Gene: C2

717
ARMD14|CO2
complement C2
protein-coding
6p21.33
Ensembl:ENSG00000166278 MIM:613927 Vega:OTTHUMG00000031190 UniprotKB:P06681
NG_011730.1
PubMed
OD|ND|AD
111   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TLR20.874
WAS0.871
ABI30.864
NCKAP1L0.864
BTK0.862
STXBP20.861
LAIR10.855
SNX200.854
TFEC0.853
PIK3AP10.849

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES5-0.422
WNT7A-0.377
ARSF-0.364
ATP2C2-0.359
HES6-0.357
CPLX3-0.355
KCNIP3-0.346
PYGM-0.331
NEU4-0.33
SNX22-0.324

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of C2 mRNA"26377693
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of C2 mRNA"21394737
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of C2 mRNA"19114083
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of C2 protein24140754
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of C2 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of C2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of C2 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of C2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of C2 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 affects the expression of C2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of C2 mRNA27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of C2 mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of C2 mRNA24449571
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of C2 mRNA26377693
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of C2 mRNA]22228805
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of C2 mRNA20660070
D004958EstradiolEstradiol affects the expression of C2 mRNA15598610
C006780bisphenol Abisphenol A results in increased expression of C2 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of C2 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of C2 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of C2 mRNA18958704
C018475butyraldehydebutyraldehyde results in increased expression of C2 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of C2 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of C2 mRNA27339419
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of C2 mRNA28472532
D002994ClofibrateClofibrate affects the expression of C2 mRNA16081524
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of C2 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of C2 mRNA23811191
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of C2 mRNA]17585979
D003471CuprizoneCuprizone results in increased expression of C2 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of C2 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of C2 mRNA21865292
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of C2 mRNA23914054
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of C2 mRNA28962523
D004008DiclofenacDiclofenac results in increased expression of C2 mRNA26934552
D004041Dietary FatsDietary Fats results in decreased expression of C2 mRNA15238619|1804283
D002117CalcitriolCalcitriol results in decreased expression of C2 mRNA26485663
D004237DiuronDiuron results in decreased expression of C2 mRNA21551480|2515243
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of C2 mRNA16174780|1755790
D005485FlutamideFlutamide results in decreased expression of C2 mRNA24136188
C069837fullerene C60fullerene C60 results in increased expression of C2 mRNA19167457
D005839GentamicinsGentamicins results in increased expression of C2 mRNA21081137|2206182
C010974glyphosateglyphosate results in increased expression of C2 mRNA17984146
D017313FenretinideFenretinide results in decreased expression of C2 mRNA28973697
C082770IMM 125IMM 125 results in increased expression of C2 mRNA21081137
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of C2 mRNA"26377693
C051890irinotecanirinotecan affects the expression of C2 mRNA20097248
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of C2 mRNA26752646
D007649KetamineKetamine results in increased expression of C2 mRNA20080153
