Gene info: ID 7189

Gene: TRAF6

GENE ID: 7189

Synonyms: MGC:3310|RNF85

Description: TNF receptor associated factor 6

Gene type: protein-coding

Location: 11p12

dbXrefs: Ensembl:ENSG00000175104 MIM:602355 Vega:OTTHUMG00000166391 UniprotKB:Q9Y4K3

RefSeq: NC_000011.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.285e-1 (AD) 3.291e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NUP205	0.855
TRPM7	0.854
UBR2	0.854
OTUD4	0.854
CDK12	0.852
DENND4A	0.837
PHC3	0.837
DCP1A	0.836
CCNT1	0.836
ATP11B	0.834

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.4
HES5	-0.397
OR4F29	-0.374
PLA2G5	-0.314
C16orf74	-0.304
BTBD17	-0.282
REN	-0.279
KLRC2	-0.274
RERGL	-0.263
DIAPH3	-0.261

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of TRAF6 mRNA"	21346803
C523934	4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester	"4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester inhibits the reaction [AGT protein modified form results in increased ubiquitination of TRAF6 protein]"	24456201
C523934	4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester	"4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester results in decreased ubiquitination of TRAF6 protein"	24456201
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of TRAF6 mRNA"	18648102
D000082	Acetaminophen	Acetaminophen affects the expression of TRAF6 mRNA	17562736
D001151	Arsenic	Arsenic results in decreased expression of TRAF6 mRNA	19654921
D001151	Arsenic	Arsenic results in decreased expression of TRAF6 protein	19654921
D001152	Arsenicals	Arsenicals results in decreased methylation of TRAF6 promoter	23315758
C006632	arsenic trioxide	arsenic trioxide results in increased expression of TRAF6 mRNA	17530438
D001241	Aspirin	Aspirin results in increased expression of TRAF6 mRNA	11906190
D000069059	Atorvastatin Calcium	[Atorvastatin Calcium co-treated with Enalapril] results in decreased expression of TRAF6 mRNA	20524934
D000069059	Atorvastatin Calcium	[Atorvastatin Calcium co-treated with telmisartan] results in decreased expression of TRAF6 mRNA	20524934
C012768	benzanthrone	benzanthrone results in increased expression of TRAF6 protein	28495615
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TRAF6 protein	25596431
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TRAF6 mRNA	22228805
D004958	Estradiol	Estradiol results in increased expression of TRAF6 mRNA	16202921
C006780	bisphenol A	bisphenol A results in decreased expression of TRAF6 mRNA	23606268
C006780	bisphenol A	[nonylphenol co-treated with bisphenol A] results in decreased expression of TRAF6 mRNA	23606268
C006780	bisphenol A	bisphenol A results in decreased expression of TRAF6 mRNA	26595511
C006780	bisphenol A	bisphenol A results in increased expression of TRAF6 mRNA	25181051
D000069286	Bortezomib	TRAF6 protein results in increased susceptibility to Bortezomib	27150054
D019256	Cadmium Chloride	[Cadmium Chloride co-treated with TNFSF11] results in increased expression of TRAF6 mRNA	21723911
C058667	cadmium selenide	[cadmium selenide co-treated with zinc sulfide] results in increased expression of TRAF6 mRNA	22342292
D002166	Camptothecin	TRAF6 mRNA results in decreased susceptibility to Camptothecin	25269479
C012843	cinnamic aldehyde	cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 mRNA]	18306459
D002994	Clofibrate	Clofibrate results in decreased expression of TRAF6 mRNA	17585979
C480342	clothianidin	clothianidin results in decreased expression of TRAF6 mRNA	29044138
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [TRAF6 protein binds to MYD88 protein]	25780291
D003300	Copper	Copper results in decreased expression of TRAF6 protein	22692975
D003474	Curcumin	Curcumin results in increased expression of TRAF6 mRNA	16101141
D016572	Cyclosporine	Cyclosporine results in increased expression of TRAF6 mRNA	25562108
C007262	deoxynivalenol	deoxynivalenol results in increased expression of TRAF6 mRNA	22846391
D003907	Dexamethasone	Dexamethasone results in decreased expression of TRAF6 mRNA	21041162
D004041	Dietary Fats	Dietary Fats results in decreased expression of TRAF6 mRNA	25016146
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of TRAF6 mRNA	21041162
D004656	Enalapril	[Atorvastatin Calcium co-treated with Enalapril] results in decreased expression of TRAF6 mRNA	20524934
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TRAF6 protein]	27890776
