Gene: TRPC4

7223
HTRP-4|HTRP4|TRP4
transient receptor potential cation channel subfamily C member 4
protein-coding
13q13.3
Ensembl:ENSG00000133107 MIM:603651 Vega:OTTHUMG00000016752 UniprotKB:Q9UBN4
NG_029849.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.459e-2 (AD)  5.884e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PI150.799
NABP10.783
STC10.767
TLR100.76
LILRB20.757
TLR10.755
CIITA0.752
CASP80.747
ALX30.747
EMILIN20.742

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.428
C1orf53-0.418
HHATL-0.395
ARSF-0.39
C9orf24-0.386
HES6-0.374
NTSR2-0.368
NEU4-0.367
HES5-0.366
KCNIP3-0.361

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0382371-oleoyl-2-acetylglycerolTRPC4 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Strontium]11830588
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [Mercuric Chloride results in increased activity of TRPC4 protein]21984481
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPC4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPC4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPC4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPC4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPC4 mRNA"27188386
C496492abrineabrine results in increased expression of TRPC4 mRNA22595364
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TRPC4 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TRPC4 protein27818125
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TRPC4 mRNA24449571
D016718Arachidonic AcidTRPC4 protein affects the reaction [Arachidonic Acid results in increased transport of Calcium]11830588
D001464BariumTRPC4 protein affects the reaction [Carbachol results in increased transport of Barium]11830588
D001464BariumTRPC4 protein results in increased transport of Barium11042129
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TRPC4 mRNA21839799
C006780bisphenol Abisphenol A results in decreased expression of TRPC4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TRPC4 gene28505145
D002118CalciumTRPC4 protein affects the reaction [Arachidonic Acid results in increased transport of Calcium]11830588
D002118CalciumTRPC4 protein affects the reaction [Carbachol results in increased transport of Calcium]11830588
D002118CalciumLEP protein promotes the reaction [TRPC4 protein results in increased transport of Calcium]20107083
D002118CalciumTRPC4 protein results in increased transport of Calcium20107083
D002118CalciumTRPC1 protein inhibits the reaction [TRPC4 protein results in increased transport of Calcium]22157757
D002118CalciumTRPC4 protein results in increased transport of Calcium22157757
D002217CarbacholTRPC4 protein affects the reaction [Carbachol results in increased transport of Barium]11830588
D002217CarbacholTRPC4 protein affects the reaction [Carbachol results in increased transport of Calcium]11830588
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of TRPC4 mRNA24763279
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPC4 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of TRPC4 mRNA26272509
D004390ChlorpyrifosChlorpyrifos affects the expression of TRPC4 mRNA22611033
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TRPC4 mRNA28628672
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of TRPC4 mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of TRPC4 mRNA26924002
C521792DMU-212DMU-212 affects the expression of TRPC4 mRNA26428916
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TRPC4 mRNA12075121
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of TRPC4 mRNA24763279
D017313FenretinideFenretinide results in decreased expression of TRPC4 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TRPC4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TRPC4 mRNA28628672
C008261lead acetatelead acetate results in increased expression of TRPC4 mRNA22674931
C008261lead acetatelead acetate results in increased expression of TRPC4 protein22674931
C100082malaoxonmalaoxon results in increased expression of TRPC4 mRNA22674931
C100082malaoxonmalaoxon results in increased expression of TRPC4 protein22674931
D008294MalathionMalathion results in increased expression of TRPC4 mRNA22674931
D008294MalathionMalathion results in increased expression of TRPC4 protein22674931
C042720mercuric bromidemercuric bromide results in decreased expression of TRPC4 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPC4 mRNA"27188386
D008627Mercuric Chloride2-aminoethoxydiphenyl borate inhibits the reaction [Mercuric Chloride results in increased activity of TRPC4 protein]21984481
D008627Mercuric ChlorideMercuric Chloride results in increased activity of TRPC4 protein21984481
D008731MethoxychlorMethoxychlor results in increased methylation of TRPC4 gene23303685
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of TRPC4 mRNA24810058
C567966ML 204ML 204 results in decreased activity of TRPC4 protein27224899
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TRPC4 mRNA26924002
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPC4 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of TRPC4 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPC4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TRPC4 mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TRPC4 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of TRPC4 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of TRPC4 mRNA18070364
D011441PropylthiouracilPropylthiouracil results in decreased expression of TRPC4 mRNA24780913
C043680ptaquilosideptaquiloside results in decreased expression of TRPC4 mRNA23274088
D012643SeleniumSelenium results in decreased expression of TRPC4 mRNA19244175
D013324StrontiumTRPC4 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Strontium]11830588
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPC4 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TRPC4 mRNA24935251|2627250
D014635Valproic AcidValproic Acid affects the expression of TRPC4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TRPC4 mRNA24383497|2493525
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TRPC4 gene25560391
C111237vorinostatvorinostat results in increased expression of TRPC4 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005262calcium channel activity-TAS-  
GO:0005515protein binding-IPI11163362  15757897  16254212  20164195  
GO:0008013beta-catenin binding-IPI19996314  
GO:0015279store-operated calcium channel activity-IBA21873635  
GO:0015279store-operated calcium channel activity-IMP16254212  
GO:0045296cadherin binding-IPI19996314  
GO:0070679inositol 1,4,5 trisphosphate binding-IBA21873635  
GO:0070679inositol 1,4,5 trisphosphate binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006816calcium ion transport-TAS8646775  
GO:0006828manganese ion transport-IBA21873635  
GO:0014051gamma-aminobutyric acid secretion-IEA-  
GO:0048709oligodendrocyte differentiation-IEA-  
GO:0051480regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0070509calcium ion import-IDA19996314  
GO:0070588calcium ion transmembrane transport-IBA21873635  
GO:0070588calcium ion transmembrane transport-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA16254212  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005901caveola-IEA-  
GO:0005911cell-cell junctioncolocalizes_withIDA19996314  
GO:0009986cell surface-IDA19996314  
GO:0016323basolateral plasma membrane-IDA19996314  
GO:0030863cortical cytoskeleton-IDA16254212  
GO:0034704calcium channel complex-IDA20164195  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-3295583TRP channelsTAS
R-HSA-373752Netrin-1 signalingIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-418890Role of second messengers in netrin-1 signalingIEA
R-HSA-422475Axon guidanceIEA
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23840757Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer. (2013)Jiang HNPLoS One