Gene: TSC2

7249
LAM|PPP1R160|TSC4
TSC complex subunit 2
protein-coding
16p13.3
Ensembl:ENSG00000103197 MIM:191092 Vega:OTTHUMG00000128745 UniprotKB:P49815
NG_005895.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.785e-1 (AD)  5.794e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUL90.948
TUBGCP60.943
KIAA0895L0.943
PTPN230.942
INTS30.938
TBCD0.935
ANAPC20.933
ATP13A10.93
SH2B10.929
GBF10.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.627
OR4F29-0.59
AGTR1-0.395
C9orf135-0.362
TFPI2-0.346
ZNF114-0.344
CD48-0.343
PROK2-0.34
CD8B-0.339
ODAM-0.334

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5696701-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one"1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one results in decreased phosphorylation of TSC2 protein"22532600
C5696701-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one"[sunitinib co-treated with 1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one] results in decreased phosphorylation of TSC2 protein"22532600
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Azathioprine promotes the reaction [MAPK1 protein binds to TSC2 protein]]23958494
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Azathioprine promotes the reaction [MAPK3 protein binds to TSC2 protein]]23958494
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [TSC2 protein mutant form results in increased expression of EIF4EBP1 protein modified form]21813464
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [TSC2 protein mutant form results in increased expression of MAPK1 protein modified form]21813464
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [TSC2 protein mutant form results in increased expression of MAPK3 protein modified form]21813464
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FSHB protein results in increased phosphorylation of TSC2 protein]17510244
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TSC2 protein mutant form results in increased expression of CCND1 protein]21813464
C0787652,3,5-(triglutathion-S-yl)hydroquinone"2,3,5-(triglutathion-S-yl)hydroquinone results in increased mutagenesis of TSC2 gene"26333016
C0787652,3,5-(triglutathion-S-yl)hydroquinone"TSC2 protein affects the reaction [2,3,5-(triglutathion-S-yl)hydroquinone results in increased expression of BRAF protein]"21813464
C0787652,3,5-(triglutathion-S-yl)hydroquinone"TSC2 protein affects the reaction [2,3,5-(triglutathion-S-yl)hydroquinone results in increased expression of CCND1 protein]"21813464
C0787652,3,5-(triglutathion-S-yl)hydroquinone"TSC2 protein affects the reaction [2,3,5-(triglutathion-S-yl)hydroquinone results in increased expression of MAPK1 protein modified form]"21813464
C0787652,3,5-(triglutathion-S-yl)hydroquinone"TSC2 protein affects the reaction [2,3,5-(triglutathion-S-yl)hydroquinone results in increased expression of MAPK3 protein modified form]"21813464
C0787652,3,5-(triglutathion-S-yl)hydroquinone"TSC2 protein affects the reaction [2,3,5-(triglutathion-S-yl)hydroquinone results in increased expression of RAF1 protein]"21813464
C0787652,3,5-(triglutathion-S-yl)hydroquinone"[TSC2 protein mutant form co-treated with 2,3,5-(triglutathion-S-yl)hydroquinone] results in increased expression of EIF4EBP1 protein modified form"21813464
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TSC2 mRNA"21346803
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of TSC2 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSC2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSC2 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of TSC2 mRNA12419474
C0415944-nonylphenol4-nonylphenol results in decreased phosphorylation of TSC2 protein26804764|2804198
C0415944-nonylphenol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of TSC2 protein]"28041982
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of TSC2 mRNA14583596
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of TSC2 protein]"28041982
D000082AcetaminophenAcetaminophen results in decreased expression of TSC2 mRNA21420995|2669055
D000082AcetaminophenAcetaminophen results in increased expression of TSC2 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of TSC2 mRNA17562736
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of TSC2 mRNA25607892
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of TSC2 protein]21195169
D013196DihydrotestosteroneDihydrotestosterone inhibits the reaction [FSHB protein results in increased phosphorylation of TSC2 protein]17510244
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TSC2 mRNA16483693
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of TSC2 mRNA25607892
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TSC2 mRNA24449571
C545357antroquinonolantroquinonol promotes the reaction [TSC2 protein binds to TSC1 protein]19723512
D001151ArsenicArsenic affects the methylation of TSC2 gene25304211
D001374Azacitidine[Azacitidine affects the methylation of TSC2 promoter] which affects the expression of TSC2 mRNA18538015|1853801
D001374AzacitidineAzacitidine results in decreased methylation of TSC2 promoter19250671
D001374AzacitidineAzacitidine results in increased expression of TSC2 mRNA19250671
D001379Azathioprine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Azathioprine promotes the reaction [MAPK1 protein binds to TSC2 protein]]23958494
