Gene: ACTG2

72
ACT|ACTA3|ACTE|ACTL3|ACTSG|VSCM
actin, gamma 2, smooth muscle, enteric
protein-coding
2p13.1
Ensembl:ENSG00000163017 MIM:102545 Vega:OTTHUMG00000129813 UniprotKB:P63267
NG_034140.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.501e-1 (AD)  8.612e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYH110.83
ACTA20.734
MYL90.716
CNN10.712
MGP0.703
PLN0.683
ITIH30.677
DES0.675
AOC30.666
KCNMB10.652

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RHO-0.224
PNPLA7-0.218
CPA4-0.214
DOK7-0.211
SLX1B-0.207
GPR3-0.207
CLDND2-0.205
OR2T33-0.197
ZNF835-0.197
CREB3L1-0.194

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ACTG2 mRNA"15059925
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of ACTG2 mRNA16460773
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased expression of ACTG2 mRNA25716159
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACTG2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACTG2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACTG2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACTG2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ACTG2 mRNA17562736
C103303alitretinoinalitretinoin results in decreased expression of ACTG2 protein16043492
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ACTG2 mRNA21298039
C006632arsenic trioxidearsenic trioxide results in increased expression of ACTG2 mRNA15894607
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of ACTG2 mRNA15894607
C015001arsenitearsenite results in increased expression of ACTG2 mRNA18296743
C015001arseniteDietary Fats promotes the reaction [arsenite results in increased expression of ACTG2 mRNA]18296743
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACTG2 mRNA20713471
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ACTG2 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACTG2 mRNA21839799
D004958EstradiolEstradiol results in decreased expression of ACTG2 mRNA25878060
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of ACTG2 mRNA26496021
C452139BIRB 796BIRB 796 results in increased expression of ACTG2 mRNA24303162
C006780bisphenol Abisphenol A results in decreased expression of ACTG2 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of ACTG2 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ACTG2 promoter23359474
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of ACTG2 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of ACTG2 mRNA24134786
C006780bisphenol Abisphenol A results in increased methylation of ACTG2 gene28505145
C099813bromochloroacetic acidbromochloroacetic acid results in decreased expression of ACTG2 mRNA16460773
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ACTG2 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of ACTG2 mRNA26079696
D002104CadmiumCadmium results in increased expression of ACTG2 mRNA24376830
C028031cadmium acetatecadmium acetate results in decreased expression of ACTG2 mRNA18155341
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ACTG2 mRNA21297351
D002220CarbamazepineCarbamazepine affects the expression of ACTG2 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ACTG2 mRNA17484886
D002330CarmustineCarmustine results in decreased expression of ACTG2 mRNA15980968
D003042CocaineCocaine results in decreased expression of ACTG2 mRNA20948987
D019327Copper SulfateCopper Sulfate results in increased expression of ACTG2 mRNA19549813
D003345CorticosteroneCorticosterone results in increased expression of ACTG2 mRNA15755911
D016572CyclosporineCyclosporine results in increased expression of ACTG2 mRNA25562108
D000069439DasatinibDasatinib results in increased expression of ACTG2 mRNA20579391
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTG2 mRNA16054899
D003907DexamethasoneDexamethasone results in increased expression of ACTG2 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ACTG2 mRNA17361019|2126653
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ACTG2 promoter23359474
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ACTG2 mRNA21266533
D004041Dietary FatsDietary Fats promotes the reaction [arsenite results in increased expression of ACTG2 mRNA]18296743
D004041Dietary FatsDietary Fats results in increased expression of ACTG2 mRNA18296743
D004041Dietary FatsDietary Fats results in increased expression of ACTG2 mRNA21852083
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ACTG2 promoter23359474
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ACTG2 mRNA21527772
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of ACTG2 mRNA25242112
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ACTG2 mRNA21658437
D002117CalcitriolCalcitriol results in increased expression of ACTG2 mRNA21592394|2648566
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of ACTG2 mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of ACTG2 mRNA"19480007
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of ACTG2 mRNA"27840820
D004237DiuronDiuron results in decreased expression of ACTG2 mRNA21551480
D004237DiuronDiuron results in increased expression of ACTG2 mRNA21551480
D000431EthanolEthanol results in increased expression of ACTG2 protein16043492
D000431EthanolVitamin A results in decreased expression of [Ethanol results in increased expression of ACTG2 protein]16043492
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ACTG2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACTG2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ACTG2 mRNA12655037|1557682
D005411Flame RetardantsFlame Retardants results in decreased expression of ACTG2 protein18550172
D005411Flame RetardantsFlame Retardants results in increased expression of ACTG2 protein18550172
D005472FluorouracilFluorouracil results in decreased expression of ACTG2 mRNA16709241
D019833GenisteinGenistein results in decreased expression of ACTG2 mRNA22228119
