Gene info: ID 7252

Gene: TSHB

GENE ID: 7252

Synonyms: TSH-B|TSH-BETA

Description: thyroid stimulating hormone beta

Gene type: protein-coding

Location: 1p13.2

dbXrefs: Ensembl:ENSG00000134200 MIM:188540 Vega:OTTHUMG00000011881 UniprotKB:P01222

RefSeq: NG_015891.1

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.240e-1 (AD) 4.693e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs1321108	chr1:115029744 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PRL	0.62
CGA	0.58
GH1	0.514
POMC	0.463
MAGEA2	0.454
KRT15	0.429
KRTAP19-6	0.428
EPS8L1	0.422
CAPNS2	0.419
CSTA	0.406

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PRSS33	-0.207
OR2L13	-0.193
DMRTC1B	-0.189
KRTAP5-11	-0.187
CLDN20	-0.186
PPIL6	-0.183
KLRG1	-0.18
IHH	-0.179
TBX10	-0.175
MAGEE2	-0.168

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [TSHB protein results in increased expression of TG protein]"	11078701
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl affects the expression of and affects the secretion of TSHB protein"	19750101
C500336	2,2',4,4',5-pentachlorobiphenyl	"2,2',4,4',5-pentachlorobiphenyl affects the expression of and affects the secretion of TSHB protein"	19750101
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TSHB mRNA"	22100034
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TSHB mRNA"	19079722
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[TSHB protein co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]	12639917
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[TSHB protein co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]	12639917
C067940	2,3,3',4,4'-pentachlorobiphenyl	"2,3,3',4,4'-pentachlorobiphenyl affects the expression of and affects the secretion of TSHB protein"	19750101
C070055	2,3',4,4',5-pentachlorobiphenyl	"2,3',4,4',5-pentachlorobiphenyl affects the expression of and affects the secretion of TSHB protein"	19750101
C541132	2,4,4',5-tetrachlorobiphenyl	"2,4,4',5-tetrachlorobiphenyl affects the expression of and affects the secretion of TSHB protein"	19750101
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of TSHB protein"	24878560
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TSHB protein"	17379623
C417190	4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine	"4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine results in increased expression of TSHB protein"	15673846\|1921161
C007294	4-methoxy-3-phenylenediamine	4-methoxy-3-phenylenediamine results in increased expression of TSHB protein	2462517\|2731155
C037112	9-deoxy-delta-9-prostaglandin D2	9-deoxy-delta-9-prostaglandin D2 promotes the reaction [TSHB protein results in increased expression of TG protein]	11078701
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [TSHB protein results in increased abundance of Hydrogen Peroxide]	11108245
D000242	Cyclic AMP	bisphenol A inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]	19766106
D000242	Cyclic AMP	"[Cobalt binds to dipyrido(3,2-a-2',3'-c)phenazine binds to N-(2-hydroxybenzyl)glycine analog] inhibits the reaction [TSHB protein results in increased abundance of Cyclic AMP]"	21072367
D000242	Cyclic AMP	Diethylstilbestrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]	19766106
D000242	Cyclic AMP	Estradiol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]	19766106
D000242	Cyclic AMP	resveratrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]	19766106
D000242	Cyclic AMP	TSHB protein inhibits the reaction [NCGC 00229600 inhibits the reaction [TSHR protein results in increased abundance of Cyclic AMP]]	21123444
D000242	Cyclic AMP	TSHB protein results in increased abundance of Cyclic AMP	21072367
D000242	Cyclic AMP	[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP	19766106
D000255	Adenosine Triphosphate	Adenosine Triphosphate inhibits the reaction [TSHB protein results in increased expression of SLC5A5 protein]	16439463
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of TSHB gene	27153756
C000188	alachlor	alachlor results in increased expression of TSHB protein	8812207
C008088	alfacalcidol	alfacalcidol promotes the reaction [Methimazole results in increased expression of TSHB protein]	9322804
C103303	alitretinoin	alitretinoin results in decreased expression of TSHB mRNA	16306084\|9092800
C103303	alitretinoin	alitretinoin results in decreased expression of TSHB protein	16306084
D000638	Amiodarone	Amiodarone results in increased expression of TSHB protein	1860199
D000638	Amiodarone	Amiodarone results in increased expression of TSHB mRNA	3427795
D000638	Amiodarone	Amiodarone results in increased expression of TSHB protein	12538616\|3427795