D001379Azathioprine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Azathioprine promotes the reaction [MAPK3 protein binds to TSC2 protein]]23958494
D001379AzathioprineAzathioprine promotes the reaction [MAPK1 protein binds to TSC2 protein]23958494
D001379AzathioprineAzathioprine promotes the reaction [MAPK3 protein binds to TSC2 protein]23958494
D001554BenzeneBenzene results in increased expression of TSC2 mRNA12928149
D001554BenzeneTRP53 protein affects the reaction [Benzene results in increased expression of TSC2 mRNA]12928149
C006780bisphenol Abisphenol A affects the expression of TSC2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of TSC2 mRNA21890461
C006780bisphenol Abisphenol A affects the expression of TSC2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of TSC2 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of TSC2 mRNA25607892
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of TSC2 mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of TSC2 mRNA27539358
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of TSC2 mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of TSC2 mRNA25607892
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TSC2 mRNA12160620
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of TSC2 protein]21195169
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of TSC2 promoter22457795
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of TSC2 protein21195169
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSC2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of TSC2 mRNA26272509
D003375CoumestrolCoumestrol results in decreased expression of TSC2 mRNA19167446
D003474CurcuminCurcumin results in decreased phosphorylation of TSC2 protein18790744
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of TSC2 mRNA25607892
D002945CisplatinCisplatin results in decreased expression of TSC2 mRNA25450742
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased activity of TSC2 protein21191146
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of TSC2 mRNA25607892
C000944dicrotophosdicrotophos results in increased expression of TSC2 mRNA28302478
D004026DieldrinDieldrin affects the expression of TSC2 mRNA22546817
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of TSC2 mRNA25607892
D004054DiethylstilbestrolTSC2 gene mutant form results in increased susceptibility to Diethylstilbestrol15937110
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of TSC2 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of TSC2 mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of TSC2 mRNA25607892
D005472FluorouracilFluorouracil results in increased expression of TSC2 mRNA16584549
C528328GSK690693GSK690693 results in decreased phosphorylation of TSC2 protein22532600
C528328GSK690693[sunitinib co-treated with GSK690693] results in decreased phosphorylation of TSC2 protein22532600
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of TSC2 mRNA12419474
D007854LeadLead affects the splicing of TSC2 mRNA28903495
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of TSC2 mRNA25607892
D008044LinuronLinuron results in increased expression of TSC2 mRNA28705778
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TSC2 mRNA12057914
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSC2 mRNA"27188386
D008727MethotrexateMethotrexate results in increased expression of TSC2 mRNA17400583
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TSC2 mRNA28001369
C044361M-VAC protocolTSC2 protein results in decreased susceptibility to M-VAC protocol15814643
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FSHB protein results in increased phosphorylation of TSC2 protein]17510244
C022838nickel chloridenickel chloride affects the expression of TSC2 mRNA22546817
C025256nonylphenolnonylphenol affects the expression of TSC2 mRNA27832966
C025589ochratoxin ATSC2 gene mutant form results in increased susceptibility to ochratoxin A17483316
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of TSC2 mRNA25607892
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of TSC2 mRNA25607892
D010100OxygenOxygen deficiency results in increased expression of TSC2 mRNA24205000
D010269ParaquatParaquat results in increased phosphorylation of TSC2 protein25092649
D010656PhenylephrinePhenylephrine results in increased phosphorylation of TSC2 protein15757502|1579532
D010656PhenylephrineSGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]15795328
D010656PhenylephrineU 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]15757502
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of TSC2 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of TSC2 mRNA25607892
D011441PropylthiouracilPropylthiouracil results in increased expression of TSC2 mRNA24780913
D011794QuercetinQuercetin results in increased expression of TSC2 mRNA14715546
C059514resveratrolresveratrol results in increased expression of TSC2 protein23292070
C059514resveratrolTSC2 gene mutant form promotes the reaction [[resveratrol co-treated with Sirolimus] results in decreased phosphorylation of RPS6 protein]24304514
C059514resveratrolTSC2 mutant form inhibits the reaction [resveratrol results in decreased phosphorylation of RPS6KB1 protein]23292070
C059514resveratrolTSC2 mutant form inhibits the reaction [resveratrol results in increased phosphorylation of GYS1 protein]23292070
