Gene: C4A

720
C4|C4A2|C4A3|C4A4|C4A6|C4AD|C4S|CO4|CPAMD2|RG
complement C4A (Rodgers blood group)
protein-coding
6p21.33
Ensembl:ENSG00000244731 MIM:120810 Vega:OTTHUMG00000031186 UniprotKB:P0C0L4
NG_011638.1
PubMed
0   ANCO-SNPs
ND
8   
5.316e-1 (AD)  3.654e-1 (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C4B0.868
LIMK20.821
MUC10.788
ITGB40.782
C1S0.779
SERPINA30.768
C1R0.766
CHI3L10.761
RGL30.749
TMBIM10.748

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.518
SMIM18-0.463
ADRA1D-0.456
ABCC12-0.454
CYP1A1-0.45
MARCH4-0.442
SLC7A4-0.44
VGF-0.437
TPBGL-0.436
PPEF1-0.436

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00028Immune Globulin HumanBiotechDrug9007-83-4Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of C4A mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of C4A mRNA"21346803
C0054642-aminothiophenol2-aminothiophenol inhibits the reaction [C4A protein binds to C1S protein]8435078
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of C4A mRNA"23196670
C5575053',4'-dimethoxy-alpha-naphthoflavone"3',4'-dimethoxy-alpha-naphthoflavone inhibits the reaction [IL1B protein results in increased expression of C4A mRNA]"21127131
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of C4A mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of C4A mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of C4A protein16687475
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of C4A promoter23359474
D003471CuprizoneCuprizone results in increased expression of C4A mRNA27523638
D003907DexamethasoneDexamethasone results in increased expression of C4A mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of C4A mRNA]20032058
C016366dibenzothiophenedibenzothiophene results in increased expression of C4A mRNA23656968
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of C4A promoter23359474
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of C4A mRNA28962523
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of C4A promoter23359474
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of C4A mRNA23550701
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of C4A mRNA23550701
C039281furanfuran results in decreased expression of C4A mRNA25539665
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of C4A mRNA17183730
D007854LeadLead affects the expression of C4A mRNA28903495
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of C4A mRNA23519560
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of C4A mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of C4A promoter"26251327
C028007nickel monoxidenickel monoxide results in increased expression of C4A mRNA19167457
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of C4A mRNA27935865
C076029olanzapineolanzapine results in decreased phosphorylation of C4A protein25821032
D017239PaclitaxelPaclitaxel results in increased expression of C4A mRNA18754875
D010396PenicillaminePenicillamine inhibits the reaction [C4A protein binds to C1S protein]8435078
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of C4A mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of C4A mRNA18467677
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of C4A mRNA27935865
C014153pirimiphos methylpirimiphos methyl results in decreased expression of C4A mRNA27845199
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of C4A mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of C4A mRNA20059764|2081375
C006253pirinixic acidpirinixic acid results in increased expression of C4A mRNA18467677
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of C4A mRNA]20059764
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of C4A mRNA]18467677
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of C4A mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of C4A mRNA23018184
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of C4A mRNA]20032058
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of C4A mRNA28300664
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of C4A mRNA28922406
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of C4A mRNA23519560
D014241TrichloroethyleneTrichloroethylene results in decreased expression of C4A mRNA19448997
D014241TrichloroethyleneTrichloroethylene results in decreased expression of C4A mRNA17905399
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of C4A mRNA17183730

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001849complement component C1q binding-IDA2395880  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0004866endopeptidase inhibitor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0006954inflammatory response-IEA-  
GO:0006956complement activation-IGI19302245  
GO:0006956complement activation-TAS-  
GO:0006958complement activation, classical pathway-IEA-  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0030449regulation of complement activation-TAS-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0045087innate immune response-IEA-  
GO:2000427positive regulation of apoptotic cell clearance-IGI19302245  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0005615extracellular space-IDA25645918  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0030054cell junction-IEA-  
GO:0030424axon-IDA26814963  
GO:0030425dendrite-IDA26814963  
GO:0043025neuronal cell body-IDA26814963  
GO:0045202synapse-IDA26814963  
GO:0070062extracellular exosome-HDA23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
hsa05150Staphylococcus aureus infection
hsa05322Systemic lupus erythematosus
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-166663Initial triggering of complementTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-174577Activation of C3 and C5TAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957275Post-translational protein phosphorylationTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10217367C4 null alleles and myocardial infarction. (1999 Apr)Nityanand SAtherosclerosis
15339882Genetic basis of tobacco smoking: strong association of a specific major histocompatibility complex haplotype on chromosome 6 with smoking behavior. (2004 Oct)Fust GInt Immunol
15727637The combination of complement deficiency and cigarette smoking as risk factor for cutaneous lupus erythematosus in men; a focus on combined C2/C4 deficiency. (2005 Feb)Boeckler PBr J Dermatol
24465950Investigation of complement component C4 copy number variation in human longevity. (2014)Flachsbart FPLoS One
17212707Human MHC region harbors both susceptibility and protective haplotypes for coronary artery disease. (2007 Jan)Palikhe ATissue Antigens
18032375Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction. (2008 Jan)Blasko BInt Immunol
17425651Smoking and a complement gene polymorphism interact in promoting cardiovascular disease morbidity and mortality. (2007 Jul)Arason GJClin Exp Immunol
23562165Age-related macular degeneration and modification of systemic complement factor H production through liver transplantation. (2013 Aug)Khandhadia SOphthalmology