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TRAF6 protein]	27890776
D000069347	Erlotinib Hydrochloride	[Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of TRAF6 mRNA	27738319
D000431	Ethanol	Ethanol results in increased expression of TRAF6 mRNA	26858005
D000431	Ethanol	Ethanol results in increased expression of TRAF6 protein	26858005
D000431	Ethanol	Fructose inhibits the reaction [Ethanol results in increased expression of TRAF6 protein]	26858005
D000431	Ethanol	Fructose promotes the reaction [Ethanol results in increased expression of TRAF6 mRNA]	26858005
D005492	Folic Acid	Folic Acid affects the expression of TRAF6 mRNA	16361273
D005557	Formaldehyde	Formaldehyde results in decreased expression of TRAF6 mRNA	20655997
D005632	Fructose	Fructose inhibits the reaction [Ethanol results in increased expression of TRAF6 protein]	26858005
D005632	Fructose	Fructose promotes the reaction [Ethanol results in increased expression of TRAF6 mRNA]	26858005
C069837	fullerene C60	fullerene C60 results in increased expression of TRAF6 mRNA	19167457
D037741	Fullerenes	Fullerenes analog affects the expression of TRAF6 mRNA	22342292
D005665	Furosemide	Furosemide affects the expression of TRAF6 mRNA	17497460
C002469	fusarenon-X	fusarenon-X results in increased expression of TRAF6 mRNA	24983900
D005688	Galactosamine	"Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]]"	28213090
D005688	Galactosamine	"[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]"	28213090
D005944	Glucosamine	Glucosamine analog inhibits the reaction [TNF results in increased expression of TRAF6 mRNA]	18173918
D005944	Glucosamine	Glucosamine inhibits the reaction [TNF results in increased expression of TRAF6 mRNA]	18173918
D006034	Glycyrrhetinic Acid	"Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]]"	28213090
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of TRAF6 mRNA	26846883
D006861	Hydrogen Peroxide	Hydrogen Peroxide promotes the reaction [TRAF6 protein binds to [IL1R1 protein binds to MYD88 protein]]	16354686
C050016	lipoarabinomannan	lipoarabinomannan inhibits the reaction [IRAK1 protein binds to TRAF6 protein]	16263713
C440499	lipopolysaccharide, Escherichia coli O111 B4	"Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]]"	28213090
C440499	lipopolysaccharide, Escherichia coli O111 B4	"[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]"	28213090
C442865	lipopolysaccharide, Helicobacter pylori	"TRAF6 protein promotes the reaction [lipopolysaccharide, Helicobacter pylori results in increased expression of CXCL8 mRNA]"	21220698
D008070	Lipopolysaccharides	Lipopolysaccharides affects the ubiquitination of TRAF6 protein	21127049
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with TNFSF11 protein] results in increased degradation of TRAF6 protein	21127049
D008070	Lipopolysaccharides	TNFAIP3 protein promotes the reaction [Lipopolysaccharides results in increased degradation of TRAF6 protein]	21127049
D008070	Lipopolysaccharides	cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 mRNA]	18306459
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TRAF6 mRNA	18306459\|2292591
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TRAF6 protein	22925919
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased ubiquitination of and results in increased activity of TRAF6 protein	22925919
D008070	Lipopolysaccharides	resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 mRNA]	22925919
D008070	Lipopolysaccharides	resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 protein]	22925919
D008070	Lipopolysaccharides	resveratrol inhibits the reaction [Lipopolysaccharides results in increased ubiquitination of and results in increased activity of TRAF6 protein]	22925919
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Titanium] affects the expression of TRAF6 mRNA	21308757
D008344	Maneb	[Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA	23963992
D008344	Maneb	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA]	23963992
C013592	mangiferin	mangiferin results in decreased expression of TRAF6 mRNA	15135318
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of TRAF6 mRNA	28001369
C022838	nickel chloride	nickel chloride results in increased expression of TRAF6 protein	21473897
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TRAF6 protein]"	24223152
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TRAF6 mRNA]"	24223152
