Gene: TPR

7175
-
translocated promoter region, nuclear basket protein
protein-coding
1q31.1
Ensembl:ENSG00000047410 MIM:189940 Vega:OTTHUMG00000035580 UniprotKB:P12270
NG_023284.1
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.045e-1 (AD)  8.244e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NBR10.907
SAMD80.895
KCTD200.89
RSF10.89
SEC630.888
CPSF20.886
SETX0.883
COPB20.882
USP80.875
EIF3A0.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.648
OR4F29-0.642
MMP23B-0.198
NANOGNB-0.195
MOGAT2-0.194
MUC12-0.182
EPPIN-0.178
PRAMEF8-0.174
RAX2-0.171
MBD3L3-0.17

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02240Quinacrine mustardSmall Molecule64046-79-3ExperimentalTarget
DB03147Flavin adenine dinucleotideSmall Molecule146-14-5ApprovedTarget
DB03470TrypanothioneSmall MoleculeExperimentalTarget
DB04299Maleic AcidSmall Molecule110-16-7ExperimentalTarget
ID Drug Name Action PubMed
C02017516 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione"16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in decreased expression of TPR mRNA"20519331
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TPR mRNA"27291303
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TPR mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of TPR mRNA"23829299
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPR mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of TPR mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TPR mRNA19770486
D001280AtrazineAtrazine results in decreased expression of TPR mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of TPR mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TPR mRNA21715664
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TPR mRNA"20018196|2623829
D004958EstradiolEstradiol results in decreased expression of TPR mRNA20068009
C044887beta-methylcholinebeta-methylcholine affects the expression of TPR mRNA21179406
D001710BiotinBiotin results in increased expression of TPR mRNA15219929
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TPR mRNA28628672
C006780bisphenol Abisphenol A affects the expression of TPR mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TPR mRNA27339419
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of TPR mRNA19395590
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of TPR mRNA24763279
D002737ChloropreneChloroprene results in increased expression of TPR mRNA23125180
D016572CyclosporineCyclosporine results in decreased expression of TPR mRNA19770486
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of TPR mRNA23640034
D013759DronabinolDronabinol results in increased expression of TPR mRNA16597638
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TPR mRNA28628672
D004237DiuronDiuron results in decreased expression of TPR mRNA25152437
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TPR protein23301498
C000499ferric oxideferric oxide analog results in decreased expression of TPR mRNA24525745
D018120FinasterideFinasteride results in increased expression of TPR mRNA24136188
D005485FlutamideFlutamide results in increased expression of TPR mRNA24136188
C001277geldanamycingeldanamycin results in increased expression of TPR mRNA26705709
D019833GenisteinESR1 promotes the reaction [Genistein results in decreased expression of TPR protein]20884965
D019833GenisteinGenistein results in decreased expression of TPR protein20884965
D005839GentamicinsGentamicins results in increased expression of TPR mRNA22061828
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of TPR mRNA24763279
D017313FenretinideFenretinide results in decreased expression of TPR mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of TPR mRNA18951874
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TPR mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TPR mRNA28628672
D048628KetolidesKetolides analog results in increased expression of TPR mRNA24967691
D008627Mercuric ChlorideMercuric Chloride affects the expression of TPR mRNA20353558
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TPR mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TPR mRNA26272509
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TPR mRNA"26251327
D009538NicotineNicotine results in increased expression of TPR mRNA16949557
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TPR mRNA25729387
C410127PCB 180PCB 180 results in decreased expression of TPR mRNA23829299
C087058penconazolepenconazole results in increased expression of TPR mRNA23811263
D010416PentachlorophenolPentachlorophenol results in increased expression of TPR mRNA23892564
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of TPR mRNA17616710
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of TPR mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of TPR mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of TPR mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPR mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TPR mRNA26272509
