Gene: TPM3

7170
CAPM1|CFTD|HEL-189|HEL-S-82p|NEM1|OK/SW-cl.5|TM-5|TM3|TM30|TM30nm|TM5|TPM3nu|TPMsk3|TRK|hscp30
tropomyosin 3
protein-coding
1q21.3
Ensembl:ENSG00000143549 MIM:191030 Vega:OTTHUMG00000035853 UniprotKB:P06753
NG_008621.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.285e-1 (AD)  6.831e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13740187chr1:154164699TPM3Promoter7.132e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARPC20.951
CDC420.923
POLE30.915
ACTR20.912
DSTN0.912
UBE2D20.912
RAB11A0.911
SUMO30.911
CHMP4B0.91
MYL12B0.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.751
OR4F29-0.736
KCNK5-0.234
MTRNR2L6-0.23
MTRNR2L10-0.217
VNN3-0.207
FAM151A-0.204
ZBTB20-0.197
NXNL1-0.197
MTRNR2L9-0.195

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB12695Phenethyl IsothiocyanateSmall Molecule2257-09-2InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of TPM3 mRNA"19162173
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TPM3 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether affects the splicing of TPM3 mRNA alternative form"25614096
C5736932-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in increased expression of TPM3 mRNA22193206
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TPM3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TPM3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TPM3 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TPM3 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TPM3 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TPM3 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TPM3 mRNA"12376462|1521517
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TPM3 mRNA"25380136
D000082AcetaminophenAcetaminophen affects the expression of TPM3 mRNA17562736
D000171AcroleinAcrolein results in increased metabolism of TPM3 protein17570602
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in increased expression of TPM3 protein26072098|2659704
D019804MesalamineMesalamine results in decreased expression of TPM3 mRNA alternative form19369484
D019804MesalamineMesalamine results in decreased expression of TPM3 protein alternative form19369484
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TPM3 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TPM3 mRNA24449571
D001151ArsenicArsenic affects the methylation of TPM3 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of TPM3 protein19364129
D001280AtrazineAtrazine results in decreased expression of TPM3 mRNA25929836
D001280AtrazineAtrazine results in increased expression of TPM3 mRNA23358194
D001280AtrazineAtrazine results in decreased expression of TPM3 protein25275270
C547126AZM551248AZM551248 results in decreased expression of TPM3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TPM3 mRNA19770486
D004958EstradiolEstradiol results in increased expression of TPM3 mRNA16474171
D004958EstradiolEstradiol results in decreased expression of TPM3 mRNA19484750
D004958EstradiolEstradiol results in increased expression of TPM3 mRNA20068009
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in decreased expression of TPM3 mRNA25270620
C044887beta-methylcholinebeta-methylcholine affects the expression of TPM3 mRNA21179406
C095105bexarotenebexarotene results in increased expression of TPM3 mRNA16648578
C110172BHTOH-QMBHTOH-QM binds to TPM3 protein16533022
C006780bisphenol Abisphenol A results in increased expression of TPM3 mRNA16474171
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TPM3 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of TPM3 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TPM3 mRNA28628672
D001761BleomycinBleomycin results in increased expression of TPM3 protein25933445
D002065BuspironeBuspirone results in decreased expression of TPM3 mRNA24136188
C018475butyraldehydebutyraldehyde results in increased expression of TPM3 mRNA26079696
D002104CadmiumCadmium results in increased expression of TPM3 mRNA18522720
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of TPM3 mRNA16644059
D002273CarcinogensCarcinogens results in increased expression of TPM3 mRNA16316942
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TPM3 mRNA23650126
C039671ciglitazoneciglitazone results in increased expression of TPM3 mRNA22193206
D002922CiguatoxinsCiguatoxins affects the expression of TPM3 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of TPM3 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of TPM3 mRNA24386269
D003042CocaineCocaine affects the expression of TPM3 mRNA20187946
D003300CopperCopper results in decreased expression of TPM3 protein22480594
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of TPM3 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of TPM3 mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of TPM3 protein19616320
D016572CyclosporineCyclosporine results in decreased expression of TPM3 mRNA19770486
C014347decitabinedecitabine affects the expression of TPM3 mRNA23300844
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of TPM3 mRNA]21095227
C014347decitabinedecitabine results in decreased expression of TPM3 protein19294695
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TPM3 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TPM3 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TPM3 mRNA17379624
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TPM3 mRNA21266533
D002945CisplatinCisplatin affects the expression of TPM3 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of TPM3 mRNA22023808
D002945CisplatinCisplatin results in decreased expression of TPM3 protein22023808
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TPM3 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TPM3 mRNA19638242|2036093
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of TPM3 mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of TPM3 mRNA"12376462
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of TPM3 mRNA25380136
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of TPM3 mRNA22193206
D004317DoxorubicinDoxorubicin results in increased oxidation of TPM3 protein28818578
C070609EMD 53998EMD 53998 analog results in decreased expression of TPM3 mRNA24977338
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TPM3 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TPM3 protein20227414
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TPM3 mRNA17555576|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TPM3 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TPM3 mRNA23649840
D018120FinasterideFinasteride results in increased expression of TPM3 mRNA24136188
D005411Flame RetardantsFlame Retardants results in increased expression of TPM3 protein18550172
D005485FlutamideFlutamide results in increased expression of TPM3 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of TPM3 mRNA23649840
D019833GenisteinGenistein results in increased expression of TPM3 mRNA16474171
D005839GentamicinsGentamicins results in increased expression of TPM3 mRNA22061828
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of TPM3 mRNA22634610