C008261lead acetatelead acetate results in increased expression of C2 mRNA22609695
D008774MethylphenidateMethylphenidate results in increased expression of C2 mRNA22470460
D009151Mustard GasMustard Gas results in increased expression of C2 mRNA18988085
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of C2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of C2 mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of C2 mRNA24136188
D009532NickelNickel results in increased expression of C2 mRNA23195993
C028007nickel monoxidenickel monoxide results in increased expression of C2 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of C2 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of C2 mRNA18042831
D052638Particulate MatterParticulate Matter results in increased expression of C2 mRNA24769257
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of C2 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of C2 mRNA20936131
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of C2 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of C2 mRNA18467677|2093613
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of C2 mRNA]18467677
D010672PhenytoinPhenytoin results in decreased expression of C2 mRNA20345932
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of C2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of C2 mRNA17426115|1795077
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of C2 mRNA]17950772|1846767
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of C2 mRNA22714537
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of C2 mRNA20660070
C005556propionaldehydepropionaldehyde results in increased expression of C2 mRNA26079696
D012822Silicon DioxideSilicon Dioxide results in increased expression of C2 mRNA22431001
C017947sodium arsenitesodium arsenite results in increased expression of C2 mRNA22714537
D012967Sodium Dodecyl SulfateC2 SNP affects the susceptibility to Sodium Dodecyl Sulfate27258892
D012999SomanSoman results in increased expression of C2 mRNA19281266
D016559TacrolimusTacrolimus results in increased expression of C2 mRNA21865292
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of C2 mRNA28300664
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of C2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of C2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of C2 mRNA15703262
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of C2 mRNA15703262|1626733
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of C2 mRNA21215274
C009495titanium dioxidetitanium dioxide affects the expression of C2 mRNA17656681|2355797
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of C2 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of C2 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased expression of C2 mRNA29154799
C029297vinylidene chloridevinylidene chloride results in increased expression of C2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005515protein binding-IPI25910212  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0006956complement activation-IMP19302245  
GO:0006956complement activation-TAS-  
GO:0006958complement activation, classical pathway-IEA-  
GO:0007584response to nutrient-IEA-  
GO:0030449regulation of complement activation-TAS-  
GO:0045087innate immune response-IEA-  
GO:2000427positive regulation of apoptotic cell clearance-IMP19302245  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-TAS8621452  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
hsa05150Staphylococcus aureus infection
hsa05322Systemic lupus erythematosus
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-166663Initial triggering of complementTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-174577Activation of C3 and C5TAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22232432Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population. (2012 Feb 16)Nakata IInvest Ophthalmol Vis Sci
