Gene info: ID 7184

Gene: HSP90B1

GENE ID: 7184

Synonyms: ECGP|GP96|GRP94|HEL-S-125m|HEL35|TRA1

Description: heat shock protein 90 beta family member 1

Gene type: protein-coding

Location: 12q23.3

dbXrefs: Ensembl:ENSG00000166598 MIM:191175 Vega:OTTHUMG00000170118 UniprotKB:P14625

RefSeq: NC_000012.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.112e-1 (AD) 9.714e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PDIA3	0.949
CALR	0.927
PTGES3	0.926
HSPA5	0.922
CCT3	0.906
TCP1	0.905
SSR2	0.902
DNAJB11	0.898
HSP90AA1	0.895
UBE2D3	0.895

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.759
OR4F29	-0.744
C16orf97	-0.172
TCL1A	-0.157
KLRB1	-0.15
KRTAP19-1	-0.143
LYZL2	-0.137
C8orf74	-0.135
HMHB1	-0.134
HES5	-0.134

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00615	Rifabutin	Small Molecule	72559-06-9	Approved\|Investigational	Target
DB02103	2-Chlorodideoxyadenosine	Small Molecule	114849-58-0	Experimental	Target
DB02424	Geldanamycin	Small Molecule	30562-34-6	Experimental\|Investigational	Target
DB02935	Diglyme	Small Molecule	111-96-6	Experimental	Target
DB03719	N-Ethyl-5'-Carboxamido Adenosine	Small Molecule		Experimental	Target
DB03758	Radicicol	Small Molecule		Experimental	Target
DB08464	METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE	Small Molecule		Experimental	Target
DB08465	2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE	Small Molecule		Experimental	Target
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HSP90B1 protein]"	25950987
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of HSP90B1 mRNA"	15375163
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of HSP90B1 mRNA"	19162173
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of HSP90B1 protein"	21673325
C587734	2,3,5-trichloro-6-phenyl-(1,4)benzoquinone	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HSP90B1 protein]"	25950987
C587734	2,3,5-trichloro-6-phenyl-(1,4)benzoquinone	"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HSP90B1 mRNA"	25950987
C587734	2,3,5-trichloro-6-phenyl-(1,4)benzoquinone	"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HSP90B1 protein"	25950987
C587734	2,3,5-trichloro-6-phenyl-(1,4)benzoquinone	"Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HSP90B1 protein]"	25950987
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of HSP90B1 mRNA"	21346803
C024709	2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone	"2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone binds to HSP90B1 protein"	16533022
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of HSP90B1 mRNA"	20206263
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane results in increased expression of HSP90B1 mRNA"	16192472
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased metabolism of HSP90B1 protein	21402099
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of HSP90B1 mRNA"	18648102
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of HSP90B1 mRNA"	19561079
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of HSP90B1 mRNA"	21346803
C026729	4-aminophenol	4-aminophenol results in increased expression of HSP90B1 protein	17567590\|1756759
C082164	4-methoxycinnamate methyl ester	4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA]	19442820
C535075	4-tosylcyclonovobiocic acid	4-tosylcyclonovobiocic acid results in increased expression of HSP90B1 protein	19118525
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide affects the expression of HSP90B1 mRNA	20829426
C057360	5-(N,N-hexamethylene)amiloride	"5-(N,N-hexamethylene)amiloride affects the expression of HSP90B1 mRNA"	19302589
C535076	7-tosylcyclonovobiocic acid	7-tosylcyclonovobiocic acid results in increased expression of HSP90B1 protein	19118525
D000082	Acetaminophen	Acetaminophen results in decreased expression of HSP90B1 mRNA	22230336\|2669055
D000082	Acetaminophen	Acetaminophen affects the expression of HSP90B1 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of HSP90B1 mRNA	11743745
D000082	Acetaminophen	PTGS2 protein affects the reaction [Acetaminophen results in increased expression of HSP90B1 mRNA]	11743745
D000111	Acetylcysteine	"Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HSP90B1 protein]"	25950987
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of HSP90B1 mRNA]	21533816
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSP90B1 protein]	25451595
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HSP90B1 protein]	21911445
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of HSP90B1 protein]	21145380
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSP90B1 mRNA]	18086661
D000171	Acrolein	Acrolein results in decreased expression of HSP90B1 mRNA	28482051
D000171	Acrolein	Acrolein results in increased expression of HSP90B1 mRNA	28119953
C016601	afimoxifene	afimoxifene results in decreased expression of HSP90B1 mRNA	16514628
