837The role of the TPH1 and TPH2 genes for nicotine dependence: a genetic association study in two different age cohorts. (2007)Reuter MNeuropsychobiology
27045756TPH1 and 5-HTTLPR Genes Specifically Interact in Opiate Dependence but Not in Alcohol Dependence. (2016)Wang TYEur Addict Res
18562131Genetic variation in the serotonin pathway and smoking cessation with nicotine replacement therapy: new data from the Patch in Practice trial and pooled analyses. (2008 Nov 1)David SPDrug Alcohol Depend
21601290Association between the TPH1 A218C polymorphism and risk of mood disorders and alcohol dependence: evidence from the current studies. (2012 Apr)Chen DJ Affect Disord