Gene: TPM1

7168
C15orf13|CMD1Y|CMH3|HEL-S-265|HTM-alpha|LVNC9|TMSA
tropomyosin 1
protein-coding
15q22.2
Ensembl:ENSG00000140416 MIM:191010 Vega:OTTHUMG00000132803 UniprotKB:P09493
NG_007557.1
PubMed
0   ANCO-SNPs
ND
1   
6.736e-1 (AD)  9.215e-3 (ND)   (Frontal_Cortex)
5.834e-1 (AD)  4.985e-3 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10403394chr15:63349192TPM12.600e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WDR820.881
UBP10.881
CEP680.878
CCNDBP10.869
UBQLN10.867
DSTN0.866
POLR2B0.865
MKRN10.864
DENR0.863
BTN2A10.862

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.596
OR4F29-0.581
PON1-0.275
CTNNA3-0.269
FOXJ1-0.262
LRAT-0.262
MTRNR2L6-0.261
S100A1-0.257
NKX2-2-0.257
FXYD3-0.251

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
DB12695Phenethyl IsothiocyanateSmall Molecule2257-09-2InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of TPM1 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TPM1 mRNA"22698814
C0166141-nitronaphthalene1-nitronaphthalene metabolite binds to TPM1 protein16453347
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of TPM1 mRNA"23829299
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TPM1 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TPM1 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of TPM1 mRNA"23829299
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TPM1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TPM1 mRNA"28973690
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TPM1 mRNA"19692669
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of TPM1 mRNA21983209
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TPM1 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TPM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TPM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPM1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TPM1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of TPM1 mRNA22112502
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Allylamine results in increased expression of TPM1 mRNA]15910882
D020106AcrylamideAcrylamide results in decreased expression of TPM1 mRNA28606764
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TPM1 mRNA27153756
D000447AldehydesAldehydes results in increased expression of TPM1 mRNA25014914
D000499AllylamineAcetylcysteine inhibits the reaction [Allylamine results in increased expression of TPM1 mRNA]15910882
D000499AllylamineAllylamine results in increased expression of TPM1 mRNA15910882
D000499AllylamineAllylamine results in increased expression of TPM1 protein15910882
D000499AllylamineHydrogen Peroxide inhibits the reaction [Allylamine results in increased expression of TPM1 mRNA]15910882
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TPM1 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of TPM1 protein16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of TPM1 mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TPM1 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of TPM1 mRNA"17331233
D001280AtrazineAtrazine results in decreased expression of TPM1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TPM1 mRNA19770486|2261060
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TPM1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TPM1 mRNA"19150397
C038328BEP protocolBEP protocol results in increased expression of TPM1 mRNA18987330
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of TPM1 mRNA]24758408
D004958EstradiolEstradiol results in increased expression of TPM1 mRNA24758408
D004958EstradiolEstradiol results in decreased expression of TPM1 mRNA19484750
D004958EstradiolEstradiol affects the expression of TPM1 mRNA15364205
C095105bexarotenebexarotene results in increased expression of TPM1 mRNA16648578
C006780bisphenol Abisphenol A affects the expression of TPM1 mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of TPM1 mRNA25047013|2927551
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TPM1 promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of TPM1 mRNA27178563
C006780bisphenol Abisphenol A results in increased expression of TPM1 mRNA25181051
C006780bisphenol Abisphenol A affects the expression of TPM1 mRNA15364205
D001761BleomycinBleomycin results in increased expression of TPM1 protein25933445
D000069286BortezomibBortezomib results in increased expression of TPM1 mRNA20977926
C032036bromobenzenebromobenzene metabolite binds to TPM1 protein17305373
D0151248-Bromo Cyclic Adenosine Monophosphate[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TPM1 mRNA16997883
D002065BuspironeBuspirone results in decreased expression of TPM1 mRNA24136188
C018475butyraldehydebutyraldehyde results in increased expression of TPM1 mRNA26079696
D002104CadmiumCadmium results in increased expression of TPM1 mRNA24376830
D002104CadmiumCadmium results in decreased expression of TPM1 mRNA17327700
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TPM1 mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TPM1 mRNA17327700
C459604candoxincandoxin results in increased expression of TPM1 mRNA16309724
D002220CarbamazepineCarbamazepine affects the expression of TPM1 mRNA25979313
D002235Carbofuran[Lindane co-treated with metolachlor co-treated with Carbofuran] results in increased expression of TPM1 mRNA21075942
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TPM1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TPM1 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TPM1 mRNA22112502
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TPM1 mRNA23650126|2527062
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TPM1 mRNA20938992
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of TPM1 mRNA]16940432
