Gene: TRPC3

7222
SCA41|TRP3
transient receptor potential cation channel subfamily C member 3
protein-coding
4q27
Ensembl:ENSG00000138741 MIM:602345 Vega:OTTHUMG00000133069 UniprotKB:Q13507
NG_030368.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.735e-1 (AD)  4.667e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PNOC0.636
VWC20.628
IGF10.627
SLC35G10.617
MYO1B0.607
ADAMTS50.607
HAPLN10.605
P2RX20.598
LBH0.589
LGI20.589

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATOH8-0.448
UHRF1-0.436
SLC14A1-0.432
FKBP5-0.431
OTOS-0.426
KIF19-0.415
PDK4-0.409
ITGB4-0.405
CHST3-0.4
ANGPTL4-0.385

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0631591-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium]19244478
C5203231-oleoyl-2-acetoyl-sn-glycerol1-oleoyl-2-acetoyl-sn-glycerol affects the reaction [TRPC3 protein results in increased transport of Barium]16055711
C5203231-oleoyl-2-acetoyl-sn-glycerolTRPC3 protein promotes the reaction [1-oleoyl-2-acetoyl-sn-glycerol results in increased transport of Calcium]15672411
C0382371-oleoyl-2-acetylglycerol1-oleoyl-2-acetylglycerol affects the reaction [TRPC3 protein affects the transport of Calcium]17351372
C0382371-oleoyl-2-acetylglycerol1-oleoyl-2-acetylglycerol promotes the reaction [TRPC3 protein results in increased transport of Barium]11042129
C0382371-oleoyl-2-acetylglycerol1-oleoyl-2-acetylglycerol promotes the reaction [TRPC3 protein results in increased transport of Calcium]12700192
C0382371-oleoyl-2-acetylglycerol1-oleoyl-2-acetylglycerol results in increased activity of TRPC3 protein16522635
C0382371-oleoyl-2-acetylglycerol1-oleoyl-2-acetylglycerol results in increased activity of TRPC3 protein18316702
C0382371-oleoyl-2-acetylglycerol1-oleoyl-2-acetylglycerol results in increased activity of TRPC3 protein22031853|2313134
C0382371-oleoyl-2-acetylglycerol[1-oleoyl-2-acetylglycerol results in increased activity of TRPC3 protein] which results in increased uptake of Calcium23131343
C0382371-oleoyl-2-acetylglycerolManganese inhibits the reaction [[1-oleoyl-2-acetylglycerol results in increased activity of TRPC3 protein] which results in increased uptake of Calcium]23131343
C0382371-oleoyl-2-acetylglycerol[Pyrazoles results in decreased activity of TRPC3 protein] inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Manganese]23131343
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TRPC3 mRNA"27291303
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TRPC3 mRNA"18648102
D020106AcrylamideAcrylamide results in decreased expression of TRPC3 mRNA28959563
D000255Adenosine Triphosphate[Pyrazoles results in decreased activity of TRPC3 protein] inhibits the reaction [Adenosine Triphosphate results in increased transport of Manganese]23131343
D000255Adenosine TriphosphateTRPC3 protein affects the reaction [Manganese inhibits the reaction [Adenosine Triphosphate results in increased uptake of Calcium]]23131343
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TRPC3 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TRPC3 protein27818125
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TRPC3 mRNA16483693
D001464Barium1-oleoyl-2-acetylglycerol promotes the reaction [TRPC3 protein results in increased transport of Barium]11042129
D001464BariumTRPC3 protein results in increased transport of Barium11042129
D001464Barium1-oleoyl-2-acetoyl-sn-glycerol affects the reaction [TRPC3 protein results in increased transport of Barium]16055711
D001464BariumTRPC3 protein results in increased transport of Barium16055711
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of TRPC3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TRPC3 mRNA22228805
D004958EstradiolEstradiol results in increased expression of TRPC3 mRNA19484750
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of TRPC3 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of TRPC3 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of TRPC3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TRPC3 gene28505145
D002110CaffeineTRPC3 protein affects the reaction [Caffeine results in increased activity of RYR1 protein]16484216
D002118Calcium1-oleoyl-2-acetylglycerol affects the reaction [TRPC3 protein affects the transport of Calcium]17351372
D002118Calcium1-oleoyl-2-acetylglycerol promotes the reaction [TRPC3 protein results in increased transport of Calcium]12700192
D002118CalciumOXT protein promotes the reaction [TRPC3 protein results in increased transport of Calcium]12700192
