Gene: TRPM2

7226
EREG1|KNP3|LTRPC2|LTrpC-2|NUDT9H|NUDT9L1|TRPC7
transient receptor potential cation channel subfamily M member 2
protein-coding
21q22.3
Ensembl:ENSG00000142185 MIM:603749 Vega:OTTHUMG00000040840 UniprotKB:O94759
NG_022913.1
PubMed
0   ANCO-SNPs
AD
1   
3.978e-1 (AD)  4.555e-2 (ND)   (Frontal_Cortex)
7.265e-1 (AD)  1.096e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RABGGTA0.929
LPCAT40.928
DGKQ0.924
GGT70.924
AP3B20.922
SLC9A10.917
TECPR10.917
TRIM30.916
ME30.915
SRRM30.915

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.552
RAI14-0.503
REST-0.501
WWTR1-0.498
HEY2-0.488
ZNF114-0.482
CNN2-0.48
MYL3-0.479
WEE1-0.477
ASB4-0.469

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of TRPM2 mRNA"21724226
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TRPM2 mRNA"21346803
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]18204483
C0859014-amylcinnamoylanthranilic acid4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]18204483
D000246Adenosine Diphosphate Ribose2-aminoethoxydiphenyl borate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]18204483
D000246Adenosine Diphosphate Ribose4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]18204483
D000246Adenosine Diphosphate RiboseAdenosine Diphosphate Ribose results in increased activity of TRPM2 protein18204483|2275000
D000246Adenosine Diphosphate RiboseCopper Sulfate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]22750002
D000246Adenosine Diphosphate Riboseferrous chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]22750002
D000246Adenosine Diphosphate Riboselead nitrate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]22750002
D000246Adenosine Diphosphate RiboseMercuric Chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]22750002
D000246Adenosine Diphosphate RiboseMiconazole inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]18204483
D000246Adenosine Diphosphate RiboseSelenium Oxides inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]22750002
D000246Adenosine Diphosphate RiboseTRPM2 protein promotes the reaction [Adenosine Diphosphate Ribose results in increased uptake of Calcium]20878536
D000246Adenosine Diphosphate RiboseAdenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]21900507
D000246Adenosine Diphosphate RiboseClotrimazole inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]21900507
D000246Adenosine Diphosphate RiboseFlufenamic Acid inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]21900507
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TRPM2 mRNA21298039
D001151ArsenicArsenic affects the methylation of TRPM2 gene25304211
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TRPM2 mRNA18804290
D002118CalciumTRPM2 protein affects the transport of Calcium16933200
D002118Calcium[Clotrimazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium]22036725
D002118Calcium[Econazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium]22036725
D002118CalciumTRPM2 protein affects the reaction [Mustard Gas results in increased abundance of Calcium]22036725
D002118CalciumTRPM2 protein results in increased transport of Calcium12529379
D002118CalciumTRPM2 protein promotes the reaction [Adenosine Diphosphate Ribose results in increased uptake of Calcium]20878536
D002118CalciumTRPM2 protein promotes the reaction [Hydrogen Peroxide results in increased uptake of Calcium]20878536
D002118CalciumAdenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]21900507
D002118CalciumCalcium affects the reaction [Hydrogen Peroxide promotes the reaction [TRPM2 protein results in increased transport of Calcium]]21900507
D002118CalciumClotrimazole inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]21900507
D002118CalciumFlufenamic Acid inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]21900507
D002118CalciumHydrogen Peroxide promotes the reaction [TRPM2 protein results in increased transport of Calcium]21900507
D002118CalciumTRPM2 protein results in increased transport of Calcium21900507
D003022Clotrimazole[Clotrimazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium]22036725
D003022ClotrimazoleClotrimazole inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]21900507
D003022ClotrimazoleClotrimazole results in decreased activity of TRPM2 protein18204483|2203672
D019327Copper SulfateCopper Sulfate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]22750002
D003471CuprizoneCuprizone results in increased expression of TRPM2 mRNA27523638
C014347decitabinedecitabine results in decreased expression of TRPM2 mRNA19194470
D004052Diethylnitrosamine[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TRPM2 mRNA16158176
D004464Econazole[Econazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium]22036725
D004464EconazoleEconazole results in decreased activity of TRPM2 protein22036725
C029451ferrous chlorideferrous chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]22750002
D005439Flufenamic AcidFlufenamic Acid inhibits the reaction [Hydrogen Peroxide results in increased activity of TRPM2 protein]16933200
D005439Flufenamic AcidFlufenamic Acid results in decreased activity of TRPM2 protein16933200
D005439Flufenamic AcidFlufenamic Acid inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]21900507