D010758PhosphorusPhosphorus results in increased expression of TPR mRNA17715259
C006253pirinixic acidpirinixic acid results in decreased expression of TPR mRNA17426115
C443641poly(propyleneimine)poly(propyleneimine) analog results in increased expression of TPR mRNA16308212
C059514resveratrolresveratrol results in decreased expression of TPR protein25505154
C059514resveratrolresveratrol results in decreased expression of TPR mRNA25905778
C089730rosiglitazonerosiglitazone results in decreased expression of TPR mRNA25572481
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of TPR mRNA19244175
D012643SeleniumSelenium results in decreased expression of TPR mRNA19244175
D012715Sesame OilSesame Oil results in increased expression of TPR mRNA29191790
C017947sodium arsenitesodium arsenite results in decreased expression of TPR mRNA12679051
C061133tamibarotenetamibarotene results in decreased expression of TPR mRNA15498508
C004648testosterone enanthatetestosterone enanthate affects the expression of TPR mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TPR mRNA18691609|2157046
D013849ThimerosalThimerosal results in decreased expression of TPR mRNA27188386
D014050TolueneToluene results in decreased expression of TPR mRNA22166486
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TPR mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of TPR mRNA23228038
D014212TretinoinTretinoin results in decreased expression of TPR mRNA15498508|2193413
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPR mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TPR mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of TPR mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of TPR mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in decreased methylation of TPR gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TPR gene25560391
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of TPR mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of TPR mRNA19244175
C111237vorinostatvorinostat results in decreased expression of TPR mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IDA17897941  
GO:0003723RNA binding-HDA22658674  
GO:0003729mRNA binding-IDA17897941  
GO:0005215transporter activityNOTIMP11952838  
GO:0005515protein binding-IPI12802065  15654337  17897941  18794356  18981471  19273613  
20133940  22253824  24581499  24970816  
GO:0015631tubulin binding-IDA20133940  
GO:0017056structural constituent of nuclear pore-IDA22253824  
GO:0031072heat shock protein binding-IDA17897941  
GO:0042803protein homodimerization activity-IDA11514627  12802065  
GO:0043495protein membrane anchorNOTIMP12802065  
GO:0051019mitogen-activated protein kinase binding-IDA18794356  
GO:0070840dynein complex binding-IDA20133940  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP21613532  
GO:0006404RNA import into nucleus-IDA9864356  
GO:0006405RNA export from nucleus-IMP11952838  
GO:0006406mRNA export from nucleus-TAS-  
GO:0006606protein import into nucleusNOTIDA9864356  
GO:0006606protein import into nucleus-IMP18794356  
GO:0006606protein import into nucleusNOTIMP11952838  
GO:0006611protein export from nucleusNOTIMP11952838  
GO:0006999nuclear pore organization-IMP15229283  
GO:0006999nuclear pore organizationNOTIMP11952838  
GO:0007094mitotic spindle assembly checkpoint-IBA21873635  
GO:0007094mitotic spindle assembly checkpoint-IMP18981471  20133940  
GO:0010793regulation of mRNA export from nucleusNOTIMP22253824  
GO:0010965regulation of mitotic sister chromatid separation-IMP20133940  
GO:0016032viral process-TAS-  
GO:0031453positive regulation of heterochromatin assembly-IMP20407419  
GO:0031647regulation of protein stabilityNOTIMP21613532  
GO:0031990mRNA export from nucleus in response to heat stress-IDA17897941  
GO:0034605cellular response to heat-IDA17897941  
GO:0035457cellular response to interferon-alpha-ISS-  
GO:0042306regulation of protein import into nucleusNOTIMP22253824  
GO:0042307positive regulation of protein import into nucleus-IMP18794356  
GO:0043578nuclear matrix organizationNOTIMP11952838  
GO:0045947negative regulation of translational initiation-IMP21613532  
GO:0046825regulation of protein export from nucleusNOTIMP22253824  
GO:0046827positive regulation of protein export from nucleus-ISS-  
GO:0046832negative regulation of RNA export from nucleus-IDA22253824  
GO:0046832negative regulation of RNA export from nucleus-IMP21613532  
GO:0051292nuclear pore complex assemblyNOTIMP12802065  
GO:0051301cell division-IEA-  
GO:0070849response to epidermal growth factor-IDA18794356  
GO:0090267positive regulation of mitotic cell cycle spindle assembly checkpoint-IMP19273613  
GO:0090316positive regulation of intracellular protein transport-IMP19273613  
GO:1901673regulation of mitotic spindle assembly-IMP19273613  
GO ID GO Term Qualifier Evidence PubMed
GO:0000776kinetochore-IDA20133940  
