Gene: TSC1

7248
LAM|TSC
TSC complex subunit 1
protein-coding
9q34.13
Ensembl:ENSG00000165699 MIM:605284 Vega:OTTHUMG00000020844 UniprotKB:Q92574
NG_012386.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.702e-1 (AD)  3.579e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC50.943
SUGP20.942
CLASP10.939
UNC13B0.939
SUPT7L0.936
GBF10.935
POGZ0.934
TNRC6A0.934
UBE4B0.933
HERC20.93

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.576
OR4F29-0.543
TFPI2-0.377
MDFI-0.373
C9orf135-0.362
AGTR1-0.358
CD8B-0.355
ZNF114-0.354
KLRC2-0.344
KLRB1-0.336

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of TSC1 mRNA"28903501
C07258116-hydroxycleroda-3,13(14)-dien-15,16-olide"16-hydroxycleroda-3,13(14)-dien-15,16-olide results in increased expression of TSC1 mRNA"21530604
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TSC1 mRNA"19114083
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of TSC1 mRNA19191707
D000082AcetaminophenAcetaminophen affects the expression of TSC1 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of TSC1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TSC1 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TSC1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TSC1 mRNA16483693
C545357antroquinonolantroquinonol promotes the reaction [TSC2 protein binds to TSC1 protein]19723512
D001104ArbutinArbutin results in increased expression of TSC1 mRNA17103032
D001280AtrazineAtrazine results in decreased expression of TSC1 mRNA22378314
D001374Azacitidine[Azacitidine affects the methylation of TSC1 promoter] which affects the expression of TSC1 mRNA18538015|1853801
C006780bisphenol Abisphenol A results in decreased expression of TSC1 mRNA21890461
C006780bisphenol Abisphenol A results in increased expression of TSC1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of TSC1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of TSC1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of TSC1 promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of TSC1 mRNA24752500
D002273CarcinogensCarcinogens results in decreased expression of TSC1 mRNA22269147
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of TSC1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TSC1 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of TSC1 mRNA19320972
C014347decitabinedecitabine affects the expression of TSC1 mRNA23300844
D002945CisplatinCisplatin affects the expression of TSC1 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of TSC1 mRNA25450742
D004008DiclofenacDiclofenac affects the expression of TSC1 mRNA24752500
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of TSC1 mRNA26924002
D004026DieldrinDieldrin affects the expression of TSC1 mRNA22546817
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of TSC1 mRNA24804967
C024629dimethyl phthalatedimethyl phthalate affects the expression of TSC1 mRNA26924002
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TSC1 mRNA17555576
C039281furanfuran results in increased methylation of TSC1 gene22079235
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of TSC1 mRNA22634610
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TSC1 mRNA21179406
C008261lead acetatelead acetate results in increased expression of TSC1 mRNA22609695
D008044LinuronLinuron results in increased expression of TSC1 mRNA28705778
C004925methylmercuric chloridemethylmercuric chloride affects the expression of TSC1 mRNA21613230
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TSC1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TSC1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TSC1 mRNA"25620056
D009532NickelNickel affects the expression of TSC1 mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of TSC1 mRNA]14575637
D010634PhenobarbitalPhenobarbital results in decreased expression of TSC1 mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of TSC1 mRNA23811191
D011374ProgesteroneProgesterone results in decreased expression of TSC1 mRNA20631399
C045950propiconazolepropiconazole results in decreased expression of TSC1 mRNA21278054
D011794QuercetinQuercetin results in increased expression of TSC1 mRNA14715546
C059514resveratrolTSC1 protein affects the reaction [resveratrol promotes the reaction [temozolomide results in decreased phosphorylation of MTOR protein]]22530672
D020123SirolimusSirolimus inhibits the reaction [TSC1 gene mutant form results in decreased phosphorylation of AKT1 protein]18495876
D020123SirolimusSirolimus inhibits the reaction [TSC1 gene mutant form results in decreased phosphorylation of GSK3B protein]18495876
D020123SirolimusSirolimus inhibits the reaction [TSC1 gene mutant form results in increased phosphorylation of RPS6KB1 protein]18495876
C017947sodium arsenitesodium arsenite results in increased expression of TSC1 mRNA16014739
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of TSC1 mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of TSC1 mRNA17555576