7590656An investigation of whether polymorphisms of cytochrome P4502E1 are genetic markers of susceptibility to alcoholic end-stage organ damage in a Chinese population. (1995 Nov)Chao YCHepatology
29801032Association of Single-Nucleotide Polymorphisms in Age-Related Macular Degeneration With Pseudodrusen: Secondary Analysis of Data From the Comparison of AMD Treatments Trials. (2018 May 3)Lin LYJAMA Ophthalmol
20028457Nicotine self-administration diminishes stress-induced norepinephrine secretion but augments adrenergic-responsiveness in the hypothalamic paraventricular nucleus and enhances adrenocorticotropic hormone and corticosterone release. (2010 Mar)Yu GJ Neurochem
9367063Genetic polymorphisms of CYP2E1, GSTM1, and GSTT1; environmental factors and risk of oral cancer. (1997 Nov)Hung HCCancer Epidemiol Biomarkers Prev
19661236Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. (2009 Dec)Reynolds RInvest Ophthalmol Vis Sci
24504680CYP1A1 and CYP2E1 genotypes and risk of esophageal squamous cell carcinoma in a high-incidence region, Kashmir. (2014 Jun)Bhat GATumour Biol
9508360Genotoxicological monitoring of 175 subjects living in the green belts, inner town or near chemical industrial estates in Greater Budapest agglomeration, Hungary. (1998 Jan 13)Major JMutat Res
1726950Human CYP1A1 (cytochrome P(1)450) gene: lack of association between the Msp I restriction fragment length polymorphism and incidence of lung cancer in a Norwegian population. (1991 Oct)Tefre TPharmacogenetics
21959373Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors. (2011 Nov)Seddon JMOphthalmology
21402993Assessing susceptibility to age-related macular degeneration with genetic markers and environmental factors. (2011 Mar)Chen YArch Ophthalmol
22933840Association analysis of genetic and environmental risk factors in the cuticular drusen subtype of age-related macular degeneration. (2012)van de Ven JPMol Vis
16758119Interaction of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferase M1 to breast cancer in Taiwanese woman without smoking and drinking habits. (2006 Nov)Wu SHBreast Cancer Res Treat
9345615Testing for interaction between maternal smoking and TGFA genotype among oral cleft cases born in Maryland 1992-1996. (1997 Sep)Beaty THCleft Palate Craniofac J
29540205The potential effect of type 2 diabetes mellitus on lumbar disc degeneration: a retrospective single-center study. (2018 Mar 14)Liu XJ Orthop Surg Res
15066702Workshop on Alcohol Use and Health Disparities 2002: a call to arms. (2004 Jan)Russo DAlcohol
18628434Genetic polymorphisms of CYP2E1 and risk of colorectal adenomas in the Self Defense Forces Health Study. (2008 Jul)Morita MCancer Epidemiol Biomarkers Prev
25624630Comparative evaluation of salivary soluble CD44 levels in periodontal health and disease. (2014 Nov-Dec)Kaur SJ Indian Soc Periodontol
18097986Review of genetics in age related macular degeneration. (2007 Oct-Dec)Montezuma SRSemin Ophthalmol
25478207Age-related macular degeneration: insights into inflammatory genes. (2014)Cascella RJ Ophthalmol
11236836Genetic determinants of alcohol addiction and metabolism: a survey in Italy. (2001 Feb)Pastorelli RAlcohol Clin Exp Res
23481534Dietary omega-3 fatty acids, other fat intake, genetic susceptibility, and progression to incident geographic atrophy. (2013 May)Reynolds ROphthalmology
23066323Nur-related receptor 1 gene polymorphisms and alcohol dependence in Mexican Americans. (2012 Oct 7)Wei YMWorld J Gastroenterol
25434319Phospholipase C epsilon 1 (PLCE1) haplotypes are associated with increased risk of gastric cancer in Kashmir Valley. (2014 Nov-Dec)Malik MASaudi J Gastroenterol
26461398Involvement of E3 Ubiquitin ligases in Cigarette Smoke associated muscle catabolism. (2014 Oct)Rom OFree Radic Biol Med
12710951The ADH3*2 and CYP2E1 c2 alleles increase the risk of alcoholism in Mexican American men. (2003 Apr)Konishi TExp Mol Pathol
25932792Effects of niacin and omega-3 fatty acids on the apolipoproteins in overweight patients with elevated triglycerides and reduced HDL cholesterol. (2015 Jun)Savinova OVAtherosclerosis