D000639	Amitriptyline	Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein]	6455462
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TSHB mRNA	16483693
C053506	ammonium perchlorate	ammonium perchlorate results in increased expression of TSHB protein	12140178\|1737962
C053506	ammonium perchlorate	[ammonium perchlorate results in increased expression of TSHB protein] which affects the abundance of Thyroid Hormones	12140178
C053506	ammonium perchlorate	ammonium perchlorate results in increased secretion of TSHB protein	20882593
D013956	Antithyroid Agents	Antithyroid Agents results in increased expression of TSHB mRNA	22571824
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of TSHB protein]	16298753
D001280	Atrazine	Atrazine results in increased expression of TSHB mRNA	25929836
D001285	Atropine	[pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein]	15891268
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of TSHB mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TSHB mRNA	21839799
D004958	Estradiol	Estradiol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]	19766106
D004958	Estradiol	Estradiol promotes the reaction [TRH protein results in increased secretion of TSHB protein]	16570238
C023888	beta-hexachlorocyclohexane	beta-hexachlorocyclohexane affects the expression of and affects the secretion of TSHB protein	19750101
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of TSHB mRNA	28167136
C006780	bisphenol A	bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of TSHB mRNA]	21684237
C006780	bisphenol A	bisphenol A results in increased expression of TSHB mRNA	21684237\|2210003
C006780	bisphenol A	bisphenol A inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]	19766106
C006780	bisphenol A	[bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased expression of TSHB mRNA	22828881
C006780	bisphenol A	[bisphenol A co-treated with Thyroxine] inhibits the reaction [CRH protein results in increased secretion of TSHB protein]	17959175
C006780	bisphenol A	[bisphenol A co-treated with Triiodothyronine] inhibits the reaction [CRH protein results in increased secretion of TSHB protein]	17959175
C006780	bisphenol A	bisphenol A inhibits the reaction [CRH protein results in increased secretion of TSHB protein]	17959175
C006780	bisphenol A	bisphenol A inhibits the reaction [TRH protein results in increased secretion of TSHB protein]	17959175
C006780	bisphenol A	bisphenol A results in decreased expression of TSHB mRNA	25181051\|2816713
C000611646	bisphenol F	bisphenol F results in decreased expression of TSHB mRNA	28167136
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased activity of TSHB protein	14751029
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased oxidation of TSHB protein	14751029
D002087	Butyrates	Butyrates results in increased expression of TSHB mRNA	14674679
D002104	Cadmium	Cadmium results in increased expression of TSHB mRNA	24521933
D002104	Cadmium	Cadmium results in decreased expression of TSHB mRNA	16948784
D002104	Cadmium	Melatonin inhibits the reaction [Cadmium results in decreased expression of TSHB mRNA]	16948784
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of TSHB mRNA	23085516
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of TSHB protein	20652474
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TSHB mRNA	16948784
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TSHB protein	26462792
D019256	Cadmium Chloride	Grape Seed Proanthocyanidins inhibits the reaction [Cadmium Chloride results in decreased expression of TSHB protein]	26462792
D019256	Cadmium Chloride	"[Hydrocarbons, Chlorinated co-treated with Cadmium Chloride co-treated with lead chloride] results in increased expression of TSHB protein"	12011480
D019256	Cadmium Chloride	Melatonin inhibits the reaction [Cadmium Chloride affects the expression of TSHB]	23085516
D019256	Cadmium Chloride	Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of TSHB mRNA]	16948784
D020111	Chlorodiphenyl (54% Chlorine)	Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of TSHB protein]	16298753
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of TSHB protein	16298753
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of TSHB protein	20655938
D020111	Chlorodiphenyl (54% Chlorine)	Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of TSHB protein]	16298753
D002994	Clofibrate	Clofibrate inhibits the reaction [Thyroxine results in decreased expression of TSHB protein]	18219302