C059514resveratrolTSC2 protein promotes the reaction [[[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6 protein]20169165
C059514resveratrol[resveratrol co-treated with Sirolimus] inhibits the reaction [TSC2 gene mutant form results in increased phosphorylation of EIF4B protein]24304514
C059514resveratrolresveratrol inhibits the reaction [Sirolimus inhibits the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1S1 protein]]24304514
C059514resveratrolresveratrol promotes the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1 protein]24304514
C059514resveratrolresveratrol promotes the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1S1 protein]24304514
C059514resveratrol[Sirolimus co-treated with resveratrol] inhibits the reaction [TSC2 gene mutant form results in increased phosphorylation of RPS6KB1 protein]24304514
C059514resveratrol[Sirolimus co-treated with resveratrol] promotes the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1 protein]24304514
C059514resveratrolTSC2 gene mutant form promotes the reaction [[Sirolimus co-treated with resveratrol] results in increased stability of PDCD4 protein]24304514
C059514resveratrolresveratrol inhibits the reaction [TSC2 protein results in decreased phosphorylation of RPS6KB1 protein]24304514
C059514resveratrolSirolimus inhibits the reaction [resveratrol inhibits the reaction [TSC2 protein results in decreased phosphorylation of RPS6KB1 protein]]24304514
C059514resveratrolTSC2 protein inhibits the reaction [resveratrol results in increased cleavage of PARP1 protein]24304514
C059514resveratrolTSC2 protein inhibits the reaction [[Sirolimus co-treated with resveratrol] results in increased cleavage of PARP1 protein]24304514
C089730rosiglitazonerosiglitazone results in increased phosphorylation of TSC2 protein17597835
C089730rosiglitazoneTSC2 mRNA affects the reaction [rosiglitazone results in decreased phosphorylation of RPS6KB1 protein]17597835
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of TSC2 mRNA21427059
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of TSC2 mRNA19244175
D012643SeleniumSelenium results in increased expression of TSC2 mRNA19244175
D020123SirolimusTSC2 gene mutant form promotes the reaction [[resveratrol co-treated with Sirolimus] results in decreased phosphorylation of RPS6 protein]24304514
D020123SirolimusTSC2 gene mutant form promotes the reaction [Sirolimus results in decreased phosphorylation of RPS6 protein]24304514
D020123Sirolimus[resveratrol co-treated with Sirolimus] inhibits the reaction [TSC2 gene mutant form results in increased phosphorylation of EIF4B protein]24304514
D020123Sirolimusresveratrol inhibits the reaction [Sirolimus inhibits the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1S1 protein]]24304514
D020123Sirolimus[Sirolimus co-treated with resveratrol] inhibits the reaction [TSC2 gene mutant form results in increased phosphorylation of RPS6KB1 protein]24304514
D020123Sirolimus[Sirolimus co-treated with resveratrol] promotes the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1 protein]24304514
D020123SirolimusSirolimus inhibits the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1 protein]24304514
D020123SirolimusSirolimus inhibits the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1S1 protein]24304514
D020123SirolimusSirolimus inhibits the reaction [TSC2 gene mutant form results in increased phosphorylation of EIF4B protein]24304514
D020123SirolimusSirolimus inhibits the reaction [TSC2 gene mutant form results in increased phosphorylation of RPS6KB1 protein]24304514
D020123SirolimusTSC2 gene mutant form promotes the reaction [[Sirolimus co-treated with resveratrol] results in increased stability of PDCD4 protein]24304514
D020123SirolimusSirolimus inhibits the reaction [resveratrol inhibits the reaction [TSC2 protein results in decreased phosphorylation of RPS6KB1 protein]]24304514
D020123SirolimusSirolimus inhibits the reaction [TSC2 gene mutant form results in increased expression of DDIT3 protein]19420259
D020123SirolimusSirolimus inhibits the reaction [TSC2 gene mutant form results in increased expression of ERO1A mRNA]19420259
D020123SirolimusSirolimus inhibits the reaction [TSC2 gene mutant form results in increased expression of HMOX1 protein]19420259
D020123SirolimusTSC2 protein inhibits the reaction [[Sirolimus co-treated with resveratrol] results in increased cleavage of PARP1 protein]24304514
C017947sodium arsenitesodium arsenite results in decreased expression of TSC2 mRNA12760830
C471405sorafenibsorafenib affects the reaction [TSC2 protein mutant form results in increased expression of EIF4EBP1 protein modified form]21813464
C471405sorafenibsorafenib affects the reaction [TSC2 protein mutant form results in increased expression of MAPK1 protein modified form]21813464
C471405sorafenibsorafenib affects the reaction [TSC2 protein mutant form results in increased expression of MAPK3 protein modified form]21813464
C471405sorafenibsorafenib inhibits the reaction [TSC2 protein mutant form results in increased expression of CCND1 protein]21813464
C473478sunitinib"[sunitinib co-treated with 1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one] results in decreased phosphorylation of TSC2 protein"22532600
C473478sunitinib[sunitinib co-treated with GSK690693] results in decreased phosphorylation of TSC2 protein22532600