C010974glyphosateglyphosate affects the expression of ACTG2 protein20045496
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ACTG2 protein]23178681
D006820Hyaluronic AcidHyaluronic Acid analog results in decreased expression of ACTG2 protein23178681
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ACTG2 protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ACTG2 protein23178681
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTG2 mRNA16054899
D007545IsoproterenolIsoproterenol results in increased expression of ACTG2 mRNA21335049
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ACTG2 mRNA26644586
D007649KetamineKetamine results in decreased expression of ACTG2 mRNA20080153
C045463leflunomideleflunomide results in increased expression of ACTG2 mRNA28988120
D019808LosartanLosartan results in decreased expression of ACTG2 mRNA15100363
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ACTG2 mRNA26378955
D015122MercaptopurineMercaptopurine results in decreased expression of ACTG2 mRNA23358152
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACTG2 mRNA"27188386
C008493methylselenic acidmethylselenic acid results in increased expression of ACTG2 mRNA18548127
D008942MitoxantroneACTG2 protein affects the susceptibility to Mitoxantrone16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ACTG2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ACTG2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ACTG2 mRNA"25554681
D009532NickelNickel results in decreased expression of ACTG2 mRNA25583101
C017557nickel subsulfidenickel subsulfide affects the expression of ACTG2 mRNA24952340
C029938nickel sulfatenickel sulfate results in increased expression of ACTG2 mRNA16780908
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ACTG2 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ACTG2 mRNA27935865
D010047Ovalbumin[Particulate Matter co-treated with Ovalbumin] results in increased expression of ACTG2 mRNA19176365
D010100OxygenOxygen results in increased expression of ACTG2 mRNA22911455
D052638Particulate Matter[Particulate Matter co-treated with Ovalbumin] results in increased expression of ACTG2 mRNA19176365
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of ACTG2 protein18550172
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ACTG2 protein18550172
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACTG2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ACTG2 mRNA26272509
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ACTG2 mRNA27935865
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ACTG2 mRNA19710929
D011374ProgesteroneProgesterone results in decreased expression of ACTG2 mRNA23018184
D011374ProgesteroneProgesterone results in increased expression of ACTG2 mRNA20864642
D011374ProgesteroneProgesterone affects the expression of ACTG2 mRNA17251523
D011441PropylthiouracilPropylthiouracil results in decreased expression of ACTG2 mRNA24780913
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of ACTG2 mRNA"21152443
C502851quinocetonequinocetone results in increased expression of ACTG2 mRNA27046791
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTG2 mRNA16054899
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ACTG2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ACTG2 mRNA22431001
D012834SilverSilver analog results in decreased expression of ACTG2 mRNA24974767
D012969Sodium FluorideSodium Fluoride results in decreased expression of ACTG2 protein27548804
C471405sorafenibsorafenib results in decreased expression of ACTG2 mRNA19338580
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ACTG2 mRNA26378955
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of ACTG2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of ACTG2 mRNA21592394
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACTG2 mRNA17942748
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ACTG2 mRNA20133372
D019772TopotecanACTG2 protein affects the susceptibility to Topotecan16217747
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of ACTG2 mRNA15894607
D014212TretinoinTretinoin results in increased expression of ACTG2 mRNA15894607
D014212TretinoinTretinoin results in decreased expression of ACTG2 protein16043492
C032910triadimefontriadimefon results in decreased expression of ACTG2 mRNA26705709
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ACTG2 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of ACTG2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ACTG2 mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of ACTG2 mRNA17292431
D014638VanadatesVanadates results in increased expression of ACTG2 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ACTG2 gene25560391
D014801Vitamin AVitamin A results in decreased expression of ACTG2 protein16043492
D014801Vitamin AVitamin A results in decreased expression of [Ethanol results in increased expression of ACTG2 protein]16043492
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ACTG2 mRNA27935865
C088658zoledronic acidzoledronic acid results in decreased expression of ACTG2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-TAS-  
GO:0010628positive regulation of gene expression-ISS-  
GO:0090131mesenchyme migration-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA23580065  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-TAS-  
GO:0030027lamellipodium-ISS-  
GO:0030175filopodium-ISS-  
GO:0032982myosin filament-ISS-  
GO:0044297cell body-ISS-  
GO:0070062extracellular exosome-HDA23533145  
GO:0071944cell periphery-IEA-  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa04270Vascular smooth muscle contraction
Reactome ID Reactome Term Evidence
R-HSA-397014Muscle contractionTAS
R-HSA-445355Smooth Muscle ContractionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18155341Gene expression profiling in human lung fibroblast following cadmium exposure. (2008 Mar)Li GYFood Chem Toxicol