D003035	Cobalt	"[Cobalt binds to dipyrido(3,2-a-2',3'-c)phenazine binds to N-(2-hydroxybenzyl)glycine analog] inhibits the reaction [TSHB protein results in increased abundance of Cyclic AMP]"	21072367
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Triiodothyronine inhibits the reaction [CRH protein results in increased secretion of TSHB protein]]	17959175
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Triiodothyronine inhibits the reaction [CRH protein results in increased secretion of TSHB protein]]	17959175
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of TSHB protein	20686340
D015230	Prostaglandin D2	Prostaglandin D2 promotes the reaction [TSHB protein results in increased expression of TG protein]	11078701
D003907	Dexamethasone	Dexamethasone promotes the reaction [Disulfiram results in decreased secretion of TSHB protein]	9681491
D003907	Dexamethasone	Dexamethasone results in increased secretion of TSHB protein	9681491
D003993	Dibutyl Phthalate	Dibutyl Phthalate affects the expression of TSHB mRNA	21544203
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene affects the expression of and affects the secretion of TSHB protein	19750101
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in decreased expression of TSHB mRNA	17056472
D003633	Dichlorodiphenyl Dichloroethylene	"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of TSHB protein"	24878560
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene affects the expression of TSHB mRNA	16764480
D003633	Dichlorodiphenyl Dichloroethylene	[Dichlorodiphenyl Dichloroethylene co-treated with Thyroxine] results in decreased expression of TSHB mRNA	16764480
D004041	Dietary Fats	Dietary Fats results in increased expression of TSHB protein	27260466
D004051	Diethylhexyl Phthalate	[bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased expression of TSHB mRNA	22828881
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TSHB protein	27565560
D004054	Diethylstilbestrol	Diethylstilbestrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]	19766106
C012457	diisopropanolnitrosamine	[diisopropanolnitrosamine co-treated with Potassium Iodide] results in increased expression of TSHB protein	29050248
D004147	Dioxins	Dioxins affects the expression of TSHB mRNA	20463971
D004147	Dioxins	Dioxins affects the expression of and affects the secretion of TSHB protein	19750101
C443808	dipyrido(3,2-a-2',3'-c)phenazine	"[Cobalt binds to dipyrido(3,2-a-2',3'-c)phenazine binds to N-(2-hydroxybenzyl)glycine analog] inhibits the reaction [TSHB protein results in increased abundance of Cyclic AMP]"	21072367
D004221	Disulfiram	Dexamethasone promotes the reaction [Disulfiram results in decreased secretion of TSHB protein]	9681491
D004221	Disulfiram	Disulfiram results in decreased secretion of TSHB protein	9681491
D007980	Levodopa	Levodopa results in decreased expression of TSHB protein	8867520
C098320	efavirenz	[efavirenz co-treated with TSHB protein] results in increased expression of SLC5A5 mRNA	16030158
C098320	efavirenz	[efavirenz co-treated with TSHB protein] results in increased expression of SLC5A5 protein	16030158
C098320	efavirenz	efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]	16030158
C098320	efavirenz	sodium perchlorate inhibits the reaction [efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]]	16030158
D015117	5,8,11,14-Eicosatetraynoic Acid	"5,8,11,14-Eicosatetraynoic Acid inhibits the reaction [TSHB protein results in increased expression of SLC5A5 mRNA]"	17962351
D004726	Endosulfan	Endosulfan results in decreased expression of TSHB mRNA	20471459
D004726	Endosulfan	Endosulfan results in decreased expression of TSHB protein	20471459
D004923	Erythrosine	Erythrosine promotes the reaction [TRH protein results in increased expression of TSHB protein]	2160137
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in increased expression of TSHB protein	16570238
D005031	Ethylenethiourea	Ethylenethiourea results in increased expression of TSHB mRNA	16837620
D005411	Flame Retardants	Flame Retardants results in increased expression of TSHB mRNA	19945756
D005411	Flame Retardants	Flame Retardants results in increased expression of TSHB mRNA	19079722
D015073	2-Acetylaminofluorene	TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TSHB mRNA]	17317680
D005472	Fluorouracil	Fluorouracil affects the expression of TSHB protein	17649788
D005473	Fluoxetine	Fluoxetine results in increased expression of TSHB mRNA	17033635
C010974	glyphosate	glyphosate results in decreased expression of TSHB protein	27916585
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins inhibits the reaction [Cadmium Chloride results in decreased expression of TSHB protein]	26462792
