Gene: TRAF1

7185
EBI6|MGC:10353
TNF receptor associated factor 1
protein-coding
9q33.2
Ensembl:ENSG00000056558 MIM:601711 Vega:OTTHUMG00000020578 UniprotKB:Q13077
NG_023346.1
PubMed
0   ANCO-SNPs
ND
4   
7.223e-1 (AD)  1.832e-1 (ND)   (Frontal_Cortex)
6.753e-1 (AD)  2.289e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FNBP10.822
USP400.807
OFD10.786
POLA10.785
CECR20.776
CDK5RAP20.774
BAZ2B0.771
NEO10.771
SNX290.763
MYO15B0.759

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.451
PNOC-0.441
VIP-0.382
DLX5-0.371
EGFL6-0.37
PTHLH-0.369
IGF1-0.367
VGF-0.367
TAC3-0.35
HAPLN1-0.344

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C50489712-(3-adamantan-1-ylureido)dodecanoic acid12-(3-adamantan-1-ylureido)dodecanoic acid affects the expression of TRAF1 mRNA19435785
C0479481'-acetoxychavicol acetate1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]15905586
C4824923,4,5,4'-tetramethoxystilbene"3,4,5,4'-tetramethoxystilbene results in decreased expression of TRAF1 mRNA"22687606
C5014744-OH-2',3,3',4',5'-pentachlorobiphenyl"4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]"14761676
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TRAF1 mRNA27153756
C006632arsenic trioxidearsenic trioxide results in increased expression of TRAF1 mRNA20458559
C006632arsenic trioxidearsenic trioxide results in increased expression of TRAF1 mRNA19730151
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of TRAF1 mRNA"24160326
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of TRAF1 mRNA"25757056
C028559bathocuproine sulfonate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]15477007
C028559bathocuproine sulfonatebathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]]15477007
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TRAF1 mRNA20064835
D001599BerberineBerberine results in increased expression of TRAF1 protein20656010
D004958EstradiolEstradiol affects the expression of TRAF1 mRNA14699072
C006780bisphenol Abisphenol A affects the expression of TRAF1 mRNA25181051
C006780bisphenol Abisphenol A results in decreased methylation of TRAF1 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of TRAF1 mRNA15003993
D002185CannabidiolCannabidiol results in increased expression of TRAF1 mRNA21542829
D002330CarmustineCarmustine results in decreased expression of TRAF1 mRNA15980968
D002784CholesterolCholesterol analog results in increased expression of TRAF1 mRNA19477266
D003300CopperCopper results in increased expression of TRAF1 mRNA24403277
D003474CurcuminCurcumin inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA]16219905
D003474CurcuminCurcumin results in decreased expression of TRAF1 protein16023083|1937256
D003474Curcumin[resveratrol co-treated with Curcumin] inhibits the reaction [IL1B protein results in decreased expression of TRAF1 protein]19889203
D016572CyclosporineCyclosporine results in increased expression of TRAF1 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of TRAF1 mRNA23958496
D013759DronabinolDronabinol results in increased expression of TRAF1 mRNA21542829
D003703DemecolcineDemecolcine results in increased expression of TRAF1 mRNA23649840
C007262deoxynivalenoldeoxynivalenol results in increased expression of TRAF1 mRNA22846391
D003907DexamethasoneDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF1 mRNA]22185406
D003907DexamethasoneDexamethasone results in decreased expression of TRAF1 mRNA22185406
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TRAF1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of TRAF1 mRNA27392435|2759478
D002945Cisplatin[Cisplatin co-treated with vinorelbine] results in decreased expression of TRAF1 mRNA21544650
D004052DiethylnitrosamineCTNNB1 protein promotes the reaction [Diethylnitrosamine results in increased expression of TRAF1 protein]20583210
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TRAF1 protein20583210
D002117CalcitriolCalcitriol results in decreased expression of TRAF1 mRNA26485663
C521792DMU-212DMU-212 results in decreased expression of TRAF1 mRNA22687606
D004391DustDust results in increased expression of TRAF1 mRNA17805423
D005492Folic AcidFolic Acid affects the expression of TRAF1 mRNA16361273
D005492Folic Acid[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of TRAF1 mRNA22975265
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of TRAF1 mRNA24657277
D005557FormaldehydeFormaldehyde results in increased expression of TRAF1 mRNA23649840
C002469fusarenon-Xfusarenon-X results in increased expression of TRAF1 mRNA24983900
C056507gemcitabinegemcitabine affects the expression of TRAF1 mRNA17039268
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of TRAF1 mRNA22634610
D017313FenretinideFenretinide inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]16230421
D017313FenretinideFenretinide results in decreased expression of TRAF1 protein16230421
C016517indole-3-carbinolindole-3-carbinol inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]15811958
D015759Ionomycin[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]15477007
D015759Ionomycinbathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]]15477007
D015759Ionomycinpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TRAF1 mRNA25613284
C051890irinotecanirinotecan metabolite results in decreased expression of TRAF1 mRNA15956246
C051890irinotecanirinotecan metabolite results in increased expression of TRAF1 mRNA15956246
C051890irinotecanirinotecan results in decreased expression of TRAF1 mRNA15956246
C051890irinotecanirinotecan results in increased expression of TRAF1 mRNA15956246
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TRAF1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TRAF1 mRNA23129625
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF1 mRNA]25890327
C008261lead acetatelead acetate results in decreased expression of TRAF1 mRNA22609695
D008070LipopolysaccharidesDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF1 mRNA]22185406
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF1 mRNA]25890327
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TRAF1 mRNA22185406|2589032
D008070LipopolysaccharidesQuercetin inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF1 mRNA]22185406
D008070Lipopolysaccharides"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF1 mRNA]"22185406
C115354lonafarniblonafarnib inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]15090542
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TRAF1 mRNA21641980
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of TRAF1 mRNA24657277
D008727MethotrexateMethotrexate results in increased expression of TRAF1 mRNA24657277
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TRAF1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TRAF1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TRAF1 mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of TRAF1 mRNA16780908
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in increased expression of TRAF1 mRNA22561872
C005290oxybenzoneoxybenzone results in decreased expression of TRAF1 mRNA22721600
D017239PaclitaxelPaclitaxel results in decreased expression of TRAF1 mRNA18058816
C002669parthenolideparthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF1 mRNA]16921510
C002669parthenolideparthenolide inhibits the reaction [VEGFA protein results in increased expression of TRAF1 mRNA]16921510
C002669parthenolideparthenolide results in decreased expression of TRAF1 mRNA16921510
C002669parthenolideparthenolide results in decreased expression of TRAF1 protein16921510
D000068437Pemetrexed[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of TRAF1 mRNA22975265
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]14761676
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of TRAF1 mRNA24583197
D011137PolystyrenesPolystyrenes analog results in increased expression of TRAF1 mRNA25102311
C023617pregna-4,17-diene-3,16-dione"pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA]"15322087
C020972pyrrolidine dithiocarbamic acid[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]15477007
C020972pyrrolidine dithiocarbamic acidbathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]]15477007
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]15477007
D011794QuercetinQuercetin inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF1 mRNA]22185406
D011794QuercetinQuercetin results in decreased expression of TRAF1 mRNA22185406
C059514resveratrolresveratrol results in increased expression of TRAF1 mRNA15280659
C059514resveratrol[resveratrol co-treated with Curcumin] inhibits the reaction [IL1B protein results in decreased expression of TRAF1 protein]19889203
D012402RotenoneRotenone affects the expression of TRAF1 mRNA23186747
D017632Asbestos, Serpentine"Asbestos, Serpentine affects the expression of TRAF1 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TRAF1 mRNA23806026|2589566
D012822Silicon DioxideSilicon Dioxide results in increased expression of TRAF1 mRNA22300531|2535159
D012822Silicon DioxideSilicon Dioxide results in increased expression of TRAF1 mRNA19073995
C017947sodium arsenitesodium arsenite results in decreased expression of TRAF1 protein12676792
D053260SootSoot results in decreased expression of TRAF1 mRNA22461453
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TRAF1 mRNA21641980
D014284Triiodothyronine"4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]"14761676
D014284TriiodothyroninePolychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]14761676
D014284TriiodothyronineTetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]14761676
D014284TriiodothyronineTetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TRAF1 protein]14761676
D014284TriiodothyronineTriiodothyronine results in increased expression of TRAF1 mRNA14761676
D014284TriiodothyronineTriiodothyronine results in increased expression of TRAF1 protein14761676
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of TRAF1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TRAF1 mRNA]14761676
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of TRAF1 protein]14761676
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRAF1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TRAF1 mRNA19520675
D013755Tetradecanoylphorbol Acetate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]15477007
D013755Tetradecanoylphorbol Acetatebathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]]15477007
D013755Tetradecanoylphorbol Acetatepyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TRAF1 mRNA25613284
D013806TheophyllineTheophylline results in decreased expression of TRAF1 mRNA16083514
C009495titanium dioxidetitanium dioxide results in decreased expression of TRAF1 mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of TRAF1 mRNA23557971
C082097tocotrienol, delta"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF1 mRNA]"22185406
C082097tocotrienol, delta"tocotrienol, delta results in increased expression of TRAF1 mRNA"22185406
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TRAF1 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of TRAF1 mRNA28818685
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TRAF1 gene25560391
D014750VincristineVincristine results in increased expression of TRAF1 mRNA23649840
C030852vinorelbine[Cisplatin co-treated with vinorelbine] results in decreased expression of TRAF1 mRNA21544650
C111237vorinostatvorinostat inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]16377638
C403304zerumbonezerumbone results in decreased expression of TRAF1 mRNA16007145