23007992CYP2E1 RsaI and 96-bp insertion genetic polymorphisms associated with risk for colorectal cancer. (2012 Sep 3)Silva TDGenet Mol Res
7702037Association study of transforming growth factor alpha (TGF alpha) TaqI polymorphism and oral clefts: indication of gene-environment interaction in a population-based sample of infants with birth defects. (1995 Apr 1)Hwang SJAm J Epidemiol
16125881Influence of genetic polymorphisms of styrene-metabolizing enzymes and smoking habits on levels of urinary metabolites after occupational exposure to styrene. (2005 Dec 30)Ma MToxicol Lett
28454298Expression and prognostic relevance of MAGE-A3 and MAGE-C2 in non-small cell lung cancer. (2017 Mar)Chen XOncol Lett
23151748The association of c-reactive protein with arterial compliance in asymptomatic young adults: the Bogalusa heart study. (2013 Apr)Sharma DJ Hum Hypertens
16834659Genetic polymorphisms in the cytochrome P450 1A1 and 2E1 genes, smoking, drinking and prostate cancer susceptibility: a case-control study in a Han nationality population in Southern China. (2006 Jun)Yang JInt J Urol
18798003Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans. (2009 Mar)Eom SYCancer Causes Control
8563770Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects. (1995 Oct)Lucas DPharmacogenetics
10630604CYP2E1 expression in human lymphocytes from various ethnic populations. (1999 Dec)Raucy JLAlcohol Clin Exp Res
7573775CYP2E1 and ALDH2 genotypes and alcohol dependence in Japanese. (1995 Jun)Iwahashi KAlcohol Clin Exp Res
26734919Ethanol metabolism, toxicity and genetic polymorphism. (1998 Jul)Iwahashi KAddict Biol
26059367Adiponectin may be a biomarker of early atherosclerosis of smokers and decreased by nicotine through KATP channel in adipocytes. (2015 Jul-Aug)Fan LHNutrition
23139769CYP2E1 RsaI/PstI polymorphism and gastric cancer susceptibility: meta-analyses based on 24 case-control studies. (2012)Zhuo WPLoS One
9731720The RsaI polymorphism of CYP2E1 and susceptibility to alcoholic liver disease in Caucasians: effect on age of presentation and dependence on alcohol dehydrogenase genotype. (1998 Aug)Grove JPharmacogenetics
19653173Plasma fibrinogen level may predict critical coronary artery stenosis in young adults with myocardial infarction. (2009)Tatli ECardiol J
8834237Polymorphisms of ethanol-oxidizing enzymes in alcoholics with inactive ALDH2. (1996 Apr)Higuchi SHum Genet
17963298CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking. (2007 Nov 21)Gao CMWorld J Gastroenterol
9163682Associations between cytochrome P4502E1 genotype, mutagen sensitivity, cigarette smoking and susceptibility to lung cancer. (1997 May)Wu XCarcinogenesis
23483202Cytochrome P450 2E1 RsaI/PstI and DraI Polymorphisms Are Risk Factors for Lung Cancer in Mongolian and Han Population in Inner Mongolia. (2011 Jun)Su XLChin J Cancer Res
9439147Association between genetic polymorphisms of the cytochromes P-450 (1A1, 2D6, and 2E1) and the susceptibility to pancreatic cancer. (1997 Jun)Lee HCKorean J Intern Med
10565156[Relationship between alcoholism and HTR2 MspI polymorphism]. (1999 Oct)Yoshihara ENihon Arukoru Yakubutsu Igakkai Zasshi
28209224Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. (2017 Feb 21)Webb TRJ Am Coll Cardiol
14535982Analysis of CYP2E1 polymorphism for the determination of genetic susceptibility to gastric cancer in Koreans. (2003 Nov)Park GTJ Gastroenterol Hepatol
19288740[Correlation of prostate cancer susceptibility with genetic polymorphism of cytochrome P450 2E1, smoking and drinking: a case-control study in the population of Nanjing area]. (2009 Jan)Yang JZhonghua Nan Ke Xue
26680667Genetic predisposition of human plasma triglyceride concentrations. (2015)Schwarzova LPhysiol Res
25422202Association of CYP2E1 and NAT2 polymorphisms with lung cancer susceptibility among Mongolian and Han populations in the Inner Mongolian region. (2014)Zhang JWAsian Pac J Cancer Prev
