Gene: TRPC6

7225
FSGS2|TRP6
transient receptor potential cation channel subfamily C member 6
protein-coding
11q22.1
Ensembl:ENSG00000137672 MIM:603652 Vega:OTTHUMG00000167483 UniprotKB:Q9Y210
NG_011476.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.503e-1 (AD)  4.337e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITGA40.595
LGI20.583
ANO10.579
SCARA50.563
TNFRSF190.549
AMOTL10.546
ALK0.542
THSD7A0.539
COL15A10.538
FER1L60.526

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NRN1L-0.378
CCL27-0.322
SLC25A48-0.321
BGLAP-0.313
CLDN9-0.309
KLF15-0.308
IZUMO4-0.307
NTSR2-0.307
GAGE10-0.305
SH2D6-0.297

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0631591-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole results in decreased activity of TRPC6 protein11179201
C0631591-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
C0631591-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
C0442951,2-dioctanoylglycerol"1,2-dioctanoylglycerol results in increased activity of TRPC6 protein"11179201
C0442951,2-dioctanoylglycerol"1,2-dioctanoylglycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]"11535132
C0442951,2-dioctanoylglycerol"1,2-dioctanoylglycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]"11535132
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased activity of TRPC6 protein]"17603544
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased activity of TRPC6 protein"11179201
C0365351,6-bis(cyclohexyloximinocarbonyl)hexane"1,6-bis(cyclohexyloximinocarbonyl)hexane results in increased activity of TRPC6 protein"11179201
C5203231-oleoyl-2-acetoyl-sn-glycerol1-oleoyl-2-acetoyl-sn-glycerol affects the reaction [TRPC6 protein affects the transport of Barium]16055711
C5203231-oleoyl-2-acetoyl-sn-glycerol1-oleoyl-2-acetoyl-sn-glycerol results in increased activity of TRPC6 protein11179201
C5203231-oleoyl-2-acetoyl-sn-glycerol1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
C5203231-oleoyl-2-acetoyl-sn-glycerol1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
C5203231-oleoyl-2-acetoyl-sn-glycerol1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]11535132
C5203231-oleoyl-2-acetoyl-sn-glycerol1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]11535132
C5203231-oleoyl-2-acetoyl-sn-glycerolFlufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
C5203231-oleoyl-2-acetoyl-sn-glycerolFlufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]]11535132
C5203231-oleoyl-2-acetoyl-sn-glycerolTRPC6 protein promotes the reaction [1-oleoyl-2-acetoyl-sn-glycerol results in increased transport of Calcium]15672411
C0382371-oleoyl-2-acetylglycerol1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein18316702
C0382371-oleoyl-2-acetylglycerolTRPC6 protein affects the susceptibility to 1-oleoyl-2-acetylglycerol22031853
C0382371-oleoyl-2-acetylglycerol1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein20177073
C0382371-oleoyl-2-acetylglycerol1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein mutant form20177073
C0382371-oleoyl-2-acetylglycerol"4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein]"20177073
C0382371-oleoyl-2-acetylglycerol8-bromocyclic GMP inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein]20177073
C0382371-oleoyl-2-acetylglycerol"KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein]]"20177073
C0382371-oleoyl-2-acetylglycerolS-Nitroso-N-Acetylpenicillamine inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein]20177073
C0382371-oleoyl-2-acetylglycerol1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein22031853
C5387582-aminoethyl diphenylborinate2-aminoethyl diphenylborinate inhibits the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
C5387582-aminoethyl diphenylborinate2-aminoethyl diphenylborinate inhibits the reaction [Thapsigargin promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
C4466024-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline"4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog results in increased phosphorylation of TRPC6 protein"20177073
C4466024-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline"KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog results in increased phosphorylation of TRPC6 protein]"20177073
C4466024-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline"4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein]"20177073
C4466024-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline"4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog results in increased phosphorylation of TRPC6 protein"20177073
C4466024-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline"KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein]]"20177073
C4466024-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline"KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog results in increased phosphorylation of TRPC6 protein]"20177073
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of TRPC6 mRNA"25912373
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRPC6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRPC6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRPC6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRPC6 mRNA"27188386
