Gene: TRAF3

7187
CAP-1|CAP1|CD40bp|CRAF1|IIAE5|LAP1|RNF118
TNF receptor associated factor 3
protein-coding
14q32.32
Ensembl:ENSG00000131323 MIM:601896 Vega:OTTHUMG00000171902 UniprotKB:Q13114
NG_027973.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.869e-1 (AD)  2.033e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24154132chr14:103367632TRAF38.800e-14Smoking27651444
cg01565703chr14:103245090TRAF35.000e-12Smoking27651444
cg15950273chr14:103367306TRAF39.500e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLGAP40.906
RAB11FIP30.906
RNF440.903
C6orf1060.899
MAFG0.898
PIP5K1C0.898
CAMTA20.895
PPP6R10.893
NACC10.893
CBX60.893

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.589
OR4F29-0.542
C1orf87-0.446
IL18RAP-0.406
S100A12-0.406
SNHG18-0.403
CCR2-0.397
MYL3-0.393
S100A8-0.393
SH2D1A-0.393

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C50489712-(3-adamantan-1-ylureido)dodecanoic acid12-(3-adamantan-1-ylureido)dodecanoic acid affects the expression of TRAF3 mRNA19435785
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of TRAF3 mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TRAF3 mRNA"27291303
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TRAF3 mRNA"21346803
C0038982-anisidine2-anisidine results in decreased expression of TRAF3 mRNA28089782
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of TRAF3 mRNA19191707
C5490664-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of TRAF3 mRNA]"26546572
D000082AcetaminophenAcetaminophen results in decreased expression of TRAF3 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of TRAF3 mRNA22230336|2906747
D020106AcrylamideAcrylamide results in increased expression of TRAF3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TRAF3 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TRAF3 mRNA24449571
D001151ArsenicArsenic affects the methylation of TRAF3 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of TRAF3 mRNA17530438
D001554BenzeneBenzene results in increased expression of TRAF3 mRNA19162166
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of TRAF3 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TRAF3 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TRAF3 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TRAF3 mRNA"19150397
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of TRAF3 mRNA]24758408
D004958EstradiolEstradiol results in increased expression of TRAF3 mRNA23019147|2475840
C006780bisphenol Abisphenol A affects the expression of TRAF3 mRNA23557687
C006780bisphenol Abisphenol A results in increased expression of TRAF3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TRAF3 gene28505145
D002101Cacodylic AcidCacodylic Acid results in decreased expression of TRAF3 mRNA15345372
D002211CapsaicinCapsaicin results in increased expression of TRAF3 mRNA19502594
D019327Copper SulfateCopper Sulfate results in increased expression of TRAF3 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of TRAF3 mRNA26577399
D003474CurcuminCurcumin results in increased expression of TRAF3 mRNA16101141
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of TRAF3 mRNA23640034
D002945Cisplatin"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of TRAF3 mRNA]"26546572
D002945CisplatinCisplatin results in increased expression of TRAF3 mRNA26546572
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of TRAF3 mRNA15766595
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TRAF3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TRAF3 mRNA17942748
C024565ethylene dichlorideethylene dichloride results in increased expression of TRAF3 mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TRAF3 mRNA23649840
C039281furanfuran results in increased expression of TRAF3 mRNA20562052|2207923
C002469fusarenon-Xfusarenon-X results in decreased expression of TRAF3 mRNA24983900
D005947GlucoseGlucose results in increased expression of TRAF3 protein25516495
D005947Glucosetempol inhibits the reaction [Glucose results in increased expression of TRAF3 protein]25516495
D005947GlucoseTRAF3 affects the reaction [Glucose results in increased cleavage of CASP3 protein]25516495
D017313FenretinideFenretinide results in increased expression of TRAF3 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TRAF3 mRNA25613284
D007530IsofluraneIsoflurane results in decreased expression of TRAF3 mRNA16978161
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TRAF3 mRNA19070373
C018091maduramicinmaduramicin results in increased expression of TRAF3 mRNA29128925
D008727MethotrexateMethotrexate results in increased expression of TRAF3 mRNA17400583
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TRAF3 mRNA23649840
C020300monomethylarsonic acidmonomethylarsonic acid results in decreased expression of TRAF3 mRNA15345372
D009151Mustard GasMustard Gas results in increased expression of TRAF3 mRNA15674843|1895507
D009532NickelNickel results in increased expression of TRAF3 mRNA24768652
C016340o,p'-DDT"o,p'-DDT results in increased expression of TRAF3 mRNA"22937105
D010269ParaquatParaquat results in decreased expression of TRAF3 mRNA18836921
C551803PCI 32765TRAF3 protein mutant form results in decreased susceptibility to PCI 3276526254443
D010424PentobarbitalPentobarbital results in decreased expression of TRAF3 mRNA16978161
D010936Plant ExtractsPlant Extracts results in increased expression of TRAF3 mRNA23557933
C045950propiconazolepropiconazole results in increased expression of TRAF3 mRNA21278054
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TRAF3 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of TRAF3 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of TRAF3 mRNA12760830
D012969Sodium FluorideSodium Fluoride results in decreased expression of TRAF3 mRNA21340527
C003377taxifolintaxifolin results in increased expression of TRAF3 mRNA17541156
C001803tempoltempol inhibits the reaction [Glucose results in increased expression of TRAF3 protein]25516495
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRAF3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TRAF3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TRAF3 mRNA12167310|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRAF3 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TRAF3 mRNA19520675
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TRAF3 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of TRAF3 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of TRAF3 mRNA23557971
D014241TrichloroethyleneTrichloroethylene results in increased expression of TRAF3 mRNA19448997
D014520UrethaneUrethane results in increased expression of TRAF3 mRNA16978161
D014635Valproic AcidValproic Acid results in increased methylation of TRAF3 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TRAF3 gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of TRAF3 mRNA19036117|2471476

