Gene: TSHR

7253
CHNG1|LGR3|hTSHR-I
thyroid stimulating hormone receptor
protein-coding
14q31.1
Ensembl:ENSG00000165409 MIM:603372 Vega:OTTHUMG00000171429 UniprotKB:P16473
NG_009206.1
PubMed
0   ANCO-SNPs
ND
21   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.656e-1 (AD)  8.288e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18625627chr14:81426015TSHR8.200e-13Smoking27651444
cg13525276chr14:81426012TSHR5.400e-10Smoking27651444
cg13525276chr14:81426012TSHR3.340e-14Smoking28686328
cg18625627chr14:81426015TSHR8.570e-13Smoking28686328
cg10825315chr14:81425912TSHR5.730e-11Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFF30.77
TG0.77
IYD0.76
TPO0.757
FOXE10.737
KRT70.71
SLC26A70.69
WDR720.654
DIO10.643
CCL210.619

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GDPD2-0.35
LGI4-0.344
SORCS2-0.324
RAB41-0.322
RHCG-0.318
CNGA4-0.316
CRB2-0.312
IZUMO4-0.312
LDHD-0.304
DUSP9-0.303

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00024Thyrotropin AlfaBiotechDrug194100-83-9ApprovedTarget
ID Drug Name Action PubMed
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of TSHR mRNA"24375616
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TSHR protein"22889935
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TSHR mRNA"22889935
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TSHR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TSHR mRNA"27188386
C5805996-OH-BDE-476-OH-BDE-47 results in decreased expression of TSHR mRNA23110413
D000082AcetaminophenAcetaminophen results in decreased expression of TSHR mRNA15976192
D020106AcrylamideAcrylamide results in decreased expression of TSHR mRNA28959563
D000242Cyclic AMPbisphenol A inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]19766106
D000242Cyclic AMPDiethylstilbestrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]19766106
D000242Cyclic AMPEstradiol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]19766106
D000242Cyclic AMPNCGC 00229600 inhibits the reaction [TSHR protein results in increased abundance of Cyclic AMP]21123444
D000242Cyclic AMPresveratrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]19766106
D000242Cyclic AMPTSHB protein inhibits the reaction [NCGC 00229600 inhibits the reaction [TSHR protein results in increased abundance of Cyclic AMP]]21123444
D000242Cyclic AMP[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP19766106
D000242Cyclic AMPTSHR protein results in increased abundance of Cyclic AMP21123444
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TSHR gene27153756
D0150812-Naphthylamine2-Naphthylamine results in increased expression of TSHR mRNA18247414
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TSHR mRNA16483693
D001374AzacitidineAzacitidine results in increased expression of TSHR mRNA17679169
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TSHR mRNA18247414
D004958EstradiolEstradiol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]19766106
D004958EstradiolEstradiol results in decreased expression of TSHR mRNA19484750
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of TSHR mRNA27685785
C006780bisphenol Abisphenol A inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]19766106
C006780bisphenol Abisphenol A results in decreased expression of TSHR mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of TSHR mRNA23238275
D001761BleomycinBleomycin results in decreased expression of TSHR mRNA15808516
C032036bromobenzenebromobenzene results in decreased expression of TSHR mRNA15976192
C032036bromobenzenebromobenzene results in increased expression of TSHR mRNA12628495
D002101Cacodylic AcidCacodylic Acid results in decreased expression of TSHR mRNA16122865
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of TSHR mRNA15976192
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) binds to and results in decreased activity of TSHR protein17062616
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased activity of TSHR protein14759065
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of TSHR mRNA18178546
D002994ClofibrateClofibrate results in increased expression of TSHR mRNA16896063
D003035Cobalt"[Cobalt binds to dipyrido(3,2-a-2',3'-c)phenazine binds to N-(2-hydroxybenzyl)glycine analog] which binds to and affects the localization of and results in increased cleavage of TSHR protein"21072367
D003035Cobalt"TSHR protein results in increased susceptibility to [Cobalt binds to dipyrido(3,2-a-2',3'-c)phenazine binds to N-(2-hydroxybenzyl)glycine analog]"21072367
D003471CuprizoneCuprizone results in decreased expression of TSHR mRNA26577399
D003634DDTDDT binds to and results in decreased activity of TSHR protein17062616
D003634DDTDDT results in decreased activity of TSHR protein14759065
D003634DDTDDT results in decreased localization of TSHR protein19214582
D003634DDTDDT affects the activity of TSHR protein21466821
D003634DDTDDT affects the localization of TSHR protein21466821
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TSHR mRNA15620428
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TSHR mRNA21266533
D004054DiethylstilbestrolDiethylstilbestrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]19766106
