Gene info: ID 7186

Gene: TRAF2

GENE ID: 7186

Synonyms: MGC:45012|RNF117|TRAP|TRAP3

Description: TNF receptor associated factor 2

Gene type: protein-coding

Location: 9q34.3

dbXrefs: Ensembl:ENSG00000127191 MIM:601895 Vega:OTTHUMG00000020952 UniprotKB:Q12933

RefSeq: NC_000009.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.720e-1 (AD) 6.327e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg13614372	chr9:139784946	TRAF2	Promoter	1.332e-4	Alcohol use disorders	26763658
cg14003265	chr9:139796499	TRAF2		3.200e-25	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DEDD2	0.891
JDP2	0.868
SIRT7	0.861
STIP1	0.858
AHSA1	0.853
FKBP4	0.846
USP21	0.844
BANP	0.842
ZDHHC18	0.84
WRAP73	0.839

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.497
OR4F29	-0.455
KLRF1	-0.403
CEACAM3	-0.401
IL18RAP	-0.396
VNN2	-0.389
KLRB1	-0.378
CEACAM4	-0.374
MEI4	-0.372
DNASE1L3	-0.365

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C047948	1'-acetoxychavicol acetate	1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRAF2 protein]	15905586
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TRAF2 protein"	25639565
C511295	2,2',4,4'-tetrabromodiphenyl ether	"troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TRAF2 protein]"	25639565
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of TRAF2 mRNA"	21346803
C003898	2-anisidine	2-anisidine results in decreased expression of TRAF2 mRNA	28089782
D000082	Acetaminophen	Acetaminophen results in increased expression of TRAF2 mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of TRAF2 mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [ERN1 protein binds to TRAF2 protein]]	24394546
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TRAF2 mRNA	19770486
D015761	4-Aminopyridine	4-Aminopyridine results in increased expression of TRAF2 mRNA	24378259
C088115	anacardic acid	anacardic acid results in decreased activity of TRAF2 protein	18349320
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of TRAF2 mRNA	24449571
D001151	Arsenic	[Arsenic co-treated with Fluorides] results in decreased expression of TRAF2 mRNA	19962721
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of TRAF2 mRNA	17530438
C006632	arsenic trioxide	arsenic trioxide results in increased expression of TRAF2 mRNA	19730151
D001280	Atrazine	Atrazine results in decreased expression of TRAF2 mRNA	22378314
D004958	Estradiol	Estradiol results in decreased expression of TRAF2 mRNA	23373633
D004958	Estradiol	Estradiol results in decreased expression of TRAF2 mRNA	18709148
C006780	bisphenol A	bisphenol A affects the expression of TRAF2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of TRAF2 mRNA	24066056
D001761	Bleomycin	Bleomycin results in decreased expression of TRAF2 protein	15371238
D020122	tert-Butylhydroperoxide	Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [ERN1 protein binds to TRAF2 protein]]	24394546
D020122	tert-Butylhydroperoxide	ETFA mutant form inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [ERN1 protein binds to TRAF2 protein]]	24394546
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide promotes the reaction [ERN1 protein binds to TRAF2 protein]	24394546
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TRAF2 mRNA	21457566
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of TRAF2 promoter	22457795
C077793	candesartan cilexetil	candesartan cilexetil results in decreased expression of TRAF2 protein	22120037
D002251	Carbon Tetrachloride	[Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in decreased expression of TRAF2 mRNA	16610055
D002994	Clofibrate	Clofibrate results in decreased expression of TRAF2 mRNA	17585979
D003042	Cocaine	Cocaine affects the expression of TRAF2 mRNA	15681117
D003078	Colchicine	TRAF2 protein affects the susceptibility to Colchicine	20159942
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of TRAF2 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of TRAF2 mRNA	19549813
D003474	Curcumin	Curcumin results in increased expression of TRAF2 mRNA	16101141
C014347	decitabine	decitabine results in increased expression of TRAF2 mRNA	27915011
D003840	Deoxycholic Acid	TRAF2 protein results in decreased susceptibility to Deoxycholic Acid	12507930
D003976	Diazinon	Diazinon results in increased expression of TRAF2 mRNA	27920530
D003976	Diazinon	Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of TRAF2 mRNA]	27920530
D003976	Diazinon	Selenium analog inhibits the reaction [Diazinon results in increased expression of TRAF2 mRNA]	27920530
C088674	dibromoacetic acid	dibromoacetic acid results in increased expression of TRAF2 mRNA	18628252
D002945	Cisplatin	Cisplatin promotes the reaction [jinfukang results in decreased expression of TRAF2 mRNA]	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of TRAF2 mRNA	27392435
D002945	Cisplatin	jinfukang promotes the reaction [Cisplatin results in decreased expression of TRAF2 mRNA]	27392435
D002945	Cisplatin	TRAF2 protein affects the susceptibility to Cisplatin	20159942
D001728	Dicumarol	Dicumarol inhibits the reaction [TRAF2 protein results in increased activity of MAPK10 protein]	10531305
D004041	Dietary Fats	Dietary Fats results in decreased expression of TRAF2 mRNA	25016146
D004642	Emodin	Emodin results in increased expression of TRAF2 mRNA	16045814
D000431	Ethanol	[Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in decreased expression of TRAF2 mRNA	16610055
D005047	Etoposide	TRAF2 protein affects the susceptibility to Etoposide	20159942
D005459	Fluorides	[Arsenic co-treated with Fluorides] results in decreased expression of TRAF2 mRNA	19962721