D006581	Hexachlorobenzene	Hexachlorobenzene affects the expression of and affects the secretion of TSHB protein	19750101
C409722	hexaconazole	hexaconazole results in increased expression of TSHB mRNA	23685399
D006843	Hydrocarbons, Chlorinated	"[Hydrocarbons, Chlorinated co-treated with Cadmium Chloride co-treated with lead chloride] results in increased expression of TSHB protein"	12011480
D006861	Hydrogen Peroxide	TSHB protein results in increased abundance of Hydrogen Peroxide	11108245
D006861	Hydrogen Peroxide	Acetylcysteine inhibits the reaction [TSHB protein results in increased abundance of Hydrogen Peroxide]	11108245
D006861	Hydrogen Peroxide	CAT protein inhibits the reaction [TSHB protein results in increased abundance of Hydrogen Peroxide]	11108245
D006861	Hydrogen Peroxide	pyrrolidine dithiocarbamic acid inhibits the reaction [TSHB protein results in increased abundance of Hydrogen Peroxide]	11108245
C082359	imidacloprid	[mancozeb co-treated with imidacloprid] results in increased expression of TSHB protein	24530807
D007454	Iodides	[Iodides deficiency co-treated with perchlorate] results in increased expression of TSHB protein	20439182
D007454	Iodides	Iodides deficiency results in increased expression of TSHB protein	18178547
D007455	Iodine	efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]	16030158
D007455	Iodine	Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]	16030158
D007455	Iodine	sodium perchlorate inhibits the reaction [efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]]	16030158
D007455	Iodine	sodium perchlorate inhibits the reaction [Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]]	16030158
D007455	Iodine	TSHB protein affects the abundance of Iodine	16030158
D007455	Iodine	Iodine deficiency results in increased secretion of TSHB protein	20882593
C008261	lead acetate	lead acetate results in decreased expression of TSHB protein	21871911
C008261	lead acetate	Thyroxine inhibits the reaction [lead acetate results in decreased expression of TSHB protein]	21871911
C029891	lead chloride	"[Hydrocarbons, Chlorinated co-treated with Cadmium Chloride co-treated with lead chloride] results in increased expression of TSHB protein"	12011480
C423914	LG 268	LG 268 results in decreased expression of TSHB mRNA	16306084
C423914	LG 268	LG 268 results in decreased expression of TSHB protein	16306084
C423914	LG 268	LG 268 results in decreased secretion of TSHB protein	16306084
C018584	linalool	linalool results in decreased expression of TSHB mRNA	20536181
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in decreased secretion of TSHB protein"	26298005
C440499	lipopolysaccharide, Escherichia coli O111 B4	"Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased secretion of TSHB protein]"	26298005
C013099	mancozeb	[mancozeb co-treated with imidacloprid] results in increased expression of TSHB protein	24530807
D009637	Masoprocol	Masoprocol inhibits the reaction [TSHB protein results in increased expression of SLC5A5 mRNA]	17962351
D008550	Melatonin	Melatonin inhibits the reaction [Cadmium Chloride affects the expression of TSHB]	23085516
D008550	Melatonin	Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of TSHB mRNA]	16948784
D008550	Melatonin	Melatonin inhibits the reaction [Cadmium results in decreased expression of TSHB mRNA]	16948784
C014655	methamidophos	methamidophos results in decreased expression of TSHB protein	15891268
C014655	methamidophos	[pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein]	15891268
D008713	Methimazole	Methimazole inhibits the reaction [TSHB protein results in increased secretion of Thyroxine]	20530234
D008713	Methimazole	alfacalcidol promotes the reaction [Methimazole results in increased expression of TSHB protein]	9322804
D008713	Methimazole	Methimazole results in increased expression of TSHB protein	9322804
D008713	Methimazole	Methimazole results in increased expression of TSHB protein	17332529
D008713	Methimazole	Methimazole results in decreased expression of TSHB mRNA	17399805
D008731	Methoxychlor	Methoxychlor affects the expression of TSHB protein	2925022
D008767	Methylmercury Compounds	[Methylmercury Compounds co-treated with Polychlorinated Biphenyls co-treated with Pesticides] results in increased expression of TSHB protein	19059321
D008779	Methylthiouracil	"Methylthiouracil inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased secretion of TSHB protein]"	26298005
C028577	monobutyl phthalate	monobutyl phthalate affects the expression of TSHB mRNA	21544203