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of TSHR mRNA15976192
C443808dipyrido(3,2-a-2',3'-c)phenazine"[Cobalt binds to dipyrido(3,2-a-2',3'-c)phenazine binds to N-(2-hydroxybenzyl)glycine analog] which binds to and affects the localization of and results in increased cleavage of TSHR protein"21072367
C443808dipyrido(3,2-a-2',3'-c)phenazine"TSHR protein results in increased susceptibility to [Cobalt binds to dipyrido(3,2-a-2',3'-c)phenazine binds to N-(2-hydroxybenzyl)glycine analog]"21072367
D004237DiuronDiuron results in increased expression of TSHR mRNA21551480|2515243
C098320efavirenzefavirenz results in increased expression of TSHR mRNA16030158
C039281furanfuran results in increased expression of TSHR mRNA25539665
D017313FenretinideFenretinide results in decreased expression of TSHR mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TSHR mRNA22802445
D008713MethimazoleMethimazole results in decreased expression of TSHR mRNA22342233
D008713MethimazoleMethimazole results in increased expression of TSHR mRNA22342233
D008713MethimazoleMethimazole results in increased expression of TSHR mRNA22342233
C403765N-(2-hydroxybenzyl)glycine"[Cobalt binds to dipyrido(3,2-a-2',3'-c)phenazine binds to N-(2-hydroxybenzyl)glycine analog] which binds to and affects the localization of and results in increased cleavage of TSHR protein"21072367
C403765N-(2-hydroxybenzyl)glycine"TSHR protein results in increased susceptibility to [Cobalt binds to dipyrido(3,2-a-2',3'-c)phenazine binds to N-(2-hydroxybenzyl)glycine analog]"21072367
C556685NCGC 00229600NCGC 00229600 inhibits the reaction [TSHR protein results in increased abundance of Cyclic AMP]21123444
C556685NCGC 00229600NCGC 00229600 results in decreased activity of TSHR protein21123444
C556685NCGC 00229600NCGC 00229600 results in decreased expression of TSHR mRNA21123444
C556685NCGC 00229600TSHB protein inhibits the reaction [NCGC 00229600 inhibits the reaction [TSHR protein results in increased abundance of Cyclic AMP]]21123444
D019829NevirapineNevirapine results in increased expression of TSHR mRNA16030158
D009532NickelNickel results in decreased expression of TSHR mRNA24768652|2558310
D009538NicotineNicotine results in increased expression of TSHR mRNA18247414
C025256nonylphenolnonylphenol results in decreased expression of TSHR mRNA15620428
C510603Org 41841Org 41841 analog binds to and results in decreased activity of TSHR protein18669595
C510603Org 41841Org 41841 analog inhibits the reaction [TSHB protein binds to and results in increased activity of TSHR protein]18669595
C510603Org 41841Org 41841 binds to and results in increased activity of TSHR protein16488885
C510603Org 41841Org 41841 binds to TSHR protein16789744
D010852PicrotoxinPicrotoxin results in increased expression of TSHR mRNA15170462
D028321Plant PreparationsPlant Preparations inhibits the reaction [TSHB protein binds to TSHR protein]14759065
D028321Plant PreparationsPlant Preparations results in decreased activity of TSHR protein14759065
D011441PropylthiouracilPropylthiouracil results in increased expression of TSHR mRNA22342233
D011794QuercetinQuercetin results in decreased expression of TSHR mRNA24447974
D011794QuercetinQuercetin results in decreased expression of TSHR protein24447974
C059514resveratrolresveratrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]19766106
C059514resveratrolresveratrol results in decreased expression of TSHR mRNA28668442
C059514resveratrolresveratrol results in decreased expression of TSHR protein28668442
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TSHR mRNA18178546
D013853ThioacetamideThioacetamide results in decreased expression of TSHR mRNA15976192
D013974ThyroxineThyroxine results in decreased activity of TSHR protein17332529
D014212TretinoinTretinoin results in decreased expression of TSHR mRNA17679169
C032910triadimefontriadimefon results in increased expression of TSHR mRNA16643972
C012589trichostatin Atrichostatin A results in increased expression of TSHR mRNA17679169
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of TSHR mRNA25646720
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in increased expression of TSHR mRNA26547027
D014635Valproic AcidValproic Acid results in decreased methylation of TSHR gene29154799
D014635Valproic AcidValproic Acid affects the expression of TSHR mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TSHR gene25560391
C551177vemurafenibBRAF protein mutant form affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TSHR mRNA]26751190
C551177vemurafenibBRAF protein mutant form affects the reaction [vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TSHR mRNA]]26751190
C551177vemurafenib[BRAF protein mutant form affects the susceptibility to vemurafenib] which affects the expression of TSHR mRNA26751190
C551177vemurafenib[TSHB protein co-treated with vemurafenib] affects the expression of TSHR mRNA26751190
C551177vemurafenibvorinostat affects the reaction [[BRAF protein mutant form affects the susceptibility to vemurafenib] which affects the expression of TSHR mRNA]26751190