D002922CiguatoxinsCiguatoxins affects the expression of TPM1 mRNA18353800
D002994ClofibrateClofibrate results in increased expression of TPM1 mRNA17585979
C480342clothianidinclothianidin results in increased expression of TPM1 mRNA29044138
C018021cobaltous chloridecobaltous chloride results in decreased expression of TPM1 mRNA19320972|1937684
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TPM1 mRNA"19167446
C030973cupric oxidecupric oxide results in decreased expression of TPM1 mRNA22077320
C057862cyanoginosin LRcyanoginosin LR results in increased expression of TPM1 mRNA17654400
D003520CyclophosphamideTPM1 protein affects the susceptibility to Cyclophosphamide16217747
D016572CyclosporineCyclosporine results in decreased expression of TPM1 mRNA25562108|2798913
C010902decabromobiphenyl etherdecabromobiphenyl ether affects the expression of TPM1 mRNA24834073
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of TPM1 mRNA23914054
D064791Desoxycorticosterone Acetate"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in increased expression of TPM1 mRNA"22228705
D003907Dexamethasone[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TPM1 mRNA16997883
D003907DexamethasoneDexamethasone results in decreased expression of TPM1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TPM1 mRNA28628672
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TPM1 mRNA16054899
D003907DexamethasoneDexamethasone results in decreased expression of TPM1 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TPM1 mRNA21266533
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TPM1 promoter23359474
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TPM1 mRNA21266533|2174549
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TPM1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TPM1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of TPM1 mRNA21151649
D002945CisplatinCisplatin results in decreased expression of TPM1 mRNA22023808
D002945CisplatinCisplatin results in decreased expression of TPM1 protein22023808
D004041Dietary FatsDietary Fats results in decreased expression of TPM1 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of TPM1 mRNA18042831|2260994
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TPM1 promoter23359474
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TPM1 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TPM1 mRNA18597072|2453584
D004052Diethylnitrosaminetroglitazone promotes the reaction [Diethylnitrosamine results in increased expression of TPM1 mRNA]18597072
C039060dihydroartemisinindihydroartemisinin analog binds to TPM1 protein26340163
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TPM1 mRNA"22485181
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of TPM1 mRNA25380136
D004237DiuronDiuron results in decreased expression of TPM1 mRNA25152437
D004237DiuronDiuron results in increased expression of TPM1 mRNA21551480
D004317DoxorubicinDoxorubicin affects the expression of TPM1 protein29385562
D004317DoxorubicinDoxorubicin results in increased expression of TPM1 mRNA28940058
D004317DoxorubicinTPM1 protein affects the susceptibility to Doxorubicin16217747
D004317Doxorubicin[Doxorubicin co-treated with MT2A protein] results in decreased expression of TPM1 protein16144979
D004317DoxorubicinDoxorubicin results in decreased expression of TPM1 protein16144979
D004317DoxorubicinDoxorubicin results in increased oxidation of TPM1 protein28818578
C070609EMD 53998EMD 53998 analog results in decreased expression of TPM1 mRNA24977338
C118739entinostatentinostat results in decreased expression of TPM1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPM1 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TPM1 mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TPM1 mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TPM1 mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TPM1 mRNA12655037
D018120FinasterideFinasteride results in increased expression of TPM1 mRNA24136188
D005411Flame RetardantsFlame Retardants results in decreased expression of TPM1 protein18550172
D005472FluorouracilTPM1 protein affects the susceptibility to Fluorouracil16217747
D005473FluoxetineFluoxetine results in decreased expression of TPM1 mRNA21852994
D005485FlutamideFlutamide results in decreased expression of TPM1 mRNA21126777
D005485FlutamideFlutamide results in increased expression of TPM1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TPM1 mRNA20938992
C056933fumonisin B1fumonisin B1 results in increased expression of TPM1 mRNA16221962
C039281furanfuran results in increased expression of TPM1 mRNA26194646
D019833GenisteinGenistein results in decreased expression of TPM1 mRNA20884965|2686566
D017313FenretinideFenretinide results in increased expression of TPM1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TPM1 mRNA21179406
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TPM1 protein21179406
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [Allylamine results in increased expression of TPM1 mRNA]15910882
C016517indole-3-carbinolindole-3-carbinol affects the expression of TPM1 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TPM1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TPM1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TPM1 mRNA16997883
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TPM1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TPM1 mRNA16054899
D007545IsoproterenolIsoproterenol results in decreased expression of TPM1 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TPM1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TPM1 mRNA24796395