C572868	N-(2-(3-chloro-5-(trifluoromethyl)-2-pyridyl)ethyl)-alpha,alpha,alpha-trifluoro-o-toluamide	"N-(2-(3-chloro-5-(trifluoromethyl)-2-pyridyl)ethyl)-alpha,alpha,alpha-trifluoro-o-toluamide results in increased expression of TSHB mRNA"	25455223
C572868	N-(2-(3-chloro-5-(trifluoromethyl)-2-pyridyl)ethyl)-alpha,alpha,alpha-trifluoro-o-toluamide	"NR1I2 protein affects the reaction [N-(2-(3-chloro-5-(trifluoromethyl)-2-pyridyl)ethyl)-alpha,alpha,alpha-trifluoro-o-toluamide results in increased expression of TSHB mRNA]"	25455223
C572868	N-(2-(3-chloro-5-(trifluoromethyl)-2-pyridyl)ethyl)-alpha,alpha,alpha-trifluoro-o-toluamide	"NR1I3 protein affects the reaction [N-(2-(3-chloro-5-(trifluoromethyl)-2-pyridyl)ethyl)-alpha,alpha,alpha-trifluoro-o-toluamide results in increased expression of TSHB mRNA]"	25455223
C403765	N-(2-hydroxybenzyl)glycine	"[Cobalt binds to dipyrido(3,2-a-2',3'-c)phenazine binds to N-(2-hydroxybenzyl)glycine analog] inhibits the reaction [TSHB protein results in increased abundance of Cyclic AMP]"	21072367
C556685	NCGC 00229600	TSHB protein inhibits the reaction [NCGC 00229600 inhibits the reaction [TSHR protein results in increased abundance of Cyclic AMP]]	21123444
D019829	Nevirapine	[Nevirapine co-treated with TSHB protein] results in increased expression of SLC5A5 mRNA	16030158
D019829	Nevirapine	[Nevirapine co-treated with TSHB protein] results in increased expression of SLC5A5 protein	16030158
D019829	Nevirapine	Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]	16030158
D019829	Nevirapine	sodium perchlorate inhibits the reaction [Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]]	16030158
D009566	Nitrates	Nitrates results in increased expression of TSHB protein	20439182
D016912	Levonorgestrel	Levonorgestrel results in increased expression of TSHB mRNA	21705715
C042670	N-vinyl-2-pyrrolidinone	[N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of TSHB protein	22037397
D015282	Octreotide	Octreotide inhibits the reaction [TRH protein affects the activity of TSHB protein]	1518433
D015282	Octreotide	Octreotide results in decreased secretion of TSHB protein	1518433\|1518435
C510603	Org 41841	Org 41841 analog inhibits the reaction [TSHB protein binds to and results in increased activity of TSHR protein]	18669595
C510603	Org 41841	Org 41841 analog inhibits the reaction [TSHB protein results in increased expression of TPO mRNA]	18669595
D010126	Ozone	[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of TSHB mRNA	25658374
C410127	PCB 180	PCB 180 affects the expression of and affects the secretion of TSHB protein	19750101
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of TSHB mRNA	22039834
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of TSHB mRNA	19945756
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of TSHB mRNA	24001430
C494474	perchlorate	perchlorate inhibits the reaction [TSHB protein results in increased secretion of Thyroxine]	20530234
C494474	perchlorate	[Iodides deficiency co-treated with perchlorate] results in increased expression of TSHB protein	20439182
C494474	perchlorate	perchlorate results in increased expression of TSHB protein	20439182
C494474	perchlorate	perchlorate results in increased expression of TSHB protein	17332529
C494474	perchlorate	perchlorate results in decreased expression of TSHB mRNA	17399805
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of TSHB mRNA	19703701
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of and results in decreased secretion of TSHB protein	19750101
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased secretion of TSHB protein	27219111
D010575	Pesticides	[Methylmercury Compounds co-treated with Polychlorinated Biphenyls co-treated with Pesticides] results in increased expression of TSHB protein	19059321
D010634	Phenobarbital	Phenobarbital results in decreased expression of TSHB protein	20932986
D010634	Phenobarbital	Phenobarbital results in increased expression of TSHB protein	22037397
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TSHB mRNA	19710929
D028321	Plant Preparations	Plant Preparations inhibits the reaction [TSHB protein binds to TSHR protein]	14759065
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls metabolite affects the expression of and affects the secretion of TSHB protein	19750101
D011078	Polychlorinated Biphenyls	[Methylmercury Compounds co-treated with Polychlorinated Biphenyls co-treated with Pesticides] results in increased expression of TSHB protein	19059321
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls results in increased expression of TSHB protein	19059321
