Gene info: ID 721

Gene: C4B

GENE ID: 721

Synonyms: C4B1|C4B12|C4B2|C4B3|C4B5|C4BD|C4B_2|C4F|CH|CO4|CPAMD3

Description: complement C4B (Chido blood group)

Gene type: protein-coding

Location: 6p21.33

dbXrefs: Ensembl:ENSG00000224389 MIM:120820 Vega:OTTHUMG00000031187 UniprotKB:P0C0L5

RefSeq: NG_011639.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 14

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C4A	0.868
LIMK2	0.827
SERPINA3	0.815
C1S	0.8
C1R	0.798
MUC1	0.796
CHI3L1	0.789
ITGB4	0.788
TMBIM1	0.781
RARRES3	0.775

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CYP1A1	-0.483
ABCC12	-0.474
ADRA1D	-0.474
MARCH4	-0.467
CRH	-0.466
PPEF1	-0.463
F7	-0.461
SLC7A4	-0.459
TPBGL	-0.447
VGF	-0.44

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00028	Immune Globulin Human	BiotechDrug	9007-83-4	Approved\|Investigational	Target
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C006718	1,12-benzoperylene	"1,12-benzoperylene results in increased expression of C4B mRNA"	26377693
C005464	2-aminothiophenol	2-aminothiophenol inhibits the reaction [C4B protein binds to C1S protein]	8435078
C496492	abrine	abrine results in increased expression of C4B mRNA	22595364
D000108	Acetylcarnitine	Acetylcarnitine results in decreased expression of C4B mRNA	19555370
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of C4B mRNA	16483693
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of C4B mRNA"	23917077
D001280	Atrazine	Atrazine results in decreased expression of C4B mRNA	25929836
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of C4B mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of C4B mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of C4B mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of C4B mRNA	23735875
C006780	bisphenol A	bisphenol A results in increased expression of C4B mRNA	27104808
D002104	Cadmium	C4B protein binds to Cadmium	23896426
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of C4B promoter	22457795
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of C4B mRNA	17484886
C010063	carbonyl sulfide	carbonyl sulfide results in increased expression of C4B mRNA	19395590
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of C4B mRNA	20938992
D002994	Clofibrate	Clofibrate results in decreased expression of C4B mRNA	23811191
C055162	clopidogrel	clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of C4B mRNA]	19172522
C024989	coenzyme Q10	coenzyme Q10 results in decreased expression of C4B mRNA	19555370
D003300	Copper	C4B protein binds to Copper	23896426
D003474	Curcumin	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C4B mRNA]	18200517
D016572	Cyclosporine	Cyclosporine results in increased expression of C4B mRNA	21865292
C093628	cyproconazole	cyproconazole results in decreased expression of C4B mRNA	22334560
C007262	deoxynivalenol	deoxynivalenol results in increased expression of C4B mRNA	22968694
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of C4B mRNA	28962523
D004008	Diclofenac	Diclofenac results in increased expression of C4B mRNA	26934552
D004041	Dietary Fats	Dietary Fats results in decreased expression of C4B mRNA	25016146
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of C4B mRNA	24535843
D004237	Diuron	Diuron results in decreased expression of C4B mRNA	21551480
C109476	epoxiconazole	epoxiconazole results in decreased expression of C4B mRNA	22334560
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of C4B mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of C4B mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of C4B mRNA	16174780
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of C4B mRNA	17108234
D018120	Finasteride	Finasteride results in decreased expression of C4B mRNA	24136188
D005485	Flutamide	Flutamide results in decreased expression of C4B mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of C4B mRNA	20938992
C039281	furan	furan results in decreased expression of C4B mRNA	26194646
D005839	Gentamicins	Gentamicins results in increased expression of C4B mRNA	22061828
C010176	halofuginone	halofuginone results in decreased expression of C4B mRNA	17180598
D007545	Isoproterenol	Isoproterenol results in increased expression of C4B mRNA	20003209
C098607	JP8 aviation fuel	JP8 aviation fuel affects the expression of C4B mRNA	15182950
D007608	Kainic Acid	Kainic Acid results in increased expression of C4B mRNA	17997037
D007854	Lead	Lead affects the expression of C4B mRNA	28903495
D064704	Levofloxacin	Levofloxacin results in increased expression of C4B mRNA	24136188