D005459	Fluorides	Fluorides results in decreased expression of TRAF2 mRNA	19962721
D005472	Fluorouracil	Fluorouracil results in decreased expression of TRAF2	10891390
C103280	goniothalamin	goniothalamin results in decreased activity of TRAF2 protein	23845509
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of TRAF2 mRNA	17183730
D006861	Hydrogen Peroxide	TRAF2 protein affects the susceptibility to Hydrogen Peroxide	20159942
D007213	Indomethacin	Indomethacin results in decreased expression of TRAF2 protein	18799549
D007530	Isoflurane	Isoflurane results in decreased expression of TRAF2 mRNA	16978161
C544151	jinfukang	Cisplatin promotes the reaction [jinfukang results in decreased expression of TRAF2 mRNA]	27392435
C544151	jinfukang	jinfukang promotes the reaction [Cisplatin results in decreased expression of TRAF2 mRNA]	27392435
C008261	lead acetate	lead acetate results in increased expression of TRAF2 mRNA	20542052
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of TRAF2 mRNA"	24972896
C018091	maduramicin	maduramicin results in increased expression of TRAF2 mRNA	29128925
D008277	Magnesium Oxide	Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of TRAF2 mRNA]	27920530
D015655	1-Methyl-4-phenylpyridinium	TXN protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TRAF2 protein]	24140863
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of TRAF2 protein	24140863
D015655	1-Methyl-4-phenylpyridinium	TXN protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TRAF2 protein]	24140863
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"TXN protein inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TRAF2 protein]"	24140863
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TRAF2 protein"	24140863
C043243	methyl tert-butyl ether	methyl tert-butyl ether affects the expression of TRAF2 mRNA	24128854
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of TRAF2 mRNA"	25554681
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of TRAF2 mRNA	20971185
C464660	obeticholic acid	obeticholic acid results in decreased expression of TRAF2 mRNA	27939613
C016340	o,p'-DDT	"o,p'-DDT analog results in decreased expression of TRAF2 mRNA"	22937105
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of TRAF2 mRNA"	22937105
D008939	Mitotane	Mitotane results in increased expression of TRAF2 mRNA	23485034
D017239	Paclitaxel	TRAF2 protein affects the susceptibility to Paclitaxel	20159942
D010269	Paraquat	Paraquat results in increased expression of TRAF2 mRNA	18836921
C002669	parthenolide	parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF2 mRNA]	16921510
C002669	parthenolide	parthenolide results in decreased expression of TRAF2 mRNA	16921510
C002669	parthenolide	parthenolide results in decreased expression of TRAF2 protein	16921510
D052638	Particulate Matter	Particulate Matter results in decreased expression of TRAF2 mRNA	24769257
C551803	PCI 32765	TRAF2 protein mutant form results in decreased susceptibility to PCI 32765	26254443
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of TRAF2 mRNA	18593933
D010424	Pentobarbital	Pentobarbital results in decreased expression of TRAF2 mRNA	16978161
C036567	perfluorodecanoic acid	perfluorodecanoic acid results in decreased expression of TRAF2 mRNA	21984479
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in decreased expression of TRAF2 mRNA	21984479
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of TRAF2 mRNA	18709148\|2198447
C014153	pirimiphos methyl	pirimiphos methyl results in decreased expression of TRAF2 mRNA	27845199
C031280	pyrazole	[Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in decreased expression of TRAF2 mRNA	16610055
D011794	Quercetin	Quercetin affects the expression of TRAF2 mRNA	23727915
C059514	resveratrol	resveratrol results in decreased expression of TRAF2 protein	17164350
D012643	Selenium	Selenium analog inhibits the reaction [Diazinon results in increased expression of TRAF2 mRNA]	27920530
D019821	Simvastatin	Simvastatin results in decreased expression of TRAF2 mRNA	17277159
C017947	sodium arsenite	sodium arsenite affects the methylation of TRAF2 gene	28589171
D013605	T-2 Toxin	T-2 Toxin results in increased expression of TRAF2 mRNA	26141394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TRAF2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TRAF2 mRNA	12167310\|1471864
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TRAF2 mRNA	19520675
D019284	Thapsigargin	Thapsigargin results in decreased expression of TRAF2 mRNA	22378314
D019284	Thapsigargin	Thapsigargin results in decreased expression of TRAF2 protein	18799549
D014118	Toxins, Biological	"Toxins, Biological affects the expression of TRAF2 mRNA"	19682533
D014212	Tretinoin	Tretinoin results in decreased expression of TRAF2 mRNA	22498432
C005865	troxerutin	"troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TRAF2 protein]"	25639565
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of TRAF2 mRNA	17183730
D014640	Vancomycin	Vancomycin results in decreased expression of TRAF2 mRNA	18930951
D014752	Vinyl Chloride	Vinyl Chloride results in increased expression of TRAF2 mRNA	18579281
C111237	vorinostat	vorinostat inhibits the reaction [TNF protein results in increased activity of TRAF2 protein]	16377638
C403304	zerumbone	zerumbone inhibits the reaction [TRAF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]	16007145
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of TRAF2 mRNA	18593933
C088658	zoledronic acid	zoledronic acid results in increased expression of TRAF2 mRNA	19036117