D007649KetamineKetamine results in increased expression of TPM1 mRNA20080153
D001556Lindane[Lindane co-treated with metolachlor co-treated with Carbofuran] results in increased expression of TPM1 mRNA21075942
D008094LithiumLithium results in decreased expression of TPM1 protein18296634
D018021Lithium ChlorideLithium Chloride results in increased expression of TPM1 mRNA23527032
D008701MethapyrileneMethapyrilene results in increased expression of TPM1 mRNA22484513
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TPM1 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TPM1 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of TPM1 protein26558463
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of TPM1 protein26558463
C008493methylselenic acidmethylselenic acid results in increased expression of TPM1 mRNA18548127
C051786metolachlor[Lindane co-treated with metolachlor co-treated with Carbofuran] results in increased expression of TPM1 mRNA21075942
D052998MicrocystinsMicrocystins results in increased expression of TPM1 protein22430071
D008942MitoxantroneTPM1 protein affects the susceptibility to Mitoxantrone16217747
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of TPM1 mRNA16809437
C406082monomethylarsonous acidmonomethylarsonous acid affects the expression of TPM1 protein24625837
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of TPM1 protein"22001959
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TPM1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TPM1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TPM1 mRNA"25554681|2562005
C031721naphthalenenaphthalene metabolite binds to TPM1 protein16453347
C031721naphthalenenaphthalene metabolite binds to TPM1 protein15892573
D009281NaphthalenesNaphthalenes results in increased expression of TPM1 protein17337753
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of TPM1 mRNA25380136
C051752nefazodonenefazodone results in increased expression of TPM1 mRNA24136188
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of TPM1 mRNA]16940432
D009532NickelNickel results in decreased expression of TPM1 mRNA24768652|2558310
D009532NickelNickel results in increased expression of TPM1 mRNA12540486
C028007nickel monoxidenickel monoxide results in increased expression of TPM1 mRNA19167457
C012655nimesulidenimesulide results in increased expression of TPM1 mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of TPM1 protein19716841
C025256nonylphenolnonylphenol affects the expression of TPM1 mRNA15364205
D009966OrphenadrineOrphenadrine affects the expression of TPM1 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of TPM1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of TPM1 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of TPM1 mRNA26516004
D000073878Palm OilPalm Oil results in increased expression of TPM1 mRNA18042831
D052638Particulate MatterParticulate Matter analog results in decreased expression of TPM1 mRNA15541757
C410127PCB 180PCB 180 results in increased expression of TPM1 mRNA23829299
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of TPM1 protein18550172
C046012pentanalpentanal results in increased expression of TPM1 mRNA26079696
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of TPM1 protein26168851
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of TPM1 mRNA22237054
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TPM1 mRNA19162173
C058305phenethyl isothiocyanateTPM1 protein binds to phenethyl isothiocyanate21838287
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TPM1 mRNA24535843
D010634PhenobarbitalPhenobarbital affects the expression of TPM1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of TPM1 mRNA25270620
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TPM1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TPM1 mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in increased expression of TPM1 mRNA15728792
C006253pirinixic acidpirinixic acid results in decreased expression of TPM1 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of TPM1 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of TPM1 mRNA19162173
D011189Potassium Chloride"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in increased expression of TPM1 mRNA"22228705
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TPM1 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in decreased expression of TPM1 protein23718831
D011374ProgesteroneProgesterone results in decreased expression of TPM1 mRNA18037150|2179573
C005556propionaldehydepropionaldehyde results in increased expression of TPM1 mRNA26079696
D011794QuercetinQuercetin results in increased expression of TPM1 mRNA21632981
D011794QuercetinQuercetin results in decreased expression of TPM1 mRNA18095365
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of TPM1 mRNA14699072
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of TPM1 mRNA16079270
D012176RetinoidsRetinoids results in decreased expression of TPM1 protein28886987
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TPM1 mRNA16054899
D012524SarinSarin results in decreased expression of TPM1 mRNA19522546
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of TPM1 protein25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TPM1 mRNA25895662
D012834SilverSilver affects the expression of TPM1 mRNA27131904
C009277sodium arsenatesodium arsenate results in decreased expression of TPM1 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of TPM1 mRNA25270620
C016104sodium bichromatesodium bichromate results in increased expression of TPM1 mRNA25993096
D017673Sodium Chloride, Dietary"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in increased expression of TPM1 mRNA"22228705