D011193	Potassium Iodide	[diisopropanolnitrosamine co-treated with Potassium Iodide] results in increased expression of TSHB protein	29050248
C009006	potassium perchlorate	potassium perchlorate results in increased expression of TSHB mRNA	22571824
C028797	pralidoxime	[pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein]	15891268
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of TSHB protein	20421340\|2065593
C045362	prochloraz	prochloraz results in decreased expression of TSHB mRNA	21158436
C045362	prochloraz	prochloraz results in decreased expression of TSHB protein	12377983
D011441	Propylthiouracil	Propylthiouracil inhibits the reaction [TSHB protein results in increased secretion of Thyroxine]	20530234
D011441	Propylthiouracil	Propylthiouracil results in increased expression of TSHB mRNA	22571824
D011441	Propylthiouracil	Propylthiouracil results in increased expression of TSHB protein	15862623\|1905932
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of TSHB mRNA	17399805
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [TSHB protein results in increased abundance of Hydrogen Peroxide]	11108245
D011794	Quercetin	Quercetin inhibits the reaction [TSHB protein results in increased expression of SLC5A5 mRNA]	17962351
C059514	resveratrol	resveratrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]	19766106
C059514	resveratrol	resveratrol results in increased expression of TSHB protein	28668442
D012974	Sodium Iodide	BRAF protein mutant form affects the reaction [TSHB protein affects the reaction [vemurafenib affects the uptake of Sodium Iodide]]	26751190
D012974	Sodium Iodide	BRAF protein mutant form affects the reaction [TSHB protein affects the reaction [[vorinostat co-treated with vemurafenib] affects the uptake of Sodium Iodide]]	26751190
D012974	Sodium Iodide	TSHB protein affects the reaction [vemurafenib affects the uptake of Sodium Iodide]	26751190
D012974	Sodium Iodide	TSHB protein affects the reaction [vorinostat affects the uptake of Sodium Iodide]	26751190
D012974	Sodium Iodide	TSHB protein affects the reaction [[vorinostat co-treated with vemurafenib] affects the uptake of Sodium Iodide]	26751190
C031068	sodium perchlorate	sodium perchlorate inhibits the reaction [efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]]	16030158
C031068	sodium perchlorate	sodium perchlorate inhibits the reaction [Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]]	16030158
C031068	sodium perchlorate	sodium perchlorate results in increased expression of TSHB mRNA	16837620
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of TSHB mRNA	18175754
D012460	Sulfasalazine	Sulfasalazine results in increased secretion of TSHB protein	12587019
D014284	Triiodothyronine	Triiodothyronine results in decreased expression of TSHB mRNA	9356215
D014284	Triiodothyronine	bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of TSHB mRNA]	21684237
D014284	Triiodothyronine	Triiodothyronine results in decreased expression of TSHB mRNA	22571824
D014284	Triiodothyronine	Triiodothyronine results in increased expression of TSHB mRNA	21684237
D014284	Triiodothyronine	TSHB protein results in increased secretion of Triiodothyronine	11288978
D014284	Triiodothyronine	Triiodothyronine results in decreased expression of TSHB mRNA	11017775
D014284	Triiodothyronine	Triiodothyronine results in decreased expression of TSHB mRNA	9092800
D014284	Triiodothyronine	[bisphenol A co-treated with Triiodothyronine] inhibits the reaction [CRH protein results in increased secretion of TSHB protein]	17959175
D014284	Triiodothyronine	Cycloheximide inhibits the reaction [Triiodothyronine inhibits the reaction [CRH protein results in increased secretion of TSHB protein]]	17959175
D014284	Triiodothyronine	Dactinomycin inhibits the reaction [Triiodothyronine inhibits the reaction [CRH protein results in increased secretion of TSHB protein]]	17959175
D014284	Triiodothyronine	Triiodothyronine inhibits the reaction [CRH protein results in increased secretion of TSHB protein]	17959175
D014284	Triiodothyronine	Triiodothyronine results in decreased expression of TSHB mRNA	28167136\|7827627
C087114	tebuconazole	tebuconazole results in increased expression of TSHB mRNA	23685399
C020806	tetrabromobisphenol A	tetrabromobisphenol A affects the expression of TSHB mRNA	22100034
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TSHB mRNA	24793433
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TSHB protein	11836014
D013849	Thimerosal	Thimerosal results in increased expression of TSHB mRNA	24675092
D013849	Thimerosal	Thimerosal results in increased expression of TSHB protein	24675092