C025256	nonylphenol	[nonylphenol co-treated with bisphenol A] results in decreased expression of TRAF6 mRNA	23606268
C025256	nonylphenol	nonylphenol results in decreased expression of TRAF6 mRNA	23606268
C507134	ON 01910	ON 01910 affects the localization of TRAF6 protein modified form	27150054
C507134	ON 01910	ON 01910 promotes the reaction [MYB protein binds to TRAF6 protein]	27150054
C507134	ON 01910	ON 01910 results in decreased expression of and results in decreased sumoylation of TRAF6 protein	27150054
D010100	Oxygen	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TRAF6 protein]"	24223152
D010100	Oxygen	Oxygen deficiency results in increased expression of TRAF6 protein	24223152
D010100	Oxygen	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TRAF6 mRNA]"	24223152
D010100	Oxygen	Oxygen deficiency results in increased expression of TRAF6 mRNA	24223152
D010269	Paraquat	epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TRAF6 protein]	27890776
D010269	Paraquat	Paraquat results in increased expression of TRAF6 protein	27890776
D010269	Paraquat	epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TRAF6 protein]	27890776
D010269	Paraquat	[Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA	23963992
D010269	Paraquat	Paraquat results in increased expression of TRAF6 protein	27890776
D010269	Paraquat	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA]	23963992
C410127	PCB 180	PCB 180 results in decreased expression of TRAF6 mRNA	23829299
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of TRAF6 mRNA	23892564
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TRAF6 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of TRAF6 mRNA	17950772
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of TRAF6 mRNA]	17950772
D011070	Poly I-C	TRAF6 mutant form inhibits the reaction [Vehicle Emissions analog promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]]	16399790
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of TRAF6 protein	23718831
D011374	Progesterone	Progesterone results in increased expression of TRAF6 mRNA	21549006
D011374	Progesterone	Progesterone results in increased expression of TRAF6 mRNA	21770760
C059514	resveratrol	resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 mRNA]	22925919
C059514	resveratrol	resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 protein]	22925919
C059514	resveratrol	resveratrol inhibits the reaction [Lipopolysaccharides results in increased ubiquitination of and results in increased activity of TRAF6 protein]	22925919
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased expression of TRAF6 mRNA]	24758933
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased expression of TRAF6 protein]	24758933
D012834	Silver	Silver results in increased expression of TRAF6 mRNA	22342292
D012838	Silymarin	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA]	23963992
D053260	Soot	Soot analog results in increased expression of TRAF6 mRNA	25451823
C084178	telmisartan	[Atorvastatin Calcium co-treated with telmisartan] results in decreased expression of TRAF6 mRNA	20524934
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TRAF6 mRNA	12167310\|1531085
D014025	Titanium	[Lipopolysaccharides co-treated with Titanium] affects the expression of TRAF6 mRNA	21308757
C009495	titanium dioxide	titanium dioxide results in decreased expression of TRAF6 mRNA	22342292
C009495	titanium dioxide	titanium dioxide analog results in increased expression of TRAF6 mRNA	25111187
C009495	titanium dioxide	titanium dioxide analog results in increased expression of TRAF6 protein	25111187
D014520	Urethane	Urethane results in increased expression of TRAF6 mRNA	28818685
D001335	Vehicle Emissions	TRAF6 mutant form inhibits the reaction [Vehicle Emissions analog promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]]	16399790
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of TRAF6 gene	25560391
C104536	xanthohumol	xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TRAF6 mRNA]	23994090
D015032	Zinc	Zinc results in increased expression of TRAF6 mRNA	19071009
D015034	Zinc Oxide	[Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TRAF6 protein	25127755
C017803	zinc protoporphyrin	zinc protoporphyrin promotes the reaction [TRAF6 protein binds to MYD88 protein]	25780291
C031238	zinc sulfide	[cadmium selenide co-treated with zinc sulfide] results in increased expression of TRAF6 mRNA	22342292