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HSP90B1 mRNA	19770486
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in decreased expression of HSP90B1 protein	26072098\|2659704
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of HSP90B1 protein	26072098\|2659704
D047310	Apigenin	Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSP90B1 protein]	20493918
D047310	Apigenin	Apigenin inhibits the reaction [Thapsigargin results in increased expression of HSP90B1 protein]	20493918
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of HSP90B1 mRNA	20458559
C006632	arsenic trioxide	arsenic trioxide results in increased expression of HSP90B1 protein	19364129
C006632	arsenic trioxide	Acetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of HSP90B1 mRNA]	21533816
C006632	arsenic trioxide	arsenic trioxide results in increased expression of HSP90B1 mRNA	21533816
C006632	arsenic trioxide	arsenic trioxide results in increased expression of HSP90B1 protein	27638049
C006632	arsenic trioxide	ATF4 protein promotes the reaction [arsenic trioxide results in increased expression of HSP90B1 protein]	27638049
C006632	arsenic trioxide	Thapsigargin promotes the reaction [arsenic trioxide results in increased expression of HSP90B1 protein]	27638049
C006632	arsenic trioxide	Acetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of HSP90B1 protein]	21145380
C006632	arsenic trioxide	arsenic trioxide results in increased expression of HSP90B1 protein	21145380
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of HSP90B1 mRNA	26976014
C015001	arsenite	arsenite results in increased methylation of HSP90B1 promoter	23974009
C547126	AZM551248	AZM551248 results in increased expression of HSP90B1 mRNA	22323515
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of HSP90B1 mRNA	26377693
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of HSP90B1 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HSP90B1 mRNA	22300585
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HSP90B1 mRNA"	26238291
D004958	Estradiol	Estradiol results in decreased expression of HSP90B1 mRNA	24349563
D004958	Estradiol	[Estradiol co-treated with ESR1 protein] results in increased expression of HSP90B1 protein	19269315
D004958	Estradiol	Estradiol results in increased expression of HSP90B1 mRNA	16514628
D004958	Estradiol	Estradiol results in increased expression of HSP90B1 protein	11568360
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in increased expression of HSP90B1 protein]	11568360
D004958	Estradiol	Estradiol results in increased expression of HSP90B1 mRNA	16192472\|1782345
C110172	BHTOH-QM	BHTOH-QM binds to HSP90B1 protein	16533022
C006780	bisphenol A	bisphenol A affects the expression of HSP90B1 mRNA	20170705
C006780	bisphenol A	[bisphenol A co-treated with ESR1 protein] results in increased expression of HSP90B1 protein	19269315
C006780	bisphenol A	bisphenol A results in decreased expression of HSP90B1 protein	21705745
C006780	bisphenol A	bisphenol A results in increased expression of HSP90B1 mRNA	26063408
C006780	bisphenol A	bisphenol A results in increased expression of HSP90B1 protein	11568360\|1246079
C006780	bisphenol A	fulvestrant inhibits the reaction [bisphenol A results in increased expression of HSP90B1 protein]	11568360
C006780	bisphenol A	bisphenol A affects the expression of HSP90B1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of HSP90B1 protein	20219716
C006780	bisphenol A	bisphenol A results in increased expression of HSP90B1 mRNA	25181051
C423844	BL 11282	BL 11282 binds to HSP90B1 protein	18420036
D001761	Bleomycin	[Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of HSP90B1 protein	24478030
D020126	Brefeldin A	Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSP90B1 protein]	20493918
D020126	Brefeldin A	Brefeldin A results in increased expression of HSP90B1 protein	20493918
C515564	bromovanin	bromovanin results in increased expression of HSP90B1 protein	21419150
D020122	tert-Butylhydroperoxide	PD 150606 inhibits the reaction [tert-Butylhydroperoxide results in increased expression of HSP90B1 protein]	16920763
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of HSP90B1 protein	16005169
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of HSP90B1 protein	16920763
C584509	C646 compound	C646 compound results in increased expression of HSP90B1 mRNA	26191083
D002104	Cadmium	Cadmium results in increased expression of HSP90B1	25805271
D002104	Cadmium	Selenium inhibits the reaction [Cadmium results in increased expression of HSP90B1]	25805271
D002104	Cadmium	Cadmium results in decreased expression of HSP90B1 mRNA	16439709
D002104	Cadmium	Cadmium results in increased expression of HSP90B1 protein	16440303
D002104	Cadmium	Cadmium results in increased expression of HSP90B1 mRNA	24084258
