Gene: NR2C2

7182
TAK1|TR4
nuclear receptor subfamily 2 group C member 2
protein-coding
3p25.1
Ensembl:ENSG00000177463 MIM:601426 Vega:OTTHUMG00000129839 UniprotKB:P49116
NC_000003.12
PubMed
0   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.308e-1 (AD)  1.525e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC12A60.891
UBE4A0.882
ASH1L0.871
NEU30.868
LNPEP0.867
PIAS10.862
PLEKHM30.86
ZNF910.858
SMCR80.856
KLHL110.856

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.387
ROM1-0.375
BCL7C-0.374
PPP1R14B-0.371
OR4F5-0.365
HMX1-0.356
RAB13-0.351
RARRES2-0.346
OR4F29-0.342
ZNF114-0.34

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2C2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2C2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2C2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2C2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2C2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2C2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NR2C2 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NR2C2 mRNA16483693
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NR2C2 mRNA"19150397
C006780bisphenol Abisphenol A affects the methylation of NR2C2 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of NR2C2 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of NR2C2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of NR2C2 mRNA29097150
D002713ChlorineChlorine results in decreased expression of NR2C2 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of NR2C2 mRNA18636392
D003300CopperCopper results in increased expression of NR2C2 mRNA24403277
D019327Copper SulfateCopper Sulfate results in increased expression of NR2C2 mRNA19549813
D003520CyclophosphamideCyclophosphamide results in increased expression of NR2C2 mRNA27281708
D016572CyclosporineCyclosporine results in increased expression of NR2C2 mRNA20106945|2556210
D003907DexamethasoneDexamethasone results in increased expression of NR2C2 mRNA19022236
D003976DiazinonDiazinon results in increased methylation of NR2C2 gene22964155
C000944dicrotophosdicrotophos results in increased expression of NR2C2 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of NR2C2 mRNA26924002
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of NR2C2 mRNA12807726
C024629dimethyl phthalatedimethyl phthalate affects the expression of NR2C2 mRNA26924002
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NR2C2 mRNA29097150
C024565ethylene dichlorideethylene dichloride results in decreased expression of NR2C2 mRNA28189721
C001277geldanamycingeldanamycin results in increased expression of NR2C2 mRNA26705709
D019833GenisteinGenistein results in decreased expression of NR2C2 mRNA16705744
D017313FenretinideFenretinide results in increased expression of NR2C2 mRNA16570282
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of NR2C2 mRNA17183730
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of NR2C2 mRNA"11578593
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NR2C2 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] affects the expression of NR2C2 mRNA26378955
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate results in increased expression of NR2C2 mRNA28349193
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NR2C2 mRNA23179753|2627250
D008767Methylmercury Compounds[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of NR2C2 mRNA20020106
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NR2C2 mRNA"20188158
C517284monomethyl phthalatemonomethyl phthalate affects the expression of NR2C2 mRNA26924002
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of NR2C2 mRNA18636392
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of NR2C2 mRNA18593933
D010634PhenobarbitalPhenobarbital results in decreased expression of NR2C2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2C2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of NR2C2 mRNA26272509
D011078Polychlorinated Biphenyls[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of NR2C2 mRNA20020106
D011374ProgesteroneProgesterone results in increased expression of NR2C2 mRNA21549006
C009277sodium arsenatesodium arsenate results in decreased expression of NR2C2 mRNA21795629
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NR2C2 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] affects the expression of NR2C2 mRNA26378955
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of NR2C2 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NR2C2 mRNA17884332
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NR2C2 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NR2C2 mRNA22298810
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of NR2C2 mRNA28973375
D013849ThimerosalThimerosal results in decreased expression of NR2C2 mRNA27188386
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2C2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of NR2C2 mRNA26272509
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NR2C2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of NR2C2 mRNA28973697
D014520UrethaneUrethane results in increased expression of NR2C2 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of NR2C2 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR2C2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NR2C2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NR2C2 mRNA26272509
D014635Valproic AcidValproic Acid results in decreased methylation of NR2C2 gene29154799
C111237vorinostatvorinostat results in decreased expression of NR2C2 mRNA27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of NR2C2 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA9556573  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10644740  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IC-  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10644740  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IC-  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA9556573  
GO:0003700DNA-binding transcription factor activity-IDA10644740  
GO:0003707steroid hormone receptor activity-IEA-  
GO:0003713transcription coactivator activity-TAS9006963  
GO:0005515protein binding-IPI12486131  16887930  
GO:0008270zinc ion binding-IEA-  
GO:0038023signaling receptor activity-TAS9006963  
GO:0043565sequence-specific DNA binding-IDA10644740  
GO:0046982protein heterodimerization activity-IDA17974920  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-TAS9006963  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0007283spermatogenesis-IEA-  
GO:0007399nervous system development-TAS9006963  
GO:0030154cell differentiation-IEA-  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA9556573  10644740  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-383280Nuclear Receptor transcription pathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22488850Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. (2012 Jun)Zuo LAm J Med Genet B Neuropsychiatr Genet