C0162768-bromocyclic GMP8-bromocyclic GMP results in increased phosphorylation of TRPC6 protein20177073
C0162768-bromocyclic GMPKT 5823 inhibits the reaction [8-bromocyclic GMP results in increased phosphorylation of TRPC6 protein]20177073
C0162768-bromocyclic GMP8-bromocyclic GMP inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein]20177073
D000109Acetylcholine1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
D000109Acetylcholine1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
D000109Acetylcholine2-aminoethyl diphenylborinate inhibits the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
D000109AcetylcholineAcetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]11535132
D000109AcetylcholineAcetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Manganese]11535132
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TRPC6 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TRPC6 protein27818125
D000584AmilorideAmiloride results in decreased activity of TRPC6 protein11179201
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TRPC6 mRNA16483693
D001464Barium1-oleoyl-2-acetoyl-sn-glycerol affects the reaction [TRPC6 protein affects the transport of Barium]16055711
D001464BariumADRA1A protein promotes the reaction [TRPC6 protein results in increased transport of Barium]11179201
D001464BariumTRPC6 protein affects the transport of Barium16055711
D001464BariumTRPC6 protein results in increased transport of Barium11179201
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of TRPC6 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of TRPC6 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TRPC6 mRNA17879257
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TRPC6 mRNA21839799
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of TRPC6 mRNA20660070
D004958EstradiolEstradiol results in increased expression of TRPC6 mRNA21795739
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of TRPC6 mRNA25912373
C006780bisphenol Abisphenol A results in decreased expression of TRPC6 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of TRPC6 mRNA25181051
D002104CadmiumCadmium results in decreased activity of TRPC6 protein11179201
D002118CalciumCASR protein promotes the reaction [TRPC6 protein results in increased uptake of Calcium]21562303
D002118Calcium[Diglycerides results in increased activity of TRPC6 protein] which results in increased abundance of Calcium14551041
D002118Calcium[Flufenamic Acid results in increased activity of TRPC6 protein] which results in increased uptake of Calcium21562303
D002118CalciumTRPC6 protein affects the transport of Calcium18209485
D002118CalciumTRPC6 protein promotes the reaction [[VEGFA protein results in increased activity of KDR protein] which results in increased abundance of Calcium]14551041
D002118CalciumTRPC6 protein results in increased uptake of Calcium21562303
D002118CalciumVEGFA protein promotes the reaction [[Diglycerides results in increased activity of TRPC6 protein] which results in increased abundance of Calcium]14551041
D002118CalciumTRPC6 protein affects the transport of Calcium18209485
D002118CalciumTRPC6 protein results in increased transport of Calcium11179201
D002118Calcium1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
D002118Calcium1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
D002118Calcium"1,2-dioctanoylglycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]"11535132
D002118Calcium1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
D002118Calcium1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]11535132
D002118Calcium2-aminoethyl diphenylborinate inhibits the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
D002118Calcium2-aminoethyl diphenylborinate inhibits the reaction [Thapsigargin promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
D002118CalciumAcetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]11535132
D002118CalciumFlufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
D002118CalciumThapsigargin promotes the reaction [TRPC6 protein results in increased uptake of Calcium]11535132
D002118CalciumTRPC6 protein affects the transport of Calcium15672411
D002118CalciumTRPC6 protein promotes the reaction [1-oleoyl-2-acetoyl-sn-glycerol results in increased transport of Calcium]15672411
D002118CalciumTRPC6 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]15672411
D002118CalciumTRPC6 protein results in increased transport of Calcium18822394
D002118CalciumTRPC6 protein results in increased uptake of Calcium11535132
D002118CalciumTRPC1 protein inhibits the reaction [TRPC6 protein results in increased transport of Calcium]22157757
D002118CalciumTRPC6 protein affects the reaction [AGT protein results in increased import of Calcium]20177073
D002118CalciumTRPC6 protein results in increased transport of Calcium22157757
D002217Carbachol"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased activity of TRPC6 protein]"17603544
D002217CarbacholCarbachol results in increased activity of TRPC6 protein17603544