D008070	Lipopolysaccharides	clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of C4B mRNA]	19172522
C015329	lycopene	lycopene results in decreased expression of C4B mRNA	19555370
D008713	Methimazole	Methimazole results in increased expression of C4B mRNA	22504374
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of C4B mRNA	20938992
D008748	Methylcholanthrene	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of C4B mRNA	23519560
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of C4B mRNA"	23634900
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of C4B mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of C4B mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased secretion of C4B protein"	25598225
C051752	nefazodone	nefazodone results in decreased expression of C4B mRNA	24136188
D009532	Nickel	C4B protein binds to Nickel	23896426
C076029	olanzapine	olanzapine affects the phosphorylation of C4B protein	25821032
D010396	Penicillamine	Penicillamine inhibits the reaction [C4B protein binds to C1S protein]	8435078
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of C4B mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of C4B mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of C4B mRNA	18467677\|2093613
C023036	perfluorooctanoic acid	PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of C4B mRNA]	18467677
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of C4B mRNA	19162173
D010578	Petroleum	Petroleum affects the expression of C4B mRNA	25208076
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in decreased expression of C4B mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in decreased expression of C4B mRNA	17426115\|1846767
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of C4B mRNA]	18467677
C006253	pirinixic acid	pirinixic acid results in decreased expression of C4B mRNA	19162173
C045950	propiconazole	propiconazole results in decreased expression of C4B mRNA	21278054\|2233456
D011441	Propylthiouracil	Propylthiouracil affects the expression of C4B mRNA	24780913
D011441	Propylthiouracil	Propylthiouracil results in increased expression of C4B mRNA	22504374
C059514	resveratrol	resveratrol results in decreased expression of C4B mRNA	19555370
D012835	Silver Nitrate	Silver Nitrate results in increased expression of C4B mRNA	22727896
C017947	sodium arsenite	sodium arsenite affects the expression of C4B mRNA	19590694
D013311	Streptozocin	Streptozocin results in increased expression of C4B mRNA	16684804
D013311	Streptozocin	vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of C4B mRNA]	16684804
D013467	Sulindac	Sulindac results in decreased expression of C4B mRNA	24136188
D016559	Tacrolimus	Tacrolimus results in increased expression of C4B mRNA	21865292
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in decreased expression of C4B mRNA	15885361
C001803	tempol	tempol results in decreased expression of C4B mRNA	19555370
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of C4B mRNA	28300664
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of C4B mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of C4B mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of C4B mRNA	28922406
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of C4B mRNA	15703262
D013755	Tetradecanoylphorbol Acetate	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of C4B mRNA	23519560
D013853	Thioacetamide	Thioacetamide results in decreased expression of C4B mRNA	23411599
D008063	Thioctic Acid	Thioctic Acid results in decreased expression of C4B mRNA	19555370
C009495	titanium dioxide	titanium dioxide affects the expression of C4B mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of C4B protein	19478969
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of C4B mRNA	20133372
C066340	tolcapone	tolcapone results in increased expression of C4B mRNA	24136188
D014302	Trinitrobenzenesulfonic Acid	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C4B mRNA]	18200517
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of C4B mRNA	18200517
C034028	vanadyl sulfate	vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of C4B mRNA]	16684804
D014640	Vancomycin	Vancomycin results in decreased expression of C4B mRNA	18930951
D014640	Vancomycin	Vancomycin results in increased expression of C4B mRNA	18930951
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical affects the expression of C4B mRNA"	25208076
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in decreased expression of C4B mRNA"	23246600
D015032	Zinc	C4B protein binds to Zinc	23896426