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004842	ubiquitin-protein transferase activity	-	EXP	15361868 17135271
GO:0004842	ubiquitin-protein transferase activity	-	IDA	15125833 17135271 19713527
GO:0004842	ubiquitin-protein transferase activity	-	TAS	-
GO:0005164	tumor necrosis factor receptor binding	-	IPI	11728344
GO:0005515	protein binding	-	IPI	10094049 10383454 10465784 10514511 10920205 11238466 11244088 11279055 11397809 11463333 11518704 11751921 12140561 12242293 12270937 12459498 12496252 12925853 14743216 14982987 15121867 15125833 15998638 16189514 16286467 16378096 16874300 16932746 17124500 17353931 17389358 17449468 17703191 17948050 18093978 18239685 18682563 18758450 19365808 19465916 19549727 19675569 19820695 20079715 20080758 20676093 21516116 21541365 21782231 21813773 21903422 21988832 22493164 22528498 22904686 22908223 23524951 25241761 25416956 25736436 25861989 26068852 27107012 27107014 27173435
GO:0008270	zinc ion binding	-	IEA	-
GO:0019901	protein kinase binding	-	IPI	19713527
GO:0031435	mitogen-activated protein kinase kinase kinase binding	-	IPI	10094049
GO:0031624	ubiquitin conjugating enzyme binding	-	IDA	23776175
GO:0031625	ubiquitin protein ligase binding	-	IPI	11279055
GO:0031996	thioesterase binding	-	IPI	11279055
GO:0042802	identical protein binding	-	IPI	19465916 21988832 22493164 25416956 27107012
GO:0042826	histone deacetylase binding	-	IPI	18093978
GO:0043422	protein kinase B binding	-	IPI	19713527
GO:0047485	protein N-terminus binding	-	IPI	14530355
GO:0061630	ubiquitin protein ligase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IMP	18093978
GO:0000187	activation of MAPK activity	-	TAS	-
GO:0000209	protein polyubiquitination	-	IDA	15125833 19675569
GO:0001503	ossification	-	IEA	-
GO:0001843	neural tube closure	-	IEA	-
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	-
GO:0002224	toll-like receptor signaling pathway	-	TAS	-
GO:0002726	positive regulation of T cell cytokine production	-	IMP	15125833
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	-	TAS	-
GO:0006974	cellular response to DNA damage stimulus	-	IEA	-
GO:0007249	I-kappaB kinase/NF-kappaB signaling	-	TAS	-
GO:0007250	activation of NF-kappaB-inducing kinase activity	-	IMP	15125833
GO:0007254	JNK cascade	-	TAS	-
GO:0016579	protein deubiquitination	-	TAS	-
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	IEA	-
GO:0030316	osteoclast differentiation	-	IEA	-
GO:0031293	membrane protein intracellular domain proteolysis	-	TAS	-
GO:0031398	positive regulation of protein ubiquitination	-	NAS	22412986
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	-	IEA	-
GO:0032147	activation of protein kinase activity	-	IDA	17135271
GO:0032743	positive regulation of interleukin-2 production	-	IMP	15125833
GO:0034162	toll-like receptor 9 signaling pathway	-	TAS	-
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	-
GO:0042088	T-helper 1 type immune response	-	IEA	-
GO:0042102	positive regulation of T cell proliferation	-	IEA	-
GO:0042475	odontogenesis of dentin-containing tooth	-	IEA	-
GO:0043011	myeloid dendritic cell differentiation	-	IEA	-
GO:0043065	positive regulation of apoptotic process	-	TAS	-
GO:0043066	negative regulation of apoptotic process	-	TAS	-
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IDA	17135271
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	TAS	-
GO:0043507	positive regulation of JUN kinase activity	-	IDA	11751921
GO:0043507	positive regulation of JUN kinase activity	-	NAS	17135271
GO:0045084	positive regulation of interleukin-12 biosynthetic process	-	IEA	-
GO:0045410	positive regulation of interleukin-6 biosynthetic process	-	IEA	-
GO:0045453	bone resorption	-	IEA	-
GO:0045672	positive regulation of osteoclast differentiation	-	IDA	17135271
GO:0045892	negative regulation of transcription, DNA-templated	-	IMP	18093978
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	11751921
GO:0045944	positive regulation of transcription by RNA polymerase II	-	NAS	22412986
GO:0048468	cell development	-	IEA	-
GO:0048661	positive regulation of smooth muscle cell proliferation	-	IEA	-
GO:0050852	T cell receptor signaling pathway	-	IMP	15125833
GO:0050852	T cell receptor signaling pathway	-	TAS	-
GO:0051023	regulation of immunoglobulin secretion	-	IEA	-
GO:0051091	positive regulation of DNA-binding transcription factor activity	-	IMP	12296995
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IDA	11279055 11751921 16378096
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IMP	12296995
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	TAS	-
GO:0051865	protein autoubiquitination	-	IDA	17135271 18093978 23776175
GO:0051865	protein autoubiquitination	-	TAS	16378096
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	-	TAS	-
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	-
GO:0070534	protein K63-linked ubiquitination	-	IDA	19713527 21068390
GO:0070534	protein K63-linked ubiquitination	-	IGI	17135271 19675569
GO:0070555	response to interleukin-1	-	IDA	17135271
GO:0071222	cellular response to lipopolysaccharide	-	IDA	23776175
GO:2000679	positive regulation of transcription regulatory region DNA binding	-	IDA	11751921