C551177vemurafenibvorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TSHR mRNA]26751190
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of TSHR mRNA25423262
C111237vorinostatBRAF protein mutant form affects the reaction [vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TSHR mRNA]]26751190
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TSHR mRNA"27188386
C111237vorinostatvorinostat affects the reaction [[BRAF protein mutant form affects the susceptibility to vemurafenib] which affects the expression of TSHR mRNA]26751190
C111237vorinostatvorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TSHR mRNA]26751190
C111237vorinostatvorinostat results in increased expression of TSHR mRNA26272509|2675119

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004996thyroid-stimulating hormone receptor activity-IBA21873635  
GO:0004996thyroid-stimulating hormone receptor activity-IMP11847099  
GO:0005515protein binding-IPI15775968  
GO:0008528G-protein coupled peptide receptor activity-IBA21873635  
GO:0038023signaling receptor activity-IMP12045258  
GO:0044877protein-containing complex binding-IDA12045258  
GO ID GO Term Qualifier Evidence PubMed
GO:0007166cell surface receptor signaling pathway-IMP12045258  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-TAS8552586  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007190activation of adenylate cyclase activity-IBA21873635  
GO:0007267cell-cell signaling-TAS7920658  
GO:0008284positive regulation of cell proliferation-TAS7920658  
GO:0009755hormone-mediated signaling pathway-IBA21873635  
GO:0038194thyroid-stimulating hormone signaling pathway-IMP11847099  
GO:0045762positive regulation of adenylate cyclase activity-IMP11847099  
GO:1904588cellular response to glycoprotein-IMP12045258  
GO:1905229cellular response to thyrotropin-releasing hormone-IMP11847099  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-IDA11847099  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS8552586  
GO:0009986cell surface-ISS-  
GO:0016323basolateral plasma membrane-IDA11847099  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
hsa05320Autoimmune thyroid disease
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375281Hormone ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
11704996Pathogenesis of ophthalmopathy in autoimmune thyroid disease. (2000 Jan)Heufelder AERev Endocr Metab Disord
29689681[Interaction between cigarette smoking and glucocorticoids therapy and therapeutic doses of radioiodine (131I) in patients with Graves' disease]. (2016)Plazinska MTPrzegl Lek
23105486Autoimmune thyroid disorders-An update. (2005 Jan)Swain MIndian J Clin Biochem
11068483[Clinical epidemiology of Basedow's disease in Belgium]. (2000 Sep)Glinoer DRev Med Brux
26567024Pathogenesis of thyroid eye disease: review and update on molecular mechanisms. (2016 Jan)Khong JJBr J Ophthalmol
23685424The influence of radioiodine therapy on ocular changes and their relation to urine cotinine level in patients with Graves' Ophthalmopathy. (2013)Czarnywojtek ANeuro Endocrinol Lett
23421108[The etiology of Graves' disease--current state of knowledge]. (2012)Hen KPrzegl Lek
11041456Limited genetic susceptibility to severe Graves' ophthalmopathy: no role for CTLA-4 but evidence for an environmental etiology. (2000 Sep)Villanueva RThyroid
25231450Thyroid autoimmunity. (2014)Wiersinga WMEndocr Dev
22242199Genetic factors of autoimmune thyroid diseases in Japanese. (2012)Ban YAutoimmune Dis
10821321Genetic and environmental factors in the aetiology of simple goitre. (2000 Apr)Brix THAnn Med
22399514Increased expression of TSH receptor by fibrocytes in thyroid-associated ophthalmopathy leads to chemokine production. (2012 May)Gillespie EFJ Clin Endocrinol Metab
24289805rs3827440, a nonsynonymous single nucleotide polymorphism within GPR174 gene in X chromosome, is associated with Graves' disease in Polish Caucasian population. (2014 Jan)Szymanski KTissue Antigens
11593897[Interactions of fibroblasts, adipocytes and immunocompeent cells in the pathogenesis of endocrine ophthalmopathy]. (2001)Heufelder AEActa Med Austriaca
10980691Thyroid-associated eye disease. (2000 Jun)Heufelder AEStrabismus
26361262Current Insights into the Pathogenesis of Graves' Ophthalmopathy. (2015 Sep)Bahn RSHorm Metab Res
11331213Effects of l-thyroxine administration, TSH-receptor antibodies and smoking on the risk of recurrence in Graves' hyperthyroidism treated with antithyroid drugs: a double-blind prospective randomized study. (2001 May)Glinoer DEur J Endocrinol
29093229The Role of Cytotoxic T-lymphocyte-associated Protein 4 (CTLA-4) Gene, Thyroid Stimulating Hormone Receptor (TSHR) Gene and Regulatory T-cells as Risk Factors for Relapse in Patients with Graves Disease. (2017 Jul)Eliana FActa Med Indones
19530272Current insights into the pathogenesis of Graves' orbitopathy. (2009 Jun)Eckstein AKHorm Metab Res
29325864Infections, genetic and environmental factors in pathogenesis of autoimmune thyroid diseases. (2018 Mar)Shukla SKMicrob Pathog
24779222[Classification and etiology of hyperthyroidism]. (2014 Mar)Lacka KPol Merkur Lekarski