D002118CalciumThapsigargin promotes the reaction [TRPC3 protein results in increased transport of Calcium]12700192
D002118CalciumTRPC3 protein affects the transport of Calcium17351372
D002118CalciumTRPC3 protein results in increased transport of Calcium12700192|1273625
D002118CalciumTRPC3 protein affects the secretion of Calcium16484216
D002118Calcium1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium]19244478
D002118Calcium[Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium19244478
D002118CalciumTRPC3 protein affects the transport of Calcium15672411
D002118CalciumTRPC3 protein promotes the reaction [1-oleoyl-2-acetoyl-sn-glycerol results in increased transport of Calcium]15672411
D002118CalciumTRPC3 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]15672411
D002118CalciumTRPC3 protein promotes the reaction [Thapsigargin results in increased transport of Calcium]15672411
D002118CalciumTRPC3 protein results in increased transport of Calcium18822394
D002118Calcium[1-oleoyl-2-acetylglycerol results in increased activity of TRPC3 protein] which results in increased uptake of Calcium23131343
D002118CalciumManganese inhibits the reaction [[1-oleoyl-2-acetylglycerol results in increased activity of TRPC3 protein] which results in increased uptake of Calcium]23131343
D002118CalciumTRPC1 protein inhibits the reaction [TRPC3 protein results in increased transport of Calcium]22157757
D002118CalciumTRPC3 protein affects the reaction [AGT protein results in increased import of Calcium]20177073
D002118CalciumTRPC3 protein affects the reaction [Manganese inhibits the reaction [Adenosine Triphosphate results in increased uptake of Calcium]]23131343
D002118CalciumTRPC3 protein results in increased transport of Calcium22157757
D016572CyclosporineCyclosporine inhibits the reaction [Thapsigargin results in increased expression of TRPC3 mRNA]19244478
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of TRPC3 mRNA23640034
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of TRPC3 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of TRPC3 mRNA18042831
C024629dimethyl phthalatedimethyl phthalate affects the expression of TRPC3 mRNA26924002
D004317DoxorubicinDoxorubicin results in increased expression of TRPC3 protein28495616
D004317Doxorubicinsalvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of TRPC3 protein]28495616
C559943ethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylateethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate results in decreased activity of TRPC3 protein27224899
D005682GadoliniumGadolinium affects the localization of and results in decreased activity of TRPC3 protein16522635
C412815GW 4064GW 4064 results in decreased expression of TRPC3 mRNA26655953
D008345ManganeseManganese inhibits the reaction [[1-oleoyl-2-acetylglycerol results in increased activity of TRPC3 protein] which results in increased uptake of Calcium]23131343
D008345Manganese[Pyrazoles results in decreased activity of TRPC3 protein] inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Manganese]23131343
D008345Manganese[Pyrazoles results in decreased activity of TRPC3 protein] inhibits the reaction [Adenosine Triphosphate results in increased transport of Manganese]23131343
D008345ManganeseTRPC3 protein affects the reaction [Manganese inhibits the reaction [Adenosine Triphosphate results in increased uptake of Calcium]]23131343
D016210Methacholine ChlorideMethacholine Chloride results in increased activity of TRPC3 protein16522635
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TRPC3 mRNA"26251327
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TRPC3 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TRPC3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TRPC3 mRNA"25554681
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TRPC3 mRNA27935865
D017239PaclitaxelPaclitaxel results in increased expression of TRPC3 protein15907983
D000073878Palm OilPalm Oil results in increased expression of TRPC3 mRNA18042831
D010269ParaquatParaquat results in decreased expression of TRPC3 mRNA23602965
D010269ParaquatParaquat results in decreased expression of TRPC3 protein23602965
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of TRPC3 mRNA22790973
D010656Phenylephrine1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium]19244478
D010656PhenylephrinePhenylephrine results in increased expression of TRPC3 mRNA19244478
D010656PhenylephrinePhenylephrine results in increased expression of TRPC3 protein19244478
