Gene: TPMT

7172
TPMTD
thiopurine S-methyltransferase
protein-coding
6p22.3
Ensembl:ENSG00000137364 MIM:187680 Vega:OTTHUMG00000014317 UniprotKB:P51580
NG_012137.2
PubMed
0   ANCO-SNPs
ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.991e-3 (AD)  2.200e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MPC20.905
PFN20.903
KCMF10.898
GAP430.895
YWHAZ0.895
UGP20.893
NDUFA50.893
UBE2E30.892
RNF110.89
VPS290.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.688
OR4F29-0.638
ZBTB20-0.332
TRPV5-0.313
VNN3-0.303
CNN2-0.3
CSAG1-0.292
SGMS2-0.29
SH2D1A-0.289
ANXA13-0.289

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01250OlsalazineSmall Molecule15722-48-2ApprovedTarget
DB00436BendroflumethiazideSmall Molecule73-48-3ApprovedEnzyme
DB00993AzathioprineSmall Molecule446-86-6ApprovedEnzyme
DB01021TrichlormethiazideSmall Molecule133-67-5ApprovedEnzyme
DB01033MercaptopurineSmall Molecule50-44-2ApprovedEnzyme
DB01327CefazolinSmall Molecule25953-19-9ApprovedEnzyme
ID Drug Name Action PubMed
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of TPMT mRNA"28433925
C0512682-hydroxychavicol2-hydroxychavicol results in increased expression of TPMT mRNA15331132
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to TPMT protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TPMT protein]26598702
C5402574-methylbenzenethiol[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol20196537
C5402574-methylbenzenethiol[S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol20196537
C5864634-nitrobenzenthiol[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol20196537
C5864634-nitrobenzenthiolS-Adenosylmethionine analog inhibits the reaction [[S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol]20196537
C5864634-nitrobenzenthiol[S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol20196537
C5864634-nitrobenzenthiolS-Adenosylmethionine inhibits the reaction [[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol]20196537
D000082AcetaminophenAcetaminophen affects the expression of TPMT mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of TPMT mRNA28959563
D012436S-Adenosylmethionine[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol20196537
D012436S-Adenosylmethionine[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol20196537
D012436S-AdenosylmethionineS-Adenosylmethionine analog inhibits the reaction [[S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol]20196537
D012436S-Adenosylmethionine[S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol20196537
D012436S-Adenosylmethionine[S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol20196537
D012436S-AdenosylmethionineS-Adenosylmethionine inhibits the reaction [[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol]20196537
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TPMT mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TPMT mRNA24449571
D001151ArsenicArsenic affects the methylation of TPMT gene25304211
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TPMT protein]26598702
D001379AzathioprineAzathioprine affects the activity of TPMT protein15571267
D001379AzathioprineTPMT gene affects the susceptibility to Azathioprine12168480|1226996
D001379AzathioprineTPMT gene polymorphism affects the susceptibility to Azathioprine12509611|1450512
D001379AzathioprineTPMT gene SNP affects the susceptibility to Azathioprine17206640|1904824
D001379AzathioprineTPMT polymorphism affects the susceptibility to Azathioprine15792824
D001379AzathioprineTPMT promoter polymorphism affects the susceptibility to Azathioprine15349717
D001379AzathioprineTPMT protein affects the metabolism of Azathioprine15349717
D001379AzathioprineTPMT protein affects the metabolism of Azathioprine11518009|1579282
D001539BendroflumethiazideBendroflumethiazide results in decreased activity of TPMT protein8866635
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TPMT mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TPMT mRNA20440473
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TPMT mRNA"19150397
D004958EstradiolEstradiol results in decreased expression of TPMT mRNA17982697
D004958Estradiol[Parathion co-treated with Estradiol] results in decreased expression of TPMT mRNA17982697
C006780bisphenol Abisphenol A results in decreased expression of TPMT mRNA26063408
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of TPMT mRNA"28433925
C006780bisphenol Abisphenol A results in decreased expression of TPMT mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of TPMT mRNA22079614
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TPMT mRNA19031917
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TPMT mRNA23741332
D004390ChlorpyrifosChlorpyrifos results in increased expression of TPMT mRNA26494550
D004390Chlorpyrifos[Malathion co-treated with Chlorpyrifos] results in decreased expression of TPMT mRNA26494550
D002994ClofibrateClofibrate results in decreased expression of TPMT mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of TPMT mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of TPMT mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of TPMT mRNA19770486|2383089
D002945CisplatinCisplatin results in increased expression of TPMT mRNA27594783
D002945CisplatinTPMT gene SNP affects the susceptibility to Cisplatin19898482
C000944dicrotophosdicrotophos results in decreased expression of TPMT mRNA28302478
C121718dicyclanildicyclanil results in increased expression of TPMT mRNA15664270
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of TPMT mRNA26924002
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of TPMT mRNA"28433925
C024629dimethyl phthalatedimethyl phthalate results in increased expression of TPMT mRNA26924002
D004237DiuronDiuron results in decreased expression of TPMT mRNA21551480
C024565ethylene dichlorideethylene dichloride results in decreased expression of TPMT mRNA28189721
D005472FluorouracilTPMT protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]18927307
C039281furanfuran results in increased methylation of TPMT gene22079235
D005665FurosemideFurosemide results in decreased activity of TPMT protein8866635
D005839GentamicinsGentamicins results in decreased expression of TPMT protein22061828
D005839GentamicinsGentamicins results in increased expression of TPMT mRNA22061828
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TPMT mRNA25613284
C051890irinotecanirinotecan analog results in increased expression of TPMT mRNA18927307
C051890irinotecanTPMT protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]18927307
D008294Malathion[Malathion co-treated with Chlorpyrifos] results in decreased expression of TPMT mRNA26494550
D008294MalathionMalathion results in decreased expression of TPMT mRNA26494550
D015122MercaptopurineTPMT gene polymorphism affects the susceptibility to Mercaptopurine14505127
D015122MercaptopurineTPMT protein affects the metabolism of Mercaptopurine12509611
D015122MercaptopurineTPMT protein affects the metabolism of Mercaptopurine16044099
D008727MethotrexateMethotrexate results in decreased expression of TPMT mRNA24449571
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TPMT mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TPMT mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TPMT mRNA"25554681
C022838nickel chloridenickel chloride affects the expression of TPMT mRNA22110744
C028007nickel monoxidenickel monoxide results in increased expression of TPMT mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TPMT mRNA25729387
C016030pantogabpantogab results in decreased expression of TPMT mRNA17379144
D010278Parathion[Parathion co-treated with Estradiol] results in decreased expression of TPMT mRNA17982697
D010278ParathionParathion results in increased expression of TPMT mRNA17982697
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TPMT mRNA23978341
D010634PhenobarbitalPhenobarbital results in increased expression of TPMT mRNA19270015
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TPMT mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of TPMT mRNA17426115
D010936Plant ExtractsPlant Extracts results in increased expression of TPMT mRNA23557933
C015586propiverinepropiverine binds to TPMT protein29273565
C009237senecioninesenecionine results in increased expression of TPMT mRNA26100227
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TPMT mRNA23221170
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TPMT mRNA21570461
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of TPMT mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TPMT mRNA25270620
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TPMT mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TPMT mRNA25613284
D013806TheophyllineTheophylline results in increased expression of TPMT mRNA16083514
D013866ThioguanineTPMT protein affects the metabolism of Thioguanine16044099
C009495titanium dioxidetitanium dioxide affects the expression of TPMT mRNA17656681
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TPMT mRNA25729387
D014237TrichlormethiazideTrichlormethiazide results in decreased activity of TPMT protein8866635
C012589trichostatin Atrichostatin A affects the expression of TPMT mRNA28542535
C057693troglitazonetroglitazone results in increased expression of TPMT mRNA28973697
C057693troglitazonetroglitazone results in decreased expression of TPMT protein21315101
D014635Valproic AcidValproic Acid affects the expression of TPMT mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TPMT mRNA23179753|2519280
D014640VancomycinVancomycin results in increased expression of TPMT mRNA18930951
C025643vinclozolinvinclozolin affects the expression of TPMT mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of TPMT mRNA18042343
C029297vinylidene chloridevinylidene chloride results in decreased expression of TPMT mRNA26682919
C111237vorinostatvorinostat results in increased expression of TPMT mRNA27188386
C111237vorinostatvorinostat results in increased expression of TPMT protein17593366