D002104	Cadmium	Cadmium results in increased expression of HSP90B1 protein	8378928
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSP90B1 protein	20071421
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of HSP90B1 mRNA	23828170
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSP90B1 protein	16440303
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSP90B1 mRNA	18636176
D019256	Cadmium Chloride	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSP90B1 mRNA]	18086661
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSP90B1 mRNA	17464326\|1808666
C040048	caffeic acid	caffeic acid promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA]	19442820
D002110	Caffeine	Caffeine results in decreased expression of HSP90B1 mRNA	25868845
D000001	Calcimycin	Calcimycin results in increased expression of HSP90B1 protein	23226310
D002211	Capsaicin	Capsaicin results in increased expression of HSP90B1 protein	18991268
D002211	Capsaicin	Capsaicin inhibits the reaction [Dietary Fats results in increased expression of HSP90B1 protein]	20359164
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of HSP90B1 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of HSP90B1 mRNA	15963578
D002251	Carbon Tetrachloride	[Dimethylformamide co-treated with Carbon Tetrachloride] results in increased expression of HSP90B1 protein	20097184
C006972	chloroacetic acid	Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSP90B1 protein]	25451595
C006972	chloroacetic acid	chloroacetic acid results in increased expression of HSP90B1 mRNA	25451595
C006972	chloroacetic acid	chloroacetic acid results in increased expression of HSP90B1 protein	25451595
C006972	chloroacetic acid	HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]	25451595
C006972	chloroacetic acid	HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]	25451595
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of HSP90B1 mRNA	23650126
C100187	chloropicrin	chloropicrin results in increased expression of HSP90B1 mRNA	26352163
D002784	Cholesterol	Cholesterol results in decreased expression of HSP90B1 protein	17029598
D002994	Clofibrate	Clofibrate results in decreased expression of HSP90B1 mRNA	22300585
D002994	Clofibrate	Clofibrate results in decreased expression of HSP90B1 mRNA	21318169
C018021	cobaltous chloride	cobaltous chloride results in increased expression of and affects the localization of HSP90B1 protein	23684559
C018021	cobaltous chloride	cobaltous chloride results in increased expression of HSP90B1 mRNA	17464326
D003300	Copper	HSP90B1 protein binds to Copper	14534351
D003300	Copper	Copper results in increased expression of HSP90B1 mRNA	25646894
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of HSP90B1 mRNA	19549813
D019327	Copper Sulfate	Copper Sulfate results in increased expression of HSP90B1 mRNA	20599845
D019327	Copper Sulfate	Copper Sulfate results in increased expression of HSP90B1 mRNA	17464326
C030123	coumarin	coumarin results in increased expression of HSP90B1 mRNA	18480146
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of HSP90B1 mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of HSP90B1 mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of HSP90B1 protein	12460799
C029892	cupric chloride	[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSP90B1 mRNA	20920558
C029892	cupric chloride	[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSP90B1 protein	20920558
C029892	cupric chloride	pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSP90B1 mRNA]	20920558
D003474	Curcumin	Curcumin inhibits the reaction [lead nitrate results in increased expression of HSP90B1 protein]	20071421
D003474	Curcumin	Curcumin analog results in decreased expression of HSP90B1 mRNA	26409325
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of HSP90B1 mRNA	11906922
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of HSP90B1 mRNA	11599041
D016572	Cyclosporine	Cyclosporine results in increased expression of HSP90B1 mRNA	19159671\|2010694
D013759	Dronabinol	Dronabinol results in decreased expression of HSP90B1 mRNA	12237329
D003907	Dexamethasone	Dexamethasone results in increased expression of HSP90B1 mRNA	21356098
D003974	Diatrizoate Meglumine	Diatrizoate Meglumine results in increased expression of HSP90B1 protein	20071420
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of HSP90B1 mRNA	17361019
D002945	Cisplatin	[Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of HSP90B1 protein	24478030
D002945	Cisplatin	Cisplatin results in decreased expression of HSP90B1 mRNA	18246545
C000944	dicrotophos	dicrotophos results in decreased expression of HSP90B1 mRNA	28302478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of HSP90B1 mRNA	26924002
D004026	Dieldrin	Dieldrin results in decreased expression of HSP90B1 mRNA	23041725
C005406	dienochlor	dienochlor results in decreased expression of HSP90B1 protein	16884889
