Gene info: ID 7204

Gene: TRIO

GENE ID: 7204

Synonyms: ARHGEF23|MEBAS|MRD44|tgat

Description: trio Rho guanine nucleotide exchange factor

Gene type: protein-coding

Location: 5p15.2

dbXrefs: Ensembl:ENSG00000038382 MIM:601893 Vega:OTTHUMG00000131057 UniprotKB:O75962

RefSeq: NG_052962.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 13

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.775e-1 (AD) 3.858e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg08761206	chr5:14354943	TRIO	Gene body	1.727e-4	Alcohol use disorders	26763658
cg01138673	chr5:14159230	TRIO	Gene body	4.355e-4	Alcohol use disorders	26763658
cg03604424	chr5:14171590	TRIO		7.500e-8	Smoking	27651444
cg10179300	chr5:14147618	TRIO		1.100e-10	Smoking	28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TGFBRAP1	0.931
ACVR1B	0.929
ARHGEF11	0.927
KPNA6	0.925
RAPGEF2	0.925
KLHL18	0.922
CSRNP2	0.922
UBN1	0.921
SUGP2	0.92
CMIP	0.92

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.548
OR4F29	-0.504
COPZ2	-0.407
HEY2	-0.395
SH2D1A	-0.395
CTNNA3	-0.368
ASB4	-0.367
SNHG18	-0.366
MYL3	-0.365
MBNL3	-0.36

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of TRIO mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of TRIO mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIO mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIO mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of TRIO mRNA	29067470
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of TRIO mRNA	21298039
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of TRIO mRNA	24449571
D001280	Atrazine	Atrazine results in decreased expression of TRIO mRNA	25929836
D001285	Atropine	Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein]	17390078
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TRIO mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TRIO mRNA	20064835\|2010694
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TRIO mRNA	19770486
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TRIO mRNA"	19150397\|2001819
D004958	Estradiol	Estradiol affects the expression of TRIO mRNA	22574217
D004958	Estradiol	Estradiol results in decreased expression of TRIO mRNA	21795739
D004958	Estradiol	[Parathion co-treated with Estradiol] results in increased expression of TRIO protein	17622325
C044887	beta-methylcholine	beta-methylcholine affects the expression of TRIO mRNA	21179406
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TRIO mRNA	28628672
D000069286	Bortezomib	Bortezomib results in decreased expression of TRIO mRNA	20977926
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of TRIO mRNA	15336504
C584509	C646 compound	C646 compound results in decreased expression of TRIO mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of TRIO mRNA	26472689
C054133	casticin	casticin results in increased expression of TRIO mRNA	28444820
D002737	Chloroprene	Chloroprene results in increased expression of TRIO mRNA	23125180
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TRIO gene	20938992
D019327	Copper Sulfate	Copper Sulfate results in increased expression of TRIO mRNA	19549813
D003471	Cuprizone	Cuprizone results in increased expression of TRIO mRNA	27523638
D016572	Cyclosporine	Cyclosporine results in increased expression of TRIO mRNA	20106945
D003703	Demecolcine	Demecolcine results in increased expression of TRIO mRNA	23649840
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TRIO mRNA	28628672
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of TRIO mRNA	24893172
D002945	Cisplatin	Cisplatin promotes the reaction [jinfukang results in decreased expression of TRIO mRNA]	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of TRIO mRNA	27392435
D002945	Cisplatin	jinfukang promotes the reaction [Cisplatin results in decreased expression of TRIO mRNA]	27392435
C000944	dicrotophos	dicrotophos results in increased expression of TRIO mRNA	28302478
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of TRIO mRNA	27638505
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of TRIO mRNA	17557909
D005485	Flutamide	Flutamide results in increased expression of TRIO mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TRIO gene	20938992
C069837	fullerene C60	fullerene C60 results in increased expression of TRIO mRNA	19167457
D017313	Fenretinide	Fenretinide results in decreased expression of TRIO mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of TRIO mRNA	18951874
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TRIO mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TRIO mRNA	28628672
C544151	jinfukang	Cisplatin promotes the reaction [jinfukang results in decreased expression of TRIO mRNA]	27392435
C544151	jinfukang	jinfukang promotes the reaction [Cisplatin results in decreased expression of TRIO mRNA]	27392435
D007854	Lead	Lead results in decreased expression of TRIO mRNA	19921347
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of TRIO mRNA"	24972896
D008070	Lipopolysaccharides	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of TRIO gene	21212295
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TRIO gene	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of TRIO mRNA	23179753\|2718838
C022838	nickel chloride	nickel chloride results in increased expression of TRIO mRNA	17312168
C022838	nickel chloride	nickel chloride affects the expression of TRIO mRNA	22110744
C028007	nickel monoxide	nickel monoxide results in increased expression of TRIO mRNA	19167457
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] affects the expression of TRIO mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased expression of TRIO mRNA	24205000
D010278	Parathion	Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein]	17390078
D010278	Parathion	[Parathion co-treated with Estradiol] results in increased expression of TRIO protein	17622325
D010278	Parathion	Parathion results in increased expression of TRIO protein	17390078\|1762232
D010634	Phenobarbital	Phenobarbital affects the methylation of TRIO gene	19233941
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIO mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of TRIO mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in increased expression of TRIO mRNA	17426115
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of TRIO protein	23718831
D012834	Silver	Silver results in decreased expression of TRIO mRNA	27131904
C009277	sodium arsenate	sodium arsenate results in decreased expression of TRIO mRNA	21795629
C009277	sodium arsenate	sodium arsenate results in increased expression of TRIO mRNA	21795629
C061133	tamibarotene	tamibarotene affects the expression of TRIO mRNA	15498508
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TRIO mRNA	21296121
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of TRIO gene	21212295
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TRIO mRNA	19465110
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TRIO mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TRIO mRNA	21215274
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased methylation of TRIO gene	26756918
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] affects the expression of TRIO mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of TRIO mRNA	15498508
D014212	Tretinoin	Tretinoin results in increased expression of TRIO mRNA	23724009
C012589	trichostatin A	trichostatin A results in increased expression of TRIO mRNA	24935251\|2627250
C057693	troglitazone	troglitazone results in decreased expression of TRIO mRNA	28973697
D014635	Valproic Acid	Valproic Acid results in decreased methylation of TRIO gene	29154799
D014750	Vincristine	Vincristine results in increased expression of TRIO mRNA	23649840