D010656Phenylephrine[Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium19244478
D010656PhenylephrineTRPC3 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]15672411
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TRPC3 mRNA27935865
D011720PyrazolesPyrazoles results in decreased activity of TRPC3 protein23131343
D011720Pyrazoles[Pyrazoles results in decreased activity of TRPC3 protein] inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Manganese]23131343
D011720Pyrazoles[Pyrazoles results in decreased activity of TRPC3 protein] inhibits the reaction [Adenosine Triphosphate results in increased transport of Manganese]23131343
D012402RotenoneRotenone results in decreased expression of TRPC3 mRNA23602965
D012402RotenoneRotenone results in decreased expression of TRPC3 protein23602965
C076944salvianolic acid Bsalvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of TRPC3 protein]28495616
D053260SootSoot results in decreased expression of TRPC3 mRNA26551751
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of TRPC3 mRNA19244478
D019284ThapsigarginThapsigargin promotes the reaction [TRPC3 protein results in increased transport of Calcium]12700192
D019284ThapsigarginCyclosporine inhibits the reaction [Thapsigargin results in increased expression of TRPC3 mRNA]19244478
D019284ThapsigarginThapsigargin results in increased expression of TRPC3 mRNA19244478
D019284ThapsigarginTRPC3 protein promotes the reaction [Thapsigargin results in increased transport of Calcium]15672411
D014212TretinoinTretinoin results in increased expression of TRPC3 mRNA21934132
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of TRPC3 mRNA19042947
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of TRPC3 mRNA23537331
C057693troglitazonetroglitazone results in decreased expression of TRPC3 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of TRPC3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of TRPC3 gene29154799
D014638VanadatesVanadates results in decreased expression of TRPC3 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TRPC3 gene25560391
C111237vorinostatvorinostat results in increased expression of TRPC3 mRNA27188386
D015029ZeranolZeranol results in increased expression of TRPC3 protein27224899

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005262calcium channel activity-TAS-  
GO:0005515protein binding-IPI10611319  15744307  15757897  17360584  20095964  
GO:0015279store-operated calcium channel activity-IBA21873635  
GO:0015279store-operated calcium channel activity-TAS9215637  
GO:0070679inositol 1,4,5 trisphosphate binding-IBA21873635  
GO:0070679inositol 1,4,5 trisphosphate binding-IDA14505576  
GO ID GO Term Qualifier Evidence PubMed
GO:0006816calcium ion transport-TAS9215637  
GO:0006828manganese ion transport-IBA21873635  
GO:0007338single fertilization-IBA21873635  
GO:0007602phototransduction-TAS9215637  
GO:0010524positive regulation of calcium ion transport into cytosol-IDA21062895  
GO:0030168platelet activation-TAS-  
GO:0033198response to ATP-IDA21062895  
GO:0051480regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0051592response to calcium ion-IDA21062895  
GO:0070588calcium ion transmembrane transport-IBA21873635  
GO:0070588calcium ion transmembrane transport-IDA21062895  
GO:0070588calcium ion transmembrane transport-TAS-  
GO:1903244positive regulation of cardiac muscle hypertrophy in response to stress-IDA19287093  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA9368034  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114508Effects of PIP2 hydrolysisTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-139853Elevation of cytosolic Ca2+ levelsTAS
R-HSA-162582Signal TransductionTAS
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-3295583TRP channelsTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373752Netrin-1 signalingIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-418346Platelet homeostasisTAS
R-HSA-418360Platelet calcium homeostasisTAS
R-HSA-418890Role of second messengers in netrin-1 signalingIEA
R-HSA-422475Axon guidanceIEA
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23840757Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer. (2013)Jiang HNPLoS One
28722770Asbestos-associated genome-wide DNA methylation changes in lung cancer. (2017 Nov 15)Kettunen EInt J Cancer
26075746Mechanisms of Cigarette Smoke Effects on Human Airway Smooth Muscle. (2015)Wylam MEPLoS One