D004041	Dietary Fats	[Streptozocin co-treated with Dietary Fats] results in increased expression of HSP90B1 mRNA	26522834
D004041	Dietary Fats	Capsaicin inhibits the reaction [Dietary Fats results in increased expression of HSP90B1 protein]	20359164
D004041	Dietary Fats	Dietary Fats results in increased expression of HSP90B1 protein	20359164
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of HSP90B1 mRNA	21318169
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of HSP90B1 protein	12460799
D004126	Dimethylformamide	[Dimethylformamide co-treated with Carbon Tetrachloride] results in increased expression of HSP90B1 protein	20097184
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of HSP90B1 mRNA	26924002
D004147	Dioxins	Dioxins affects the expression of HSP90B1 mRNA	20463971
D004237	Diuron	Diuron results in decreased expression of HSP90B1 mRNA	21551480
D004298	Dopamine	Dopamine results in increased expression of HSP90B1 protein	24675778
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA]"	19442820
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in decreased expression of HSP90B1 protein"	18422750
D004391	Dust	Dust results in increased expression of HSP90B1 mRNA	17805423
D004726	Endosulfan	Endosulfan results in decreased expression of HSP90B1 protein	16884889
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of HSP90B1 mRNA	24534155
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HSP90B1 protein	23301498
D000431	Ethanol	Ethanol results in increased expression of HSP90B1 mRNA	28119953
D000431	Ethanol	Ethanol affects the expression of HSP90B1 protein	22960358
D000431	Ethanol	Ethanol results in increased expression of HSP90B1 mRNA	28119953
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of HSP90B1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of HSP90B1 mRNA	20170705\|2686566
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of HSP90B1 mRNA	23649840
D005047	Etoposide	[Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of HSP90B1 protein	24478030
D011345	Fenofibrate	Fenofibrate results in increased expression of HSP90B1 mRNA	21318169
C070081	fulvestrant	fulvestrant results in decreased expression of HSP90B1 mRNA	16514628
C070081	fulvestrant	fulvestrant inhibits the reaction [bisphenol A results in increased expression of HSP90B1 protein]	11568360
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in increased expression of HSP90B1 protein]	11568360
C001277	geldanamycin	geldanamycin binds to HSP90B1 protein	8617772
C001277	geldanamycin	[geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein]	8617772
D019833	Genistein	Genistein results in increased expression of HSP90B1 mRNA	26865667
D005839	Gentamicins	HSP90B1 protein binds to Gentamicins	21785162
D005839	Gentamicins	Gentamicins results in increased expression of HSP90B1 protein	17567590
D005897	Glafenine	Glafenine results in increased expression of HSP90B1 mRNA	24136188
D005944	Glucosamine	Glucosamine results in increased expression of HSP90B1 protein	15618547
D005944	Glucosamine	Glucosamine results in decreased expression of HSP90B1 mRNA	17178593
D005944	Glucosamine	Glucosamine results in decreased expression of HSP90B1 mRNA	17109745
D005947	Glucose	Glucose deficiency results in increased secretion of HSP90B1 protein	24802182
D005947	Glucose	Glucose results in decreased expression of HSP90B1 mRNA	17178593
D006820	Hyaluronic Acid	Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of HSP90B1 protein]	23178681
D006820	Hyaluronic Acid	Hyaluronic Acid analog results in decreased expression of HSP90B1 protein	23178681
D006861	Hydrogen Peroxide	Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of HSP90B1 protein]	23178681
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of HSP90B1 protein	23178681
C001654	hyperforin	hyperforin affects the expression of HSP90B1 protein	15095150
C082359	imidacloprid	imidacloprid results in decreased expression of HSP90B1 protein	16884889
C016517	indole-3-carbinol	indole-3-carbinol results in increased expression of HSP90B1 mRNA	16192472
D007213	Indomethacin	Indomethacin results in increased expression of HSP90B1 mRNA	28201806
D007460	Iodoacetamide	Iodoacetamide results in decreased expression of HSP90B1 protein	16005169
D007460	Iodoacetamide	Iodoacetamide results in increased expression of HSP90B1 protein	16920763
D007460	Iodoacetamide	PD 150606 inhibits the reaction [Iodoacetamide results in increased expression of HSP90B1 protein]	16920763
D007545	Isoproterenol	Isoproterenol results in decreased expression of HSP90B1 mRNA	20003209
C008261	lead acetate	lead acetate affects the expression of HSP90B1 mRNA	21829687
C008261	lead acetate	lead acetate results in increased expression of HSP90B1 mRNA	17464326
C017461	lead nitrate	Curcumin inhibits the reaction [lead nitrate results in increased expression of HSP90B1 protein]	20071421
