Gene: CRISP2

7180
CRISP-2|CT36|GAPDL5|TPX1|TSP1
cysteine rich secretory protein 2
protein-coding
6p12.3
Ensembl:ENSG00000124490 MIM:187430 Vega:OTTHUMG00000014822 UniprotKB:P16562
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.417e-2 (AD)  3.043e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLITRK60.758
ISL10.757
SLC5A70.754
LHX80.721
DDC0.716
NKX2-10.712
SLC18A30.711
SFTA30.702
IRX10.69
DGKK0.681

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC17A7-0.438
TESPA1-0.4
SOHLH1-0.388
TNNT2-0.381
NEUROD2-0.379
TBR1-0.351
KCNS1-0.346
CUX2-0.346
EMX1-0.341
CBLN2-0.334

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of CRISP2 mRNA"23829299
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of CRISP2 mRNA"23829299
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CRISP2 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CRISP2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CRISP2 mRNA16483693
D001151ArsenicArsenic affects the methylation of CRISP2 gene25304211
C015001arsenitearsenite results in increased methylation of CRISP2 promoter23974009
D001280AtrazineAtrazine results in increased expression of CRISP2 mRNA22378314
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CRISP2 mRNA18164116
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of CRISP2 mRNA23650126
C014347decitabinedecitabine results in increased expression of CRISP2 mRNA19401350
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CRISP2 mRNA18164116
D004317DoxorubicinDoxorubicin results in decreased expression of CRISP2 mRNA16404146
C052034fenoxycarbfenoxycarb results in increased expression of CRISP2 mRNA27553699
C039281furanfuran results in increased methylation of CRISP2 gene22079235
C017461lead nitratelead nitrate results in decreased expression of CRISP2 mRNA21628963
D018021Lithium ChlorideLithium Chloride results in decreased expression of CRISP2 mRNA15711924
C046012pentanalpentanal results in increased expression of CRISP2 mRNA26079696
C006253pirinixic acidpirinixic acid results in increased expression of CRISP2 mRNA20813756
D012969Sodium FluorideSodium Fluoride results in increased expression of CRISP2 protein28918527
C012589trichostatin Atrichostatin A results in decreased expression of CRISP2 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased methylation of CRISP2 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of CRISP2 mRNA15901671
C025643vinclozolinvinclozolin results in increased expression of CRISP2 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-TAS8665901  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22792237Different genes interact with particulate matter and tobacco smoke exposure in affecting lung function decline in the general population. (2012)Curjuric IPLoS One