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004842	ubiquitin-protein transferase activity	-	IDA	15258597 20577214
GO:0005164	tumor necrosis factor receptor binding	-	IPI	11279055 11728344
GO:0005174	CD40 receptor binding	-	ISS	-
GO:0005515	protein binding	-	IPI	8069916 8565075 8612133 8943045 9020361 9153189 9705938 10514511 10521462 10892748 11112773 11278723 11466612 11777919 11798190 11907583 14743216 15121867 16189514 16282325 16311516 16611992 16636664 16713569 17353931 17389591 19332782 19805025 20447407 20562859 20676093 21516116 21525013 21653699 21782231 21810480 21903422 21988832 22904686 23088713 23524849 23890813 23955153 24658140 25029497 25241761 25260751 25416956 25609706 25852190 25910212 26871637 27135603
GO:0008270	zinc ion binding	-	IEA	-
GO:0019899	enzyme binding	-	IPI	16636664
GO:0019901	protein kinase binding	-	IPI	10650002
GO:0019903	protein phosphatase binding	-	IPI	15696169
GO:0031435	mitogen-activated protein kinase kinase kinase binding	-	IEA	-
GO:0031625	ubiquitin protein ligase binding	-	IPI	11279055
GO:0031996	thioesterase binding	-	IPI	11279055
GO:0042802	identical protein binding	-	IPI	8069916 9020361 14743216 16189514 20562859 25416956
GO:0044877	protein-containing complex binding	-	IEA	-
GO:0046625	sphingolipid binding	-	IDA	20577214