23577725Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis. (2013 May)Naj ACAnn Hum Genet
19250143Comparison of genetic polymorphisms of CYP2E1, ADH2, and ALDH2 genes involved in alcohol metabolism in Koreans and four other ethnic groups. (2009 Apr)Kang TSJ Clin Pharm Ther
17427487[The influence of genetic polymorphism of CYP2E1 on the development of alcohol liver cirrhosis]. (2006)Cichoz-Lach HWiad Lek
26851767Serum thyroglobulin as a biomarker of iodine deficiency in adult populations. (2016 Sep)Krejbjerg AClin Endocrinol (Oxf)
19117936Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. (2009 May)Seddon JMInvest Ophthalmol Vis Sci
23835954Essential amino acid leucine and proteasome inhibitor MG132 attenuate cigarette smoke induced catabolism in C2 myotubes. (2013)Rom OAdv Exp Med Biol
26903162[Expression and Clinical Significance of MAGE-C2 in Lung Adenocarcinoma]. (2016 Feb)Guo KZhongguo Fei Ai Za Zhi
9156693Lung cancer risk in relation to the CYP2E1 Rsa I genetic polymorphism among African-Americans and Caucasians in Los Angeles County. (1996 Apr)London SJPharmacogenetics
21807600Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration. (2011 Jul)Hageman GSHum Genomics
18034693A haplotype analysis of CYP2E1 polymorphisms in relation to alcoholic phenotypes in Mexican Americans. (2007 Dec)Yang MAlcohol Clin Exp Res
8519505Molecular pharmacology of alpha 2-adrenoceptor subtypes. (1995 Aug)Aantaa RAnn Med
28735646Hyperhomocysteinemia and Age-related Macular Degeneration: Role of Inflammatory Mediators and Pyroptosis; A Proposal. (2017 Aug)Singh MMed Hypotheses
12707490CYP2E1 and clinical features in alcoholics. (2003)Nakamura KNeuropsychobiology
15643916Oral clefts, maternal smoking, and TGFA: a meta-analysis of gene-environment interaction. (2005 Jan)Zeiger JSCleft Palate Craniofac J
12441166Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones. (2003 Jan)Nagy JNeurochem Int
27787372Does CYP2E1 RsaI/PstI polymorphism confer head and neck carcinoma susceptibility?: A meta-analysis based on 43 studies. (2016 Oct)Zhuo XMedicine (Baltimore)
28168336Predictors of cervical lordosis loss after laminoplasty in patients with cervical spondylotic myelopathy. (2017 Apr)Zhang JTEur Spine J
16425350Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer. (2005 Nov 14)Duarte MCWorld J Gastroenterol
27775434Resistin may be an independent predictor of subclinical atherosclerosis formale smokers. (2017 May - Jun)He YBiomarkers
9828267A study for the proper application of urinary naphthols, new biomarkers for airborne polycyclic aromatic hydrocarbons. (1999 Jan)Yang MArch Environ Contam Toxicol
15727637The combination of complement deficiency and cigarette smoking as risk factor for cutaneous lupus erythematosus in men; a focus on combined C2/C4 deficiency. (2005 Feb)Boeckler PBr J Dermatol
11377232Elucidation of CYP2E1 5' regulatory RsaI/Pstl allelic variants and their role in risk for oral cancer. (2001 Jul)Liu SOral Oncol
20090206The molecular genetic basis of age-related macular degeneration: an overview. (2009 Dec)Katta SJ Genet
23792774The effects of acetaldehyde and acrolein on muscle catabolism in C2 myotubes. (2013 Dec)Rom OFree Radic Biol Med
29649666A retrospective study: Does cigarette smoking induce cervical disc degeneration? (2018 May)Chen ZInt J Surg
25655794Risk Prediction for Progression of Macular Degeneration: 10 Common and Rare Genetic Variants, Demographic, Environmental, and Macular Covariates. (2015 Apr)Seddon JMInvest Ophthalmol Vis Sci
11675150CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people. (2001 Dec 10)Quinones LCancer Lett
20661821Association of xenobiotic metabolizing enzymes genetic polymorphisms with esophageal cancer in Kashmir Valley and influence of environmental factors. (2010)Malik MANutr Cancer
27099955Single-Nucleotide Polymorphisms Associated With Age-Related Macular Degeneration and Lesion Phenotypes in the Comparison of Age-Related Macular Degeneration Treatments Trials. (2016 Jun 1)Maguire MGJAMA Ophthalmol