C473478sunitinib[sunitinib co-treated with temsirolimus] results in decreased phosphorylation of TSC2 protein22532600
C401859temsirolimus[sunitinib co-treated with temsirolimus] results in decreased phosphorylation of TSC2 protein22532600
D013739Testosterone[AR mutant form co-treated with Testosterone] results in increased expression of TSC2 protein21036700
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TSC2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased phosphorylation of TSC2 protein23639626
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of TSC2 protein15757502
D013755Tetradecanoylphorbol AcetateU 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of TSC2 protein]15757502
C113580U 0126U 0126 inhibits the reaction [FSHB protein results in increased phosphorylation of TSC2 protein]17510244
C113580U 0126U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]15757502
C113580U 0126U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of TSC2 protein]15757502
D014635Valproic AcidValproic Acid results in increased methylation of TSC2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of TSC2 mRNA19136453|2142705
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TSC2 gene25560391
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of TSC2 mRNA25607892
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of TSC2 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of TSC2 mRNA19244175
C111237vorinostatTSC2 protein promotes the reaction [vorinostat results in increased cleavage of MAP1LC3B protein]17881280
D015032ZincZinc results in increased expression of TSC2 mRNA19071009

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IBA21873635  
GO:0005096GTPase activator activity-IDA9045618  
GO:0005515protein binding-IPI9580671  9809973  10585443  12176984  12364343  12438239  
12468542  12582162  15161933  15175323  15324660  16636147  
17353931  17693255  17979178  18381890  18692468  19389623  
20169078  20169165  20412061  20618440  21134130  24255178  
25263562  27451907  
GO:0019902phosphatase binding-IDA19389623  
GO:0031267small GTPase binding-IPI25936802  
GO:0042803protein homodimerization activity-IPI10585443  
GO:0051879Hsp90 protein binding-IPI29127155  
GO ID GO Term Qualifier Evidence PubMed
GO:0001843neural tube closure-ISS-  
GO:0006469negative regulation of protein kinase activity-ISS-  
GO:0006606protein import into nucleus-ISS-  
GO:0006897endocytosis-TAS9045618  
GO:0007507heart development-ISS-  
GO:0008104protein localization-ISS-  
GO:0008285negative regulation of cell proliferation-ISS-  
GO:0014067negative regulation of phosphatidylinositol 3-kinase signaling-ISS-  
GO:0016032viral process-IEA-  
GO:0016192vesicle-mediated transport-TAS9045618  
GO:0016239positive regulation of macroautophagy-IGI23778976  
GO:0030100regulation of endocytosis-ISS-  
GO:0030178negative regulation of Wnt signaling pathway-IBA21873635  
GO:0032007negative regulation of TOR signaling-IBA21873635  
GO:0032007negative regulation of TOR signaling-IGI23778976  
GO:0043276anoikis-IGI23778976  
GO:0043491protein kinase B signaling-ISS-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0046626regulation of insulin receptor signaling pathway-ISS-  
GO:0046627negative regulation of insulin receptor signaling pathway-IBA21873635  
GO:0048009insulin-like growth factor receptor signaling pathway-ISS-  
GO:0050918positive chemotaxis-ISS-  
GO:0051056regulation of small GTPase mediated signal transduction-IEA-  
GO:0051726regulation of cell cycle-IBA21873635  
GO:0051898negative regulation of protein kinase B signaling-IBA21873635  
GO:0051898negative regulation of protein kinase B signaling-ISS-  
GO:1901525negative regulation of mitophagy-NAS26735435  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA17114346  
GO:0005634nucleusNOTIDA16636147  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA9580671  16636147  
GO:0005737cytoplasmcolocalizes_withIDA17114346  
GO:0005764lysosome-IDA25936802  
GO:0005794Golgi apparatus-IDA8806680  
GO:0005794Golgi apparatusNOTIDA10585443  
GO:0005829cytosol-IDA10585443  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IDA16636147  
GO:0033596TSC1-TSC2 complex-IBA21873635  
GO:0033596TSC1-TSC2 complex-IDA9580671  
GO:0048471perinuclear region of cytoplasm-IDA8806680  
KEGG ID KEGG Term
hsa04115p53 signaling pathway
hsa04150mTOR signaling pathway
hsa04910Insulin signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1632852MacroautophagyTAS
R-HSA-1643685DiseaseTAS
R-HSA-165159mTOR signallingTAS
R-HSA-165181Inhibition of TSC complex formation by PKBTAS
R-HSA-198323AKT phosphorylates targets in the cytosolTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-380972Energy dependent regulation of mTOR by LKB1-AMPKTAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5674400Constitutive Signaling by AKT1 E17K in CancerTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8854214TBC/RABGAPsTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301399Tuberous Sclerosis Complex (1993)Northrup H-
24727895Differential involvement of gp130 signalling pathways in modulating tobacco carcinogen-induced lung tumourigenesis. (2015 Mar 19)Miller AOncogene
21751195Interactions between environmental factors and polymorphisms in angiogenesis pathway genes in esophageal adenocarcinoma risk: a case-only study. (2012 Feb 1)Zhai RCancer