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TRPC6 mRNA16644059
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of TRPC6 mRNA24763279
D002509CephaloridineCephaloridine results in increased expression of TRPC6 mRNA18500788
D002586CesiumTRPC6 protein results in increased transport of Cesium11179201
D002737ChloropreneChloroprene results in decreased expression of TRPC6 mRNA23125180
D003471CuprizoneCuprizone results in decreased expression of TRPC6 mRNA26577399
D004075DiglyceridesDiglycerides results in increased activity of TRPC6 protein14551041
D004075Diglycerides[Diglycerides results in increased activity of TRPC6 protein] which results in increased abundance of Calcium14551041
D004075DiglyceridesVEGFA protein promotes the reaction [[Diglycerides results in increased activity of TRPC6 protein] which results in increased abundance of Calcium]14551041
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of TRPC6 mRNA"19480007
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [INS protein results in increased expression of TRPC6 protein]22031853
C007517diphenyleneiodoniumdiphenyleneiodonium results in decreased expression of TRPC6 protein22031853
D004317DoxorubicinDoxorubicin results in increased expression of TRPC6 protein28495616
D004317Doxorubicinsalvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of TRPC6 protein]28495616
C118739entinostatentinostat results in increased expression of TRPC6 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRPC6 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TRPC6 mRNA17351261
D005419FlavonoidsFlavonoids results in increased expression of TRPC6 mRNA18035473
D005439Flufenamic AcidFlufenamic Acid results in increased activity of TRPC6 protein14551041|2156230
D005439Flufenamic Acid[Flufenamic Acid results in increased activity of TRPC6 protein] which results in increased uptake of Calcium21562303
D005439Flufenamic AcidFlufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
D005439Flufenamic AcidFlufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]]11535132
C039281furanfuran results in increased expression of TRPC6 mRNA27387713
D005682GadoliniumGadolinium results in decreased activity of TRPC6 protein11179201
C001277geldanamycingeldanamycin results in increased expression of TRPC6 mRNA26705709
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of TRPC6 mRNA24763279
C023427guanosine 5'-O-(2-thiodiphosphate)guanosine 5'-O-(2-thiodiphosphate) results in decreased activity of TRPC6 protein11179201
D016244Guanosine 5'-O-(3-Thiotriphosphate)Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of TRPC6 protein11179201
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of TRPC6 protein22031853
D007501IronTRPC6 protein results in increased uptake of Iron14640978
C073601KT 5823"KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog results in increased phosphorylation of TRPC6 protein]"20177073
C073601KT 5823KT 5823 inhibits the reaction [8-bromocyclic GMP results in increased phosphorylation of TRPC6 protein]20177073
C073601KT 5823"KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein]]"20177073
C073601KT 5823"KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog results in increased phosphorylation of TRPC6 protein]"20177073
D007811LanthanumLanthanum results in decreased activity of TRPC6 protein11179201
D007811LanthanumLanthanum results in decreased activity of TRPC6 protein22031853
C008261lead acetatelead acetate results in increased expression of TRPC6 mRNA22613225
D008094LithiumTRPC6 protein results in increased transport of Lithium11179201
D008345ManganeseTRPC6 protein results in increased transport of Manganese11179201
D008345Manganese"1,2-dioctanoylglycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]"11535132
D008345Manganese1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]11535132
D008345ManganeseAcetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Manganese]11535132
D008345ManganeseFlufenamic Acid inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Manganese]]11535132
D008345ManganeseTRPC6 protein results in increased uptake of Manganese11535132
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [INS protein results in increased expression of TRPC6 protein]22031853
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin results in decreased expression of TRPC6 protein22031853
C070571ML 7ML 7 results in decreased activity of TRPC6 protein17603544
C056218ML 9ML 9 results in decreased activity of TRPC6 protein17603544
D009151Mustard GasMustard Gas results in increased expression of TRPC6 mRNA15674844
D009532NickelNickel affects the expression of TRPC6 mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of TRPC6 mRNA]14575637
D026423S-Nitroso-N-AcetylpenicillamineS-Nitroso-N-Acetylpenicillamine inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein]20177073
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of TRPC6 mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRPC6 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of TRPC6 mRNA26272509