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004674	protein serine/threonine kinase activity	-	IEA	-
GO:0005085	guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005089	Rho guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005515	protein binding	-	IPI	17043677 19846667 22666460
GO:0005524	ATP binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006468	protein phosphorylation	-	IEA	-
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway	-	TAS	8643598
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0035023	regulation of Rho protein signal transduction	-	IEA	-
GO:0043065	positive regulation of apoptotic process	-	TAS	-
GO:0045599	negative regulation of fat cell differentiation	-	ISS	-
GO:0051056	regulation of small GTPase mediated signal transduction	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-193648	NRAGE signals death through JNK	TAS
R-HSA-193704	p75 NTR receptor-mediated signalling	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-194840	Rho GTPase cycle	TAS
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373752	Netrin-1 signaling	TAS
R-HSA-373752	Netrin-1 signaling	IEA
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-416482	G alpha (12/13) signalling events	TAS
R-HSA-418885	DCC mediated attractive signaling	TAS
R-HSA-418885	DCC mediated attractive signaling	IEA
R-HSA-422475	Axon guidance	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-73887	Death Receptor Signalling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25324711	Initial puffing behaviors and subjective responses differ between an electronic nicotine delivery system and traditional cigarettes. (2014)	Norton KJ	Tob Induc Dis
20375196	Genetic association between single nucleotide polymorphisms in the paraoxonase 1 (PON1) gene and small-for-gestational-age birth in related and unrelated subjects. (2010 May 1)	Infante-Rivard C	Am J Epidemiol
11454503	A case-control study of nonsyndromic oral clefts in Maryland. (2001 Aug)	Beaty TH	Ann Epidemiol
16357593	Xenobiotic-metabolizing genes and small-for-gestational-age births: interaction with maternal smoking. (2006 Jan)	Infante-Rivard C	Epidemiology
14745296	Association of GABRG3 with alcohol dependence. (2004 Jan)	Dick DM	Alcohol Clin Exp Res
15690551	No association of the GABAA receptor genes on chromosome 5 with alcoholism in the collaborative study on the genetics of alcoholism sample. (2005 Jan 5)	Dick DM	Am J Med Genet B Neuropsychiatr Genet
22564423	Matrix metalloproteinase-2 and -9 in glioblastoma: a trio of old drugs-captopril, disulfiram and nelfinavir-are inhibitors with potential as adjunctive treatments in glioblastoma. (2012 Apr)	Kast RE	Arch Med Res
26306329	The Molecular Neurobiology of Twelve Steps Program & Fellowship: Connecting the Dots for Recovery. (2015)	Blum K	J Reward Defic Syndr
21401569	Combining disease models to test for gene-environment interaction in nuclear families. (2011 Dec)	Hoffmann TJ	Biometrics
23512105	Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (2013 Jul)	Beaty TH	Hum Genet
27591263	Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy. (2016 Oct)	Morales E	Int J Epidemiol
11754469	Testing candidate genes for non-syndromic oral clefts using a case-parent trio design. (2002 Jan)	Beaty TH	Genet Epidemiol
21189065	Interactions between small ubiquitin-like modifier 1 and nonsyndromic orofacial clefts. (2011 Apr)	Jia ZL	DNA Cell Biol