23835952Involvement of NF-kappaB and muscle specific E3 ubiquitin ligase MuRF1 in cigarette smoke-induced catabolism in C2 myotubes. (2013)Kaisari SAdv Exp Med Biol
8651460Cytochrome P4502E1 genotypes, alcoholism, and alcoholic cirrhosis in Han Chinese and Atayal Natives of Taiwan. (1996 Feb)Carr LGAlcohol Clin Exp Res
26598194[The relationship between chronic periodontitis and the instability of carotid atherosclerotic plaque by serum level of MMP-9, MCP-1 and MMP-7]. (2015 Oct)Li FShanghai Kou Qiang Yi Xue
15990071Subacute cutaneous lupus erythematosus: 25-year evolution of a prototypic subset (subphenotype) of lupus erythematosus defined by characteristic cutaneous, pathological, immunological, and genetic findings. (2005 Jun)Sontheimer RDAutoimmun Rev
27170480Genetic factors associated with the development of age-related macular degeneration. (2016)Sergejeva OMedicina (Kaunas)
9211568Molecular genetic aspects of alcohol metabolism and alcoholism. (1997 May)Agarwal DPPharmacopsychiatry
2894391Specific modulation by ethanol of the protein synthesis pattern in the C2 rat hepatoma cell line. (1988 Feb)Chobert MNJ Hepatol
25345946[Correlation of polymorphisms of adiponectin receptor 2 gene +33371Gln/Arg, cytochrome P4502E1 gene Rsa I and smoking with nonalcoholic fatty liver disease]. (2014 Oct)Zhang CNan Fang Yi Ke Da Xue Xue Bao
20401433Genetic polymorphism of alcohol-metabolizing enzyme and alcohol dependence in Polish men. (2010 Mar)Cichoz-Lach HBraz J Med Biol Res
22273503Association of polymorphisms in C2, CFB and C3 with exudative age-related macular degeneration in a Korean population. (2012 Mar)Kim SJExp Eye Res
10754425The human serotonin receptor gene (HTR2) MspI polymorphism in Japanese schizophrenic and alcoholic patients. (2000)Yoshihara ENeuropsychobiology
21432295Genetic polymorphisms ofCYP2A6 andCYP2E1 with tobacco smoking is not associated with risk of urothelial cancer. (2002 Jul)Tsukino HEnviron Health Prev Med
15615180[Subarachnoidal hemorrhage from saccular aneurysms as a cause of natural death]. (2004 Jul-Aug)Nikolic SSrp Arh Celok Lek
15318112ADH1B*1, ADH1C*2, DRD2 (-141C Ins), and 5-HTTLPR are associated with alcoholism in Mexican American men living in Los Angeles. (2004 Aug)Konishi TAlcohol Clin Exp Res
27026963OUTCOME OF ROTATOR CUFF REPAIR IN SNYDER TYPE Cl AND C2 LESIONS, CONSIDERING SMOKERS AND NONSMOKERS. (2010 Nov-Dec)Junior SCRev Bras Ortop
11748356Association between polymorphisms of ethanol-metabolizing enzymes and susceptibility to alcoholic cirrhosis in a Korean male population. (2001 Dec)Lee HCJ Korean Med Sci
11323399Effects of occupation, lifestyle and genetic polymorphisms of CYP1A1, CYP2E1, GSTM1 and GSTT1 on urinary 1-hydroxypyrene and 2-naphthol concentrations. (2001 May)Nan HMCarcinogenesis
23262287Cigarette smoke and muscle catabolism in C2 myotubes. (2013 Jan-Feb)Rom OMech Ageing Dev
8135667[Relationship between alcoholism and genotypes of acetaldehyde-metabolizing enzymes]. (1994 Feb)Iwahashi KArukoru Kenkyuto Yakubutsu Ison
21447678Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration. (2011 Jun 28)Yu YInvest Ophthalmol Vis Sci
21187017[Study on the association between genetic polymorphism of CYP2E1, GSTM1 and susceptibility of lung cancer]. (2005 Feb 20)Li DZhongguo Fei Ai Za Zhi
12211622Contribution of genetic polymorphisms in ethanol-metabolizing enzymes to problem drinking behavior in middle-aged Japanese men. (2002 Jul)Sun FBehav Genet
29643318Plasma Xanthine Oxidoreductase Activity as a Novel Biomarker of Metabolic Disorders in a General Population. (2018 Apr 10)Furuhashi MCirc J
19796841CYP2E1 Rsa I/Pst I polymorphism is associated with lung cancer risk among Asians. (2010 Jul)Zhan PLung Cancer
12759747Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and the risk of hepatocellular carcinoma. (2003 Jun)Munaka MJ Cancer Res Clin Oncol
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