C017461	lead nitrate	lead nitrate results in increased expression of HSP90B1 mRNA	20071421
C017461	lead nitrate	lead nitrate results in increased expression of HSP90B1 protein	20071421
C017461	lead nitrate	pyrazolanthrone inhibits the reaction [lead nitrate results in increased expression of HSP90B1 protein]	20071421
C017461	lead nitrate	lead nitrate results in decreased expression of HSP90B1 mRNA	26976014
C052901	lemongrass oil	lemongrass oil affects the expression of HSP90B1 mRNA	25976427
D008070	Lipopolysaccharides	Lipopolysaccharides affects the localization of HSP90B1 protein	17475668
D008070	Lipopolysaccharides	Vaticanol B inhibits the reaction [Lipopolysaccharides affects the localization of HSP90B1 protein]	17475668
D008094	Lithium	Lithium results in increased expression of HSP90B1 mRNA	16236328
D008094	Lithium	Lithium results in increased expression of HSP90B1 protein	16236328\|1829663
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of HSP90B1 mRNA	21641980
C025340	manganese chloride	manganese chloride results in increased expression of HSP90B1 mRNA	23934647\|2394812
C025340	manganese chloride	manganese chloride results in increased expression of HSP90B1 protein	23934647\|2394812
C025340	manganese chloride	SNCA protein promotes the reaction [manganese chloride results in increased expression of HSP90B1 mRNA]	23934647
C025340	manganese chloride	SNCA protein promotes the reaction [manganese chloride results in increased expression of HSP90B1 protein]	23934647
C009760	mequinol	[mequinol co-treated with ESR1 protein] results in increased expression of HSP90B1 protein	19269315
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of HSP90B1 mRNA	20353558
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of HSP90B1 protein	10696793
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of HSP90B1 mRNA	17464326
D008724	Methomyl	Methomyl results in decreased expression of HSP90B1 protein	16271832
D008727	Methotrexate	Methotrexate affects the expression of HSP90B1 mRNA	18502557
C013598	methoxyacetic acid	methoxyacetic acid results in increased phosphorylation of HSP90B1 protein	11794376
D008731	Methoxychlor	Methoxychlor affects the expression of HSP90B1 mRNA	20829426
D008731	Methoxychlor	Methoxychlor results in increased expression of HSP90B1 protein	12460799
C005219	methyl cellosolve	methyl cellosolve metabolite results in increased phosphorylation of HSP90B1 protein	11794376
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of HSP90B1 mRNA	17961207
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of HSP90B1 mRNA	23103053
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of HSP90B1 mRNA	28001369
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of HSP90B1 mRNA	20039754
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of HSP90B1 mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of HSP90B1 mRNA"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of HSP90B1 promoter"	26251327
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in increased expression of HSP90B1 mRNA	12634122
D008743	Methyl Parathion	Methyl Parathion results in increased expression of HSP90B1 mRNA	22182705
D008743	Methyl Parathion	Methyl Parathion results in increased expression of HSP90B1 protein	22182705
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of HSP90B1 mRNA	24810058
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of HSP90B1 protein	24675778
D015655	1-Methyl-4-phenylpyridinium	U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of HSP90B1 mRNA]	12710931
C008493	methylselenic acid	HSPA5 protein inhibits the reaction [methylselenic acid results in increased expression of HSP90B1 protein]	16204082
C008493	methylselenic acid	methylselenic acid results in increased expression of HSP90B1 protein	16204082
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of HSP90B1 mRNA	26924002
D009020	Morphine	Morphine results in decreased expression of HSP90B1 protein	23056601
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of HSP90B1 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of HSP90B1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of HSP90B1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of HSP90B1 mRNA"	25620056
D009532	Nickel	Nickel results in increased expression of HSP90B1 mRNA	24084258
C119536	nickel acetate	nickel acetate affects the expression of HSP90B1 mRNA	23828170
C119536	nickel acetate	nickel acetate affects the expression of HSP90B1 protein	23828170
C119536	nickel acetate	nickel acetate results in increased expression of HSP90B1 mRNA	17464326
C022838	nickel chloride	nickel chloride results in increased expression of HSP90B1 mRNA	24612858
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in decreased expression of HSP90B1 protein	19716841
C025589	ochratoxin A	ochratoxin A results in decreased expression of HSP90B1 mRNA	14994279
C025589	ochratoxin A	ochratoxin A results in increased expression of HSP90B1 mRNA	14994279
D016627	Oxidopamine	Oxidopamine results in increased expression of HSP90B1 mRNA	12486162
D010100	Oxygen	Oxygen deficiency results in increased expression of HSP90B1 mRNA	24205000
D010269	Paraquat	Paraquat results in increased expression of HSP90B1 mRNA	17935786
D052638	Particulate Matter	Particulate Matter results in decreased expression of HSP90B1 mRNA	24769257
C100442	PD 150606	PD 150606 inhibits the reaction [Iodoacetamide results in increased expression of HSP90B1 protein]	16920763
C100442	PD 150606	PD 150606 inhibits the reaction [tert-Butylhydroperoxide results in increased expression of HSP90B1 protein]	16920763
C100442	PD 150606	PD 150606 inhibits the reaction [Thapsigargin results in increased cleavage of HSP90B1 protein]	16920763
C100442	PD 150606	PD 150606 inhibits the reaction [Vitamin K 3 results in increased expression of HSP90B1 protein]	16920763
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of HSP90B1 protein	19954255
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of HSP90B1 protein	19954255
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of HSP90B1 mRNA	24642059
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of HSP90B1 mRNA	19429403
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of HSP90B1 mRNA	18611081
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HSP90B1 mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of HSP90B1 mRNA	19429403
C006253	pirinixic acid	pirinixic acid results in decreased expression of HSP90B1 mRNA	21318169\|2381119
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in decreased expression of HSP90B1 mRNA]	21318169
C443641	poly(propyleneimine)	poly(propyleneimine) analog results in increased expression of HSP90B1 mRNA	16308212
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of HSP90B1 mRNA	18332044
C035988	procymidone	procymidone results in decreased expression of HSP90B1 mRNA	15686871
D011374	Progesterone	Progesterone affects the expression of HSP90B1 mRNA	17251523
C015586	propiverine	propiverine binds to HSP90B1 protein	29273565
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of HSP90B1 mRNA	24780913
C100573	prostaglandin A1	prostaglandin A1 analog results in increased metabolism of HSP90B1 protein	19800325
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [lead nitrate results in increased expression of HSP90B1 protein]	20071421
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSP90B1 mRNA]	20920558
C031280	pyrazole	pyrazole results in increased expression of HSP90B1 mRNA	17945193
C020972	pyrrolidine dithiocarbamic acid	[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSP90B1 mRNA	20920558
C020972	pyrrolidine dithiocarbamic acid	[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSP90B1 protein	20920558
C020972	pyrrolidine dithiocarbamic acid	pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSP90B1 mRNA]	20920558
D011794	Quercetin	Quercetin results in increased expression of HSP90B1 mRNA	21356098
D011794	Quercetin	Quercetin results in increased expression of HSP90B1 protein	15221776
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of HSP90B1 mRNA	16514628
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of HSP90B1 mRNA	19167446
D015474	Isotretinoin	Isotretinoin results in decreased expression of HSP90B1 mRNA	20436886
C089730	rosiglitazone	rosiglitazone affects the expression of HSP90B1 protein	19556978
D012643	Selenium	Selenium inhibits the reaction [Cadmium results in increased expression of HSP90B1]	25805271
D012643	Selenium	[Selenium co-treated with Vitamin E] results in decreased expression of HSP90B1 mRNA	19244175
D012643	Selenium	Selenium results in decreased expression of HSP90B1 mRNA	19244175
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of HSP90B1 mRNA"	25324550
D012822	Silicon Dioxide	Silicon Dioxide analog affects the secretion of HSP90B1 protein	25895662
C534922	SNX 2112	SNX 2112 results in decreased expression of HSP90B1 protein	23777986
C009277	sodium arsenate	sodium arsenate results in decreased expression of HSP90B1 mRNA	24349563
C017947	sodium arsenite	sodium arsenite results in decreased expression of HSP90B1 mRNA	28595984
C017947	sodium arsenite	Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HSP90B1 protein]	21911445
C017947	sodium arsenite	sodium arsenite results in decreased expression of HSP90B1 mRNA	19822182
C017947	sodium arsenite	sodium arsenite results in increased expression of HSP90B1 protein	21911445
C016104	sodium bichromate	sodium bichromate results in increased expression of HSP90B1 mRNA	12325037
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of HSP90B1 protein	27548804
D013311	Streptozocin	[Streptozocin co-treated with Dietary Fats] results in increased expression of HSP90B1 mRNA	26522834
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of HSP90B1 mRNA	21641980
C059873	sulfamethoxazole hydroxylamine	sulfamethoxazole hydroxylamine results in decreased expression of HSP90B1 protein	16005169
D013605	T-2 Toxin	T-2 Toxin affects the expression of HSP90B1 protein	26141394
C061133	tamibarotene	tamibarotene results in decreased expression of HSP90B1 mRNA	15498508
D013629	Tamoxifen	Tamoxifen affects the expression of HSP90B1 mRNA	17555576
D013629	Tamoxifen	Tamoxifen results in increased expression of HSP90B1 protein	12460799
C004648	testosterone enanthate	testosterone enanthate affects the expression of HSP90B1 mRNA	17440010
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HSP90B1 mRNA	24349563
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HSP90B1 mRNA	21998131
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HSP90B1 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HSP90B1 mRNA	26290441
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HSP90B1 protein	16548065
D013752	Tetracycline	Tetracycline results in increased expression of HSP90B1 mRNA	16917069
D019284	Thapsigargin	Thapsigargin results in increased expression of HSP90B1 protein	20071421
D019284	Thapsigargin	4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA]	19442820
D019284	Thapsigargin	caffeic acid promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA]	19442820
D019284	Thapsigargin	"Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA]"	19442820
D019284	Thapsigargin	Thapsigargin results in decreased expression of HSP90B1 mRNA	19442820
D019284	Thapsigargin	Thapsigargin results in increased expression of HSP90B1 mRNA	15292203\|2237831
D019284	Thapsigargin	Thapsigargin results in increased expression of HSP90B1 protein	17416481
D019284	Thapsigargin	Apigenin inhibits the reaction [Thapsigargin results in increased expression of HSP90B1 protein]	20493918
D019284	Thapsigargin	Thapsigargin promotes the reaction [arsenic trioxide results in increased expression of HSP90B1 protein]	27638049
D019284	Thapsigargin	Thapsigargin results in increased expression of HSP90B1 protein	20493918
D019284	Thapsigargin	Thapsigargin results in increased expression of HSP90B1 protein	17416481
D019284	Thapsigargin	PD 150606 inhibits the reaction [Thapsigargin results in increased cleavage of HSP90B1 protein]	16920763
D019284	Thapsigargin	Thapsigargin results in decreased expression of HSP90B1 protein	16920763
D019284	Thapsigargin	Thapsigargin results in increased cleavage of HSP90B1 protein	16920763
D019284	Thapsigargin	Thapsigargin results in increased expression of HSP90B1 protein	16759985\|1692076
C009495	titanium dioxide	titanium dioxide results in increased expression of HSP90B1 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution analog results in increased expression of HSP90B1 mRNA	20920546
C082097	tocotrienol, delta	"tocotrienol, delta results in increased expression of HSP90B1 mRNA"	21356098
D014118	Toxins, Biological	"Toxins, Biological affects the expression of HSP90B1 mRNA"	19682533
D014212	Tretinoin	Tretinoin results in increased expression of HSP90B1 mRNA	18230668\|2053023
D014212	Tretinoin	Tretinoin results in decreased expression of HSP90B1 mRNA	15498508
C012589	trichostatin A	trichostatin A affects the expression of HSP90B1 mRNA	28542535
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of HSP90B1 mRNA	21346803
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HSP90B1 mRNA"	26743178
D014315	Triterpenes	Triterpenes results in decreased expression of HSP90B1 protein	18422750
D014415	Tunicamycin	Tunicamycin results in increased expression of HSP90B1 protein	20071421
D014415	Tunicamycin	Tunicamycin results in increased expression of HSP90B1 protein	17416481
D014415	Tunicamycin	Tunicamycin results in increased expression of HSP90B1 mRNA	15049342\|2237831
D014415	Tunicamycin	Tunicamycin results in increased expression of HSP90B1 protein	17416481
D014415	Tunicamycin	Tunicamycin results in increased expression of HSP90B1 protein	20477944
D014415	Tunicamycin	Tunicamycin results in increased expression of HSP90B1 protein	15049342\|1741648
D014415	Tunicamycin	Tunicamycin results in increased expression of HSP90B1 protein	15049342\|1741648
C113580	U 0126	U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of HSP90B1 mRNA]	12710931
D014635	Valproic Acid	Valproic Acid affects the expression of HSP90B1 mRNA	17292431
D014635	Valproic Acid	Valproic Acid inhibits the reaction [WFS1 protein binds to HSP90B1 protein]	19125190
D014635	Valproic Acid	Valproic Acid results in decreased expression of HSP90B1 mRNA	21318169
D014635	Valproic Acid	Valproic Acid results in increased expression of HSP90B1 protein	16236328
C522219	Vaticanol B	Vaticanol B inhibits the reaction [Lipopolysaccharides affects the localization of HSP90B1 protein]	17475668
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of HSP90B1 gene	25560391
C490154	versipelostatin	versipelostatin results in decreased expression of HSP90B1 mRNA	21526763
C025643	vinclozolin	vinclozolin results in decreased expression of HSP90B1 mRNA	15686871
D014800	Vitallium	Vitallium analog results in decreased expression of HSP90B1 mRNA	23825117
D012256	Riboflavin	Riboflavin results in increased expression of HSP90B1 mRNA	21356098
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in decreased expression of HSP90B1 mRNA	19244175
D014810	Vitamin E	Vitamin E results in decreased expression of HSP90B1 mRNA	19244175
D024483	Vitamin K 3	Vitamin K 3 affects the expression of HSP90B1 mRNA	20829426
D024483	Vitamin K 3	PD 150606 inhibits the reaction [Vitamin K 3 results in increased expression of HSP90B1 protein]	16920763
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of HSP90B1 mRNA	18086661
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of HSP90B1 protein	16920763
C111237	vorinostat	vorinostat results in decreased expression of HSP90B1 protein	17593366
C009684	withaferin A	withaferin A results in increased expression of HSP90B1 protein	23226310
D015032	Zinc	Zinc deficiency results in increased expression of HSP90B1 mRNA	22171008
D015034	Zinc Oxide	Zinc Oxide analog results in increased expression of HSP90B1 mRNA	25680694

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	IDA	11958450
GO:0005509	calcium ion binding	-	TAS	10497210
GO:0005515	protein binding	-	IPI	9596688 11907036 11958450 15845869 18264092 23349634 23995768
GO:0005524	ATP binding	-	IEA	-
GO:0019903	protein phosphatase binding	-	IDA	19000834
GO:0050750	low-density lipoprotein particle receptor binding	-	IDA	15082773
GO:0051082	unfolded protein binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001666	response to hypoxia	-	IDA	15620698
GO:0002224	toll-like receptor signaling pathway	-	TAS	-
GO:0006898	receptor-mediated endocytosis	-	TAS	-
GO:0015031	protein transport	-	NAS	15845869
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0030433	ubiquitin-dependent ERAD pathway	-	IMP	18264092
GO:0030970	retrograde protein transport, ER to cytosol	-	IMP	25660456
GO:0031247	actin rod assembly	-	IDA	19000834
GO:0034975	protein folding in endoplasmic reticulum	-	TAS	22013210
GO:0034976	response to endoplasmic reticulum stress	-	TAS	22934019
GO:0036500	ATF6-mediated unfolded protein response	-	TAS	-
GO:0043066	negative regulation of apoptotic process	-	IMP	10497210 15192333
GO:0043066	negative regulation of apoptotic process	-	TAS	16130169
GO:0043666	regulation of phosphoprotein phosphatase activity	-	IDA	19000834
GO:0043687	post-translational protein modification	-	TAS	-
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0051208	sequestering of calcium ion	-	NAS	15192333
GO:0071318	cellular response to ATP	-	IDA	19000834

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005634	nucleus	-	HDA	21630459
GO:0005783	endoplasmic reticulum	-	IDA	17344063
GO:0005783	endoplasmic reticulum	-	TAS	16130169
GO:0005788	endoplasmic reticulum lumen	-	IDA	10497210
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0005789	endoplasmic reticulum membrane	-	IDA	10497210
GO:0005829	cytosol	-	IDA	9596688
GO:0005886	plasma membrane	-	IEA	-
GO:0005925	focal adhesion	-	HDA	21423176
GO:0016020	membrane	-	HDA	19946888
GO:0030496	midbody	-	IDA	15166316
GO:0031012	extracellular matrix	-	HDA	23658023
GO:0032991	protein-containing complex	-	IDA	23349634
GO:0034663	endoplasmic reticulum chaperone complex	-	IEA	-
GO:0042470	melanosome	-	IEA	-
GO:0048471	perinuclear region of cytoplasm	-	IDA	10497210
GO:0070062	extracellular exosome	-	HDA	19199708 20458337
GO:0071682	endocytic vesicle lumen	-	TAS	-

KEGG ID	KEGG Term
hsa04141	Protein processing in endoplasmic reticulum
hsa04621	NOD-like receptor signaling pathway
hsa05200	Pathways in cancer
hsa05215	Prostate cancer

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1679131	Trafficking and processing of endosomal TLR	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	IEA
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	TAS
R-HSA-3000480	Scavenging by Class A Receptors	IEA
R-HSA-3000480	Scavenging by Class A Receptors	TAS
R-HSA-381033	ATF6 (ATF6-alpha) activates chaperones	TAS
R-HSA-381119	Unfolded Protein Response (UPR)	TAS
R-HSA-381183	ATF6 (ATF6-alpha) activates chaperone genes	TAS
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-5653656	Vesicle-mediated transport	IEA
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6785807	Interleukin-4 and 13 signaling	TAS
R-HSA-8957275	Post-translational protein phosphorylation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26318431	Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma. (2016 Feb)	Sun W	Tumour Biol