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of TPM3 protein]23178681
D006820Hyaluronic AcidHyaluronic Acid analog results in decreased expression of TPM3 protein23178681
C029424hydrazinehydrazine results in increased expression of TPM3 protein15370871
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of TPM3 protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of TPM3 protein23178681
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TPM3 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TPM3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TPM3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TPM3 mRNA28628672
C410337K 7174K 7174 results in decreased expression of TPM3 mRNA24086573
D048628KetolidesKetolides analog results in increased expression of TPM3 mRNA24967691
D007854LeadLead affects the expression of TPM3 mRNA28903495
D064704LevofloxacinLevofloxacin results in decreased expression of TPM3 mRNA24136188
D001556LindaneLindane affects the expression of TPM3 mRNA17785943
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TPM3 mRNA16415329
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of TPM3 mRNA27544571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TPM3 mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TPM3 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of TPM3 protein"22001959
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of TPM3 mRNA25380136
C051752nefazodonenefazodone results in increased expression of TPM3 mRNA24136188
D009532NickelNickel results in increased expression of TPM3 mRNA25583101
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of TPM3 mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of TPM3 protein19716841
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of TPM3 mRNA20971185
C025589ochratoxin Aochratoxin A results in increased expression of TPM3 mRNA22124623
D010047Ovalbumin[Particulate Matter co-treated with Ovalbumin] results in increased expression of TPM3 mRNA19176365
D052638Particulate MatterParticulate Matter results in increased expression of TPM3 mRNA24769257
D052638Particulate Matter[Particulate Matter co-treated with Ovalbumin] results in increased expression of TPM3 mRNA19176365
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TPM3 mRNA"25510870
C087058penconazolepenconazole results in increased expression of TPM3 mRNA23811263
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of TPM3 protein18550172
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TPM3 mRNA19162173
C058305phenethyl isothiocyanateTPM3 protein binds to phenethyl isothiocyanate21838287
C006253pirinixic acidpirinixic acid results in decreased expression of TPM3 mRNA18445702
C006253pirinixic acidpirinixic acid results in decreased expression of TPM3 mRNA19162173
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of TPM3 mRNA16474171
D059808PolyphenolsPolyphenols results in decreased expression of TPM3 mRNA16293270
D011899Ranitidine[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TPM3 mRNA16415329
C059514resveratrolresveratrol results in decreased expression of TPM3 protein25505154
C089730rosiglitazonePPARG protein promotes the reaction [rosiglitazone results in decreased expression of TPM3 protein alternative form]19369484
C089730rosiglitazonerosiglitazone affects the expression of TPM3 protein19556978
C089730rosiglitazonerosiglitazone results in decreased expression of TPM3 protein alternative form19369484
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of TPM3 mRNA]21095227
C009277sodium arsenatesodium arsenate results in increased expression of TPM3 mRNA23922661
C017947sodium arsenitesodium arsenite results in increased expression of TPM3 protein23570992
C016104sodium bichromatesodium bichromate results in increased expression of TPM3 mRNA25993096
D012969Sodium FluorideSodium Fluoride results in increased expression of TPM3 protein28918527
D012999SomanSoman results in increased expression of TPM3 mRNA19281266
D053260SootSoot results in increased expression of TPM3 mRNA26551751
D012460SulfasalazineSulfasalazine results in decreased expression of TPM3 mRNA alternative form19369484
D012460SulfasalazineSulfasalazine results in decreased expression of TPM3 protein alternative form19369484
D013629TamoxifenTamoxifen affects the expression of TPM3 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TPM3 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TPM3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TPM3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TPM3 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TPM3 mRNA16054898
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine affects the expression of TPM3 protein"25852303
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TPM3 mRNA28943392
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TPM3 protein22609517
D014212TretinoinTretinoin results in decreased expression of TPM3 mRNA23724009
C012589trichostatin Atrichostatin A results in decreased expression of TPM3 mRNA15901671
C012589trichostatin Atrichostatin A results in decreased expression of TPM3 protein19294695
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TPM3 mRNA"26179874
C080163trovafloxacintrovafloxacin results in decreased expression of TPM3 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of TPM3 mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of TPM3 mRNA23179753|2800136
D014640VancomycinVancomycin results in decreased expression of TPM3 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TPM3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI14743216  16189514  17353931  21516116  23892143  25416956  
25910212  27107012  
GO:0051015actin filament binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-IBA21873635  
GO:0006936muscle contraction-TAS-  
GO:0007015actin filament organization-IBA21873635  
GO:0030049muscle filament sliding-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001725stress fiber-IDA16236705  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-NAS3418707  
GO:0005856cytoskeleton-TAS16130169  
GO:0005862muscle thin filament tropomyosin-TAS3018581  
GO:0005884actin filament-IBA21873635  
GO:0015629actin cytoskeleton-IDA-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04260Cardiac muscle contraction
hsa05200Pathways in cancer
hsa05216Thyroid cancer
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-390522Striated Muscle ContractionTAS
R-HSA-397014Muscle contractionTAS
R-HSA-445355Smooth Muscle ContractionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18242762EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas. (2008 Aug)Shinmura KLung Cancer
25567305[Detection of ROS1 gene rearrangement by FISH and analysis of its clinical features in non-small cell lung cancer patients]. (2014 Oct)Cheng HZhonghua Zhong Liu Za Zhi
25180059Detecting ALK, ROS1 and RET Fusion Genes in Cell Block Samples. (2014 Jun)Zhao CTransl Oncol
26200269Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung. (2015 Aug)Shim HSJ Thorac Oncol