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008119thiopurine S-methyltransferase activity-IBA21873635  
GO:0008119thiopurine S-methyltransferase activity-IDA657528  18484748  
GO:0008119thiopurine S-methyltransferase activity-TAS-  
GO:1904047S-adenosyl-L-methionine binding-IDA657528  18484748  
GO ID GO Term Qualifier Evidence PubMed
GO:0006139nucleobase-containing compound metabolic process-TAS8316220  
GO:0017144drug metabolic process-IDA657528  18484748  
GO:0032259methylation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00983Drug metabolism - other enzymes
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156581MethylationTAS
R-HSA-1643685DiseaseTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-5578995Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)TAS
R-HSA-5579029Metabolic disorders of biological oxidation enzymesTAS
R-HSA-5668914Diseases of metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24548628Genetic variation at the CYP2C19 gene associated with metabolic syndrome susceptibility in a South Portuguese population: results from the pilot study of the European Health Examination Survey in Portugal. (2014 Feb 18)Gaio VDiabetol Metab Syndr
8392551Diethyldithiocarbamate S-methylation: evidence for catalysis by human liver thiol methyltransferase and thiopurine methyltransferase. (1993 Jul)Glauser TAJ Pharmacol Exp Ther
9780130Clinical implications of thiopurine methyltransferase--optimization of drug dosage and potential drug interactions. (1998 Oct)Lennard LTher Drug Monit
22385887High prevalence of polymorphism and low activity of thiopurine methyltransferase in patients with inflammatory bowel disease. (2012 Apr)Larussa TEur J Intern Med
25968584Body Mass Index and Smoking Affect Thioguanine Nucleotide Levels in Inflammatory Bowel Disease. (2015 Aug)Poon SSJ Crohns Colitis
23845145Risk factors for serious adverse effects of thiopurines in patients with Crohn's disease. (2013 Jul)Mazor YCurr Drug Saf