D012999SomanSoman results in increased expression of TPM1 mRNA19281266
C016766sulforafanTPM1 protein binds to sulforafan21838287
D013629TamoxifenTamoxifen affects the expression of TPM1 mRNA14699072
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of TPM1 protein27239688
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TPM1 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of TPM1 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TPM1 mRNA18796159
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TPM1 mRNA18796159
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TPM1 mRNA27136898
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TPM1 protein19201780
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TPM1 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of TPM1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of TPM1 mRNA23557971
D019772TopotecanTPM1 protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of TPM1 mRNA25729387
D014212TretinoinTretinoin affects the expression of TPM1 protein15789344
C032910triadimefontriadimefon results in decreased expression of TPM1 mRNA26705709
C012589trichostatin Atrichostatin A results in decreased expression of TPM1 mRNA15901671
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPM1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TPM1 mRNA26272509
C012589trichostatin Atrichostatin A results in increased expression of TPM1 mRNA26705709
C012589trichostatin Atrichostatin A results in decreased expression of TPM1 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TPM1 mRNA"26179874
C057693troglitazonetroglitazone promotes the reaction [Diethylnitrosamine results in increased expression of TPM1 mRNA]18597072
D017974Uranium CompoundsUranium Compounds results in decreased expression of TPM1 mRNA19654044
D014520UrethaneUrethane results in decreased expression of TPM1 mRNA16289808
C406224valdecoxibvaldecoxib results in increased expression of TPM1 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of TPM1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of TPM1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TPM1 mRNA24935251|2800136
D014635Valproic AcidValproic Acid results in increased expression of TPM1 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased expression of TPM1 mRNA15901671
C034028vanadyl sulfatevanadyl sulfate results in decreased expression of TPM1 mRNA16330358
D014640VancomycinVancomycin results in decreased expression of TPM1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions analog results in decreased expression of TPM1 mRNA15541757
C025643vinclozolinvinclozolin affects the expression of TPM1 mRNA19015723
D014800VitalliumVitallium analog results in decreased expression of TPM1 mRNA23825117
D015032ZincZinc deficiency results in decreased expression of TPM1 mRNA19111725
D015032ZincZinc deficiency results in decreased expression of TPM1 protein22689922

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-TAS12686598  
GO:0005200structural constituent of cytoskeleton-TAS12686598  
GO:0005515protein binding-IPI16189514  21516116  25416956  26871637  
GO:0008092cytoskeletal protein binding-IPI17987659  
GO:0008307structural constituent of muscle-TAS8205619  
GO:0042802identical protein binding-ISS-  
GO:0042803protein homodimerization activity-ISS-  
GO:0046982protein heterodimerization activity-ISS-  
GO:0051015actin filament binding-IBA21873635  
GO:0051015actin filament binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001701in utero embryonic development-IEA-  
GO:0003065positive regulation of heart rate by epinephrine-ISS17556658  
GO:0006936muscle contraction-IBA21873635  
GO:0006936muscle contraction-TAS-  
GO:0006937regulation of muscle contraction-TAS3336363  
GO:0007010cytoskeleton organization-TAS12686598  
GO:0007015actin filament organization-IBA21873635  
GO:0008016regulation of heart contraction-TAS8205619  
GO:0008360regulation of cell shape-IMP21817107  
GO:0030049muscle filament sliding-ISS11136687  
GO:0030049muscle filament sliding-TAS-  
GO:0030336negative regulation of cell migration-ISS15897890  
GO:0031529ruffle organization-ISS15897890  
GO:0032781positive regulation of ATPase activity-ISS11136687  
GO:0034614cellular response to reactive oxygen species-IEP12686598  
GO:0042060wound healing-ISS17721995  
GO:0045214sarcomere organization-IMP11273725  
GO:0045785positive regulation of cell adhesion-ISS17721995  
GO:0051496positive regulation of stress fiber assembly-ISS15897890  
GO:0055010ventricular cardiac muscle tissue morphogenesis-IMP11136687  
GO:0060048cardiac muscle contraction-IBA21873635  
GO:0060048cardiac muscle contraction-IMP11136687  
GO:1904706negative regulation of vascular smooth muscle cell proliferation-IMP21817107  
GO:1904753negative regulation of vascular associated smooth muscle cell migration-IMP21817107  
GO ID GO Term Qualifier Evidence PubMed
GO:0001725stress fiber-IDA12686598  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-TAS16130169  
GO:0005862muscle thin filament tropomyosin-TAS8205619  
GO:0005884actin filament-IBA21873635  
GO:0015629actin cytoskeleton-IDA-  
GO:0030017sarcomere-TAS16754800  
GO:0031941filamentous actin-IEA-  
GO:0032059bleb-IMP12686598  
GO:0032587ruffle membrane-IDA12686598  
KEGG ID KEGG Term
hsa04260Cardiac muscle contraction
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-390522Striated Muscle ContractionTAS
R-HSA-397014Muscle contractionTAS
R-HSA-445355Smooth Muscle ContractionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25607530Clinical and tumor significance of tropomyosin-1 expression levels in renal cell carcinoma. (2015 Mar)Wang JOncol Rep