D005439Flufenamic AcidFlufenamic Acid results in decreased activity of TRPM2 protein22036725
D0150732-Acetylaminofluorene[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TRPM2 mRNA16158176
D006861Hydrogen PeroxideFlufenamic Acid inhibits the reaction [Hydrogen Peroxide results in increased activity of TRPM2 protein]16933200
D006861Hydrogen PeroxideHydrogen Peroxide results in increased activity of TRPM2 protein16933200
D006861Hydrogen PeroxideTRPM2 protein promotes the reaction [Hydrogen Peroxide results in increased uptake of Calcium]20878536
D006861Hydrogen PeroxideCalcium affects the reaction [Hydrogen Peroxide promotes the reaction [TRPM2 protein results in increased transport of Calcium]]21900507
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [TRPM2 protein results in increased transport of Calcium]21900507
D006861Hydrogen PeroxideHydrogen Peroxide results in increased activity of TRPM2 protein18204483
C017461lead nitratelead nitrate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]22750002
D008094LithiumLithium inhibits the reaction [Monensin results in increased expression of TRPM2 protein alternative form]20799912
D008627Mercuric ChlorideMercuric Chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]22750002
D008748MethylcholanthreneMethylcholanthrene results in increased expression of TRPM2 mRNA18804290
D008825MiconazoleMiconazole inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]18204483
D008985MonensinLithium inhibits the reaction [Monensin results in increased expression of TRPM2 protein alternative form]20799912
D008985MonensinMonensin results in decreased expression of TRPM2 protein alternative form20799912
D008985MonensinMonensin results in increased expression of TRPM2 protein alternative form20799912
D009151Mustard Gas[Clotrimazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium]22036725
D009151Mustard Gas[Econazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium]22036725
D009151Mustard GasTRPM2 protein affects the reaction [Mustard Gas results in increased abundance of Calcium]22036725
D009151Mustard GasTRPM2 protein affects the susceptibility to Mustard Gas22036725
D009966OrphenadrineOrphenadrine affects the expression of TRPM2 mRNA23665939
C006253pirinixic acidpirinixic acid results in decreased expression of TRPM2 mRNA20813756
D011441PropylthiouracilPropylthiouracil results in decreased expression of TRPM2 mRNA24780913
D012402RotenoneRotenone results in increased expression of TRPM2 mRNA23602965
D064588Selenium OxidesSelenium Oxides inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]22750002
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRPM2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TRPM2 mRNA21724226
D013853ThioacetamideThioacetamide results in decreased expression of TRPM2 mRNA23411599
D014635Valproic AcidValproic Acid results in increased methylation of TRPM2 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005261cation channel activity-IMP27068538  
GO:0005262calcium channel activity-TAS-  
GO:0005272sodium channel activity-IEA-  
GO:0005509calcium ion binding-IMP19171771  
GO:0015278calcium-release channel activity-IMP27068538  
GO:0016787hydrolase activityNOTIMP27383051  
GO:0099604ligand-gated calcium channel activity-IDA19171771  
GO ID GO Term Qualifier Evidence PubMed
GO:0001659temperature homeostasis-ISS-  
GO:0002407dendritic cell chemotaxis-ISS-  
GO:0006816calcium ion transport-TAS9806837  
GO:0014074response to purine-containing compound-IMP19171771  
GO:0035584calcium-mediated signaling using intracellular calcium source-ISS-  
GO:0035725sodium ion transmembrane transport-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0051209release of sequestered calcium ion into cytosol-IMP27068538  
GO:0051209release of sequestered calcium ion into cytosol-ISS-  
GO:0051489regulation of filopodium assembly-IMP27068538  
GO:0070301cellular response to hydrogen peroxide-IDA27068538  
GO:0070588calcium ion transmembrane transport-TAS-  
GO:0071277cellular response to calcium ion-IMP19171771  
GO:0071415cellular response to purine-containing compound-ISS-  
GO:0071502cellular response to temperature stimulus-ISS-  
GO:0071577zinc ion transmembrane transport-IMP27068538  
GO:0097028dendritic cell differentiation-ISS-  
GO:0097553calcium ion transmembrane import into cytosol-IMP19171771  27068538  
GO:0098703calcium ion import across plasma membrane-ISS-  
GO:2000249regulation of actin cytoskeleton reorganization-IMP27068538  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-IDA27068538  
GO:0005765lysosomal membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IMP19171771  
GO:0005887integral component of plasma membrane-ISS-  
GO:0030659cytoplasmic vesicle membrane-ISS-  
GO:0035579specific granule membrane-TAS-  
GO:0042995cell projection-IEA-  
GO:0043204perikaryon-IEA-  
GO:0070821tertiary granule membrane-TAS-  
GO:0101003ficolin-1-rich granule membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-3295583TRP channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29491840Neuropathic Pain: Delving into the Oxidative Origin and the Possible Implication of Transient Receptor Potential Channels. (2018)Carrasco CFront Physiol