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001848	complement binding	-	IDA	2395880
GO:0004252	serine-type endopeptidase activity	-	TAS	-
GO:0004866	endopeptidase inhibitor activity	-	IEA	-
GO:0030246	carbohydrate binding	-	IDA	2395880

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006508	proteolysis	-	IEA	-
GO:0006954	inflammatory response	-	IEA	-
GO:0006956	complement activation	-	IGI	19302245
GO:0006956	complement activation	-	TAS	-
GO:0006958	complement activation, classical pathway	-	IEA	-
GO:0008228	opsonization	-	TAS	22333221
GO:0010951	negative regulation of endopeptidase activity	-	IEA	-
GO:0030449	regulation of complement activation	-	TAS	-
GO:0032490	detection of molecule of bacterial origin	-	IDA	22333221
GO:0045087	innate immune response	-	IEA	-
GO:2000427	positive regulation of apoptotic cell clearance	-	IGI	19302245

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	HDA	16502470
GO:0005615	extracellular space	-	IDA	2395880 22333221
GO:0005886	plasma membrane	-	TAS	-
GO:0030054	cell junction	-	IEA	-
GO:0030424	axon	-	IEA	-
GO:0030425	dendrite	-	IEA	-
GO:0044216	other organism cell	-	IDA	22333221
GO:0045202	synapse	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	23533145
GO:0072562	blood microparticle	-	HDA	22516433

KEGG ID	KEGG Term
hsa04610	Complement and coagulation cascades
hsa05150	Staphylococcus aureus infection
hsa05322	Systemic lupus erythematosus

Reactome ID	Reactome Term	Evidence
R-HSA-166658	Complement cascade	TAS
R-HSA-166663	Initial triggering of complement	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-174577	Activation of C3 and C5	TAS
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-8957275	Post-translational protein phosphorylation	TAS
R-HSA-977606	Regulation of Complement cascade	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
10217367	C4 null alleles and myocardial infarction. (1999 Apr)	Nityanand S	Atherosclerosis
7832094	Serum glycoproteins and severity of coronary atherosclerosis. (1995 Feb)	Mori T	Am Heart J
24621201	Tag SNPs in complement receptor-1 contribute to the susceptibility to non-small cell lung cancer. (2014 Mar 12)	Yu X	Mol Cancer
15339882	Genetic basis of tobacco smoking: strong association of a specific major histocompatibility complex haplotype on chromosome 6 with smoking behavior. (2004 Oct)	Fust G	Int Immunol
8864252	Relation of C4b-binding protein to athero-sclerosis of the descending thoracic aorta. (1996)	Kimoto K	Artery
15727637	The combination of complement deficiency and cigarette smoking as risk factor for cutaneous lupus erythematosus in men; a focus on combined C2/C4 deficiency. (2005 Feb)	Boeckler P	Br J Dermatol
24465950	Investigation of complement component C4 copy number variation in human longevity. (2014)	Flachsbart F	PLoS One
1829572	The natural anticoagulant protein S is decreased in male smokers. (1991 Jul)	Scott BD	Am Heart J
17212707	Human MHC region harbors both susceptibility and protective haplotypes for coronary artery disease. (2007 Jan)	Palikhe A	Tissue Antigens
18032375	Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction. (2008 Jan)	Blasko B	Int Immunol
28434814	Novel protein biomarkers associated with coronary artery disease in statin-treated patients with familial hypercholesterolemia. (2017 May - Jun)	Bos S	J Clin Lipidol
17425651	Smoking and a complement gene polymorphism interact in promoting cardiovascular disease morbidity and mortality. (2007 Jul)	Arason GJ	Clin Exp Immunol
12671737	Genetic determinants of variation in the plasma levels of the C4b-binding protein (C4BP) in Spanish families. (2003 Mar)	Esparza-Gordillo J	Immunogenetics
12482406	Protein C pathway impairment in nonsymptomatic cigarette smokers. (2002 Jul-Aug)	Fernandez JA	Blood Cells Mol Dis