C031760	thiocyanate	thiocyanate results in increased expression of TSHB protein	20439182
D013890	Thiourea	Thiourea results in increased expression of TSHB mRNA	9356215
D013890	Thiourea	Thiourea results in increased expression of TSHB mRNA	17888916
D013890	Thiourea	Thyroxine inhibits the reaction [Thiourea results in increased expression of TSHB mRNA]	17888916
D013974	Thyroxine	Thyroxine results in decreased expression of TSHB mRNA	9356215
D013974	Thyroxine	Methimazole inhibits the reaction [TSHB protein results in increased secretion of Thyroxine]	20530234
D013974	Thyroxine	perchlorate inhibits the reaction [TSHB protein results in increased secretion of Thyroxine]	20530234
D013974	Thyroxine	Propylthiouracil inhibits the reaction [TSHB protein results in increased secretion of Thyroxine]	20530234
D013974	Thyroxine	TSHB protein results in increased secretion of Thyroxine	20530234
D013974	Thyroxine	Thyroxine results in decreased expression of TSHB mRNA	22571824
D013974	Thyroxine	[bisphenol A co-treated with Thyroxine] inhibits the reaction [CRH protein results in increased secretion of TSHB protein]	17959175
D013974	Thyroxine	Thyroxine inhibits the reaction [CRH protein results in increased secretion of TSHB protein]	17959175
D013974	Thyroxine	Clofibrate inhibits the reaction [Thyroxine results in decreased expression of TSHB protein]	18219302
D013974	Thyroxine	Thyroxine inhibits the reaction [lead acetate results in decreased expression of TSHB protein]	21871911
D013974	Thyroxine	Thyroxine results in decreased expression of TSHB protein	18219302
D013974	Thyroxine	[Dichlorodiphenyl Dichloroethylene co-treated with Thyroxine] results in decreased expression of TSHB mRNA	16764480
D013974	Thyroxine	Thyroxine results in decreased expression of TSHB mRNA	16764480
D013974	Thyroxine	Thyroxine inhibits the reaction [Thiourea results in increased expression of TSHB mRNA]	17888916
D013974	Thyroxine	Thyroxine results in decreased expression of TSHB mRNA	17403546
D013974	Thyroxine	Thyroxine results in increased expression of TSHB mRNA	17403546
D013963	Thyroid Hormones	[ammonium perchlorate results in increased expression of TSHB protein] which affects the abundance of Thyroid Hormones	12140178
D014112	Toxaphene	Toxaphene results in increased expression of TSHB protein	8933632
D014118	Toxins, Biological	"Toxins, Biological affects the expression of TSHB mRNA"	19682533
D014212	Tretinoin	Tretinoin inhibits the reaction [TSHB protein results in increased expression of SLC5A5 protein]	16439463
C032910	triadimefon	triadimefon results in increased expression of TSHB mRNA	22004968
D014274	Trifluralin	Trifluralin results in increased expression of and results in increased secretion of TSHB protein	18582544
C005445	triphenyl phosphate	triphenyl phosphate results in increased expression of TSHB mRNA	25646720
D014635	Valproic Acid	Valproic Acid results in decreased methylation of TSHB gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of TSHB gene	25560391
C551177	vemurafenib	BRAF protein mutant form affects the reaction [TSHB protein affects the reaction [vemurafenib affects the uptake of Sodium Iodide]]	26751190
C551177	vemurafenib	BRAF protein mutant form affects the reaction [TSHB protein affects the reaction [[vorinostat co-treated with vemurafenib] affects the uptake of Sodium Iodide]]	26751190
C551177	vemurafenib	TSHB protein affects the reaction [vemurafenib affects the uptake of Sodium Iodide]	26751190
C551177	vemurafenib	TSHB protein affects the reaction [[vorinostat co-treated with vemurafenib] affects the uptake of Sodium Iodide]	26751190
C551177	vemurafenib	BRAF protein mutant form affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of SLC5A5 mRNA]	26751190
C551177	vemurafenib	BRAF protein mutant form affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TG mRNA]	26751190
C551177	vemurafenib	BRAF protein mutant form affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TPO mRNA]	26751190
C551177	vemurafenib	BRAF protein mutant form affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TSHR mRNA]	26751190
C551177	vemurafenib	BRAF protein mutant form affects the reaction [vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of SLC5A5 mRNA]]	26751190
C551177	vemurafenib	BRAF protein mutant form affects the reaction [vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TG mRNA]]	26751190
C551177	vemurafenib	BRAF protein mutant form affects the reaction [vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TPO mRNA]]	26751190
C551177	vemurafenib	BRAF protein mutant form affects the reaction [vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TSHR mRNA]]	26751190