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002726	positive regulation of T cell cytokine production	-	IMP	15125833
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	TAS	-
GO:0007165	signal transduction	-	TAS	8702708
GO:0007249	I-kappaB kinase/NF-kappaB signaling	-	TAS	-
GO:0007250	activation of NF-kappaB-inducing kinase activity	-	IMP	15125833
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	-	TAS	-
GO:0016579	protein deubiquitination	-	TAS	-
GO:0030163	protein catabolic process	-	IEA	-
GO:0032743	positive regulation of interleukin-2 production	-	IMP	15125833
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	IDA	11907583
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	-
GO:0034351	negative regulation of glial cell apoptotic process	-	IEA	-
GO:0034622	cellular protein-containing complex assembly	-	ISS	-
GO:0034976	response to endoplasmic reticulum stress	-	NAS	10650002
GO:0042981	regulation of apoptotic process	-	IDA	11907583
GO:0043507	positive regulation of JUN kinase activity	-	IDA	11907583
GO:0051023	regulation of immunoglobulin secretion	-	IEA	-
GO:0051091	positive regulation of DNA-binding transcription factor activity	-	IMP	12296995
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IDA	11279055
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IMP	12296995 15121867
GO:0051291	protein heterooligomerization	-	IEA	-
GO:0051865	protein autoubiquitination	-	IDA	20577214
GO:0051865	protein autoubiquitination	-	TAS	16378096
GO:0065003	protein-containing complex assembly	-	TAS	8702708
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	-	TAS	14685163 22013210
GO:0070207	protein homotrimerization	-	IPI	20447407
GO:0070534	protein K63-linked ubiquitination	-	IDA	15258597 20577214
GO:0071550	death-inducing signaling complex assembly	-	TAS	-
GO:0071732	cellular response to nitric oxide	-	IEA	-
GO:0090073	positive regulation of protein homodimerization activity	-	IMP	11278723
GO:0097300	programmed necrotic cell death	-	IEA	-
GO:1901215	negative regulation of neuron death	-	TAS	18221368
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors	-	TAS	-
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	-	TAS	-
GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	-	IEA	-
GO:1903721	positive regulation of I-kappaB phosphorylation	-	IEA	-
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	-	IMP	21525013

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000151	ubiquitin ligase complex	-	IPI	17314283
GO:0005654	nucleoplasm	-	TAS	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0005938	cell cortex	-	IEA	-
GO:0009898	cytoplasmic side of plasma membrane	-	ISS	-
GO:0012506	vesicle membrane	-	IEA	-
GO:0035631	CD40 receptor complex	-	ISS	-
GO:0045121	membrane raft	-	IEA	-
GO:0097057	TRAF2-GSTP1 complex	-	IDA	16636664
GO:1990597	AIP1-IRE1 complex	-	IEA	-
GO:1990604	IRE1-TRAF2-ASK1 complex	-	IDA	23000344

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04141	Protein processing in endoplasmic reticulum
hsa04210	Apoptosis
hsa04380	Osteoclast differentiation
hsa04622	RIG-I-like receptor signaling pathway
hsa04920	Adipocytokine signaling pathway
hsa05160	Hepatitis C
hsa05200	Pathways in cancer
hsa05222	Small cell lung cancer

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-140534	Ligand-dependent caspase activation	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	TAS
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	IEA
R-HSA-3371378	Regulation by c-FLIP	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5213460	RIPK1-mediated regulated necrosis	TAS
R-HSA-5218859	Regulated Necrosis	TAS
R-HSA-5218900	CASP8 activity is inhibited	TAS
R-HSA-5357769	Caspase activation via extrinsic apoptotic signalling pathway	TAS
R-HSA-5357786	TNFR1-induced proapoptotic signaling	TAS
R-HSA-5357801	Programmed Cell Death	TAS
R-HSA-5357905	Regulation of TNFR1 signaling	TAS
R-HSA-5357956	TNFR1-induced NFkappaB signaling pathway	TAS
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	TAS
R-HSA-5675482	Regulation of necroptotic cell death	TAS
R-HSA-5676594	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689880	Ub-specific processing proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-69416	Dimerization of procaspase-8	TAS
R-HSA-73887	Death Receptor Signalling	TAS
R-HSA-75893	TNF signaling	TAS
R-HSA-933541	TRAF6 mediated IRF7 activation	TAS
R-HSA-933542	TRAF6 mediated NF-kB activation	TAS
R-HSA-933542	TRAF6 mediated NF-kB activation	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25332681	Diet and lifestyle factors modify immune/inflammation response genes to alter breast cancer risk and prognosis: the Breast Cancer Health Disparities Study. (2014 Dec)	Slattery ML	Mutat Res
22199996	Tumor necrosis factor-related genes and colon and rectal cancer. (2011)	Slattery ML	Int J Mol Epidemiol Genet
26518718	Identification of gene markers in the development of smoking-induced lung cancer. (2016 Jan 15)	Yang Z	Gene