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005164tumor necrosis factor receptor binding-IPI11728344  
GO:0005515protein binding-IPI8069916  8612133  9208847  11279055  11907583  14743216  
20447407  21516116  21988832  23088713  23524849  25241761  
25416956  26871637  27107012  
GO:0008270zinc ion binding-IEA-  
GO:0031625ubiquitin protein ligase binding-IPI11279055  
GO:0031996thioesterase binding-IPI11279055  
GO:0042802identical protein binding-IPI8069916  14743216  25416956  27107012  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0007165signal transduction-IEA-  
GO:0010803regulation of tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA10692572  
GO:0065003protein-containing complex assembly-TAS8069916  
GO:2001236regulation of extrinsic apoptotic signaling pathway-IDA10692572  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS8069916  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa05200Pathways in cancer
hsa05222Small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-5357905Regulation of TNFR1 signalingTAS
R-HSA-5357956TNFR1-induced NFkappaB signaling pathwayTAS
R-HSA-73887Death Receptor SignallingTAS
R-HSA-75893TNF signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24489016Association of rheumatoid arthritis susceptibility gene with lipid profiles in patients with rheumatoid arthritis. (2014 Jun)Davis LARheumatology (Oxford)
23288628Genetics of rheumatoid arthritis - a comprehensive review. (2013 Oct)Kurko JClin Rev Allergy Immunol
20439292Genetic variants in the prediction of rheumatoid arthritis. (2010 Sep)van der Helm-van Mil AHAnn Rheum Dis
20046016[Is rheumatoid arthritis without anti-citrullinated peptide antibody a genetically distinct subset?]. (2009 Dec)Ohmura KNihon Rinsho Meneki Gakkai Kaishi