C047246temozolomideTSC1 protein affects the reaction [resveratrol promotes the reaction [temozolomide results in decreased phosphorylation of MTOR protein]]22530672
C047246temozolomideTSC1 protein affects the reaction [temozolomide results in decreased phosphorylation of MTOR protein]22530672
D013739Testosterone[AR mutant form co-treated with Testosterone] affects the expression of TSC1 protein21036700
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TSC1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TSC1 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TSC1 mRNA22298810
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of TSC1 mRNA]14575637
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TSC1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of TSC1 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of TSC1 mRNA19136453
D014638VanadatesVanadates results in decreased expression of TSC1 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9580671  9809973  10585443  15324660  17353931  17355907  
17658474  17693255  18381890  18692468  20368287  20412061  
21134130  25263562  
GO:0030544Hsp70 protein binding-IDA29127155  
GO:0032794GTPase activating protein binding-IEA-  
GO:0042030ATPase inhibitor activity-IDA29127155  
GO:0047485protein N-terminus binding-IPI10806479  12226091  
GO:0051087chaperone binding-IPI10585443  
GO:0051879Hsp90 protein binding-IPI29127155  
GO ID GO Term Qualifier Evidence PubMed
GO:0001822kidney development-IEA-  
GO:0001843neural tube closure-IEA-  
GO:0001952regulation of cell-matrix adhesion-IMP10806479  
GO:0002250adaptive immune response-IEA-  
GO:0006407rRNA export from nucleus-IMP17308101  
GO:0006417regulation of translation-IDA17308101  
GO:0006813potassium ion transport-IEA-  
GO:0007160cell-matrix adhesion-IMP10806479  
GO:0008285negative regulation of cell proliferation-IMP10915759  
GO:0008344adult locomotory behavior-ISS-  
GO:0010977negative regulation of neuron projection development-IEA-  
GO:0016239positive regulation of macroautophagy-IEA-  
GO:0016242negative regulation of macroautophagy-ISS-  
GO:0017148negative regulation of translation-IMP17308101  
GO:0021766hippocampus development-IEA-  
GO:0021987cerebral cortex development-IEA-  
GO:0030030cell projection organization-IEA-  
GO:0032007negative regulation of TOR signaling-IBA21873635  
GO:0032007negative regulation of TOR signaling-IMP17308101  28215400  
GO:0032007negative regulation of TOR signaling-ISS-  
GO:0032780negative regulation of ATPase activity-IDA29127155  
GO:0032868response to insulin-IDA16996505  
GO:0032956regulation of actin cytoskeleton organization-IBA21873635  
GO:0034260negative regulation of GTPase activity-IEA-  
GO:0042552myelination-IEA-  
GO:0043379memory T cell differentiation-IEA-  
GO:0043666regulation of phosphoprotein phosphatase activity-IMP17308101  
GO:0045792negative regulation of cell size-IEA-  
GO:0045859regulation of protein kinase activity-IEA-  
GO:0046323glucose import-IEA-  
GO:0046627negative regulation of insulin receptor signaling pathway-IBA21873635  
GO:0050808synapse organization-IEA-  
GO:0050821protein stabilization-IDA11175345  
GO:0050821protein stabilization-IMP29127155  
GO:0051291protein heterooligomerization-IEA-  
GO:0051492regulation of stress fiber assembly-IDA10806479  
GO:0051496positive regulation of stress fiber assembly-IEA-  
GO:0051726regulation of cell cycle-IBA21873635  
GO:0051894positive regulation of focal adhesion assembly-IDA10806479  
GO:0055007cardiac muscle cell differentiation-IEA-  
GO:0090630activation of GTPase activity-IDA10806479  
GO:0090650cellular response to oxygen-glucose deprivation-ISS-  
GO:1901214regulation of neuron death-ISS-  
GO:1903204negative regulation of oxidative stress-induced neuron death-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-IDA9580671  
GO:0005811lipid droplet-IDA-  
GO:0005829cytosol-IDA10585443  
GO:0005829cytosol-TAS-  
GO:0005884actin filamentcolocalizes_withIDA10806479  
GO:0005886plasma membrane-TAS-  
GO:0005938cell cortex-IDA10806479  
GO:0016020membrane-IDA16636147  
GO:0030027lamellipodium-IDA10806479  
GO:0030426growth cone-IEA-  
GO:0032991protein-containing complex-IDA10585443  
GO:0033596TSC1-TSC2 complex-IBA21873635  
GO:0033596TSC1-TSC2 complex-IDA9580671  
GO:0048471perinuclear region of cytoplasm-ISS-  
GO:0101031chaperone complex-IDA29127155  
KEGG ID KEGG Term
hsa04150mTOR signaling pathway
hsa04910Insulin signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1632852MacroautophagyTAS
R-HSA-165159mTOR signallingTAS
R-HSA-165181Inhibition of TSC complex formation by PKBTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-380972Energy dependent regulation of mTOR by LKB1-AMPKTAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8854214TBC/RABGAPsTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301399Tuberous Sclerosis Complex (1993)Northrup H-
27352265Bladder Cancer and Genetic Mutations. (2015 Sep)Zhang XCell Biochem Biophys
25484085Autophagy and ethanol neurotoxicity. (2014)Luo JAutophagy