GO:0000776kinetochoreNOTIDA19273613  
GO:0000776kinetochorecolocalizes_withIDA18981471  
GO:0005634nucleus-IDA15654337  
GO:0005635nuclear envelope-IDA17098863  24970816  
GO:0005643nuclear pore-IBA21873635  
GO:0005643nuclear pore-IDA9828100  9864356  11514627  12802065  18981471  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA11952838  12802065  
GO:0005868cytoplasmic dynein complex-IDA20133940  
GO:0019898extrinsic component of membrane-IDA12802065  
GO:0031965nuclear membrane-IDA9024684  9828100  9864356  11514627  11839768  11952838  12802065  15229283  18794356  20407419  22253824  
GO:0034399nuclear periphery-IDA9024684  11514627  11839768  11952838  15229283  22401879  
GO:0042405nuclear inclusion body-IDA11514627  11839768  
GO:0044615nuclear pore nuclear basket-IDA9024684  11839768  15229283  
GO:0072686mitotic spindle-IDA20133940  
KEGG ID KEGG Term
hsa03013RNA transport
hsa05200Pathways in cancer
hsa05216Thyroid cancer
Reactome ID Reactome Term Evidence
R-HSA-1169408ISG15 antiviral mechanismTAS
R-HSA-1169410Antiviral mechanism by IFN-stimulated genesTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1430728MetabolismTAS
R-HSA-159227Transport of the SLBP independent Mature mRNATAS
R-HSA-159230Transport of the SLBP Dependant Mature mRNATAS
R-HSA-159231Transport of Mature mRNA Derived from an Intronless TranscriptTAS
R-HSA-159234Transport of Mature mRNAs Derived from Intronless TranscriptsTAS
R-HSA-159236Transport of Mature mRNA derived from an Intron-Containing TranscriptTAS
R-HSA-162587HIV Life CycleTAS
R-HSA-162599Late Phase of HIV Life CycleTAS
R-HSA-162906HIV InfectionIEA
R-HSA-162906HIV InfectionTAS
R-HSA-162909Host Interactions of HIV factorsIEA
R-HSA-162909Host Interactions of HIV factorsTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-1643685DiseaseIEA
R-HSA-165054Rev-mediated nuclear export of HIV RNATAS
R-HSA-168253Host Interactions with Influenza FactorsTAS
R-HSA-168254Influenza InfectionTAS
R-HSA-168255Influenza Life CycleTAS
R-HSA-168256Immune SystemTAS
R-HSA-168271Transport of Ribonucleoproteins into the Host NucleusTAS
R-HSA-168273Influenza Viral RNA Transcription and ReplicationTAS
R-HSA-168274Export of Viral Ribonucleoproteins from NucleusTAS
R-HSA-168276NS1 Mediated Effects on Host PathwaysTAS
R-HSA-168325Viral Messenger RNA SynthesisTAS
R-HSA-168333NEP/NS2 Interacts with the Cellular Export MachineryTAS
R-HSA-170822Regulation of Glucokinase by Glucokinase Regulatory ProteinTAS
R-HSA-176033Interactions of Vpr with host cellular proteinsTAS
R-HSA-177243Interactions of Rev with host cellular proteinsIEA
R-HSA-177243Interactions of Rev with host cellular proteinsTAS
R-HSA-180746Nuclear import of Rev proteinIEA
R-HSA-180910Vpr-mediated nuclear import of PICsTAS
R-HSA-191859snRNP AssemblyTAS
R-HSA-194441Metabolism of non-coding RNATAS
R-HSA-211000Gene Silencing by RNATAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2980766Nuclear Envelope BreakdownTAS
R-HSA-2990846SUMOylationTAS
R-HSA-2990846SUMOylationIEA
R-HSA-3108214SUMOylation of DNA damage response and repair proteinsTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsIEA
R-HSA-3301854Nuclear Pore Complex (NPC) DisassemblyTAS
R-HSA-3371453Regulation of HSF1-mediated heat shock responseTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-4551638SUMOylation of chromatin organization proteinsTAS
R-HSA-4570464SUMOylation of RNA binding proteinsTAS
R-HSA-4615885SUMOylation of DNA replication proteinsIEA
R-HSA-4615885SUMOylation of DNA replication proteinsTAS
R-HSA-5578749Transcriptional regulation by small RNAsTAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619107Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)TAS
R-HSA-5619115Disorders of transmembrane transportersTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-5663205Infectious diseaseIEA
R-HSA-597592Post-translational protein modificationTAS
R-HSA-597592Post-translational protein modificationIEA
R-HSA-6784531tRNA processing in the nucleusTAS
R-HSA-68875Mitotic ProphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-70171GlycolysisTAS
R-HSA-70326Glucose metabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS
R-HSA-72202Transport of Mature Transcript to CytoplasmTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-72306tRNA processingTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953854Metabolism of RNATAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
8088267Lymphocyte beta-adrenergic receptors in young subjects with peripheral or central obesity: relationship with central haemodynamics and left ventricular function. (1994 Jun)Merlino GEur Heart J
18627323Effect of two low-dose gestodene containing monophasic oral contraceptives on hemostasis in Bulgarian women. (2008 Aug)Uchikova EExpert Opin Pharmacother
23925944Nicotine induces alteration of H3K27 demethylase UTX in kidney cancer cell. (2014 Mar)Guo XHum Exp Toxicol