D010656PhenylephrineTRPC6 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]15672411
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TRPC6 mRNA19710929
D011188PotassiumTRPC6 protein results in increased transport of Potassium11179201
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of TRPC6 mRNA20660070
D011374ProgesteroneProgesterone results in decreased expression of TRPC6 mRNA20726854
D011441PropylthiouracilPropylthiouracil results in increased expression of TRPC6 mRNA24780913
D017382Reactive Oxygen Species[AGT protein modified form results in increased abundance of Reactive Oxygen Species] which results in increased activity of TRPC6 protein24037962
C059514resveratrolresveratrol results in increased activity of TRPC6 protein23435869
D012413RubidiumTRPC6 protein results in increased transport of Rubidium11179201
C076944salvianolic acid Bsalvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of TRPC6 protein]28495616
D000068677Sildenafil CitrateSildenafil Citrate results in increased phosphorylation of TRPC6 protein20177073
D012964SodiumTRPC6 protein results in increased transport of Sodium11179201
C017947sodium arsenitesodium arsenite results in decreased expression of TRPC6 mRNA25493608
D053260SootSoot results in decreased expression of TRPC6 mRNA26551751
D013324StrontiumTRPC6 protein results in increased transport of Strontium11179201
D010042OuabainOuabain results in increased expression of TRPC6 protein19897708
D010042OuabainSLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]19897708
D010042OuabainTRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]19897708
D010042OuabainTRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]19897708|1989770
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRPC6 mRNA21570461
D019284Thapsigargin2-aminoethyl diphenylborinate inhibits the reaction [Thapsigargin promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]11535132
D019284ThapsigarginThapsigargin promotes the reaction [TRPC6 protein results in increased uptake of Calcium]11535132
C009495titanium dioxidetitanium dioxide results in increased expression of TRPC6 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of TRPC6 mRNA25729387
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of TRPC6 mRNA]14575637
C012589trichostatin Atrichostatin A results in increased expression of TRPC6 mRNA26705709
D014635Valproic AcidValproic Acid results in increased expression of TRPC6 mRNA24383497
C025643vinclozolinvinclozolin results in increased expression of TRPC6 mRNA23869203
C017967W 7W 7 results in decreased activity of TRPC6 protein17603544
D015029ZeranolZeranol results in increased expression of TRPC6 protein27224899

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005261cation channel activity-IDA19936226  23291369  
GO:0005262calcium channel activity-TAS-  
GO:0005515protein binding-IPI15757897  23171048  
GO:0015279store-operated calcium channel activity-IBA21873635  
GO:0030276clathrin binding-IEA-  
GO:0042803protein homodimerization activity-IDA23291369  
GO:0042805actinin binding-IEA-  
GO:0051117ATPase binding-IEA-  
GO:0070679inositol 1,4,5 trisphosphate binding-IBA21873635  
GO:0070679inositol 1,4,5 trisphosphate binding-IDA14505576  
GO ID GO Term Qualifier Evidence PubMed
GO:0006812cation transport-TAS9930701  
GO:0006828manganese ion transport-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-IEA-  
GO:0007338single fertilization-IBA21873635  
GO:0007568aging-IEA-  
GO:0010800positive regulation of peptidyl-threonine phosphorylation-IEA-  
GO:0030168platelet activation-TAS-  
GO:0030182neuron differentiation-IEA-  
GO:0032414positive regulation of ion transmembrane transporter activity-IDA10998353  
GO:0045666positive regulation of neuron differentiation-IEA-  
GO:0050774negative regulation of dendrite morphogenesis-IEA-  
GO:0051480regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0051928positive regulation of calcium ion transport-IDA10998353  
GO:0070301cellular response to hydrogen peroxide-IEA-  
GO:0070588calcium ion transmembrane transport-IBA21873635  
GO:0070588calcium ion transmembrane transport-TAS-  
GO:0071456cellular response to hypoxia-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA23171048  
GO:0005886plasma membrane-IDA10998353  23291369  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016020membrane-IDA23171048  
GO:0036057slit diaphragm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114508Effects of PIP2 hydrolysisTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-139853Elevation of cytosolic Ca2+ levelsTAS
R-HSA-162582Signal TransductionTAS
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-3295583TRP channelsTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373752Netrin-1 signalingIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-418346Platelet homeostasisTAS
R-HSA-418360Platelet calcium homeostasisTAS
R-HSA-418890Role of second messengers in netrin-1 signalingIEA
R-HSA-422475Axon guidanceIEA
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23840757Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer. (2013)Jiang HNPLoS One