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-TAS-  
GO:0005164tumor necrosis factor receptor binding-IPI11728344  
GO:0005515protein binding-IPI7527023  8612133  10791955  12005438  12270937  14743216  
19419966  19893624  20080758  20138174  20174559  21903422  
23153539  23333941  23871208  25241761  
GO:0008270zinc ion binding-IEA-  
GO:0019901protein kinase binding-IEA-  
GO:0019903protein phosphatase binding-IPI23871208  
GO:0031625ubiquitin protein ligase binding-IPI11279055  
GO:0031996thioesterase binding-IPI11279055  
GO ID GO Term Qualifier Evidence PubMed
GO:0001817regulation of cytokine production-ISS-  
GO:0002224toll-like receptor signaling pathway-ISS-  
GO:0006915apoptotic process-IEA-  
GO:0007165signal transduction-TAS7530216  
GO:0008063Toll signaling pathway-IEA-  
GO:0016567protein ubiquitination-IEA-  
GO:0016579protein deubiquitination-TAS-  
GO:0030162regulation of proteolysis-IMP20185819  
GO:0032088negative regulation of NF-kappaB transcription factor activity-IMP20185819  
GO:0032648regulation of interferon-beta production-ISS-  
GO:0033209tumor necrosis factor-mediated signaling pathway-IMP20185819  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0035666TRIF-dependent toll-like receptor signaling pathway-TAS-  
GO:0042981regulation of apoptotic process-IEA-  
GO:0045087innate immune response-IEA-  
GO:0050688regulation of defense response to virus-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IEA-  
GO:0005768endosome-IEA-  
GO:0005829cytosol-TAS-  
GO:0009898cytoplasmic side of plasma membrane-ISS-  
GO:0035631CD40 receptor complex-ISS-  
KEGG ID KEGG Term
hsa04620Toll-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa05222Small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1643685DiseaseTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5260271Diseases of Immune SystemTAS
R-HSA-5602358Diseases associated with the TLR signaling cascadeTAS
R-HSA-5602571TRAF3 deficiency - HSETAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5676594TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689896Ovarian tumor domain proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-9013973TICAM1-dependent activation of IRF3/IRF7TAS
R-HSA-918233TRAF3-dependent IRF activation pathwayTAS
R-HSA-936440Negative regulators of DDX58/IFIH1 signalingTAS
R-HSA-936964Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25631445Comprehensive genomic characterization of head and neck squamous cell carcinomas. (2015 Jan 29)-Nature
21605946Development of a multicomponent prediction model for acute esophagitis in lung cancer patients receiving chemoradiotherapy. (2011 Oct 1)De Ruyck KInt J Radiat Oncol Biol Phys