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	18093978
GO:0005737	cytoplasm	-	IDA	16378096 18093978
GO:0005811	lipid droplet	-	ISS	-
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IDA	18093978
GO:0005886	plasma membrane	-	TAS	-
GO:0005938	cell cortex	-	IEA	-
GO:0009898	cytoplasmic side of plasma membrane	-	ISS	-
GO:0010008	endosome membrane	-	TAS	-
GO:0032991	protein-containing complex	-	IDA	23776175
GO:0035631	CD40 receptor complex	-	ISS	-
GO:0048471	perinuclear region of cytoplasm	-	IDA	11751921

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04120	Ubiquitin mediated proteolysis
hsa04144	Endocytosis
hsa04380	Osteoclast differentiation
hsa04620	Toll-like receptor signaling pathway
hsa04621	NOD-like receptor signaling pathway
hsa04622	RIG-I-like receptor signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa05140	Leishmaniasis
hsa05142	Chagas disease (American trypanosomiasis)
hsa05145	Toxoplasmosis
hsa05160	Hepatitis C
hsa05200	Pathways in cancer
hsa05222	Small cell lung cancer

Reactome ID	Reactome Term	Evidence
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-168638	NOD1/2 Signaling Pathway	TAS
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-168927	TICAM1, RIP1-mediated IKK complex recruitment	TAS
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	TAS
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	IEA
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-193639	p75NTR signals via NF-kB	TAS
R-HSA-193692	Regulated proteolysis of p75NTR	TAS
R-HSA-193704	p75 NTR receptor-mediated signalling	TAS
R-HSA-193704	p75 NTR receptor-mediated signalling	IEA
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-202403	TCR signaling	TAS
R-HSA-202424	Downstream TCR signaling	TAS
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	TAS
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	IEA
R-HSA-205043	NRIF signals cell death from the nucleus	TAS
R-HSA-205043	NRIF signals cell death from the nucleus	IEA
R-HSA-209543	p75NTR recruits signalling complexes	TAS
R-HSA-209560	NF-kB is activated and signals survival	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	TAS
R-HSA-2871837	FCERI mediated NF-kB activation	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-448424	Interleukin-17 signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-450294	MAP kinase activation	TAS
R-HSA-450302	activated TAK1 mediates p38 MAPK activation	TAS
R-HSA-450321	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	TAS
R-HSA-5607764	CLEC7A (Dectin-1) signaling	TAS
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689880	Ub-specific processing proteases	TAS
R-HSA-5689896	Ovarian tumor domain proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS
R-HSA-73887	Death Receptor Signalling	TAS
R-HSA-73887	Death Receptor Signalling	IEA
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9014325	TICAM1,TRAF6-dependent induction of TAK1 complex	TAS
R-HSA-9020702	Interleukin-1 signaling	TAS
R-HSA-933541	TRAF6 mediated IRF7 activation	TAS
R-HSA-933542	TRAF6 mediated NF-kB activation	TAS
R-HSA-933542	TRAF6 mediated NF-kB activation	IEA
R-HSA-937039	IRAK1 recruits IKK complex	TAS
R-HSA-937041	IKK complex recruitment mediated by RIP1	TAS
R-HSA-937042	IRAK2 mediated activation of TAK1 complex	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-937072	TRAF6-mediated induction of TAK1 complex within TLR4 complex	TAS
R-HSA-975110	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975144	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS
R-HSA-975163	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	TAS
R-HSA-975871	MyD88 cascade initiated on plasma membrane	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
16620395	Toll-like receptor-4 mediates cigarette smoke-induced cytokine production by human macrophages. (2006 Apr 19)	Karimi K	Respir Res
25214962	TRAF6 polymorphisms not associated with the susceptibility to and severity of sepsis in a Chinese population. (2010)	Fang Y	World J Emerg Med