C551177	vemurafenib	[TSHB protein co-treated with vemurafenib] affects the expression of SLC5A5 mRNA	26751190
C551177	vemurafenib	[TSHB protein co-treated with vemurafenib] affects the expression of TG mRNA	26751190
C551177	vemurafenib	[TSHB protein co-treated with vemurafenib] affects the expression of TPO mRNA	26751190
C551177	vemurafenib	[TSHB protein co-treated with vemurafenib] affects the expression of TSHR mRNA	26751190
C551177	vemurafenib	TSHB protein promotes the reaction [[vemurafenib co-treated with vorinostat] results in increased expression of SLC5A5 protein]	26751190
C551177	vemurafenib	vorinostat affects the reaction [[BRAF protein mutant form affects the susceptibility to vemurafenib] affects the reaction [TSHB protein affects the expression of SLC5A5 mRNA]]	26751190
C551177	vemurafenib	vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of SLC5A5 mRNA]	26751190
C551177	vemurafenib	vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TG mRNA]	26751190
C551177	vemurafenib	vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TPO mRNA]	26751190
C551177	vemurafenib	vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TSHR mRNA]	26751190
D014700	Verapamil	Verapamil inhibits the reaction [TRH protein results in increased secretion of TSHB protein]	7851873
C025643	vinclozolin	vinclozolin results in decreased expression of TSHB protein	17980475
D014810	Vitamin E	Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of TSHB protein]	16298753
C111237	vorinostat	BRAF protein mutant form affects the reaction [TSHB protein affects the reaction [[vorinostat co-treated with vemurafenib] affects the uptake of Sodium Iodide]]	26751190
C111237	vorinostat	TSHB protein affects the reaction [vorinostat affects the uptake of Sodium Iodide]	26751190
C111237	vorinostat	TSHB protein affects the reaction [[vorinostat co-treated with vemurafenib] affects the uptake of Sodium Iodide]	26751190
C111237	vorinostat	BRAF protein mutant form affects the reaction [vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of SLC5A5 mRNA]]	26751190
C111237	vorinostat	BRAF protein mutant form affects the reaction [vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TG mRNA]]	26751190
C111237	vorinostat	BRAF protein mutant form affects the reaction [vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TPO mRNA]]	26751190
C111237	vorinostat	BRAF protein mutant form affects the reaction [vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TSHR mRNA]]	26751190
C111237	vorinostat	TSHB protein promotes the reaction [[vemurafenib co-treated with vorinostat] results in increased expression of SLC5A5 protein]	26751190
C111237	vorinostat	vorinostat affects the reaction [[BRAF protein mutant form affects the susceptibility to vemurafenib] affects the reaction [TSHB protein affects the expression of SLC5A5 mRNA]]	26751190
C111237	vorinostat	vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of SLC5A5 mRNA]	26751190
C111237	vorinostat	vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TG mRNA]	26751190
C111237	vorinostat	vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TPO mRNA]	26751190
C111237	vorinostat	vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TSHR mRNA]	26751190
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of TSHB"	26950620
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in decreased expression of TSHB protein"	25179371

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005179	hormone activity	CONTRIBUTES_TO	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007186	G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007267	cell-cell signaling	-	TAS	2792087
GO:0009653	anatomical structure morphogenesis	-	TAS	2792087
GO:0009755	hormone-mediated signaling pathway	-	IBA	21873635
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0016486	peptide hormone processing	-	TAS	-
GO:0033189	response to vitamin A	-	IEA	-
GO:0043627	response to estrogen	-	IEA	-
GO:0051592	response to calcium ion	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005737	cytoplasm	-	IBA	21873635

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction
hsa05320	Autoimmune thyroid disease

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-209776	Amine-derived hormones	TAS
R-HSA-209822	Glycoprotein hormones	TAS
R-HSA-209952	Peptide hormone biosynthesis	TAS
R-HSA-209968	Thyroxine biosynthesis	TAS
R-HSA-2980736	Peptide hormone metabolism	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375281	Hormone ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal