Gene info: ID 718

Gene: C3

GENE ID: 718

Synonyms: AHUS5|ARMD9|ASP|C3a|C3b|CPAMD1|HEL-S-62p

Description: complement C3

Gene type: protein-coding

Location: 19p13.3

dbXrefs: Ensembl:ENSG00000125730 MIM:120700 Vega:OTTHUMG00000150335 UniprotKB:P01024

RefSeq: NG_009557.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 134

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.674e-1 (AD) 3.001e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
AIF1	0.945
CSF1R	0.937
APBB1IP	0.925
LAPTM5	0.924
C1QA	0.924
LY86	0.922
C1QC	0.917
CD74	0.916
ITGB2	0.916
SYK	0.915

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HES5	-0.411
ATP2C2	-0.348
ZSCAN1	-0.337
KCNIP3	-0.322
FAM180B	-0.319
ATOH7	-0.318
WNT7A	-0.315
ARSF	-0.313
CPLX3	-0.311
MARCH4	-0.306

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02147	Cyclo-Tetrametavanadate	Small Molecule		Experimental	Target
DB00028	Immune Globulin Human	BiotechDrug	9007-83-4	Approved\|Investigational	Target
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB01915	S-Hydroxycysteine	Small Molecule	-	Experimental	Target
DB06492	Mirococept	BiotechDrug	507453-82-9	Investigational	Target
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C541120	11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol	"11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol inhibits the reaction [Cadmium Chloride results in increased expression of C3 mRNA]"	22127542
C541120	11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol	"11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol inhibits the reaction [Estradiol results in increased expression of C3 mRNA]"	22127542
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of C3 mRNA"	18281256
C033146	1-hydroxypyrene	1-hydroxypyrene results in increased expression of C3 mRNA	22989670
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of C3 protein"	21673325
C035476	2,2',4,4'-tetrahydroxybenzophenone	"2,2',4,4'-tetrahydroxybenzophenone results in increased expression of C3 mRNA"	15458795
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of C3 protein"	11390168
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in decreased expression of C3 mRNA	25088246
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of C3 mRNA"	20206263
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of C3 mRNA"	23196670
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of C3 mRNA"	24172598
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of C3 mRNA"	24172598
C035419	3,4-dihydroxybenzohydroxamic acid	"3,4-dihydroxybenzohydroxamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of C3 mRNA]"	25843059
C035419	3,4-dihydroxybenzohydroxamic acid	"3,4-dihydroxybenzohydroxamic acid results in decreased expression of C3 mRNA"	25843059
C557505	3',4'-dimethoxy-alpha-naphthoflavone	"3',4'-dimethoxy-alpha-naphthoflavone inhibits the reaction [IL1B protein results in increased expression of C3 mRNA]"	21127131
C557505	3',4'-dimethoxy-alpha-naphthoflavone	"3',4'-dimethoxy-alpha-naphthoflavone inhibits the reaction [IL1B protein results in increased expression of C3 protein]"	21127131
C557505	3',4'-dimethoxy-alpha-naphthoflavone	"[[3',4'-dimethoxy-alpha-naphthoflavone results in increased activity of AHR protein] which results in decreased expression of CD55 protein] which results in increased expression of C3 protein"	22553215
C557505	3',4'-dimethoxy-alpha-naphthoflavone	"[3',4'-dimethoxy-alpha-naphthoflavone results in increased activity of AHR protein] which results in increased expression of C3 protein modified form"	22553215
C557505	3',4'-dimethoxy-alpha-naphthoflavone	"AHR protein promotes the reaction [3',4'-dimethoxy-alpha-naphthoflavone inhibits the reaction [IL1B protein results in increased expression of C3 mRNA]]"	21127131
C486184	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of C3 mRNA"	12399409
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of C3 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C3 mRNA"	27188386
C041594	4-nonylphenol	4-nonylphenol affects the expression of C3 mRNA	15792627
C105260	4-tert-octylphenol	4-tert-octylphenol results in increased expression of C3 mRNA	10822019\|1108622
C105260	4-tert-octylphenol	4-tert-octylphenol results in increased expression of C3 protein	11086226
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C3 mRNA"	27188386
C475050	7alpha-methyl-17alpha-ethynylestradiol	7alpha-methyl-17alpha-ethynylestradiol results in increased expression of C3 mRNA	12117614
C119737	8-prenylnaringenin	8-prenylnaringenin results in increased expression of C3 mRNA	16522720
C091375	9-phenanthrol	9-phenanthrol results in increased expression of C3 mRNA	22989670
C496492	abrine	abrine results in increased expression of C3 mRNA	22595364
D000082	Acetaminophen	Acetaminophen results in decreased expression of C3 mRNA	27761495
D000082	Acetaminophen	Acetaminophen results in decreased expression of C3 protein	22319198
D000082	Acetaminophen	Acetaminophen results in increased expression of C3 protein	22319198
D000082	Acetaminophen	C3 protein affects the susceptibility to Acetaminophen	22319198
D000082	Acetaminophen	cobra venom factor inhibits the reaction [Acetaminophen results in increased expression of C3 protein]	22319198
D000082	Acetaminophen	[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of C3 protein	25499718
D000082	Acetaminophen	Acetaminophen affects the expression of C3 protein	16687475
D000111	Acetylcysteine	[Acetylcysteine co-treated with Atorvastatin Calcium] inhibits the reaction [sodium arsenite results in increased activity of C3 protein modified form]	20946910
C006418	adrenocorticotropin zinc	adrenocorticotropin zinc results in increased expression of C3 mRNA	19920212
C016601	afimoxifene	afimoxifene results in increased expression of C3 protein	11390168
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of C3 gene	27153756
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of C3 mRNA	21298039
D000537	Aluminum Oxide	"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of C3 protein"	25598225
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of C3 mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of C3 mRNA"	22863853
D000728	Androgens	Androgens results in increased expression of C3 mRNA	12974607
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of C3 mRNA	24449571
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in increased expression of C3 mRNA"	22352330
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of C3 mRNA	15372504
D000069059	Atorvastatin Calcium	[Acetylcysteine co-treated with Atorvastatin Calcium] inhibits the reaction [sodium arsenite results in increased activity of C3 protein modified form]	20946910
C547126	AZM551248	AZM551248 results in increased expression of C3 mRNA	22323515
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of C3 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of C3 gene	25435355
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of C3 mRNA	19770486\|2012785
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of C3 mRNA	22228805
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of C3 mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of C3 mRNA	18191855\|1961957
D004958	Estradiol	Estradiol affects the expression of C3 mRNA	15598610
D004958	Estradiol	Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of C3 mRNA]	16977382
D004958	Estradiol	Estradiol results in decreased activity of C3 protein	18615583
D004958	Estradiol	Estradiol results in increased expression of C3 mRNA	12370124\|1528915
D004958	Estradiol	Estradiol results in increased expression of C3 protein	11390168
D004958	Estradiol	"11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol inhibits the reaction [Estradiol results in increased expression of C3 mRNA]"	22127542
D004958	Estradiol	Estradiol affects the expression of C3 mRNA	18790044\|2477782
D004958	Estradiol	Estradiol results in increased expression of C3 mRNA	11086226\|1545692
D004958	Estradiol	Estradiol results in increased expression of C3 protein	11086226
D004958	Estradiol	Genistein inhibits the reaction [Estradiol affects the expression of C3 mRNA]	17049845
D004958	Estradiol	Progesterone inhibits the reaction [Estradiol affects the expression of C3 mRNA]	24777823
C095105	bexarotene	bexarotene results in decreased expression of C3 mRNA	16648578
C006780	bisphenol A	bisphenol A results in increased expression of C3 mRNA	23798566
C006780	bisphenol A	bisphenol A affects the expression of C3 mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of C3 mRNA	26788107
C006780	bisphenol A	bisphenol A results in decreased expression of C3 protein	26788107
C006780	bisphenol A	bisphenol A results in increased expression of C3 mRNA	10822019\|1108622
C006780	bisphenol A	bisphenol A results in increased expression of C3 protein	11086226
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of C3 mRNA	18804290
D002104	Cadmium	C3 protein binds to Cadmium	23896426
D002104	Cadmium	Cadmium affects the expression of C3 mRNA	21120746
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of C3 mRNA	18213484
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of C3 mRNA	18804290
D019256	Cadmium Chloride	"11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol inhibits the reaction [Cadmium Chloride results in increased expression of C3 mRNA]"	22127542
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of C3 mRNA	19703529
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of C3 mRNA	12858169\|2212754
D019256	Cadmium Chloride	fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of C3 mRNA]	12858169
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of C3 mRNA	17484886
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of C3 mRNA	24763279
D002746	Chlorpromazine	[Chlorpromazine co-treated with Cholic Acids] affects the expression of C3 mRNA	27344345
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of C3 mRNA	27344345
D002793	Cholic Acids	[Chlorpromazine co-treated with Cholic Acids] affects the expression of C3 mRNA	27344345
D002793	Cholic Acids	[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of C3 mRNA	27344345
D002793	Cholic Acids	[Methyltestosterone co-treated with Cholic Acids] affects the expression of C3 mRNA	27344345
D002809	Chondroitin Sulfates	Chondroitin Sulfates analog results in increased cleavage of C3 protein	18434646
C023600	chromic oxide	chromic oxide results in decreased expression of C3 mRNA	15003702
D002857	Chromium	Chromium results in increased expression of C3 mRNA	18084045
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of C3 mRNA	15003702
C418118	CI 1044	CI 1044 results in increased expression of C3 mRNA	17569694
D002922	Ciguatoxins	Ciguatoxins affects the expression of C3 mRNA	18353800
C018021	cobaltous chloride	cobaltous chloride results in decreased secretion of C3 protein	22079246
C016310	cobra venom factor	cobra venom factor results in increased expression of C3 protein	19428933
C016310	cobra venom factor	CFB protein affects the reaction [cobra venom factor results in decreased expression of C3 protein]	11724962
C016310	cobra venom factor	CFD protein affects the reaction [[cobra venom factor co-treated with Magnesium] results in increased cleavage of and results in increased activity of C3 protein]	11724962
C016310	cobra venom factor	[cobra venom factor co-treated with Magnesium] results in increased cleavage of and results in increased activity of C3 protein	11724962
C016310	cobra venom factor	cobra venom factor inhibits the reaction [Acetaminophen results in increased expression of C3 protein]	22319198
C016310	cobra venom factor	cobra venom factor inhibits the reaction [Ozone results in increased expression of C3 protein]	14701711
C016310	cobra venom factor	cobra venom factor results in decreased expression of C3 protein	11724962
C016310	cobra venom factor	cobra venom factor results in decreased secretion of C3 protein	22136142
C016310	cobra venom factor	cobra venom factor results in increased cleavage of and results in increased activity of C3 protein	17916747
C016310	cobra venom factor	cobra venom factor inhibits the reaction [Puromycin Aminonucleoside results in increased expression of C3 protein]	9250166
D003078	Colchicine	Colchicine results in increased expression of C3 mRNA	20624997
D003300	Copper	C3 protein binds to Copper	23896426
D003345	Corticosterone	Corticosterone affects the expression of C3 mRNA	18363858
D003471	Cuprizone	Cuprizone results in increased expression of C3 mRNA	27523638
D003474	Curcumin	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C3 mRNA]	18200517
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of C3 mRNA	21041162
D016572	Cyclosporine	Cyclosporine results in decreased expression of C3 mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in increased expression of C3 mRNA	21865292
C004742	daidzein	daidzein results in increased expression of C3 mRNA	10822019
D003613	Danazol	Danazol results in increased expression of C3 protein	4014294
C007262	deoxynivalenol	deoxynivalenol results in increased expression of C3 mRNA	22968694
D003907	Dexamethasone	Dexamethasone results in increased expression of C3 mRNA	21041162\|2273378
D003907	Dexamethasone	Dexamethasone promotes the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]	11566438
D002945	Cisplatin	[Cisplatin co-treated with panobinostat] affects the expression of C3 mRNA	21791302
D002945	Cisplatin	Cisplatin results in increased expression of C3 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased secretion of C3 protein	28885000
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of C3 mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in decreased expression of C3 mRNA	18042831\|1903023
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate affects the expression of C3 mRNA	27405655
C058705	diethyl malate	diethyl malate affects the expression of C3 mRNA	24814887
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of C3 mRNA	12370124\|1528915
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of C3 protein	11390168
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of C3 mRNA	17011747
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of C3 mRNA	27638505
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of C3 mRNA"	19480007
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of C3 mRNA	26924002
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased metabolism of C3 protein	29267982
D004237	Diuron	Diuron metabolite results in increased expression of C3 mRNA	24172598
D004237	Diuron	Diuron metabolite results in increased expression of C3 mRNA	24172598
D004317	Doxorubicin	C3 gene mutant form results in decreased susceptibility to Doxorubicin	16951374
D004317	Doxorubicin	C3 protein results in increased susceptibility to Doxorubicin	18039928
D004317	Doxorubicin	Doxorubicin results in increased activity of C3 protein	16951374
D004317	Doxorubicin	Doxorubicin results in increased expression of C3 mRNA	15033991
D004317	Doxorubicin	CFD gene mutant form inhibits the reaction [Doxorubicin results in increased activity of C3 protein]	16951374
D004317	Doxorubicin	Doxorubicin results in increased secretion of C3 protein	28885000
D004726	Endosulfan	Endosulfan results in decreased expression of C3 mRNA	18790044
C118739	entinostat	entinostat results in increased expression of C3 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C3 mRNA"	27188386
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of C3 mRNA	27344345
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of C3 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of C3 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of C3 mRNA	16174780\|1940095
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of C3 mRNA	17942748
D004997	Ethinyl Estradiol	Dexamethasone promotes the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]	11566438
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of C3 mRNA	17351261
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of C3 mRNA	10822019\|1133165
D004997	Ethinyl Estradiol	fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]	16639590
D004997	Ethinyl Estradiol	Levonorgestrel inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]	11566438
D004997	Ethinyl Estradiol	Medroxyprogesterone Acetate inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]	11566438
D004997	Ethinyl Estradiol	Mifepristone inhibits the reaction [Medroxyprogesterone Acetate inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]]	11566438\|1680694
D004997	Ethinyl Estradiol	Mifepristone promotes the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]	11566438
D004997	Ethinyl Estradiol	Progesterone inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]	11566438
D004997	Ethinyl Estradiol	trimegestone inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]	11566438
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of C3 mRNA	27776689
D015025	Zearalenone	Zearalenone results in increased expression of C3 mRNA	17557909
C017690	fenvalerate	fenvalerate affects the expression of and results in increased activity of C3 protein	21557984
C017690	fenvalerate	fenvalerate affects the expression of C3 protein	21557984
D005485	Flutamide	Flutamide results in increased expression of C3 mRNA	17420220
D005485	Flutamide	[vinclozolin co-treated with procymidone co-treated with Flutamide] results in increased expression of C3 mRNA	17420220
D005492	Folic Acid	[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of C3 mRNA	22975265
D005492	Folic Acid	[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of C3 protein	22975265
D005492	Folic Acid	[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of C3 mRNA	24657277
D005492	Folic Acid	Folic Acid deficiency results in increased expression of C3 mRNA	24657277
D005492	Folic Acid	Folic Acid deficiency results in increased expression of C3 protein	24657277
D005620	Freund's Adjuvant	Freund's Adjuvant results in decreased expression of C3 mRNA	20349343
C070081	fulvestrant	fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of C3 mRNA]	12858169
C070081	fulvestrant	fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]	16639590
C070081	fulvestrant	fulvestrant inhibits the reaction [Triclosan results in increased expression of C3 mRNA]	22062131
C070081	fulvestrant	fulvestrant results in increased expression of C3 mRNA	11086226
C070081	fulvestrant	fulvestrant results in increased expression of C3 protein	11086226
C039281	furan	furan results in decreased expression of C3 mRNA	15120968\|2619464
D019833	Genistein	Genistein results in increased expression of C3 mRNA	20884965
D019833	Genistein	Genistein results in decreased expression of C3 mRNA	21048042
D019833	Genistein	Genistein results in increased expression of C3 mRNA	15289156\|1698526
D019833	Genistein	Genistein inhibits the reaction [Estradiol affects the expression of C3 mRNA]	17049845
D019833	Genistein	Genistein results in increased expression of C3 mRNA	11331651\|2038159
D019833	Genistein	Isoflavones inhibits the reaction [Genistein results in increased expression of C3 mRNA]	20381596
D005839	Gentamicins	Gentamicins results in increased expression of C3 mRNA	21081137
D005947	Glucose	Glucose results in increased expression of C3 mRNA	17178593
D005947	Glucose	[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of C3 mRNA	23199288
C004312	glycidol	glycidol results in increased expression of C3 mRNA	24915197
C010974	glyphosate	glyphosate affects the expression of C3 mRNA	25434756
C010974	glyphosate	glyphosate results in decreased expression of C3 mRNA	27463640
D006046	Gold	[Polyethyleneimine binds to Gold] which results in decreased expression of C3 mRNA	28433809
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of C3 mRNA	24763279
C412815	GW 4064	GW 4064 results in increased expression of C3 mRNA	26655953
D006493	Heparin	Heparin results in decreased expression of C3 protein	10568115\|7948777
D017313	Fenretinide	Fenretinide results in increased expression of C3 mRNA	28973697
C029424	hydrazine	hydrazine results in increased expression of C3 mRNA	15282401
D007052	Ibuprofen	Ibuprofen affects the expression of C3 mRNA	17070997
C082770	IMM 125	IMM 125 results in increased expression of C3 mRNA	21081137
C020758	indium trichloride	indium trichloride results in decreased expression of C3 protein	19539025
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of C3 mRNA	25613284
D007529	Isoflavones	Isoflavones inhibits the reaction [Genistein results in increased expression of C3 mRNA]	20381596
D007545	Isoproterenol	Isoproterenol results in decreased expression of C3 mRNA	24286936
D007545	Isoproterenol	Isoproterenol results in increased expression of C3 mRNA	20003209
D007545	Isoproterenol	Isoproterenol results in decreased expression of C3 mRNA	24286936
D007545	Isoproterenol	Isoproterenol results in increased expression of C3 mRNA	24286936
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of C3 mRNA]	25890327
D007854	Lead	C3 protein binds to Lead	23896426
C052901	lemongrass oil	lemongrass oil affects the expression of C3 mRNA	25976427
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in increased expression of C3 mRNA"	23090859
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 affects the expression of C3 mRNA"	24972896
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of C3 protein"	25772430
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of C3 mRNA"	19264136
D008070	Lipopolysaccharides	"3,4-dihydroxybenzohydroxamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of C3 mRNA]"	25843059
D008070	Lipopolysaccharides	CFP gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of C3 protein]	17916747
D008070	Lipopolysaccharides	Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of C3 mRNA]	16977382
D008070	Lipopolysaccharides	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of C3 mRNA]	25890327
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of C3 mRNA	16977382\|2584305
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of C3 protein	17916747
D008274	Magnesium	CFD protein affects the reaction [[cobra venom factor co-treated with Magnesium] results in increased cleavage of and results in increased activity of C3 protein]	11724962
D008274	Magnesium	[cobra venom factor co-treated with Magnesium] results in increased cleavage of and results in increased activity of C3 protein	11724962
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of C3 mRNA	26378955
C013592	mangiferin	mangiferin results in decreased expression of C3 mRNA	15135318
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]	11566438
D017258	Medroxyprogesterone Acetate	Mifepristone inhibits the reaction [Medroxyprogesterone Acetate inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]]	11566438\|1680694
D008627	Mercuric Chloride	Mercuric Chloride results in decreased expression of C3 mRNA	22136142
D008628	Mercury	Mercury affects the expression of C3 protein	22030286
D016210	Methacholine Chloride	C3 protein affects the susceptibility to [Ozone co-treated with Methacholine Chloride]	14701711
D008727	Methotrexate	[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of C3 mRNA	24657277
D008727	Methotrexate	Methotrexate results in increased expression of C3 mRNA	17400583\|2465727
D008727	Methotrexate	Methotrexate results in increased expression of C3 protein	24657277
D008727	Methotrexate	Methotrexate affects the expression of C3 mRNA	18502557
D008731	Methoxychlor	Methoxychlor metabolite results in increased expression of C3 protein	11390168
D008731	Methoxychlor	Methoxychlor results in increased expression of C3 protein	11390168
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of C3 mRNA	16257430
D008748	Methylcholanthrene	Methylcholanthrene affects the expression of C3 mRNA	18804290
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of C3 mRNA	23103053
C043243	methyl tert-butyl ether	methyl tert-butyl ether affects the expression of C3 mRNA	24128854
D008777	Methyltestosterone	[Methyltestosterone co-treated with Cholic Acids] affects the expression of C3 mRNA	27344345
D015735	Mifepristone	Mifepristone inhibits the reaction [Medroxyprogesterone Acetate inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]]	11566438\|1680694
D015735	Mifepristone	Mifepristone inhibits the reaction [Triclosan results in increased expression of C3 mRNA]	22062131
D015735	Mifepristone	Mifepristone promotes the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]	11566438
C010052	mizoribine	mizoribine inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of C3 protein]	8919236
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of C3 mRNA	26924002
D009151	Mustard Gas	Mustard Gas results in increased expression of C3 protein	15953574
D009151	Mustard Gas	Mustard Gas results in increased expression of C3 mRNA	18988085
D009183	Mycotoxins	Mycotoxins results in decreased expression of C3 mRNA	19818335
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of C3 mRNA"	23634900
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of C3 mRNA"	23845593\|2555468
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of C3 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of C3 protein"	25598225
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of C3"	21654424
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of C3 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased secretion of C3 protein"	25598225
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of C3 mRNA"	24911292
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of C3 mRNA	27344345
C490266	neoechinulin A	neoechinulin A results in increased expression of C3 mRNA	19818335
D009532	Nickel	C3 protein binds to Nickel	23896426
D009532	Nickel	Nickel results in increased expression of C3 mRNA	25583101
C022838	nickel chloride	nickel chloride affects the expression of C3 mRNA	22110744
C028007	nickel monoxide	nickel monoxide results in increased expression of C3 mRNA	19167457
C017557	nickel subsulfide	nickel subsulfide results in increased expression of C3 mRNA	21086188
D005996	Nitroglycerin	Nitroglycerin results in increased expression of C3 protein alternative form	10884648
C025256	nonylphenol	nonylphenol results in increased expression of C3 protein	11390168
C025256	nonylphenol	nonylphenol results in increased expression of C3 mRNA	11086226
C025256	nonylphenol	nonylphenol results in increased expression of C3 protein	11086226
D016912	Levonorgestrel	Levonorgestrel inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]	11566438
C076029	olanzapine	olanzapine affects the phosphorylation of C3 protein	25821032
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of C3 mRNA"	24096037
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of C3 protein"	11390168
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of C3 mRNA"	10822019\|1108622
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of C3 protein"	11086226
D010100	Oxygen	[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of C3 mRNA	23199288
D010126	Ozone	C3 protein affects the susceptibility to [Ozone co-treated with Methacholine Chloride]	14701711
D010126	Ozone	cobra venom factor inhibits the reaction [Ozone results in increased expression of C3 protein]	14701711
D010126	Ozone	Ozone results in increased expression of C3 protein	14701711
D010126	Ozone	Ozone results in decreased expression of C3 mRNA	16716893
D017239	Paclitaxel	Paclitaxel results in increased expression of C3 mRNA	18754875
D000073878	Palm Oil	Palm Oil results in decreased expression of C3 mRNA	18042831
C496932	panobinostat	[Cisplatin co-treated with panobinostat] affects the expression of C3 mRNA	21791302
D052638	Particulate Matter	C3 protein alternative form results in increased susceptibility to Particulate Matter	20504758
D052638	Particulate Matter	Particulate Matter results in increased expression of C3 mRNA	28412507
D052638	Particulate Matter	Particulate Matter results in increased expression of C3 protein	17520064
D000068437	Pemetrexed	[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of C3 mRNA	22975265
D000068437	Pemetrexed	[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of C3 protein	22975265
D010396	Penicillamine	Penicillamine results in increased expression of C3 mRNA	19575532
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of C3 mRNA	23602845
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of C3 mRNA	19429403\|2093613
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of C3 protein	26879310
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of C3 mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of C3 mRNA	18804290
C008814	peroben	peroben results in increased activity of C3 protein	157301
D010634	Phenobarbital	Phenobarbital affects the expression of C3 mRNA	19159669
D010634	Phenobarbital	Phenobarbital affects the expression of C3 protein	16099942
C029217	phenyl-N-tert-butylnitrone	phenyl-N-tert-butylnitrone results in decreased expression of C3 mRNA	23199288
C029217	phenyl-N-tert-butylnitrone	phenyl-N-tert-butylnitrone results in decreased expression of C3 protein	23199288
C006253	pirinixic acid	pirinixic acid affects the expression of C3 protein	16099942
D010975	Platelet Aggregation Inhibitors	Platelet Aggregation Inhibitors results in decreased metabolism of C3 protein	18165780
D011094	Polyethyleneimine	[Polyethyleneimine binds to Gold] which results in decreased expression of C3 mRNA	28433809
D059808	Polyphenols	Polyphenols results in decreased expression of C3 mRNA	16293270
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of C3 mRNA	22714537
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of C3 mRNA	28903501
C035988	procymidone	procymidone results in increased expression of C3 mRNA	17420220
C035988	procymidone	[vinclozolin co-treated with procymidone co-treated with Flutamide] results in increased expression of C3 mRNA	17420220
D011374	Progesterone	Progesterone inhibits the reaction [C3 protein results in increased phosphorylation of PRKCA protein]	18615583
D011374	Progesterone	Progesterone inhibits the reaction [C3 protein results in increased phosphorylation of PRKCZ protein]	18615583
D011374	Progesterone	Progesterone results in decreased activity of C3 protein	18615583
D011374	Progesterone	Progesterone inhibits the reaction [Estradiol affects the expression of C3 mRNA]	24777823
D011374	Progesterone	Progesterone inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]	11566438
D015742	Propofol	[Triglycerides co-treated with Propofol] results in increased expression of C3 protein modified form	15983144
C030101	protamine heparin aggregate	protamine heparin aggregate results in increased expression of C3 protein modified form	2785004
D011692	Puromycin Aminonucleoside	cobra venom factor inhibits the reaction [Puromycin Aminonucleoside results in increased expression of C3 protein]	9250166
D011692	Puromycin Aminonucleoside	mizoribine inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of C3 protein]	8919236
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in decreased expression of C3 protein	8919236
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of C3 protein	9250166
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of C3 mRNA	27029645
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of C3 mRNA	12370124
D017382	Reactive Oxygen Species	C3 results in increased abundance of Reactive Oxygen Species	23199288
D012110	Reserpine	Reserpine affects the expression of C3 mRNA	18363858
C059514	resveratrol	resveratrol results in increased expression of C3 mRNA	25888808
C059514	resveratrol	resveratrol results in increased expression of C3 protein	25954969
D015474	Isotretinoin	Isotretinoin results in increased expression of C3 mRNA	20436886
C539676	rEV576 protein, tick	"rEV576 protein, tick affects the expression of and affects the activity of C3 protein"	17215252
C116926	rofecoxib	rofecoxib results in increased expression of C3 mRNA	17070997
C049705	S-1,2-dichlorovinyl-N-acetylcysteine	"S-1,2-dichlorovinyl-N-acetylcysteine affects the expression of C3 mRNA"	16844155
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of C3 mRNA"	24160326
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of C3 mRNA	25895662
D020123	Sirolimus	Sirolimus results in decreased expression of C3 mRNA	21865292
C017947	sodium arsenite	sodium arsenite results in decreased expression of C3 mRNA	19590694
C017947	sodium arsenite	sodium arsenite affects the methylation of C3 gene	28589171
C017947	sodium arsenite	sodium arsenite affects the expression of C3 mRNA	17450228
C017947	sodium arsenite	sodium arsenite results in increased expression of C3 mRNA	21911445
C017947	sodium arsenite	[Acetylcysteine co-treated with Atorvastatin Calcium] inhibits the reaction [sodium arsenite results in increased activity of C3 protein modified form]	20946910
C017947	sodium arsenite	sodium arsenite results in increased activity of C3 protein modified form	20946910
C016104	sodium bichromate	sodium bichromate results in decreased expression of C3 mRNA	22155349\|2256133
C016104	sodium bichromate	sodium bichromate results in increased expression of C3 mRNA	22561333
D012999	Soman	Soman results in increased expression of C3 mRNA	19281266
D053260	Soot	Soot results in increased expression of C3 mRNA	22461453\|2655175
D013205	Staphylococcal Protein A	Staphylococcal Protein A results in increased expression of C3 protein alternative form	15384034
C024075	styrofoam	styrofoam analog results in increased expression of C3 protein	19428933
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of C3 mRNA	26378955
C016766	sulforafan	sulforafan results in increased expression of C3 mRNA	26833863
D016559	Tacrolimus	Tacrolimus results in increased expression of C3 mRNA	21865292
D013629	Tamoxifen	Tamoxifen affects the expression of C3 mRNA	17555576
D013629	Tamoxifen	Tamoxifen results in increased expression of C3 mRNA	12370124\|1940095
D013629	Tamoxifen	Tamoxifen results in increased expression of C3 protein	11390168
D013629	Tamoxifen	Tamoxifen results in increased expression of C3 mRNA	19400957
D013739	Testosterone	Testosterone inhibits the reaction [C3 protein results in increased phosphorylation of PRKCA protein]	18615583
D013739	Testosterone	Testosterone inhibits the reaction [C3 protein results in increased phosphorylation of PRKCZ protein]	18615583
D013739	Testosterone	Testosterone results in decreased activity of C3 protein	18615583
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of C3 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of C3 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of C3 mRNA]	14728982
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of C3 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of C3 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of C3 mRNA	14728982
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of C3 mRNA	25613284
D013792	Thalidomide	Thalidomide results in decreased expression of C3 protein	2985516
C009495	titanium dioxide	titanium dioxide results in increased expression of C3 mRNA	21259345\|2355797
C402696	TMC 120A	TMC 120A results in increased expression of C3 mRNA	19818335
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of C3 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of C3 protein	19478969
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of C3 mRNA	28111298
D014050	Toluene	Toluene results in decreased expression of C3 mRNA	22166486
D014050	Toluene	Toluene results in increased expression of C3 mRNA	22166486
D014118	Toxins, Biological	"Toxins, Biological affects the expression of C3 mRNA"	19682533
D014204	Trenbolone Acetate	Trenbolone Acetate affects the expression of C3 protein	24072461
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of C3 mRNA	19448997
D014241	Trichloroethylene	Trichloroethylene results in increased expression of C3 protein	24974766
D014260	Triclosan	fulvestrant inhibits the reaction [Triclosan results in increased expression of C3 mRNA]	22062131
D014260	Triclosan	Mifepristone inhibits the reaction [Triclosan results in increased expression of C3 mRNA]	22062131
D014260	Triclosan	Triclosan results in increased expression of C3 mRNA	22062131
D014280	Triglycerides	[Triglycerides co-treated with Propofol] results in increased expression of C3 protein modified form	15983144
C050319	trimegestone	trimegestone inhibits the reaction [Ethinyl Estradiol results in increased expression of C3 mRNA]	11566438
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of C3 mRNA	16141432
D014302	Trinitrobenzenesulfonic Acid	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C3 mRNA]	18200517
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of C3 mRNA	17982090\|1820051
C057693	troglitazone	troglitazone results in decreased expression of C3 mRNA	25572481
D014635	Valproic Acid	Valproic Acid affects the expression of C3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of C3 mRNA	29154799
D014640	Vancomycin	Vancomycin results in decreased expression of C3 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of C3 protein	17520064
C025643	vinclozolin	[vinclozolin co-treated with procymidone co-treated with Flutamide] results in increased expression of C3 mRNA	17420220
C025643	vinclozolin	vinclozolin results in decreased expression of C3 mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in increased expression of C3 mRNA	26682919
D002762	Cholecalciferol	Cholecalciferol results in increased expression of C3 mRNA	17170073
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in decreased expression of C3 mRNA"	23246600
D015032	Zinc	C3 protein binds to Zinc	23896426
C016837	zinc chloride	zinc chloride results in increased expression of C3 mRNA	19428942
D019287	Zinc Sulfate	[Zinc Sulfate co-treated with CR1L protein] results in increased expression of C3 protein	15086380
C088658	zoledronic acid	zoledronic acid results in increased expression of C3 mRNA	24714768
D015054	Zymosan	CD55 protein affects the reaction [Zymosan results in increased activity of C3 protein]	9892684
D015054	Zymosan	CFB gene mutant form inhibits the reaction [Zymosan results in increased expression of C3 protein]	17916747
D015054	Zymosan	Zymosan results in increased activity of C3 protein	9892684
D015054	Zymosan	Zymosan results in increased expression of C3 protein	17916747

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004252	serine-type endopeptidase activity	-	TAS	-
GO:0004866	endopeptidase inhibitor activity	-	IEA	-
GO:0005102	signaling receptor binding	-	TAS	9164946
GO:0005515	protein binding	-	IPI	7483825 11705926 12438350 12540846 16530040 19255449 21317894 26627825
GO:0031715	C5L2 anaphylatoxin chemotactic receptor binding	-	IDA	15833747

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001798	positive regulation of type IIa hypersensitivity	-	IEA	-
GO:0001934	positive regulation of protein phosphorylation	-	IDA	15833747
GO:0001970	positive regulation of activation of membrane attack complex	-	IEA	-
GO:0006508	proteolysis	-	IEA	-
GO:0006631	fatty acid metabolic process	-	IEA	-
GO:0006911	phagocytosis, engulfment	-	ISS	-
GO:0006954	inflammatory response	-	IEA	-
GO:0006955	immune response	-	TAS	4097977
GO:0006956	complement activation	-	IMP	19302245
GO:0006956	complement activation	-	TAS	-
GO:0006957	complement activation, alternative pathway	-	TAS	-
GO:0006958	complement activation, classical pathway	-	IEA	-
GO:0007165	signal transduction	-	TAS	10085065
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0010575	positive regulation of vascular endothelial growth factor production	-	IDA	16452172
GO:0010828	positive regulation of glucose transmembrane transport	-	IDA	9059512 15833747
GO:0010866	regulation of triglyceride biosynthetic process	-	IDA	10432298
GO:0010884	positive regulation of lipid storage	-	IDA	9555951
GO:0010951	negative regulation of endopeptidase activity	-	IEA	-
GO:0030449	regulation of complement activation	-	TAS	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0043687	post-translational protein modification	-	TAS	-
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway	-	IDA	15833747
GO:0045766	positive regulation of angiogenesis	-	IEA	-
GO:0050776	regulation of immune response	-	TAS	-
GO:0097242	amyloid-beta clearance	-	ISS	-
GO:2000427	positive regulation of apoptotic cell clearance	-	IMP	19302245

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	HDA	16502470 23580065
GO:0005615	extracellular space	-	IDA	25645918
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0032991	protein-containing complex	-	IEA	-
GO:0034774	secretory granule lumen	-	TAS	-
GO:0035578	azurophil granule lumen	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	21362503 23533145
GO:0072562	blood microparticle	-	HDA	22516433

KEGG ID	KEGG Term
hsa04145	Phagosome
hsa04610	Complement and coagulation cascades
hsa05140	Leishmaniasis
hsa05142	Chagas disease (American trypanosomiasis)
hsa05150	Staphylococcus aureus infection
hsa05322	Systemic lupus erythematosus

Reactome ID	Reactome Term	Evidence
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-166658	Complement cascade	TAS
R-HSA-166663	Initial triggering of complement	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-173736	Alternative complement activation	TAS
R-HSA-174577	Activation of C3 and C5	TAS
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-8957275	Post-translational protein phosphorylation	TAS
R-HSA-977606	Regulation of Complement cascade	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21197116	Genome-wide association analyses of genetic, phenotypic, and environmental risks in the age-related eye disease study. (2010 Dec 17)	Ryu E	Mol Vis
19168221	Complement component C3 and risk of age-related macular degeneration. (2009 Mar)	Despriet DD	Ophthalmology
979280	Lack of association of genetic traits with alcoholism; C3, Ss and ABO systems. (1976 Sep)	Winokur G	J Stud Alcohol
20525804	Cigarette smoke inhibits engulfment of apoptotic cells by macrophages through inhibition of actin rearrangement. (2011 Apr)	Minematsu N	Am J Respir Cell Mol Biol
9508360	Genotoxicological monitoring of 175 subjects living in the green belts, inner town or near chemical industrial estates in Greater Budapest agglomeration, Hungary. (1998 Jan 13)	Major J	Mutat Res
20926148	Human plasma complement C3 is independently associated with coronary heart disease, but only in heavy smokers (the CODAM study). (2012 Jan 26)	van Greevenbroek MM	Int J Cardiol
10665780	Immunological parameters in patients suffering from alcohol-dependence syndrome. (2000 Jan)	Leksowski W	Immunopharmacology
21114489	The cross-sectional association between insulin resistance and circulating complement C3 is partly explained by plasma alanine aminotransferase, independent of central obesity and general inflammation (the CODAM study). (2011 Apr)	van Greevenbroek MM	Eur J Clin Invest
21402993	Assessing susceptibility to age-related macular degeneration with genetic markers and environmental factors. (2011 Mar)	Chen Y	Arch Ophthalmol
24839820	Determination of reference intervals for serum complement C3 and C4 levels in Chinese Han ethnic males. (2014)	Qin X	Clin Lab
19999660	[Identification of susceptibility genes for age-related macular degeneration--a success story of molecular genetics]. (2009)	Seitsonen S	Duodecim
29801032	Association of Single-Nucleotide Polymorphisms in Age-Related Macular Degeneration With Pseudodrusen: Secondary Analysis of Data From the Comparison of AMD Treatments Trials. (2018 May 3)	Lin LY	JAMA Ophthalmol
22933840	Association analysis of genetic and environmental risk factors in the cuticular drusen subtype of age-related macular degeneration. (2012)	van de Ven JP	Mol Vis
22699933	Are circulating autoantibodies to ABCC3 transporter a potential biomarker for lung cancer? (2012 Oct)	Liu L	J Cancer Res Clin Oncol
19899988	Association of c3 gene polymorphisms with neovascular age-related macular degeneration in a chinese population. (2009 Aug)	Pei XT	Curr Eye Res
20576771	Determination of a gene and environment risk model for age-related macular degeneration. (2010 Oct)	Gibson J	Br J Ophthalmol
21959373	Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors. (2011 Nov)	Seddon JM	Ophthalmology
26522359	[Qibaipingfei Capsule down-regulate the levels of calcineurin and nuclear factor of activated T-cells isoform c3 (NFATc3) in chronic obstructive pulmonary disease]. (2015 Nov)	Zhu J	Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
11959386	Different associations of C-reactive protein, fibrinogen and C3 with traditional risk factors in middle-aged men. (2002 Apr)	Muscari A	Int J Cardiol
23377670	Synergistic effect between lipoprotein lipase and apolipoprotein C3 genes in determining the severity of coronary artery disease. (2013 Jun)	Abd-El-Aziz TA	J Cardiovasc Transl Res
18325906	C3 R102G polymorphism increases risk of age-related macular degeneration. (2008 Jun 15)	Spencer KL	Hum Mol Genet
7686471	The effects of ethanol on EEG activity in males at risk for alcoholism. (1993 Jun)	Cohen HL	Electroencephalogr Clin Neurophysiol
20130705	A genetic approach to stratification of risk for age-related macular degeneration. (2010 Feb)	Zanke B	Can J Ophthalmol
14563253	[Basal immunological parameters in a group of retirees]. (2003 Sep)	Lazaro del Nogal M	Rev Clin Esp
29279246	Complement system biomarkers in first episode psychosis. (2017 Dec 23)	Kopczynska M	Schizophr Res
19661236	Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. (2009 Dec)	Reynolds R	Invest Ophthalmol Vis Sci
26824674	Interactions of Environmental Factors and APOA1-APOC3-APOA4-APOA5 Gene Cluster Gene Polymorphisms with Metabolic Syndrome. (2016)	Wu Y	PLoS One
9045748	Changes in immunologic cell surface markers during cocaine withdrawal in pregnant women. (1996 Dec)	Johnson TR	Brain Behav Immun
24498031	Massive withdrawal symptoms and affective vulnerability are associated with variants of the CHRNA4 gene in a subgroup of smokers. (2014)	Lazary J	PLoS One
11712826	Conditional risk factors in men with previous myocardial infarction: relevance of C3 and homocysteine. (2001 Oct)	Muscari A	Acta Cardiol
25478207	Age-related macular degeneration: insights into inflammatory genes. (2014)	Cascella R	J Ophthalmol
26986712	Risk factors for superficial vein thrombosis in patients with primary chronic venous disease. (2016 Jan)	Musil D	Vasa
21689990	Cervical spine bone mineral density as a function of vertebral level and anatomic location. (2011 Jul)	Anderst WJ	Spine J
23481534	Dietary omega-3 fatty acids, other fat intake, genetic susceptibility, and progression to incident geographic atrophy. (2013 May)	Reynolds R	Ophthalmology
23066323	Nur-related receptor 1 gene polymorphisms and alcohol dependence in Mexican Americans. (2012 Oct 7)	Wei YM	World J Gastroenterol
22486223	Adolescence and parental history of alcoholism: insights from the sleep EEG. (2012 Sep)	Tarokh L	Alcohol Clin Exp Res
22534714	Influence of hypertension, obesity and nicotine abuse on quantitative and qualitative changes in acute-phase proteins in patients with essential hypertension. (2012 May)	Cymerys M	Med Sci Monit
22466360	Short stature is an independent risk marker for mortality and incident coronary heart disease only in women: a structural relationship? (2012 Jun)	Onat A	Anadolu Kardiyol Derg
12736856	[HIV-infection, HAART (highly-active antiretroviral therapy) and hyperlipidemia]. (2003 May 9)	Hirsch HH	Dtsch Med Wochenschr
25932792	Effects of niacin and omega-3 fatty acids on the apolipoproteins in overweight patients with elevated triglycerides and reduced HDL cholesterol. (2015 Jun)	Savinova OV	Atherosclerosis
28671968	Systemic complement activation in central serous chorioretinopathy. (2017)	van Dijk EHC	PLoS One
22138144	Dietary fat, abdominal obesity and smoking modulate the relationship between plasma complement component 3 concentrations and metabolic syndrome risk. (2012 Feb)	Phillips CM	Atherosclerosis
22951857	Dysfunction of high-density lipoprotein and its apolipoproteins: new mechanisms underlying cardiometabolic risk in the population at large. (2012 Jun)	Onat A	Turk Kardiyol Dern Ars
12125914	The effect of cigarette smoking on ceruloplasmin and C3 complement: risk of cardiovascular disease (atherosclerosis). (2002 Mar)	Tungtrongchitr R	Asian Pac J Allergy Immunol
21169531	Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility. (2011 Mar)	Spencer KL	Invest Ophthalmol Vis Sci
16947780	Association of HLA-C3 and smoking with vasculitis in patients with rheumatoid arthritis. (2006 Sep)	Turesson C	Arthritis Rheum
24557084	Growth of geographic atrophy on fundus autofluorescence and polymorphisms of CFH, CFB, C3, FHR1-3, and ARMS2 in age-related macular degeneration. (2014 May)	Caire J	JAMA Ophthalmol
22273503	Association of polymorphisms in C2, CFB and C3 with exudative age-related macular degeneration in a Korean population. (2012 Mar)	Kim SJ	Exp Eye Res
27175676	Superior Glucose Tolerance and Metabolomic Profiles, Independent of Adiposity, in HIV-Infected Women Compared With Men on Antiretroviral Therapy. (2016 May)	Koethe JR	Medicine (Baltimore)
21786608	[Clinical and laboratory detection of phenotypic characteristics in patients with high hypertriglyceridemia]. (2011 May)	Rozhkova TA	Klin Lab Diagn
24548420	The relationship between cotinine concentrations and inflammatory markers among highly secondhand smoke exposed non-smoking adolescents. (2014 Mar)	Matsunaga Y	Cytokine
17568238	Complement C3 and C4 in plasma and incidence of myocardial infarction and stroke: a population-based cohort study. (2007 Jun)	Engstrom G	Eur J Cardiovasc Prev Rehabil
15236122	[Biochemical and immunological effects of ionizing radiation in radiology staff members]. (2004 Jun)	Serhatlioglu S	Tani Girisim Radyol
19913840	Serum complement C3: a determinant of cardiometabolic risk, additive to the metabolic syndrome, in middle-aged population. (2010 May)	Onat A	Metabolism
24711457	Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation. (2014 May 23)	Kunchithapautham K	J Biol Chem
15488874	A prospective study of the APOA1 XmnI and APOC3 SstI polymorphisms in the APOA1/C3/A4 gene cluster and risk of incident myocardial infarction in men. (2004 Nov)	Liu S	Atherosclerosis
23584701	Interleukin 8 promoter polymorphism predicts the initial response to bevacizumab treatment for exudative age-related macular degeneration. (2013 Oct)	Hautamaki A	Retina
9878681	Ionizing radiation and genetic risks. VI. Chronic multifactorial diseases: a review of epidemiological and genetical aspects of coronary heart disease, essential hypertension and diabetes mellitus. (1999 Jan)	Sankaranarayanan K	Mutat Res
20481208	[Diagnostics of moderate and high hypertriglyceridemia in patients in polyclinic practice: primary and secondary lipid metabolic disorders]. (2010)	Rozhkova TA	Ter Arkh
29237409	IgA nephropathy featuring massive wire loop-like deposits in two patients with alcoholic cirrhosis. (2017 Dec 13)	Takada D	BMC Nephrol
16363249	Complement C3 and C-reactive protein levels in patients with stable coronary artery disease. (2005 Nov)	Ajjan R	Thromb Haemost
24174622	Complement c3 is inversely associated with habitual intake of provitamin A but not with dietary fat, fatty acids, or vitamin E in middle-aged to older white adults and positively associated with intake of retinol in middle-aged to older white women. (2014 Jan)	van Greevenbroek MM	J Nutr
21419112	Complement C3 and cleavage products in cardiometabolic risk. (2011 Jun 11)	Onat A	Clin Chim Acta
23816731	Double-positive Goodpasture's syndrome with concomitant active pulmonary tuberculosis. (2013 Jul)	Kashif W	Saudi J Kidney Dis Transpl
29424826	How Do Patients Respond to Genetic Testing for Age-related Macular Degeneration? (2018 Mar)	McCarty CA	Optom Vis Sci
19900229	Serum apolipoprotein C-III in high-density lipoprotein: a key diabetogenic risk factor in Turks. (2009 Oct)	Onat A	Diabet Med
26154559	The genetic variant rs4073 A-->T of the Interleukin-8 promoter region is associated with the earlier onset of exudative age-related macular degeneration. (2015 Dec)	Hautamaki A	Acta Ophthalmol
9524743	Long-term monitoring of the immune reactivity of stainless steel welders. (1998 Feb)	Hanovcova I	Cent Eur J Public Health
12819653	A comparison of acute phase proteins and traditional risk factors as markers of combined plaque and intima-media thickness and plaque density in carotid and femoral arteries. (2003 Jul)	Muscari A	Eur J Vasc Endovasc Surg
19048105	Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration. (2008)	Seitsonen SP	PLoS One
24675670	Impact of the common genetic associations of age-related macular degeneration upon systemic complement component C3d levels. (2014)	Ristau T	PLoS One
2001156	Immune complexes in the choroid plexus in liver cirrhosis. (1991 Mar)	Pittella JE	Arch Pathol Lab Med
24235017	Allergy is a protective factor against age-related macular degeneration. (2014 Jan 9)	Ristau T	Invest Ophthalmol Vis Sci
19117936	Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. (2009 May)	Seddon JM	Invest Ophthalmol Vis Sci
21589926	Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks. (2011 May 11)	Turner SD	PLoS One
22808203	The SNP (rs2230500) in PRKCH decreases the risk of carotid intima-media thickness in a Chinese young adult population. (2012)	Wu L	PLoS One
1833599	Mechanisms of serum-enhanced adhesion of human alveolar macrophages to epithelial cells. (1991)	McGowan SE	Lung
16862049	A prospective study of upper aerodigestive tract manifestations of mucous membrane pemphigoid. (2006 Jul)	Alexandre M	Medicine (Baltimore)
19234341	Complement component 3 (C3) haplotypes and risk of advanced age-related macular degeneration. (2009 Jul)	Park KH	Invest Ophthalmol Vis Sci
21807600	Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration. (2011 Jul)	Hageman GS	Hum Genomics
12726989	On the mammalian acetone metabolism: from chemistry to clinical implications. (2003 May 2)	Kalapos MP	Biochim Biophys Acta
15487975	Cross-sectional study of complement C3 as a coronary risk factor among men and women. (2005 Feb)	Onat A	Clin Sci (Lond)
20157618	Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort. (2010 Feb 10)	McKay GJ	Mol Vis
28735646	Hyperhomocysteinemia and Age-related Macular Degeneration: Role of Inflammatory Mediators and Pyroptosis; A Proposal. (2017 Aug)	Singh M	Med Hypotheses
11270684	Variable effects of the APOC3-482C > T variant on insulin, glucose and triglyceride concentrations in different ethnic groups. (2001 Feb)	Waterworth DM	Diabetologia
23562165	Age-related macular degeneration and modification of systemic complement factor H production through liver transplantation. (2013 Aug)	Khandhadia S	Ophthalmology
1902064	Complement activation by cigarette smoke. (1991 Apr)	Robbins RA	Am J Physiol
16295318	Ethanol-induced dysfunction of hepatocytes and leukocytes in patients without liver failure. (2004 Jan-Jun)	Gheorghiu M	Roum Arch Microbiol Immunol
25402348	Combined effects of genetic and non-genetic risk factors affect response to ranibizumab in exudative age-related macular degeneration. (2015 Sep)	Piermarocchi S	Acta Ophthalmol
27138278	Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes. (2016)	Rasmussen MK	PLoS One
17179996	Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence. (2007 May)	Li MD	Mol Psychiatry
15643610	Natural haplotypes in the regulatory sequences affect human alcohol dehydrogenase 1C (ADH1C) gene expression. (2005 Feb)	Chen HJ	Hum Mutat
22551349	Leucocyte telomere length in age-related macular degeneration. (2013 Aug)	Immonen I	Acta Ophthalmol
8706247	Transferrin C3 offers protection against smoking-associated lung cancer? (1996 Jul)	Sikstrom C	Carcinogenesis
25893111	Association of OCT derived drusen measurements with AMD associated-genotypic SNPs in Amish population. (2015)	Chavali VR	J Clin Med
27420564	No Sex Differences in the Frequencies of Common Single Nucleotide Polymorphisms Associated with Age-Related Macular Degeneration. (2017 Mar)	Popp NA	Curr Eye Res
51135	Association and linkage between alcoholism and eleven serological markers. (1975 Jul)	Hill SY	J Stud Alcohol
28479470	Third- versus Second-Generation Stent Graft for Endovascular Aneurysm Repair: A Device-Specific Analysis. (2017 Oct)	Bergonti M	Ann Vasc Surg
11377232	Elucidation of CYP2E1 5' regulatory RsaI/Pstl allelic variants and their role in risk for oral cancer. (2001 Jul)	Liu S	Oral Oncol
23954767	Curcumin analog 1, 5-bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibits enhanced ability on Nrf2 activation and protection against acrolein-induced ARPE-19 cell toxicity. (2013 Nov 1)	Li Y	Toxicol Appl Pharmacol
15983323	Effect of hepatic lipase -514C->T polymorphism and its interactions with apolipoprotein C3 -482C->T and apolipoprotein E exon 4 polymorphisms on the risk of nephropathy in chinese type 2 diabetic patients. (2005 Jul)	Baum L	Diabetes Care
20090206	The molecular genetic basis of age-related macular degeneration: an overview. (2009 Dec)	Katta S	J Genet
29649666	A retrospective study: Does cigarette smoking induce cervical disc degeneration? (2018 May)	Chen Z	Int J Surg
26425622	When Coke Is Not Hydrating: Cocaine-Induced Acute Interstitial Nephritis. (2014 Jul-Sep)	Bahaa Aldeen M	J Investig Med High Impact Case Rep
25655794	Risk Prediction for Progression of Macular Degeneration: 10 Common and Rare Genetic Variants, Demographic, Environmental, and Macular Covariates. (2015 Apr)	Seddon JM	Invest Ophthalmol Vis Sci
22206689	Triacylglycerols and body fat mass are possible independent predictors of C3 in apparently healthy young Brazilian adults. (2012 May)	Volp AC	Nutrition
15061604	Correlation between body mass index and others risk factors for cardiovascular disease in women compared with men. (2003 Dec)	Capuano V	Monaldi Arch Chest Dis
27099955	Single-Nucleotide Polymorphisms Associated With Age-Related Macular Degeneration and Lesion Phenotypes in the Comparison of Age-Related Macular Degeneration Treatments Trials. (2016 Jun 1)	Maguire MG	JAMA Ophthalmol
25885788	Bone mineral density and carotid atherosclerosis in systemic lupus erythematosus: a controlled cross-sectional study. (2015 Mar 25)	Ajeganova S	Arthritis Res Ther
6884449	Protein components of bronchoalveolar lavage fluids from non-smokers and smokers. (1983 Jul)	Gotoh T	Eur J Respir Dis
28720541	Biological sources of variation of serum adiponectin among healthy individuals in comparison with related nutritional and inflammatory markers. (2017 Sep)	Shimizu Y	Clin Chim Acta
22247473	Prospective assessment of genetic effects on progression to different stages of age-related macular degeneration using multistate Markov models. (2012 Mar)	Yu Y	Invest Ophthalmol Vis Sci
27170480	Genetic factors associated with the development of age-related macular degeneration. (2016)	Sergejeva O	Medicina (Kaunas)
6789730	Plasma proteins of the bronchoalveolar surface of the lungs of smokers and nonsmokers. (1981 Jul)	Bell DY	Am Rev Respir Dis
25773367	Support vector machine and fuzzy C-mean clustering-based comparative evaluation of changes in motor cortex electroencephalogram under chronic alcoholism. (2015 Jul)	Kumar S	Med Biol Eng Comput
20620767	Markers of inflammation in men with small abdominal aortic aneurysm. (2010 Jul)	Parry DJ	J Vasc Surg
23054755	Circulating autoantibody to ABCC3 may be a potential biomarker for esophageal squamous cell carcinoma. (2013 May)	Cheng Y	Clin Transl Oncol
8117391	The changes of some immunological parameters in subjects exposed to asbestos in dependence on age, duration of exposure, radiological findings and smoking habits. (1993 Nov)	Hurbankova M	Zentralbl Hyg Umweltmed
22460246	Influence of genetic variants in the apolipoprotein A5 and C3 gene on lipids, lipoproteins, and its association with coronary artery disease in Indians. (2010 Sep)	Bhanushali AA	J Community Genet
7878554	Airways inflammation in subjects with chronic bronchitis who have never smoked. (1994 Dec)	Lusuardi M	Thorax
22949303	High-sensitivity C-reactive protein, disease activity, and cardiovascular risk factors in systemic lupus erythematosus. (2013 Mar)	Mok CC	Arthritis Care Res (Hoboken)
25246028	Unfavorable inflammatory profile in adults at risk of type 2 diabetes identified by hemoglobin A1c levels according to the American Diabetes Association criteria. (2015 Apr)	Fiorentino TV	Acta Diabetol
16283247	Weight gain in relation to plasma levels of complement factor 3: results from a population-based cohort study. (2005 Dec)	Engstrom G	Diabetologia
24819254	Complement component 3 is a prognostic factor of nonsmall cell lung cancer. (2014 Aug)	Lin K	Mol Med Rep
26387083	Apolipoprotein A5 and apolipoprotein C3 single nucleotide polymorphisms are correlated with an increased risk of coronary heart disease: a case-control and meta-analysis study. (2015 Sep 19)	Yang G	Lipids Health Dis
21846943	Putative roles of circulating resistin in patients with asthma, COPD and cigarette smokers. (2011)	Al Mutairi SS	Dis Markers
21447678	Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration. (2011 Jun 28)	Yu Y	Invest Ophthalmol Vis Sci
24500020	Distinct associations of complement C3a and its precursor C3 with atherosclerosis and cardiovascular disease. The CODAM study. (2014 Jun)	Hertle E	Thromb Haemost
20044088	Association of plasma soluble E-selectin and adiponectin with carotid plaque in patients with systemic lupus erythematosus. (2010 Jun)	Reynolds HR	Atherosclerosis
25835239	Serum vitamin B12 levels during the first trimester of pregnancy correlate with newborn screening markers of vitamin B12 deficiency. (2014)	Dayaldasani A	Int J Vitam Nutr Res
15682656	Association of HLA phenotype with primary non-response to recombinant hepatitis B vaccine: a study from north India. (2004 Jul-Sep)	Das K	Trop Gastroenterol
25457880	The tag SNP rs10746463 in decay-accelerating factor is associated with the susceptibility to gastric cancer. (2015 Feb)	Song Q	Mol Immunol
16714057	Serum gamma glutamyltransferase as a marker of metabolic syndrome and coronary disease likelihood in nondiabetic middle-aged and elderly adults. (2006 Aug)	Onat A	Prev Med
3156879	Cigarette smoke can activate the alternative pathway of complement in vitro by modifying the third component of complement. (1985 Mar)	Kew RR	J Clin Invest